//Created by libAntimony v2.4 // Warnings from automatic translation: // Unable to figure out how to translate an assignment to "partialdiff(L)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. // Unable to figure out how to translate an assignment to "partialdiff(R)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. // Unable to figure out how to translate an assignment to "partialdiff(C)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. // Unable to figure out how to translate an assignment to "partialdiff(CGrb)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. // Unable to figure out how to translate an assignment to "partialdiff(CGrbSos)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. // Unable to figure out how to translate an assignment to "partialdiff(Grb)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. // Unable to figure out how to translate an assignment to "partialdiff(Sos)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. // Unable to figure out how to translate an assignment to "partialdiff(GrbSos)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. // Unable to figure out how to translate an assignment to "partialdiff(pSos)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. // Unable to figure out how to translate an assignment to "partialdiff(pRaf)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. // Unable to figure out how to translate an assignment to "partialdiff(pMEK)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. // Unable to figure out how to translate an assignment to "partialdiff(ppMEK)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. // Unable to figure out how to translate an assignment to "partialdiff(pERK)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. // Unable to figure out how to translate an assignment to "partialdiff(ppERK)/partialdiff(unknown-element)" in the Antimony format. This variable may have been left undefined in that component. model maly_wiley_lauffenburger_2004_version01__environment(time_) // Variable initializations: time_ = ; end model maly_wiley_lauffenburger_2004_version01__L(L, time_) // Variable initializations: L = 1.0E-9; DL = 1.0E-12; time_ = ; end model maly_wiley_lauffenburger_2004_version01__R(R, kon, koff, C, L, time_) // Variable initializations: R = 2.0E16; kon = ; koff = ; C = ; L = ; time_ = ; end model maly_wiley_lauffenburger_2004_version01__C(C, kon, koff, kagc, kdgc, kagsc, kdgsc, R, L, Grb, CGrb, GrbSos, CGrbSos, time_) // Variable initializations: C = 2.0E16; kon = ; koff = ; kagc = ; kdgc = ; kagsc = ; kdgsc = ; R = ; L = ; Grb = ; CGrb = ; GrbSos = ; CGrbSos = ; time_ = ; end model maly_wiley_lauffenburger_2004_version01__CGrb(CGrb, kagc, kdgc, kasc, kdsc, C, Grb, Sos, CGrbSos, time_) // Variable initializations: CGrb = 0.0; kagc = ; kdgc = ; kasc = ; kdsc = ; C = ; Grb = ; Sos = ; CGrbSos = ; time_ = ; end model maly_wiley_lauffenburger_2004_version01__CGrbSos(CGrbSos, kasc, kdsc, kagsc, kdgsc, C, GrbSos, Sos, CGrb, time_) // Variable initializations: CGrbSos = 0.0; kasc = ; kdsc = ; kagsc = ; kdgsc = ; C = ; GrbSos = ; Sos = ; CGrb = ; time_ = ; end model maly_wiley_lauffenburger_2004_version01__Grb(Grb, kasg, kdsg, D, GrbSos, Sos, time_) // Variable initializations: Grb = 5.0E-8; kasg = ; kdsg = ; D = ; GrbSos = ; Sos = ; time_ = ; end model maly_wiley_lauffenburger_2004_version01__Sos(Sos, kasg, kdsg, kps, kdps, D, Grb, GrbSos, pSos, ppERK, time_) // Variable initializations: Sos = 5.0E-8; kasg = ; kdsg = ; kps = ; kdps = ; D = ; Grb = ; GrbSos = ; pSos = ; ppERK = ; time_ = ; end model maly_wiley_lauffenburger_2004_version01__GrbSos(GrbSos, kasg, kdsg, D, Grb, Sos, time_) // Variable