//Created by libAntimony v2.4
model kholodenko_demin_moehren_hoek_1999_version03__environment(time_)

  // Variable initializations:
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__EGF(EGF, v1, time_)

  // Rate Rules:
  EGF' = - v1;

  // Variable initializations:
  EGF = 680;
  v1 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__R(R, v1, time_)

  // Rate Rules:
  R' = - v1;

  // Variable initializations:
  R = 100;
  v1 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__Ra(Ra, v1, v2, time_)

  // Rate Rules:
  Ra' = v1 - 2 * v2;

  // Variable initializations:
  Ra = 0;
  v1 = ;
  v2 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__R2(R2, v2, v3, v4, time_)

  // Rate Rules:
  R2' = (v2 + v4) - v3;

  // Variable initializations:
  R2 = 0;
  v2 = ;
  v3 = ;
  v4 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__RP(RP, v3, v7, v11, v15, v18, v20, v4, v5, v9, v13, time_)

  // Rate Rules:
  RP' = (v3 + v7 + v11 + v15 + v18 + v20) - (v4 + v5 + v9 + v13);

  // Variable initializations:
  RP = 0;
  v3 = ;
  v7 = ;
  v11 = ;
  v15 = ;
  v18 = ;
  v20 = ;
  v4 = ;
  v5 = ;
  v9 = ;
  v13 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__R_PL(R_PL, v5, v6, time_)

  // Rate Rules:
  R_PL' = v5 - v6;

  // Variable initializations:
  R_PL = 0;
  v5 = ;
  v6 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__R_PLP(R_PLP, v6, v7, time_)

  // Rate Rules:
  R_PLP' = v6 - v7;

  // Variable initializations:
  R_PLP = 0;
  v6 = ;
  v7 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__R_G(R_G, v9, v10, time_)

  // Rate Rules:
  R_G' = v9 - v10;

  // Variable initializations:
  R_G = 0;
  v9 = ;
  v10 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__R_G_S(R_G_S, v10, v11, time_)

  // Rate Rules:
  R_G_S' = v10 - v11;

  // Variable initializations:
  R_G_S = 0;
  v10 = ;
  v11 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__R_Sh(R_Sh, v13, v14, time_)

  // Rate Rules:
  R_Sh' = v13 - v14;

  // Variable initializations:
  R_Sh = 0;
  v13 = ;
  v14 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__R_ShP(R_ShP, v14, v24, v15, v17, time_)

  // Rate Rules:
  R_ShP' = v14 - (v24 + v15 + v17);

  // Variable initializations:
  R_ShP = 0;
  v14 = ;
  v24 = ;
  v15 = ;
  v17 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__R_Sh_G(R_Sh_G, v17, v18, v19, time_)

  // Rate Rules:
  R_Sh_G' = v17 - (v18 + v19);

  // Variable initializations:
  R_Sh_G = 0;
  v17 = ;
  v18 = ;
  v19 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__R_Sh_G_S(R_Sh_G_S, v19, v20, v24, time_)

  // Rate Rules:
  R_Sh_G_S' = (v19 + v24) - v20;

  // Variable initializations:
  R_Sh_G_S = 0;
  v19 = ;
  v20 = ;
  v24 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__G_S(G_S, v11, v23, v12, v24, time_)

  // Rate Rules:
  G_S' = (v11 + v23) - (v12 + v24);

  // Variable initializations:
  G_S = 0;
  v11 = ;
  v23 = ;
  v12 = ;
  v24 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__ShP(ShP, v15, v23, v21, v16, time_)

  // Rate Rules:
  ShP' = (v15 + v23) - (v21 + v16);

  // Variable initializations:
  ShP = 0;
  v15 = ;
  v23 = ;
  v21 = ;
  v16 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__Sh_G(Sh_G, v18, v21, v22, time_)

  // Rate Rules:
  Sh_G' = (v18 + v21) - v22;

  // Variable initializations:
  Sh_G = 0;
  v18 = ;
  v21 = ;
  v22 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__Sh_G_S(Sh_G_S, v20, v22, v23, time_)

  // Rate Rules:
  Sh_G_S' = (v20 + v22) - v23;

  // Variable initializations:
  Sh_G_S = 0;
  v20 = ;
  v22 = ;
  v23 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__PLC_gamma(PLC_gamma, v8, v5, time_)

  // Rate Rules:
  PLC_gamma' = v8 - v5;

  // Variable initializations:
  PLC_gamma = 105;
  v8 = ;
  v5 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__PLC_gamma_P(PLC_gamma_P, v7, v8, v25, time_)

  // Rate Rules:
  PLC_gamma_P' = v7 - (v8 + v25);

