//Created by libAntimony v2.4
model romond_rustici_gonze_goldbeter_1999_version01__environment(time_)

  // Variable initializations:
  time_ = ;
end

model romond_rustici_gonze_goldbeter_1999_version01__parameters(H_1, H_2, H_3, H_4, K_1, K_2, K_3, K_4, V_M1, V_M3, U_M1, U_M3, V_2, V_4, U_2, U_4, K_c1, K_c2, K_d1, K_d2, v_d1, v_d2, v_i1, v_i2, k_d1, k_d2, K_im1, K_im2)

  // Variable initializations:
  H_1 = 0.01;
  H_2 = 0.01;
  H_3 = 0.01;
  H_4 = 0.01;
  K_1 = 0.01;
  K_2 = 0.01;
  K_3 = 0.01;
  K_4 = 0.01;
  V_M1 = 0.3;
  V_M3 = 0.1;
  U_M1 = 0.3;
  U_M3 = 0.1;
  V_2 = 0.15;
  V_4 = 0.05;
  U_2 = 0.15;
  U_4 = 0.05;
  K_c1 = 0.5;
  K_c2 = 0.5;
  K_d1 = 0.02;
  K_d2 = 0.02;
  v_d1 = 0.025;
  v_d2 = 0.025;
  v_i1 = 0.05;
  v_i2 = 0.05;
  k_d1 = 0.001;
  k_d2 = 0.001;
  K_im1 = 0.03;
  K_im2 = 0.03;
end

model romond_rustici_gonze_goldbeter_1999_version01__C_1(C_1, v_i1, v_d1, k_d1, K_im1, M_2, X_1, K_d1, time_)

  // Rate Rules:
  C_1' = ((v_i1 * K_im1) / (K_im1 + M_2) - (v_d1 * X_1 * C_1) / (K_d1 + C_1)) - k_d1 * C_1;

  // Variable initializations:
  C_1 = 2;
  v_i1 = ;
  v_d1 = ;
  k_d1 = ;
  K_im1 = ;
  M_2 = ;
  X_1 = ;
  K_d1 = ;
  time_ = ;
end

model romond_rustici_gonze_goldbeter_1999_version01__M_1(M_1, V_1, V_2, K_1, K_2, time_)

  // Rate Rules:
  M_1' = (V_1 * (1 - M_1)) / (K_1 + (1 - M_1)) - (V_2 * M_1) / (K_2 + M_1);

  // Variable initializations:
  M_1 = 1;
  V_1 = ;
  V_2 = ;
  K_1 = ;
  K_2 = ;
  time_ = ;
end

model romond_rustici_gonze_goldbeter_1999_version01__X_1(X_1, V_3, V_4, K_3, K_4, time_)

  // Rate Rules:
  X_1' = (V_3 * (1 - X_1)) / (K_3 + (1 - X_1)) - (V_4 * X_1) / (K_4 + X_1);

  // Variable initializations:
  X_1 = 0;
  V_3 = ;
  V_4 = ;
  K_3 = ;
  K_4 = ;
  time_ = ;
end

model romond_rustici_gonze_goldbeter_1999_version01__C_2(C_2, v_i2, v_d2, k_d2, K_im2, M_1, X_2, K_d2, time_)

  // Rate Rules:
  C_2' = ((v_i2 * K_im2) / (K_im2 + M_1) - (v_d2 * X_2 * C_2) / (K_d2 + C_2)) - k_d2 * C_2;

  // Variable initializations:
  C_2 = 0;
  v_i2 = ;
  v_d2 = ;
  k_d2 = ;
  K_im2 = ;
  M_1 = ;
  X_2 = ;
  K_d2 = ;
  time_ = ;
end

model romond_rustici_gonze_goldbeter_1999_version01__M_2(M_2, U_1, U_2, H_1, H_2, time_)

  // Rate Rules:
  M_2' = (U_1 * (1 - M_2)) / (H_1 + (1 - M_2)) - (U_2 * M_2) / (H_2 + M_2);

