//Created by libAntimony v2.4 model ueda_2001__environment(time_) // Variable initializations: time_ = ; end model ueda_2001__Per_m(Per_m, PT_n, CC_n, time_, D0, a, r) // Rate Rules: Per_m' = (C1 + S1 * ((power(CC_n / A1, a) + B1) / (1.0 + power(PT_n / R1, r) + power(CC_n / A1, a) + B1))) - (D1 * (Per_m / (L1 + Per_m)) + D0 * Per_m); // Variable initializations: Per_m = 0.5; B1 = 0.0; C1 = 0.0; S1 = 1.45; D1 = 0.94; L1 = 0.3; R1 = 1.02; A1 = 0.45; PT_n = ; CC_n = ; time_ = ; D0 = ; a = ; r = ; end model ueda_2001__Per_c(Per_c, V1, V2, Per_m, Tim_c, PT_c, time_, D0) // Rate Rules: Per_c' = (S2 * Per_m + V2 * PT_c) - (V1 * Per_c * Tim_c + D2 * Dbt_c * (Per_c / (L2 + Per_c)) + D0 * Per_c); // Variable initializations: Per_c = 0.6; S2 = 0.48; D2 = 0.44; L2 = 0.2; Dbt_c = 1.0; V1 = ; V2 = ; Per_m = ; Tim_c = ; PT_c = ; time_ = ; D0 = ; end model ueda_2001__Tim_m(Tim_m, PT_n, CC_n, time_, D0, a, r) // Rate Rules: Tim_m' = (C2 + S3 * ((power(CC_n / A2, a) + B2) / (1.0 + power(PT_n / R2, r) + power(CC_n / A2, a) + B2))) - (D3 * (Tim_m / (L3 + Tim_m)) + D0 * Tim_m); // Variable initializations: Tim_m = 0.7; B2 = 0.0; C2 = 0.0; S3 = 1.45; D3 = 0.94; L3 = 0.3; R2 = 1.02; A2 = 0.45; PT_n = ; CC_n = ; time_ = ; D0 = ; a = ; r = ; end model ueda_2001__Tim_c(Tim_c, V1, V2, Tim_m, Per_c, PT_c, time_, D0) // Rate Rules: Tim_c' = (S4 * Tim_m + V2 * PT_c) - (V1 * Per_c * Tim_c + D4 * (Tim_c / (L4 + Tim_c)) + D0 * Tim_c); // Variable initializations: Tim_c = 0.8; S4 = 0.48; D4 = 0.44; L4 = 0.2; V1 = ; V2 = ; Tim_m = ; Per_c = ; PT_c = ; time_ = ; D0 = ; end model ueda_2001__PT_c(PT_c, K1, K2, T1, T2, V1, V2, Tim_c, Per_c, PT_n, time_, D0) // Rate Rules: PT_c' = (V1 * Per_c * Tim_c + T2 * (PT_n / (K2 + PT_n))) - (V2 * PT_c + T1 * (PT_c / (K1 + PT_c)) + D5 * (PT_c / (L5 + PT_c)) + D0 * PT_c); // Variable initializations: PT_c = 0.9; D5 = 0.44; L5 = 0.2; K1 = ; K2 = ; T1 = ; T2 = ; V1 = ; V2 = ; Tim_c = ; Per_c = ; PT_n = ; time_ = ; D0 = ; end model ueda_2001__PT_n(PT_n, K1, K2, T1, T2, PT_c, time_, D0) // Rate Rules: PT_n' = T1 * (PT_c / (K1 + PT_c)) - (T2 * (PT_n / (K2 + PT_n)) + D6 * (PT_n / (L6 + PT_n)) + D0 * PT_n); // Variable initializations: PT_n = 1.0; D6 = 0.29; L6 = 0.2; K1 = ; K2 = ; T1 = ; T2 = ; PT_c = ; time_ = ; D0 = ; end model ueda_2001__Clk_m(Clk_m, CC_n, PT_n, time_, D0, a, r) // Rate Rules: Clk_m' = (C3 + S5 * ((power(PT_n / A3, a) + B3) / (1.0 + power(CC_n / R3, r) + power(PT_n / A3, a) + B3))) - (D7 * (Clk_m / (L7 + Clk_m)) + D0 * Clk_m); // Variable