  // Variable initializations:
  PLC_gamma_P = 0;
  v7 = ;
  v8 = ;
  v25 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__PLC_gamma_P_I(PLC_gamma_P_I, v25, time_)

  // Rate Rules:
  PLC_gamma_P_I' = v25;

  // Variable initializations:
  PLC_gamma_P_I = 0;
  v25 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__Grb(Grb, v12, v9, v17, v21, time_)

  // Rate Rules:
  Grb' = v12 - (v9 + v17 + v21);

  // Variable initializations:
  Grb = 85;
  v12 = ;
  v9 = ;
  v17 = ;
  v21 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__Shc(Shc, v16, v13, time_)

  // Rate Rules:
  Shc' = v16 - v13;

  // Variable initializations:
  Shc = 150;
  v16 = ;
  v13 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__SOS(SOS, v12, v10, v19, v22, time_)

  // Rate Rules:
  SOS' = v12 - (v10 + v19 + v22);

  // Variable initializations:
  SOS = 34;
  v12 = ;
  v10 = ;
  v19 = ;
  v22 = ;
  time_ = ;
end

model kholodenko_demin_moehren_hoek_1999_version03__v1(v1, R, EGF, Ra)

  // Assignment Rules:
  v1 := k1 * R * EGF - k1_ * Ra;

  // Variable initializations:
  R = ;
  EGF = ;
  Ra = ;
  k1 = 0.003;
  k1_ = 0.06;
end

model kholodenko_demin_moehren_hoek_1999_version03__v2(v2, R2, Ra)

  // Assignment Rules:
  v2 := k2 * Ra * Ra - k2_ * R2;

  // Variable initializations:
  R2 = ;
  Ra = ;
  k2 = 0.01;
  k2_ = 0.1;
end

model kholodenko_demin_moehren_hoek_1999_version03__v3(v3, R2, RP)

  // Assignment Rules:
  v3 := k3 * R2 - k3_ * RP;

  // Variable initializations:
  R2 = ;
  RP = ;
  k3 = 1;
  k3_ = 0.01;
end

model kholodenko_demin_moehren_hoek_1999_version03__v4(v4, RP)

  // Assignment Rules:
  v4 := (V4 * RP) / (K4 + RP);

  // Variable initializations:
  RP = ;
  K4 = 50;
  V4 = 450;
end

model kholodenko_demin_moehren_hoek_1999_version03__v5(v5, R_PL, PLC_gamma, RP)

  // Assignment Rules:
  v5 := k5 * RP * PLC_gamma - k5_ * R_PL;

  // Variable initializations:
  R_PL = ;
  PLC_gamma = ;
  RP = ;
  k5 = 0.06;
  k5_ = 0.2;
end

model kholodenko_demin_moehren_hoek_1999_version03__v6(v6, R_PL, R_PLP)

  // Assignment Rules:
  v6 := k6 * R_PL - k6_ * R_PLP;

  // Variable initializations:
  R_PL = ;
  R_PLP = ;
  k6 = 1;
  k6_ = 0.05;
end

model kholodenko_demin_moehren_hoek_1999_version03__v7(v7, R_PLP, PLC_gamma_P, RP)

  // Assignment Rules:
  v7 := k7 * R_PLP - k7_ * RP * PLC_gamma_P;

  // Variable initializations:
  R_PLP = ;
  PLC_gamma_P = ;
  RP = ;
  k7 = 0.3;
  k7_ = 0.006;
end

model kholodenko_demin_moehren_hoek_1999_version03__v8(v8, PLC_gamma_P)

  // Assignment Rules:
  v8 := (V8 * PLC_gamma_P) / (K8 + PLC_gamma_P);

  // Variable initializations:
  PLC_gamma_P = ;
  K8 = 100;
  V8 = 1;
end

model kholodenko_demin_moehren_hoek_1999_version03__v9(v9, R_G, Grb, RP)

  // Assignment Rules:
  v9 := k9 * RP * Grb - k9_ * R_G;

  // Variable initializations:
  R_G = ;
  Grb = ;
  RP = ;
  k9 = 0.003;
  k9_ = 0.05;
end

model kholodenko_demin_moehren_hoek_1999_version03__v10(v10, R_G_S, SOS, R_G)

  // Assignment Rules:
  v10 := k10 * R_G * SOS - k10_ * R_G_S;

  // Variable initializations:
  R_G_S = ;
  SOS = ;
  R_G = ;
  k10 = 0.01;
  k10_ = 0.06;
end

model kholodenko_demin_moehren_hoek_1999_version03__v11(v11, R_G_S, G_S, RP)

