//Created by libAntimony v2.4 model vempati_model_2007__environment(time_) // Variable initializations: time_ = ; end model vempati_model_2007__v1(v1, pM9, M3, M3_pM9, kon_M3pM9, koff_M3pM9) // Assignment Rules: v1 := kon_M3pM9 * M3 * pM9 - koff_M3pM9 * M3_pM9; // Variable initializations: pM9 = ; M3 = ; M3_pM9 = ; kon_M3pM9 = ; koff_M3pM9 = ; end model vempati_model_2007__v2(v2, M3_pM9, kact_M3pM9) // Assignment Rules: v2 := kact_M3pM9 * M3_pM9; // Variable initializations: M3_pM9 = ; kact_M3pM9 = ; end model vempati_model_2007__v3(v3, M3_T1, M3, T1, kon_M3T1, koff_M3T1) // Assignment Rules: v3 := kon_M3T1 * M3 * T1 - koff_M3T1 * M3_T1; // Variable initializations: M3_T1 = ; M3 = ; T1 = ; kon_M3T1 = ; koff_M3T1 = ; end model vempati_model_2007__v4(v4, pM9_T1, pM9, T1, kon_pM9T1, koff_pM9T1) // Assignment Rules: v4 := kon_pM9T1 * pM9 * T1 - koff_pM9T1 * pM9_T1; // Variable initializations: pM9_T1 = ; pM9 = ; T1 = ; kon_pM9T1 = ; koff_pM9T1 = ; end model vempati_model_2007__v5(v5, pM9_T1, M3, M3_pM9_T1, kon_M3pM9T1, koff_M3pM9T1) // Assignment Rules: v5 := kon_M3pM9T1 * pM9_T1 * M3 - koff_M3pM9T1 * M3_pM9_T1; // Variable initializations: pM9_T1 = ; M3 = ; M3_pM9_T1 = ; kon_M3pM9T1 = ; koff_M3pM9T1 = ; end model vempati_model_2007__v6(v6, M3_pM9_T1, kact_M3pM9T1) // Assignment Rules: v6 := kact_M3pM9T1 * M3_pM9_T1; // Variable initializations: M3_pM9_T1 = ; kact_M3pM9T1 = ; end model vempati_model_2007__v7(v7, M9_T1_star, T1, M9, kon_M9T1_star, koff_M9T1_star) // Assignment Rules: v7 := kon_M9T1_star * T1 * M9 - koff_M9T1_star * M9_T1_star; // Variable initializations: M9_T1_star = ; T1 = ; M9 = ; kon_M9T1_star = ; koff_M9T1_star = ; end model vempati_model_2007__v8(v8, M9_T1_star, M9_T1, kon_M9T1, koff_M9T1) // Assignment Rules: v8 := kon_M9T1 * M9_T1_star - koff_M9T1 * M9_T1; // Variable initializations: M9_T1_star = ; M9_T1 = ; kon_M9T1 = ; koff_M9T1 = ; end model vempati_model_2007__v9(v9, M9_T1_M3, M9, M3_T1, kon_M9_M3T1, koff_M9_M3T1) // Assignment Rules: v9 := kon_M9_M3T1 * M9_T1_M3 - koff_M9_M3T1 * M9 * M3_T1; // Variable initializations: M9_T1_M3 = ; M9 = ; M3_T1 = ; kon_M9_M3T1 = ; koff_M9_M3T1 = ; end model vempati_model_2007__v10(v10, pM9_T1, M3, pM9_T1_M3, kon_M3_pM9T1, koff_M3_pM9T1) // Assignment Rules: v10 := kon_M3_pM9T1 * pM9_T1 * M3 - koff_M3_pM9T1 * pM9_T1_M3; // Variable initializations: pM9_T1 = ; M3 = ; pM9_T1_M3 = ; kon_M3_pM9T1 = ; koff_M3_pM9T1 = ; end model vempati_model_2007__v11(v11, pM9, M3_T1, pM9_T1_M3, kon_pM9T1M3, koff_pM9T1M3) // Assignment