//Created by libAntimony v2.4
model kongas_model_2001__environment(time_)

  // Variable initializations:
  time_ = ;
end

model kongas_model_2001__ATP(ATP, V_hyd, V_MMCK, J_ATP, V_cyt, time_)

  // Rate Rules:
  ATP' = (J_ATP - (V_hyd + V_MMCK)) / V_cyt;

  // Variable initializations:
  ATP = 9644.425;
  V_hyd = ;
  V_MMCK = ;
  J_ATP = ;
  V_cyt = ;
  time_ = ;
end

model kongas_model_2001__ADP(ADP, V_hyd, V_MMCK, J_ADP, V_cyt, time_)

  // Rate Rules:
  ADP' = (J_ADP + V_hyd + V_MMCK) / V_cyt;

  // Variable initializations:
  ADP = 60.0;
  V_hyd = ;
  V_MMCK = ;
  J_ADP = ;
  V_cyt = ;
  time_ = ;
end

model kongas_model_2001__PCr(PCr, V_MMCK, J_PCr, V_cyt, time_)

  // Rate Rules:
  PCr' = (J_PCr + V_MMCK) / V_cyt;

  // Variable initializations:
  PCr = 12500.0;
  V_MMCK = ;
  J_PCr = ;
  V_cyt = ;
  time_ = ;
end

model kongas_model_2001__Cr(Cr, V_MMCK, J_Cr, V_cyt, time_)

  // Rate Rules:
  Cr' = (J_Cr - V_MMCK) / V_cyt;

  // Variable initializations:
  Cr = 13500.0;
  V_MMCK = ;
  J_Cr = ;
  V_cyt = ;
  time_ = ;
end

model kongas_model_2001__Pi(Pi_, V_hyd, J_Pi, V_cyt, time_)

  // Rate Rules:
  Pi_' = (J_Pi + V_hyd) / V_cyt;

  // Variable initializations:
  Pi_ = 8000.0;
  V_hyd = ;
  J_Pi = ;
  V_cyt = ;
  time_ = ;
end

model kongas_model_2001__ATP_i(ATP_i, V_MiCK, V_syn, J_ATP, V_ims, time_)

  // Rate Rules:
  ATP_i' = -(J_ATP + V_syn + V_MiCK) / V_ims;

  // Variable initializations:
  ATP_i = 9644.425;
  V_MiCK = ;
  V_syn = ;
  J_ATP = ;
  V_ims = ;
  time_ = ;
end

model kongas_model_2001__ADP_i(ADP_i, V_MiCK, V_syn, J_ADP, V_ims, time_)

  // Rate Rules:
  ADP_i' = ((V_syn + V_MiCK) - J_ADP) / V_ims;

  // Variable initializations:
  ADP_i = 2.5;
  V_MiCK = ;
  V_syn = ;
  J_ADP = ;
  V_ims = ;
  time_ = ;
end

model kongas_model_2001__PCr_i(PCr_i, V_MiCK, J_PCr, V_ims, time_)

  // Rate Rules:
  PCr_i' = (V_MiCK - J_PCr) / V_ims;

  // Variable initializations:
  PCr_i = 12500.0;
  V_MiCK = ;
  J_PCr = ;
  V_ims = ;
  time_ = ;
end

model kongas_model_2001__Cr_i(Cr_i, V_MiCK, J_Cr, V_ims, time_)

  // Rate Rules:
  Cr_i' = -(V_MiCK + J_Cr) / V_ims;

  // Variable initializations:
  Cr_i = 13500.0;
  V_MiCK = ;
  J_Cr = ;
  V_ims = ;
  time_ = ;
end

model kongas_model_2001__Pi_i(Pi_i, V_syn, J_Pi, V_ims, time_)

  // Rate Rules:
  Pi_i' = (V_syn - J_Pi) / V_ims;

  // Variable initializations:
  Pi_i = 8000.0;
  V_syn = ;
  J_Pi = ;
  V_ims = ;
  time_ = ;
end

model kongas_model_2001__V_MMCK(V_MMCK, ATP, ADP, PCr, Cr)

  // Assignment Rules:
  V_MMCK := (Vf * ((ATP * Cr) / (Kia * Kb)) - Vb * ((ADP * PCr) / (Kic * Kd))) / Den_MMCK;
  Den_MMCK := 1.0 + Cr / Kib + PCr / Kid + ATP * (1.0 / Kia + Cr / (Kia * Kb)) + ADP * (1.0 / Kic + PCr / (Kid * Kc) + Cr / (Kic * KIb));
  KIb := Kib;
  Kc := (Kic * Kd) / Kid;

  // Variable initializations:
  ATP = ;
  ADP = ;
  PCr = ;
  Cr = ;
  Kia = 9.0E2;
  Kb = 1.55E4;
  Kib = 3.49E4;
  Kic = 2.224E2;
  Kd = 1.67E3;
  Kid = 4.73E3;
  Vf = 6.966E3;
  Vb = 2.925E4;
end

model kongas_model_2001__V_MiCK(V_MiCK, ATP_i, ADP_i, PCr_i, Cr_i)

  // Assignment Rules:
  V_MiCK := (Vf * ((ATP_i * Cr_i) / (Kia * Kb)) - Vb * ((ADP_i * PCr_i) / (Kic * Kd))) / Den_MiCK;
  Den_MiCK := 1.0 + Cr_i / Kib + PCr_i / Kid + ATP_i * (1.0 / Kia + Cr_i / (Kia * Kb)) + ADP_i * (1.0 / Kic + PCr_i / (Kid * Kc) + Cr_i / (Kic * KIb));
  KIb := Kib;
  Kc := (Kic * Kd) / Kid;