  // Assignment Rules:
  v11 := k11 * R_G_S - k11_ * RP * G_S;

  // Variable initializations:
  R_G_S = ;
  G_S = ;
  RP = ;
  k11 = 0.03;
  k11_ = 4.5e-3;
end

model kholodenko_demin_moehren_hoek_1999_version03__v12(v12, G_S, SOS, Grb)

  // Assignment Rules:
  v12 := k12 * G_S - k12_ * Grb * SOS;

  // Variable initializations:
  G_S = ;
  SOS = ;
  Grb = ;
  k12 = 1.5e-3;
  k12_ = 1e-4;
end

model kholodenko_demin_moehren_hoek_1999_version03__v13(v13, R_Sh, Shc, RP)

  // Assignment Rules:
  v13 := k13 * RP * Shc - k13_ * R_Sh;

  // Variable initializations:
  R_Sh = ;
  Shc = ;
  RP = ;
  k13 = 0.09;
  k13_ = 0.6;
end

model kholodenko_demin_moehren_hoek_1999_version03__v14(v14, R_Sh, R_ShP)

  // Assignment Rules:
  v14 := k14 * R_Sh - k14_ * R_ShP;

  // Variable initializations:
  R_Sh = ;
  R_ShP = ;
  k14 = 6;
  k14_ = 0.06;
end

model kholodenko_demin_moehren_hoek_1999_version03__v15(v15, R_ShP, RP, ShP)

  // Assignment Rules:
  v15 := k15 * R_ShP - k15_ * ShP * RP;

  // Variable initializations:
  R_ShP = ;
  RP = ;
  ShP = ;
  k15 = 0.3;
  k15_ = 9e-4;
end

model kholodenko_demin_moehren_hoek_1999_version03__v16(v16, ShP)

  // Assignment Rules:
  v16 := (V16 * ShP) / (K16 + ShP);

  // Variable initializations:
  ShP = ;
  K16 = 340;
  V16 = 1.7;
end

model kholodenko_demin_moehren_hoek_1999_version03__v17(v17, R_ShP, Grb, R_Sh_G)

  // Assignment Rules:
  v17 := k17 * R_ShP * Grb - k17_ * R_Sh_G;

  // Variable initializations:
  R_ShP = ;
  Grb = ;
  R_Sh_G = ;
  k17 = 0.003;
  k17_ = 0.1;
end

model kholodenko_demin_moehren_hoek_1999_version03__v18(v18, R_Sh_G, RP, Sh_G)

  // Assignment Rules:
  v18 := k18 * R_Sh_G - k18_ * RP * Sh_G;

  // Variable initializations:
  R_Sh_G = ;
  RP = ;
  Sh_G = ;
  k18 = 0.3;
  k18_ = 9e-4;
end

model kholodenko_demin_moehren_hoek_1999_version03__v19(v19, R_Sh_G_S, SOS, R_Sh_G)

  // Assignment Rules:
  v19 := k19 * R_Sh_G * SOS - k19_ * R_Sh_G_S;

  // Variable initializations:
  R_Sh_G_S = ;
  SOS = ;
  R_Sh_G = ;
  k19 = 0.01;
  k19_ = 2.14e-2;
end

model kholodenko_demin_moehren_hoek_1999_version03__v20(v20, Sh_G_S, RP, R_Sh_G_S)

  // Assignment Rules:
  v20 := k20 * R_Sh_G_S - k20_ * Sh_G_S * RP;

  // Variable initializations:
  Sh_G_S = ;
  RP = ;
  R_Sh_G_S = ;
  k20 = 0.12;
  k20_ = 2.4e-4;
end

model kholodenko_demin_moehren_hoek_1999_version03__v21(v21, Sh_G, Grb, ShP)

  // Assignment Rules:
  v21 := k21 * ShP * Grb - k21_ * Sh_G;

  // Variable initializations:
  Sh_G = ;
  Grb = ;
  ShP = ;
  k21 = 0.003;
  k21_ = 0.1;
end

model kholodenko_demin_moehren_hoek_1999_version03__v22(v22, Sh_G_S, SOS, Sh_G)

  // Assignment Rules:
  v22 := k22 * Sh_G * SOS - k22_ * Sh_G_S;

  // Variable initializations:
  Sh_G_S = ;
  SOS = ;
  Sh_G = ;
  k22 = 0.03;
  k22_ = 0.064;
end

model kholodenko_demin_moehren_hoek_1999_version03__v23(v23, G_S, ShP, Sh_G_S)

  // Assignment Rules:
  v23 := k23 * Sh_G_S - k23_ * ShP * G_S;