Rules: v11 := kon_pM9T1M3 * pM9 * M3_T1 - koff_pM9T1M3 * pM9_T1_M3; // Variable initializations: pM9 = ; M3_T1 = ; pM9_T1_M3 = ; kon_pM9T1M3 = ; koff_pM9T1M3 = ; end model vempati_model_2007__v12(v12, M3, pM9_T1_M3, M3_pM9_T1_M3, kon_M3pM9T1M3, koff_M3pM9T1M3) // Assignment Rules: v12 := kon_M3pM9T1M3 * M3 * pM9_T1_M3 - koff_M3pM9T1M3 * M3_pM9_T1_M3; // Variable initializations: M3 = ; pM9_T1_M3 = ; M3_pM9_T1_M3 = ; kon_M3pM9T1M3 = ; koff_M3pM9T1M3 = ; end model vempati_model_2007__v13(v13, M3_pM9_T1_M3, kact_M3pM9T1M3) // Assignment Rules: v13 := kact_M3pM9T1M3 * M3_pM9_T1_M3; // Variable initializations: M3_pM9_T1_M3 = ; kact_M3pM9T1M3 = ; end model vempati_model_2007__v14(v14, M9_T1_M3, kact_M9T1M3) // Assignment Rules: v14 := kact_M9T1M3 * M9_T1_M3; // Variable initializations: M9_T1_M3 = ; kact_M9T1M3 = ; end model vempati_model_2007__v15(v15, pM9, Tr, Tr_pM9, kon_TrpM9, koff_TrpM9) // Assignment Rules: v15 := kon_TrpM9 * Tr * pM9 - koff_TrpM9 * Tr_pM9; // Variable initializations: pM9 = ; Tr = ; Tr_pM9 = ; kon_TrpM9 = ; koff_TrpM9 = ; end model vempati_model_2007__v16(v16, Tr_pM9, kact_TrpM9) // Assignment Rules: v16 := kact_TrpM9 * Tr_pM9; // Variable initializations: Tr_pM9 = ; kact_TrpM9 = ; end model vempati_model_2007__v17(v17, pM9_T1, Tr, Tr_pM9_T1, kon_TrpM9T1, koff_TrpM9T1) // Assignment Rules: v17 := kon_TrpM9T1 * pM9_T1 * Tr - koff_TrpM9T1 * Tr_pM9_T1; // Variable initializations: pM9_T1 = ; Tr = ; Tr_pM9_T1 = ; kon_TrpM9T1 = ; koff_TrpM9T1 = ; end model vempati_model_2007__v18(v18, Tr_pM9_T1, kact_TrpM9T1) // Assignment Rules: v18 := kact_TrpM9T1 * Tr_pM9_T1; // Variable initializations: Tr_pM9_T1 = ; kact_TrpM9T1 = ; end model vempati_model_2007__v19(v19, Tr, pM9_T1_M3, Tr_pM9_T1_M3, kon_TrpM9T1M3, koff_TrpM9T1M3) // Assignment Rules: v19 := kon_TrpM9T1M3 * Tr * pM9_T1_M3 - koff_TrpM9T1M3 * Tr_pM9_T1_M3; // Variable initializations: Tr = ; pM9_T1_M3 = ; Tr_pM9_T1_M3 = ; kon_TrpM9T1M3 = ; koff_TrpM9T1M3 = ; end model vempati_model_2007__v20(v20, Tr_pM9_T1_M3, kact_TrpM9T1M3) // Assignment Rules: v20 := kact_TrpM9T1M3 * Tr_pM9_T1_M3; // Variable initializations: Tr_pM9_T1_M3 = ; kact_TrpM9T1M3 = ; end model vempati_model_2007__pM9(pM9, v1, v4, v15, v11, time_) // Rate Rules: pM9' = -(v1 + v4 + v15 + v11); // Variable initializations: pM9 = 3e-7; v1 = ; v4 = ; v15 = ; v11 = ; time_ = ; end model vempati_model_2007__M3(M3, v1, v2, v3, v5, v6, v10, v12, v13, v14, time_) // Rate Rules: M3' = (v2 + v6 + v13 + v14) - (v1 + v3 + v5 + v10 + v12); // Variable