//Created by libAntimony v2.4
model novak_1997__environment(time_)

  // Variable initializations:
  time_ = ;
end

model novak_1997__rate_constants(k1, k2, k2_, k3, k4, k5, k6, k6_, k7, k7r, k8, k8r, kwee, k25, ku, kp, kur, ku2, kur2, kc, kcr, kw, kwr, ki, kir, mu, Kmu2, Kmur2, Kmi, Kmir, Kmw, Kmwr, Kmu, Kmur, Kmc, Kmcr, Kmp, Cdc25, UbE, UbE2, Wee1)

  // Assignment Rules:
  k2 := V2_ * (1 - UbE) + V2 * UbE;
  k6 := V6_ * (1 - UbE2) + V6 * UbE2;
  kwee := Vw_ * (1 - Wee1) + Vw * Wee1;
  k25 := V25_ * (1 - Cdc25) + V25 * Cdc25;

  // Variable initializations:
  k1 = 0.015;
  k2_ = 0.05;
  k3 = 0.09375;
  k4 = 0.1875;
  k5 = 0.00175;
  k6_ = 0;
  k7 = 100;
  k7r = 0.1;
  k8 = 10;
  k8r = 0.1;
  ku = 0.2;
  kp = 3.25;
  kur = 0.1;
  ku2 = 1;
  kur2 = 0.3;
  kc = 1;
  kcr = 0.25;
  kw = 1;
  kwr = 0.25;
  ki = 0.4;
  kir = 0.1;
  mu = 0.00495;
  Kmu2 = 0.05;
  Kmur2 = 0.05;
  Kmi = 0.01;
  Kmir = 0.01;
  Kmw = 0.1;
  Kmwr = 0.1;
  Kmu = 0.01;
  Kmur = 0.01;
  Kmc = 0.1;
  Kmcr = 0.1;
  Kmp = 0.001;
  V2 = 0.25;
  V2_ = 0.0075;
  V6 = 7.5;
  V6_ = 0.0375;
  V25 = 0.5;
  V25_ = 0.025;
  Vw = 0.35;
  Vw_ = 0.035;
  Cdc25 = ;
  UbE = ;
  UbE2 = ;
  Wee1 = ;
end

model novak_1997__concentration_variables(SPF, MPF, G1K, G2K, PG2)

  // Assignment Rules:
  SPF := MPF + alpha * G1K;
  MPF := G2K + beta * PG2;

  // Variable initializations:
  alpha = 0.25;
  beta = 0.05;
  G1K = ;
  G2K = ;
  PG2 = ;
end

model novak_1997__G2K(G2K, k1, k2, k4, k7, k7r, k25, kwee, PG2, G2R, R, time_)

  // Rate Rules:
  G2K' = (k1 + k25 * PG2 + (k7r + k4) * G2R) - (k2 + kwee + k7 * R) * G2K;

  // Variable initializations:
  G2K = 0;
  k1 = ;
  k2 = ;
  k4 = ;
  k7 = ;
  k7r = ;
  k25 = ;
  kwee = ;
  PG2 = ;
  G2R = ;
  R = ;
  time_ = ;
end

model novak_1997__R(R, k3, k4, kp, k7, k8, k8r, Kmp, k7r, k2, k2_, k6_, G1R, G2K, G1K, PG2, PG2R, G2R, SPF, mass, time_)

  // Rate Rules:
  R' = (k3 + (k7r + k2 + k2_) * (G2R + PG2R) + (k8r + k6_) * G1R) - (k4 * R + k7 * R * (G2K + PG2) + k8 * R * G1K + (kp * R * SPF * mass) / (Kmp + R));

  // Variable initializations:
  R = 0.4;
  k3 = ;
  k4 = ;
  kp = ;
  k7 = ;
  k8 = ;
  k8r = ;
  Kmp = ;
  k7r = ;
  k2 = ;
  k2_ = ;
  k6_ = ;
  G1R = ;
  G2K = ;
  G1K = ;
  PG2 = ;
  PG2R = ;
  G2R = ;
  SPF = ;
  mass = ;
  time_ = ;
end

model novak_1997__G1K(G1K, k5, k6, k8, k4, k8r, G1R, R, time_)