  // Variable initializations:
  G_S = ;
  ShP = ;
  Sh_G_S = ;
  k23 = 0.1;
  k23_ = 0.021;
end

model kholodenko_demin_moehren_hoek_1999_version03__v24(v24, R_Sh_G_S, G_S, R_ShP)

  // Assignment Rules:
  v24 := k24 * R_ShP * G_S - k24_ * R_Sh_G_S;

  // Variable initializations:
  R_Sh_G_S = ;
  G_S = ;
  R_ShP = ;
  k24 = 0.009;
  k24_ = 4.29e-2;
end

model kholodenko_demin_moehren_hoek_1999_version03__v25(v25, PLC_gamma_P, PLC_gamma_P_I)

  // Assignment Rules:
  v25 := k25 * PLC_gamma_P - k25_ * PLC_gamma_P_I;

  // Variable initializations:
  PLC_gamma_P = ;
  PLC_gamma_P_I = ;
  k25 = 1;
  k25_ = 0.03;
end

model kholodenko_demin_moehren_hoek_1999_version03__combined_concs(RP, R_PL, R_PLP, R_G, R_G_S, R_Sh, R_ShP, R_Sh_G, R_Sh_G_S, PLC_gamma_P, ShP, Sh_G, Sh_G_S)

  // Assignment Rules:
  totEGFRphos := 2 * (RP + R_PL + R_PLP + R_G + R_G_S + R_Sh + R_ShP + R_Sh_G + R_Sh_G_S);
  totPLCgammaphos := R_PLP + PLC_gamma_P;
  totGrb_EGFR := R_G + R_G_S + R_Sh_G + R_Sh_G_S;
  totGrb_Shc := R_Sh_G + Sh_G + R_Sh_G_S + Sh_G_S;
  totShcphos := R_ShP + R_Sh_G + R_Sh_G_S + ShP + Sh_G + Sh_G_S;
  totShc_EGFR := R_ShP + R_Sh_G + R_Sh_G_S;
  totSOS_EGFR := R_G_S + R_Sh_G_S;

  // Variable initializations:
  RP = ;
  R_PL = ;
  R_PLP = ;
  R_G = ;
  R_G_S = ;
  R_Sh = ;
  R_ShP = ;
  R_Sh_G = ;
  R_Sh_G_S = ;
  PLC_gamma_P = ;
  ShP = ;
  Sh_G = ;
  Sh_G_S = ;
end

model *kholodenko_demin_moehren_hoek_1999_version03____main()