initializations: Clk_m = 0.1; B3 = 0.6; C3 = 0.0; S5 = 1.63; D7 = 0.54; L7 = 0.13; R3 = 0.89; A3 = 0.8; CC_n = ; PT_n = ; time_ = ; D0 = ; a = ; r = ; end model ueda_2001__Clk_c(Clk_c, V3, V4, Clk_m, Cyc_c, CC_c, time_, D0) // Rate Rules: Clk_c' = (S6 * Clk_m + V4 * CC_c) - (V3 * Clk_c * Cyc_c + D8 * (Clk_c / (L8 + Clk_c)) + D0 * Clk_c); // Variable initializations: Clk_c = 0.2; S6 = 0.47; D8 = 0.6; L8 = 0.2; V3 = ; V4 = ; Clk_m = ; Cyc_c = ; CC_c = ; time_ = ; D0 = ; end model ueda_2001__Cyc_c(Cyc_c) // Variable initializations: Cyc_c = 1.0; end model ueda_2001__CC_c(CC_c, K3, K4, T3, T4, V3, V4, Cyc_c, Clk_c, CC_n, time_, D0) // Rate Rules: CC_c' = (V3 * Clk_c * Cyc_c + T4 * (CC_n / (K4 + CC_n))) - (V4 * CC_c + T3 * (CC_c / (K3 + CC_c)) + D9 * (CC_c / (L9 + CC_c)) + D0 * CC_c); // Variable initializations: CC_c = 0.3; D9 = 0.6; L9 = 0.2; K3 = ; K4 = ; T3 = ; T4 = ; V3 = ; V4 = ; Cyc_c = ; Clk_c = ; CC_n = ; time_ = ; D0 = ; end model ueda_2001__CC_n(CC_n, K3, K4, T3, T4, CC_c, time_, D0) // Rate Rules: CC_n' = T3 * (CC_c / (K3 + CC_c)) - (T4 * (CC_n / (K4 + CC_n)) + D10 * (CC_n / (L10 + CC_n)) + D0 * CC_n); // Variable initializations: CC_n = 0.4; D10 = 0.3; L10 = 0.2; K3 = ; K4 = ; T3 = ; T4 = ; CC_c = ; time_ = ; D0 = ; end model ueda_2001__parameters(K1, K2, K3, K4, V1, V2, V3, V4, T1, T2, T3, T4, a, r, D0) // Variable initializations: K1 = 2.0; K2 = 2.0; K3 = 2.0; K4 = 2.0; V1 = 1.45; V2 = 1.45; V3 = 1.63; V4 = 1.63; T1 = 1.73; T2 = 0.72; T3 = 1.63; T4 = 0.52; a = 1.0; r = 4.0; D0 = 0.012; end model *ueda_2001____main() // Sub-modules, and any changes to those submodules: environment: ueda_2001__environment(time_); Per_m: ueda_2001__Per_m(Per_m0, PT_n0, CC_n0, time_, D0, a, r); Per_c: ueda_2001__Per_c(Per_c0, V1, V2, Per_m0, Tim_c0, PT_c0, time_, D0); Tim_m: ueda_2001__Tim_m(Tim_m0, PT_n0, CC_n0, time_, D0, a, r); Tim_c: ueda_2001__Tim_c(Tim_c0, V1, V2, Tim_m0, Per_c0, PT_c0, time_, D0); PT_c: ueda_2001__PT_c(PT_c0, K1, K2, T1, T2, V1, V2, Tim_c0, Per_c0, PT_n0, time_, D0); PT_n: ueda_2001__PT_n(PT_n0, K1, K2, T1, T2, PT_c0, time_, D0); Clk_m: ueda_2001__Clk_m(Clk_m0, CC_n0, PT_n0, time_, D0, a, r); Clk_c: ueda_2001__Clk_c(Clk_c0, V3, V4, Clk_m0, Cyc_c0, CC_c0, time_, D0); Cyc_c: ueda_2001__Cyc_c(Cyc_c0); CC_c: ueda_2001__CC_c(CC_c0, K3, K4, T3, T4, V3, V4, Cyc_c0, Clk_c0, CC_n0, time_, D0); CC_n: ueda_2001__CC_n(CC_n0, K3, K4, T3, T4, CC_c0, time_, D0); parameters: ueda_2001__parameters(K1, K2, K3, K4, V1, V2, V3, V4, T1, T2, T3, T4, a, r, D0); end