initializations: M3 = 5e-8; v1 = ; v2 = ; v3 = ; v5 = ; v6 = ; v10 = ; v12 = ; v13 = ; v14 = ; time_ = ; end model vempati_model_2007__M3_pM9(M3_pM9, v1, v2, time_) // Rate Rules: M3_pM9' = v1 - v2; // Variable initializations: M3_pM9 = 0; v1 = ; v2 = ; time_ = ; end model vempati_model_2007__T1(T1, v3, v4, v7, time_) // Rate Rules: T1' = -(v3 + v4 + v7); // Variable initializations: T1 = 3e-7; v3 = ; v4 = ; v7 = ; time_ = ; end model vempati_model_2007__M3_T1(M3_T1, v3, v9, v11, time_) // Rate Rules: M3_T1' = (v3 + v9) - v11; // Variable initializations: M3_T1 = 0; v3 = ; v9 = ; v11 = ; time_ = ; end model vempati_model_2007__pM9_T1(pM9_T1, v4, v5, v10, v17, time_) // Rate Rules: pM9_T1' = v4 - (v5 + v10 + v17); // Variable initializations: pM9_T1 = 0; v4 = ; v5 = ; v10 = ; v17 = ; time_ = ; end model vempati_model_2007__M3_pM9_T1(M3_pM9_T1, v5, v6, time_) // Rate Rules: M3_pM9_T1' = v5 - v6; // Variable initializations: M3_pM9_T1 = 0; v5 = ; v6 = ; time_ = ; end model vempati_model_2007__M9_T1_star(M9_T1_star, v7, v14, v8, time_) // Rate Rules: M9_T1_star' = (v7 + v14) - v8; // Variable initializations: M9_T1_star = 0; v7 = ; v14 = ; v8 = ; time_ = ; end model vempati_model_2007__M9(M9, v2, v7, v9, v16, time_) // Rate Rules: M9' = (v2 + v9 + v16) - v7; // Variable initializations: M9 = 0; v2 = ; v7 = ; v9 = ; v16 = ; time_ = ; end model vempati_model_2007__M9_T1(M9_T1, v8, v18, time_) // Rate Rules: M9_T1' = v8 + v18; // Variable initializations: M9_T1 = 0; v8 = ; v18 = ; time_ = ; end model vempati_model_2007__pM9_T1_M3(pM9_T1_M3, v10, v11, v12, v19, time_) // Rate Rules: pM9_T1_M3' = (v10 + v11) - (v12 + v19); // Variable initializations: pM9_T1_M3 = 0; v10 = ; v11 = ; v12 = ; v19 = ; time_ = ; end model vempati_model_2007__M3_pM9_T1_M3(M3_pM9_T1_M3, v13, v12, time_) // Rate Rules: M3_pM9_T1_M3' = v12 - v13; // Variable initializations: M3_pM9_T1_M3 = 0; v13 = ; v12 = ; time_ = ; end model vempati_model_2007__M9_T1_M3(M9_T1_M3, v9, v13, v14, v20, time_) // Rate Rules: M9_T1_M3' = (v13 + v20) - (v14 + v9); // Variable initializations: M9_T1_M3 = 0; v9 = ; v13 = ; v14 = ; v20 = ; time_ = ; end model vempati_model_2007__Tr(Tr, v15, v16, v17, v18, v19, v20, time_) // Rate Rules: Tr' = (v16 + v18 + v20) - (v15 + v17 + v19); // Variable initializations: Tr = 1e-7; v15 = ; v16 = ; v17 = ; v18 = ; v19 = ; v20 = ; time_ = ; end model vempati_model_2007__Tr_pM9(Tr_pM9, v15, v16, time_) // Rate Rules: Tr_pM9' = v15 - v16; // Variable initializations: Tr_pM9 = 0; v15 = ; v16 = ; time_ = ; end model vempati_model_2007__Tr_pM9_T1(Tr_pM9_T1, v17, v18, time_) // Rate Rules: Tr_pM9_T1' = v17 - v18; // Variable initializations: Tr_pM9_T1 = 0; v17 = ; v18 = ; time_ = ; end model vempati_model_2007__Tr_pM9_T1_M3(Tr_pM9_T1_M3, v19, v20, time_) // Rate Rules: Tr_pM9_T1_M3' = v19 - v20; // Variable initializations: Tr_pM9_T1_M3 = 0; v19 = ; v20 = ; time_ = ; end model vempati_model_2007__kinetic_parameters(kon_pM9T1, koff_pM9T1, kon_pM9T1M3, koff_pM9T1M3, kon_M3pM9, koff_M3pM9, kon_M3pM9T1, koff_M3pM9T1, kon_M3pM9T1M3, koff_M3pM9T1M3, kon_M3T1, koff_M3T1, kon_M9T1_star, koff_M9T1_star, kon_M9T1, koff_M9T1, kon_M3_pM9T1, koff_M3_pM9T1, kon_TrpM9, koff_TrpM9, kon_TrpM9T1, koff_TrpM9T1, kon_TrpM9T1M3, koff_TrpM9T1M3, kon_M9_M3T1, koff_M9_M3T1, kact_M3pM9T1, kact_M3pM9T1M3, kact_M9T1M3, kact_TrpM9, kact_TrpM9T1, kact_TrpM9T1M3, kact_M3pM9) // Variable initializations: kon_pM9T1 = 3.4e4; koff_pM9T1 = 7.48e-5; kon_pM9T1M3 = 3.4e4; koff_pM9T1M3 = 7.48e-5; kon_M3pM9 = 1e4; koff_M3pM9 = 0.001; kon_M3pM9T1 = 1e4; koff_M3pM9T1 = 0.001; kon_M3pM9T1M3 = 1e4; koff_M3pM9T1M3 = 0.001; kon_M3T1 = 1.9e6; koff_M3T1 = 1.26e-4; kon_M9T1_star = 5.6e6; koff_M9T1_star = 1.6e-5; kon_M9T1 = 6.3e-4; koff_M9T1 = 2.5e-4; kon_M3_pM9T1 = 1.9e6; koff_M3_pM9T1 = 1.26e-4; kon_TrpM9 = 1e4; koff_TrpM9 = 0.007; kon_TrpM9T1 = 1e4; koff_TrpM9T1 = 0.007; kon_TrpM9T1M3 = 1e4; koff_TrpM9T1M3 = 0.007; kon_M9_M3T1 = 7.48e-5; koff_M9_M3T1 = 3.4e4; kact_M3pM9T1 = 0.00057; kact_M3pM9T1M3 = 0.00057; kact_M9T1M3 = 1.26e-4; kact_TrpM9 = 0.002; kact_TrpM9T1 = 0.0006; kact_TrpM9T1M3 = 0.0006; kact_M3pM9 = 0.0019; end model *vempati_model_2007____main() // Sub-modules, and any changes to those submodules: environment: vempati_model_2007__environment(time_); v1: vempati_model_2007__v1(v110, pM90, M30, M3_pM90, kon_M3pM9, koff_M3pM9); v2: vempati_model_2007__v2(v21, M3_pM90, kact_M3pM9); v3: vempati_model_2007__v3(v30, M3_T10, M30, T10, kon_M3T1, koff_M3T1); v4: vempati_model_2007__v4(v40, pM9_T10, pM90, T10, kon_pM9T1, koff_pM9T1); v5: vempati_model_2007__v5(v50, pM9_T10, M30, M3_pM9_T10, kon_M3pM9T1, koff_M3pM9T1); v6: vempati_model_2007__v6(v60, M3_pM9_T10, kact_M3pM9T1); v7: vempati_model_2007__v7(v70, M9_T1_star0, T10, M90, kon_M9T1_star, koff_M9T1_star); v8: vempati_model_2007__v8(v80, M9_T1_star0, M9_T10, kon_M9T1, koff_M9T1); v9: vempati_model_2007__v9(v90, M9_T1_M30, M90, M3_T10, kon_M9_M3T1, koff_M9_M3T1); v10: vempati_model_2007__v10(v100, pM9_T10, M30, pM9_T1_M30, kon_M3_pM9T1, koff_M3_pM9T1); v11: vempati_model_2007__v11(v111, pM90, M3_T10, pM9_T1_M30, kon_pM9T1M3, koff_pM9T1M3); v12: vempati_model_2007__v12(v120, M30, pM9_T1_M30, M3_pM9_T1_M30, kon_M3pM9T1M3, koff_M3pM9T1M3); v13: vempati_model_2007__v13(v130, M3_pM9_T1_M30, kact_M3pM9T1M3); v14: vempati_model_2007__v14(v140, M9_T1_M30, kact_M9T1M3); v15: vempati_model_2007__v15(v150, pM90, Tr0, Tr_pM90, kon_TrpM9, koff_TrpM9); v16: vempati_model_2007__v16(v160, Tr_pM90, kact_TrpM9); v17: vempati_model_2007__v17(v170, pM9_T10, Tr0, Tr_pM9_T10, kon_TrpM9T1, koff_TrpM9T1); v18: vempati_model_2007__v18(v180, Tr_pM9_T10, kact_TrpM9T1); v19: vempati_model_2007__v19(v190, Tr0, pM9_T1_M30, Tr_pM9_T1_M30, kon_TrpM9T1M3, koff_TrpM9T1M3); v20: vempati_model_2007__v20(v200, Tr_pM9_T1_M30, kact_TrpM9T1M3); pM9: vempati_model_2007__pM9(pM90, v110, v40, v150, v111, time_); M3: vempati_model_2007__M3(M30, v110, v21, v30, v50, v60, v100, v120, v130, v140, time_); M3_pM9: vempati_model_2007__M3_pM9(M3_pM90, v110, v21, time_); T1: vempati_model_2007__T1(T10, v30, v40, v70, time_); M3_T1: vempati_model_2007__M3_T1(M3_T10, v30, v90, v111, time_); pM9_T1: vempati_model_2007__pM9_T1(pM9_T10, v40, v50, v100, v170, time_); M3_pM9_T1: vempati_model_2007__M3_pM9_T1(M3_pM9_T10, v50, v60, time_); M9_T1_star: vempati_model_2007__M9_T1_star(M9_T1_star0, v70, v140, v80, time_); M9: vempati_model_2007__M9(M90, v21, v70, v90, v160, time_); M9_T1: vempati_model_2007__M9_T1(M9_T10, v80, v180, time_); pM9_T1_M3: vempati_model_2007__pM9_T1_M3(pM9_T1_M30, v100, v111, v120, v190, time_); M3_pM9_T1_M3: vempati_model_2007__M3_pM9_T1_M3(M3_pM9_T1_M30, v130, v120, time_); M9_T1_M3: vempati_model_2007__M9_T1_M3(M9_T1_M30, v90, v130, v140, v200, time_); Tr: vempati_model_2007__Tr(Tr0, v150, v160, v170, v180, v190, v200, time_); Tr_pM9: vempati_model_2007__Tr_pM9(Tr_pM90, v150, v160, time_); Tr_pM9_T1: vempati_model_2007__Tr_pM9_T1(Tr_pM9_T10, v170, v180, time_); Tr_pM9_T1_M3: vempati_model_2007__Tr_pM9_T1_M3(Tr_pM9_T1_M30, v190, v200, time_); kinetic_parameters: vempati_model_2007__kinetic_parameters(kon_pM9T1, koff_pM9T1, kon_pM9T1M3, koff_pM9T1M3, kon_M3pM9, koff_M3pM9, kon_M3pM9T1, koff_M3pM9T1, kon_M3pM9T1M3, koff_M3pM9T1M3, kon_M3T1, koff_M3T1, kon_M9T1_star, koff_M9T1_star, kon_M9T1, koff_M9T1, kon_M3_pM9T1, koff_M3_pM9T1, kon_TrpM9, koff_TrpM9, kon_TrpM9T1, koff_TrpM9T1, kon_TrpM9T1M3, koff_TrpM9T1M3, kon_M9_M3T1, koff_M9_M3T1, kact_M3pM9T1, kact_M3pM9T1M3, kact_M9T1M3, kact_TrpM9, kact_TrpM9T1, kact_TrpM9T1M3, kact_M3pM9); end