  // Sub-modules, and any changes to those submodules:
  environment: kholodenko_demin_moehren_hoek_1999_version03__environment(time_);
  EGF: kholodenko_demin_moehren_hoek_1999_version03__EGF(EGF0, v110, time_);
  R: kholodenko_demin_moehren_hoek_1999_version03__R(R0, v110, time_);
  Ra: kholodenko_demin_moehren_hoek_1999_version03__Ra(Ra0, v110, v26, time_);
  R2: kholodenko_demin_moehren_hoek_1999_version03__R2(R20, v26, v30, v40, time_);
  RP: kholodenko_demin_moehren_hoek_1999_version03__RP(RP0, v30, v70, v111, v150, v180, v200, v40, v50, v90, v130, time_);
  R_PL: kholodenko_demin_moehren_hoek_1999_version03__R_PL(R_PL0, v50, v60, time_);
  R_PLP: kholodenko_demin_moehren_hoek_1999_version03__R_PLP(R_PLP0, v60, v70, time_);
  R_G: kholodenko_demin_moehren_hoek_1999_version03__R_G(R_G0, v90, v100, time_);
  R_G_S: kholodenko_demin_moehren_hoek_1999_version03__R_G_S(R_G_S0, v100, v111, time_);
  R_Sh: kholodenko_demin_moehren_hoek_1999_version03__R_Sh(R_Sh0, v130, v140, time_);
  R_ShP: kholodenko_demin_moehren_hoek_1999_version03__R_ShP(R_ShP0, v140, v240, v150, v170, time_);
  R_Sh_G: kholodenko_demin_moehren_hoek_1999_version03__R_Sh_G(R_Sh_G0, v170, v180, v190, time_);
  R_Sh_G_S: kholodenko_demin_moehren_hoek_1999_version03__R_Sh_G_S(R_Sh_G_S0, v190, v200, v240, time_);
  G_S: kholodenko_demin_moehren_hoek_1999_version03__G_S(G_S0, v111, v230, v120, v240, time_);
  ShP: kholodenko_demin_moehren_hoek_1999_version03__ShP(ShP0, v150, v230, v210, v160, time_);
  Sh_G: kholodenko_demin_moehren_hoek_1999_version03__Sh_G(Sh_G0, v180, v210, v220, time_);
  Sh_G_S: kholodenko_demin_moehren_hoek_1999_version03__Sh_G_S(Sh_G_S0, v200, v220, v230, time_);
  PLC_gamma: kholodenko_demin_moehren_hoek_1999_version03__PLC_gamma(PLC_gamma0, v80, v50, time_);
  PLC_gamma_P: kholodenko_demin_moehren_hoek_1999_version03__PLC_gamma_P(PLC_gamma_P0, v70, v80, v250, time_);
  PLC_gamma_P_I: kholodenko_demin_moehren_hoek_1999_version03__PLC_gamma_P_I(PLC_gamma_P_I0, v250, time_);
  Grb: kholodenko_demin_moehren_hoek_1999_version03__Grb(Grb0, v120, v90, v170, v210, time_);
  Shc: kholodenko_demin_moehren_hoek_1999_version03__Shc(Shc0, v160, v130, time_);
  SOS: kholodenko_demin_moehren_hoek_1999_version03__SOS(SOS0, v120, v100, v190, v220, time_);
  v1: kholodenko_demin_moehren_hoek_1999_version03__v1(v110, R0, EGF0, Ra0);
  v2: kholodenko_demin_moehren_hoek_1999_version03__v2(v26, R20, Ra0);
  v3: kholodenko_demin_moehren_hoek_1999_version03__v3(v30, R20, RP0);
  v4: kholodenko_demin_moehren_hoek_1999_version03__v4(v40, RP0);
  v5: kholodenko_demin_moehren_hoek_1999_version03__v5(v50, R_PL0, PLC_gamma0, RP0);
  v6: kholodenko_demin_moehren_hoek_1999_version03__v6(v60, R_PL0, R_PLP0);
  v7: kholodenko_demin_moehren_hoek_1999_version03__v7(v70, R_PLP0, PLC_gamma_P0, RP0);
  v8: kholodenko_demin_moehren_hoek_1999_version03__v8(v80, PLC_gamma_P0);
  v9: kholodenko_demin_moehren_hoek_1999_version03__v9(v90, R_G0, Grb0, RP0);
  v10: kholodenko_demin_moehren_hoek_1999_version03__v10(v100, R_G_S0, SOS0, R_G0);
  v11: kholodenko_demin_moehren_hoek_1999_version03__v11(v111, R_G_S0, G_S0, RP0);
  v12: kholodenko_demin_moehren_hoek_1999_version03__v12(v120, G_S0, SOS0, Grb0);
  v13: kholodenko_demin_moehren_hoek_1999_version03__v13(v130, R_Sh0, Shc0, RP0);
  v14: kholodenko_demin_moehren_hoek_1999_version03__v14(v140, R_Sh0, R_ShP0);
  v15: kholodenko_demin_moehren_hoek_1999_version03__v15(v150, R_ShP0, RP0, ShP0);
  v16: kholodenko_demin_moehren_hoek_1999_version03__v16(v160, ShP0);
  v17: kholodenko_demin_moehren_hoek_1999_version03__v17(v170, R_ShP0, Grb0, R_Sh_G0);
  v18: kholodenko_demin_moehren_hoek_1999_version03__v18(v180, R_Sh_G0, RP0, Sh_G0);
  v19: kholodenko_demin_moehren_hoek_1999_version03__v19(v190, R_Sh_G_S0, SOS0, R_Sh_G0);
  v20: kholodenko_demin_moehren_hoek_1999_version03__v20(v200, Sh_G_S0, RP0, R_Sh_G_S0);
  v21: kholodenko_demin_moehren_hoek_1999_version03__v21(v210, Sh_G0, Grb0, ShP0);
  v22: kholodenko_demin_moehren_hoek_1999_version03__v22(v220, Sh_G_S0, SOS0, Sh_G0);
  v23: kholodenko_demin_moehren_hoek_1999_version03__v23(v230, G_S0, ShP0, Sh_G_S0);
  v24: kholodenko_demin_moehren_hoek_1999_version03__v24(v240, R_Sh_G_S0, G_S0, R_ShP0);
  v25: kholodenko_demin_moehren_hoek_1999_version03__v25(v250, PLC_gamma_P0, PLC_gamma_P_I0);
  combined_concs: kholodenko_demin_moehren_hoek_1999_version03__combined_concs(RP0, R_PL0, R_PLP0, R_G0, R_G_S0, R_Sh0, R_ShP0, R_Sh_G0, R_Sh_G_S0, PLC_gamma_P0, ShP0, Sh_G0, Sh_G_S0);
end