initializations: GrbSos = 0.0; kasg = ; kdsg = ; D = ; Grb = ; Sos = ; time_ = ; end model maly_wiley_lauffenburger_2004_version01__pSos(pSos, kps, kdps, D, ppERK, Sos, time_) // Variable initializations: pSos = 0.0; kps = ; kdps = ; D = ; ppERK = ; Sos = ; time_ = ; end model maly_wiley_lauffenburger_2004_version01__pRaf(pRaf, D, time_) // Variable initializations: pRaf = 0.0; K2 = 8.0E-9; V2 = 7.5E-9; D = ; time_ = ; end model maly_wiley_lauffenburger_2004_version01__pMEK(pMEK, K4, k4, K5, V5, ppMEK, pRaf, D, time_) // Variable initializations: pMEK = 0.0; MEKtot = 3.0E-7; k3 = 0.75; K3 = 1.5E-8; K6 = 1.5E-8; V6 = 2.25E-8; K4 = ; k4 = ; K5 = ; V5 = ; ppMEK = ; pRaf = ; D = ; time_ = ; end model maly_wiley_lauffenburger_2004_version01__ppMEK(ppMEK, K4, k4, K5, V5, pMEK, pRaf, D, time_) // Variable initializations: ppMEK = 0.0; K4 = ; k4 = ; K5 = ; V5 = ; pMEK = ; pRaf = ; D = ; time_ = ; end model maly_wiley_lauffenburger_2004_version01__pERK(pERK, K8, k8, K9, V9, ppERK, ppMEK, D, time_) // Variable initializations: pERK = 0.0; ERKtot = 3.0E-7; k7 = 0.75; K7 = 1.5E-8; K10 = 1.5E-8; V10 = 1.0E-8; K8 = ; k8 = ; K9 = ; V9 = ; ppERK = ; ppMEK = ; D = ; time_ = ; end model maly_wiley_lauffenburger_2004_version01__ppERK(ppERK, K8, k8, K9, V9, pERK, ppMEK, D, time_) // Variable initializations: ppERK = 0.0; K8 = ; k8 = ; K9 = ; V9 = ; pERK = ; ppMEK = ; D = ; time_ = ; end model maly_wiley_lauffenburger_2004_version01__parameters(kon, koff, kasg, kdsg, kagc, kdgc, kagsc, kdgsc, kasc, kdsc, kps, kdps, D, K4, k4, K5, V5, K8, k8, K9, V9) // Variable initializations: kon = 1.67E6; koff = 1.67E-3; kasg = 1.0E5; kdsg = 1.5E-3; kagc = 3.0E6; kdgc = 5.0E-2; kagsc = 4.5E6; kdgsc = 3.0E-2; kasc = 1.0E7; kdsc = 6.0E-2; kps = 1.0E9; kdps = 1.0E-3; D = 1.0E-12; K4 = 1.5E-8; k4 = 0.75; K5 = 1.5E-8; V5 = 2.25E-8; K8 = 1.5E-8; k8 = 0.75; K9 = 1.5E-8; V9 = 1.0E-8; end model *maly_wiley_lauffenburger_2004_version01____main() // Sub-modules, and any changes to those submodules: environment: maly_wiley_lauffenburger_2004_version01__environment(time_); L: maly_wiley_lauffenburger_2004_version01__L(L0, time_); R: maly_wiley_lauffenburger_2004_version01__R(R0, kon, koff, C0, L0, time_); C: maly_wiley_lauffenburger_2004_version01__C(C0, kon, koff, kagc, kdgc, kagsc, kdgsc, R0, L0, Grb0, CGrb0, GrbSos0, CGrbSos0, time_); CGrb: maly_wiley_lauffenburger_2004_version01__CGrb(CGrb0, kagc, kdgc, kasc, kdsc, C0, Grb0, Sos0, CGrbSos0, time_); CGrbSos: maly_wiley_lauffenburger_2004_version01__CGrbSos(CGrbSos0, kasc, kdsc, kagsc, kdgsc, C0, GrbSos0, Sos0, CGrb0, time_); Grb: maly_wiley_lauffenburger_2004_version01__Grb(Grb0, kasg, kdsg, D, GrbSos0, Sos0, time_); Sos: maly_wiley_lauffenburger_2004_version01__Sos(Sos0, kasg, kdsg, kps, kdps, D, Grb0, GrbSos0, pSos0, ppERK0, time_); GrbSos: maly_wiley_lauffenburger_2004_version01__GrbSos(GrbSos0, kasg, kdsg, D, Grb0, Sos0, time_); pSos: maly_wiley_lauffenburger_2004_version01__pSos(pSos0, kps, kdps, D, ppERK0, Sos0, time_); pRaf: maly_wiley_lauffenburger_2004_version01__pRaf(pRaf0, D, time_); pMEK: maly_wiley_lauffenburger_2004_version01__pMEK(pMEK0, K4, k4, K5, V5, ppMEK0, pRaf0, D, time_); ppMEK: maly_wiley_lauffenburger_2004_version01__ppMEK(ppMEK0, K4, k4, K5, V5, pMEK0, pRaf0, D, time_); pERK: maly_wiley_lauffenburger_2004_version01__pERK(pERK0, K8, k8, K9, V9, ppERK0, ppMEK0, D, time_); ppERK: maly_wiley_lauffenburger_2004_version01__ppERK(ppERK0, K8, k8, K9, V9, pERK0, ppMEK0, D, time_); parameters: maly_wiley_lauffenburger_2004_version01__parameters(kon, koff, kasg, kdsg, kagc, kdgc, kagsc, kdgsc, kasc, kdsc, kps, kdps, D, K4, k4, K5, V5, K8, k8, K9, V9); end