  // Rate Rules:
  G1K' = (k5 + (k8r + k4) * G1R) - (k6 + k8 * R) * G1K;

  // Variable initializations:
  G1K = 0;
  k5 = ;
  k6 = ;
  k8 = ;
  k4 = ;
  k8r = ;
  G1R = ;
  R = ;
  time_ = ;
end

model novak_1997__G2R(G2R, k7, k4, k2, k7r, k2_, G2K, R, time_)

  // Rate Rules:
  G2R' = k7 * R * G2K - (k7r + k4 + k2 + k2_) * G2R;

  // Variable initializations:
  G2R = 0;
  k7 = ;
  k4 = ;
  k2 = ;
  k7r = ;
  k2_ = ;
  G2K = ;
  R = ;
  time_ = ;
end

model novak_1997__IE(IE, ki, kir, Kmi, Kmir, MPF, time_)

  // Rate Rules:
  IE' = (ki * MPF * (1 - IE)) / ((Kmi + 1) - IE) - (kir * IE) / (Kmir + IE);

  // Variable initializations:
  IE = 0;
  ki = ;
  kir = ;
  Kmi = ;
  Kmir = ;
  MPF = ;
  time_ = ;
end

model novak_1997__UbE2(UbE2, ku2, kur2, Kmu2, Kmur2, MPF, time_)

  // Rate Rules:
  UbE2' = (ku2 * MPF * (1 - UbE2)) / ((Kmu2 + 1) - UbE2) - (kur2 * UbE2) / (Kmur2 + UbE2);

  // Variable initializations:
  UbE2 = 0;
  ku2 = ;
  kur2 = ;
  Kmu2 = ;
  Kmur2 = ;
  MPF = ;
  time_ = ;
end

model novak_1997__Wee1(Wee1, kwr, kw, Kmwr, Kmw, MPF, time_)

  // Rate Rules:
  Wee1' = (kwr * (1 - Wee1)) / ((Kmwr + 1) - Wee1) - (kw * MPF * Wee1) / (Kmw + Wee1);

  // Variable initializations:
  Wee1 = 0;
  kwr = ;
  kw = ;
  Kmwr = ;
  Kmw = ;
  MPF = ;
  time_ = ;
end

model novak_1997__PG2(PG2, k2, k7, k4, k25, kwee, k7r, PG2R, G2K, R, time_)

  // Rate Rules:
  PG2' = (kwee * G2K + (k7r + k4) * PG2R) - (k25 + k2 + k7 * R) * PG2;

  // Variable initializations:
  PG2 = 0;
  k2 = ;
  k7 = ;
  k4 = ;
  k25 = ;
  kwee = ;
  k7r = ;
  PG2R = ;
  G2K = ;
  R = ;
  time_ = ;
end

model novak_1997__G1R(G1R, k8, k4, k6_, k8r, G1K, R, time_)

  // Rate Rules:
  G1R' = k8 * R * G1K - (k8r + k4 + k6_) * G1R;

  // Variable initializations:
  G1R = 0;
  k8 = ;
  k4 = ;
  k6_ = ;
  k8r = ;
  G1K = ;
  R = ;
  time_ = ;
end

model novak_1997__PG2R(PG2R, k7, k4, k2, k2_, k7r, PG2, R, time_)

  // Rate Rules:
  PG2R' = k7 * R * PG2 - (k7r + k4 + k2 + k2_) * PG2R;

  // Variable initializations:
  PG2R = 0;
  k7 = ;
  k4 = ;
  k2 = ;
  k2_ = ;
  k7r = ;
  PG2 = ;
  R = ;
  time_ = ;
end

model novak_1997__UbE(UbE, kur, ku, Kmur, Kmu, IE, time_)

  // Rate Rules:
  UbE' = (ku * IE * (1 - UbE)) / ((Kmu + 1) - UbE) - (kur * UbE) / (Kmur + UbE);

  // Variable initializations:
  UbE = 1;
  kur = ;
  ku = ;
  Kmur = ;
  Kmu = ;
  IE = ;
  time_ = ;
end

model novak_1997__mass(mass, mu, time_)

  // Rate Rules:
  mass' = mu * mass;