  // Variable initializations:
  ATP_i = ;
  ADP_i = ;
  PCr_i = ;
  Cr_i = ;
  Kia = 7.5E2;
  Kb = 5.2E3;
  Kib = 2.88E4;
  Kic = 2.048E2;
  Kd = 5.0E2;
  Kid = 1.6E3;
  Vf = 2.658E3;
  Vb = 1.116E4;
end

model kongas_model_2001__V_hyd(V_hyd)

  // Variable initializations:
  V_hyd = 4.6E3;
end

model kongas_model_2001__V_syn(V_syn, Pi_i, ADP_i)

  // Assignment Rules:
  V_syn := V_syn_max * ((ADP_i * Pi_i) / (KPi * KADP * Den_syn));
  Den_syn := 1.0 + ADP_i / KADP + Pi_i / KPi + (ADP_i * Pi_i) / (KADP * KPi);

  // Variable initializations:
  Pi_i = ;
  ADP_i = ;
  KPi = 20.0;
  KADP = 8.0E2;
  V_syn_max = 4.6E3;
end

model kongas_model_2001__J_ATP(J_ATP, ATP_i, ATP)

  // Assignment Rules:
  J_ATP := R_ATP * (ATP_i - ATP);

  // Variable initializations:
  ATP_i = ;
  ATP = ;
  R_ATP = 8.16;
end

model kongas_model_2001__J_ADP(J_ADP, ADP_i, ADP)

  // Assignment Rules:
  J_ADP := R_ADP * (ADP_i - ADP);

  // Variable initializations:
  ADP_i = ;
  ADP = ;
  R_ADP = 8.16;
end

model kongas_model_2001__J_PCr(J_PCr, PCr_i, PCr)

  // Assignment Rules:
  J_PCr := R_PCr * (PCr_i - PCr);

  // Variable initializations:
  PCr_i = ;
  PCr = ;
  R_PCr = 14.6;
end

model kongas_model_2001__J_Cr(J_Cr, Cr_i, Cr)

  // Assignment Rules:
  J_Cr := R_Cr * (Cr_i - Cr);

  // Variable initializations:
  Cr_i = ;
  Cr = ;
  R_Cr = 14.6;
end

model kongas_model_2001__J_Pi(J_Pi, Pi_i, Pi_)

  // Assignment Rules:
  J_Pi := R_Pi * (Pi_i - Pi_);

  // Variable initializations:
  Pi_i = ;
  Pi_ = ;
  R_Pi = 18.4;
end

model kongas_model_2001__fractional_volumes(V_cyt, V_ims)

  // Variable initializations:
  V_cyt = 0.75;
  V_ims = 0.0625;
end

model *kongas_model_2001____main()

  // Sub-modules, and any changes to those submodules:
  environment: kongas_model_2001__environment(time_);
  ATP: kongas_model_2001__ATP(ATP0, V_hyd0, V_MMCK0, J_ATP0, V_cyt, time_);
  ADP: kongas_model_2001__ADP(ADP0, V_hyd0, V_MMCK0, J_ADP0, V_cyt, time_);
  PCr: kongas_model_2001__PCr(PCr0, V_MMCK0, J_PCr0, V_cyt, time_);
  Cr: kongas_model_2001__Cr(Cr0, V_MMCK0, J_Cr0, V_cyt, time_);
  Pi_: kongas_model_2001__Pi(Pi_0, V_hyd0, J_Pi0, V_cyt, time_);
  ATP_i: kongas_model_2001__ATP_i(ATP_i0, V_MiCK0, V_syn0, J_ATP0, V_ims, time_);
  ADP_i: kongas_model_2001__ADP_i(ADP_i0, V_MiCK0, V_syn0, J_ADP0, V_ims, time_);
  PCr_i: kongas_model_2001__PCr_i(PCr_i0, V_MiCK0, J_PCr0, V_ims, time_);
  Cr_i: kongas_model_2001__Cr_i(Cr_i0, V_MiCK0, J_Cr0, V_ims, time_);
  Pi_i: kongas_model_2001__Pi_i(Pi_i0, V_syn0, J_Pi0, V_ims, time_);
  V_MMCK: kongas_model_2001__V_MMCK(V_MMCK0, ATP0, ADP0, PCr0, Cr0);
  V_MiCK: kongas_model_2001__V_MiCK(V_MiCK0, ATP_i0, ADP_i0, PCr_i0, Cr_i0);
  V_hyd: kongas_model_2001__V_hyd(V_hyd0);
  V_syn: kongas_model_2001__V_syn(V_syn0, Pi_i0, ADP_i0);
  J_ATP: kongas_model_2001__J_ATP(J_ATP0, ATP_i0, ATP0);
  J_ADP: kongas_model_2001__J_ADP(J_ADP0, ADP_i0, ADP0);
  J_PCr: kongas_model_2001__J_PCr(J_PCr0, PCr_i0, PCr0);
  J_Cr: kongas_model_2001__J_Cr(J_Cr0, Cr_i0, Cr0);
  J_Pi: kongas_model_2001__J_Pi(J_Pi0, Pi_i0, Pi_0);
  fractional_volumes: kongas_model_2001__fractional_volumes(V_cyt, V_ims);
end