  // Variable initializations:
  M_2 = 0;
  U_1 = ;
  U_2 = ;
  H_1 = ;
  H_2 = ;
  time_ = ;
end

model romond_rustici_gonze_goldbeter_1999_version01__X_2(X_2, U_3, U_4, H_3, H_4, time_)

  // Rate Rules:
  X_2' = (U_3 * (1 - X_2)) / (H_3 + (1 - X_2)) - (U_4 * X_2) / (H_4 + X_2);

  // Variable initializations:
  X_2 = 0;
  U_3 = ;
  U_4 = ;
  H_3 = ;
  H_4 = ;
  time_ = ;
end

model romond_rustici_gonze_goldbeter_1999_version01__V_1(V_1, V_M1, C_1, K_c1)

  // Assignment Rules:
  V_1 := (C_1 / (K_c1 + C_1)) * V_M1;

  // Variable initializations:
  V_M1 = ;
  C_1 = ;
  K_c1 = ;
end

model romond_rustici_gonze_goldbeter_1999_version01__V_3(V_3, V_M3, M_1)

  // Assignment Rules:
  V_3 := M_1 * V_M3;

  // Variable initializations:
  V_M3 = ;
  M_1 = ;
end

model romond_rustici_gonze_goldbeter_1999_version01__U_1(U_1, U_M1, C_2, K_c2)

  // Assignment Rules:
  U_1 := (C_2 / (K_c2 + C_2)) * U_M1;

  // Variable initializations:
  U_M1 = ;
  C_2 = ;
  K_c2 = ;
end

model romond_rustici_gonze_goldbeter_1999_version01__U_3(U_3, U_M3, M_2)

  // Assignment Rules:
  U_3 := M_2 * U_M3;

  // Variable initializations:
  U_M3 = ;
  M_2 = ;
end

model *romond_rustici_gonze_goldbeter_1999_version01____main()

  // Sub-modules, and any changes to those submodules:
  environment: romond_rustici_gonze_goldbeter_1999_version01__environment(time_);
  parameters: romond_rustici_gonze_goldbeter_1999_version01__parameters(H_1, H_2, H_3, H_4, K_1, K_2, K_3, K_4, V_M1, V_M3, U_M1, U_M3, V_2, V_4, U_2, U_4, K_c1, K_c2, K_d1, K_d2, v_d1, v_d2, v_i1, v_i2, k_d1, k_d2, K_im1, K_im2);
  C_1: romond_rustici_gonze_goldbeter_1999_version01__C_1(C_10, v_i1, v_d1, k_d1, K_im1, M_20, X_10, K_d1, time_);
  M_1: romond_rustici_gonze_goldbeter_1999_version01__M_1(M_10, V_10, V_2, K_1, K_2, time_);
  X_1: romond_rustici_gonze_goldbeter_1999_version01__X_1(X_10, V_30, V_4, K_3, K_4, time_);
  C_2: romond_rustici_gonze_goldbeter_1999_version01__C_2(C_20, v_i2, v_d2, k_d2, K_im2, M_10, X_20, K_d2, time_);
  M_2: romond_rustici_gonze_goldbeter_1999_version01__M_2(M_20, U_10, U_2, H_1, H_2, time_);
  X_2: romond_rustici_gonze_goldbeter_1999_version01__X_2(X_20, U_30, U_4, H_3, H_4, time_);
  V_1: romond_rustici_gonze_goldbeter_1999_version01__V_1(V_10, V_M1, C_10, K_c1);
  V_3: romond_rustici_gonze_goldbeter_1999_version01__V_3(V_30, V_M3, M_10);
  U_1: romond_rustici_gonze_goldbeter_1999_version01__U_1(U_10, U_M1, C_20, K_c2);
  U_3: romond_rustici_gonze_goldbeter_1999_version01__U_3(U_30, U_M3, M_20);
end