  // Variable initializations:
  mass = 0.5;
  mu = ;
  time_ = ;
end

model novak_1997__Cdc25(Cdc25, kcr, kc, Kmcr, Kmc, MPF, time_)

  // Rate Rules:
  Cdc25' = (kc * MPF * (1 - Cdc25)) / ((Kmc + 1) - Cdc25) - (kcr * Cdc25) / (Kmcr + Cdc25);

  // Variable initializations:
  Cdc25 = 0;
  kcr = ;
  kc = ;
  Kmcr = ;
  Kmc = ;
  MPF = ;
  time_ = ;
end

model novak_1997__Cig2_total(Cig2_total, G1K, G1R, time_)

  // Assignment Rules:
  Cig2_total := G1K + G1R;

  // Variable initializations:
  G1K = ;
  G1R = ;
  time_ = ;
end

model novak_1997__Rum1_total(Rum1_total, R, G1R, G2R, PG2R, time_)

  // Assignment Rules:
  Rum1_total := R + G1R + G2R + PG2R;

  // Variable initializations:
  R = ;
  G1R = ;
  G2R = ;
  PG2R = ;
  time_ = ;
end

model novak_1997__Cdc13_total(Cdc13_total, G2K, G2R, PG2, PG2R, time_)

  // Assignment Rules:
  Cdc13_total := G2K + G2R + PG2 + PG2R;

  // Variable initializations:
  G2K = ;
  G2R = ;
  PG2 = ;
  PG2R = ;
  time_ = ;
end

model *novak_1997____main()

  // Sub-modules, and any changes to those submodules:
  environment: novak_1997__environment(time_);
  rate_constants: novak_1997__rate_constants(k1, k2, k2_, k3, k4, k5, k6, k6_, k7, k7r, k8, k8r, kwee, k25, ku, kp, kur, ku2, kur2, kc, kcr, kw, kwr, ki, kir, mu, Kmu2, Kmur2, Kmi, Kmir, Kmw, Kmwr, Kmu, Kmur, Kmc, Kmcr, Kmp, Cdc250, UbE0, UbE20, Wee10);
  concentration_variables: novak_1997__concentration_variables(SPF, MPF, G1K0, G2K0, PG20);
  G2K: novak_1997__G2K(G2K0, k1, k2, k4, k7, k7r, k25, kwee, PG20, G2R0, R0, time_);
  R: novak_1997__R(R0, k3, k4, kp, k7, k8, k8r, Kmp, k7r, k2, k2_, k6_, G1R0, G2K0, G1K0, PG20, PG2R0, G2R0, SPF, mass0, time_);
  G1K: novak_1997__G1K(G1K0, k5, k6, k8, k4, k8r, G1R0, R0, time_);
  G2R: novak_1997__G2R(G2R0, k7, k4, k2, k7r, k2_, G2K0, R0, time_);
  IE: novak_1997__IE(IE0, ki, kir, Kmi, Kmir, MPF, time_);
  UbE2: novak_1997__UbE2(UbE20, ku2, kur2, Kmu2, Kmur2, MPF, time_);
  Wee1: novak_1997__Wee1(Wee10, kwr, kw, Kmwr, Kmw, MPF, time_);
  PG2: novak_1997__PG2(PG20, k2, k7, k4, k25, kwee, k7r, PG2R0, G2K0, R0, time_);
  G1R: novak_1997__G1R(G1R0, k8, k4, k6_, k8r, G1K0, R0, time_);
  PG2R: novak_1997__PG2R(PG2R0, k7, k4, k2, k2_, k7r, PG20, R0, time_);
  UbE: novak_1997__UbE(UbE0, kur, ku, Kmur, Kmu, IE0, time_);
  mass: novak_1997__mass(mass0, mu, time_);
  Cdc25: novak_1997__Cdc25(Cdc250, kcr, kc, Kmcr, Kmc, MPF, time_);
  Cig2_total: novak_1997__Cig2_total(Cig2_total0, G1K0, G1R0, time_);
  Rum1_total: novak_1997__Rum1_total(Rum1_total0, R0, G1R0, G2R0, PG2R0, time_);
  Cdc13_total: novak_1997__Cdc13_total(Cdc13_total0, G2K0, G2R0, PG20, PG2R0, time_);
end