//Created by libAntimony v2.4
model maldonado_2006__environment(time_)

  // Variable initializations:
  time_ = ;
end

model maldonado_2006__A_B(A_B, r_B)

  // Assignment Rules:
  A_B := power(r_B, 2) * pi;

  // Variable initializations:
  r_B = ;
end

model maldonado_2006__r_B(r_B, xc, xb, xy, time_)

  // Rate Rules:
  r_B' = ((k_for / X_b) * xb + (1 / X_y) * xy) - ((k_res / X_c) * xc + k_rB * r_B);

  // Variable initializations:
  r_B = 0.9912;
  X_c = 9.127e-4;
  X_b = 7.282e-4;
  X_y = 7.300e-3;
  k_rB = 1.0e0;
  k_for = 1.0e-3;
  k_res = 10.0e-3;
  xc = ;
  xb = ;
  xy = ;
  time_ = ;
end

model maldonado_2006__xy(xy, xb, time_)

  // Rate Rules:
  xy' = k_byp * (xb - X_bss) - k_yd * (xy - X_yss);

  // Variable initializations:
  xy = 7.300e-3;
  X_bss = 7.282e-4;
  X_yss = 7.300e-3;
  k_byp = 1.00e-1;
  k_yd = 1.00e0;
  xb = ;
  time_ = ;
end

model maldonado_2006__F_sti(F_sti, xy, F_s)

  // Assignment Rules:
  F_sti := (F_s * xy) / (1 + exp(-(k_Fs * F_s + k_y * xy)));

  // Variable initializations:
  k_Fs = 1.00e0;
  k_y = 1.00e0;
  xy = ;
  F_s = ;
end

model maldonado_2006__F_s(F_s, A_B, time_)

  // Assignment Rules:
  F_s := F_a / A_B;
  F_a := piecewise( 10000.0 , ( geq(time_, 100.0)) && (time_ < 130.0 ), 100.0 );

  // Variable initializations:
  A_B = ;
  time_ = ;
end

model maldonado_2006__x_no(x_no, F_sti, time_)

  // Rate Rules:
  x_no' = (k_yno * F_sti + X_noe) - k_nod * x_no;

  // Variable initializations:
  x_no = 0.02;
  X_noe = 0e0;
  k_yno = 2e4;
  k_nod = 1e3;
  F_sti = ;
  time_ = ;
end

model maldonado_2006__x_pge(x_pge, F_sti, x_no, time_)

  // Rate Rules:
  x_pge' = (k_ypge * F_sti + k_nopge * x_no + X_pgex) - k_pged * x_pge;

  // Variable initializations:
  x_pge = 0.01;
  X_pgex = 0e0;
  k_pged = 1e2;
  k_nopge = 1e0;
  k_ypge = 1e2;
  F_sti = ;
  x_no = ;
  time_ = ;
end

model maldonado_2006__x_opg(x_opg, Io, K_o_p, xr, x_no, pi_c, time_)

  // Rate Rules:
  x_opg' = ((K_o_p / 1) * pi_c * xr + Io + k_nopg * x_no) - k_opgd * x_opg;

  // Variable initializations:
  x_opg = 0.01;
  k_opgd = 3.5e-1;
  k_nopg = 1e1;
  Io = ;
  K_o_p = ;
  xr = ;
  x_no = ;
  pi_c = ;
  time_ = ;
end

model maldonado_2006__x_kl(x_kl, pi_L, Io, K_o_p, xb, xr, x_no, x_opg, pi_p, time_)

  // Assignment Rules:
  pi_L := ((((k3 / k4) * K_l_p) * pi_p * xb) / (1 + (k3 * K) / k4 + (k1 / (k2 * ko)) * (((K_o_p / 1) / pi_p) * xr + Io))) * (1 + Il / rl);

  // Rate Rules:
  x_kl' = (rl + Il) - (k_nokl * x_no + rl * ((1 + (k1 / k2) * x_opg + (k3 / k4) * K) / (K_l_p * pi_p * xb)) * x_kl);

  // Variable initializations:
  x_kl = 0.01;
  K_l_p = 3e6;
  K = 10;
  k_nokl = 1e2;
  Il = 0;
  rl = 1e3;
  k1 = 1e-2;
  k2 = 10;
  k3 = 5.8e-4;
  k4 = 1.7e-2;
  ko = 0.35;
  Io = ;
  K_o_p = ;
  xb = ;
  xr = ;
  x_no = ;
  x_opg = ;
  pi_p = ;
  time_ = ;
end

model maldonado_2006__xr(xr, x_pge, D_B, pi_c, time_)

  // Rate Rules:
  xr' = (D_R * pi_c + k_pger * x_pge) - (D_B / pi_c) * xr;

  // Variable initializations:
  xr = 7.734e-4;
  D_R = 7e-4;
  k_pger = 1e-4;
  x_pge = ;
  D_B = ;
  pi_c = ;
  time_ = ;
end

model maldonado_2006__xb(xb, xr, D_B, pi_c, time_)

  // Rate Rules:
  xb' = (D_B / pi_c) * xr - k_B * xb;

  // Variable initializations:
  xb = 7.282e-4;
  k_B = 0.189;
  xr = ;
  D_B = ;
  pi_c = ;
  time_ = ;
end

model maldonado_2006__xc(xc, pi_c, pi_L, time_)

  // Rate Rules:
  xc' = D_C * pi_L - D_A * pi_c * xc;

  // Variable initializations:
  xc = 9.127e-4;
  D_C = 0.189;
  D_A = 0.7;
  pi_c = ;
  pi_L = ;
  time_ = ;
end

model maldonado_2006__model_parameters(D_B, pi_c, pi_p, K_o_p, Io, xc)

  // Assignment Rules:
  D_B := f0 * dB;
  pi_c := (xc + f0 * C_s) / (xc + C_s);
  pi_p := (P + P_0) / (P + P_s);
  P := IP / kP;
  P_0 := SP / kP;
  P_s := k6 / k5;

  // Variable initializations:
  K_o_p = 2e5;
  Io = 0.0;
  f0 = 0.05;
  dB = 0.7;
  C_s = 5e-3;
  SP = 250;
  k5 = 0.02;
  k6 = 3;
  IP = 0;
  kP = 86;
  xc = ;
end

model *maldonado_2006____main()

  // Sub-modules, and any changes to those submodules:
  environment: maldonado_2006__environment(time_);
  A_B: maldonado_2006__A_B(A_B0, r_B0);
  r_B: maldonado_2006__r_B(r_B0, xc0, xb0, xy0, time_);
  xy: maldonado_2006__xy(xy0, xb0, time_);
  F_sti: maldonado_2006__F_sti(F_sti0, xy0, F_s0);
  F_s: maldonado_2006__F_s(F_s0, A_B0, time_);
  x_no: maldonado_2006__x_no(x_no0, F_sti0, time_);
  x_pge: maldonado_2006__x_pge(x_pge0, F_sti0, x_no0, time_);
  x_opg: maldonado_2006__x_opg(x_opg0, Io, K_o_p, xr0, x_no0, pi_c, time_);
  x_kl: maldonado_2006__x_kl(x_kl0, pi_L, Io, K_o_p, xb0, xr0, x_no0, x_opg0, pi_p, time_);
  xr: maldonado_2006__xr(xr0, x_pge0, D_B, pi_c, time_);
  xb: maldonado_2006__xb(xb0, xr0, D_B, pi_c, time_);
  xc: maldonado_2006__xc(xc0, pi_c, pi_L, time_);
  model_parameters: maldonado_2006__model_parameters(D_B, pi_c, pi_p, K_o_p, Io, xc0);
end