Jglut Jgk glubasa1 gluamp 1 glustep time_ 2 60000 gluper GeStep glustep gluamp time_ steptime 1000 1 time_ steptime 1000 glustep gluamp time_ steptime 1000 0 time_ steptime 1000 1 0 time_ steptime 1000 0 kappa Jgk JPFK kappa JPFK 0.5 JGPDH 0.3 G6P Vglut Ge Gi Kglut Kglut Ge Kglut Gi Vgk Gi ngk Kgk ngk Gi ngk 0.2 FBP 1 pfkbas cat topa16 cat topb bottom16 topa15 weight16 bottom15 weight16 weight15 1 AMP K1 FBP K2 F6P 2 1 K3 ATP 2 1 K4 AMP FBP K1 K2 AMP F6P 2 1 K1 K3 famp AMP ATP 2 1 K1 K4 fmt FBP ATP 2 1 K2 K4 fbt F6P ATP 2 1 fatp K3 K4 AMP FBP F6P 2 1 K1 K2 K3 ffbp famp FBP F6P 2 ATP 2 1 K2 K3 K4 ffbp fbt fatp AMP F6P 2 ATP 2 1 K1 K3 K4 famp fmt fatp AMP FBP ATP 2 1 K1 K2 K4 fbt fmt AMP FBP F6P 2 ATP 2 1 K1 K2 K3 K4 ffbp famp fbt fmt fatp FBP F6P 2 1 K2 K3 ffbp 0 topa1 topa2 weight3 topa3 weight4 topa4 topa5 topa6 weight7 topa7 weight8 topa8 topa9 topa10 weight11 topa11 weight12 topa12 topa13 topa14 1 bottom1 weight2 bottom2 weight3 bottom3 weight4 bottom4 weight5 bottom5 weight6 bottom6 weight7 bottom7 weight8 bottom8 weight9 bottom9 weight10 bottom10 weight11 bottom11 weight12 bottom12 weight13 bottom13 weight14 bottom14 weight15 0.5 Atot rad ADP ADP Atot 2 4 ADP 2 ADP 2 ATP ky JGPDH kg JGPDH r y I_K I_Ca I_K_Ca I_K_ATP cm n_infinity n tau_n 0.5 1 v -16 11.2 1 0.035 v -16 22.4 gK n v vK 0.5 1 v -20 24 gCa m_infinity v vCa gkCa 1 KD Ca nh v vK gkATP_bar katpo v vK 20 topo bottomo 0.08 1 2 MgADP 17 0.89 MgADP 17 2 1 MgADP 17 2 1 ADP3 26 ATP4 1 0.165 ADP 0.135 ADP 0.05 ATP fcyt Jmem Jer fer sigmav Jer alpha 1 I_Ca kPMCA Ca Jleak JSERCA kSERCA Ca pleak Caer Ca I_infinity I tau_I I_max Ca delta ki delta Ca delta