//Created by libAntimony v2.4

// Warnings from automatic translation:
//    Unable to figure out how to translate an assignment to "partialdiff(G)/partialdiff(unknown-element)" in the Antimony format.  This variable may have been left undefined in that component.
//    Unable to figure out how to translate an assignment to "partialdiff(G)/partialdiff(unknown-element)" in the Antimony format.  This variable may have been left undefined in that component.
//    Unable to figure out how to translate an assignment to "partialdiff(G)/partialdiff(unknown-element)" in the Antimony format.  This variable may have been left undefined in that component.
//    Unable to figure out how to translate an assignment to "partialdiff(I)/partialdiff(unknown-element)" in the Antimony format.  This variable may have been left undefined in that component.
//    Unable to figure out how to translate an assignment to "partialdiff(I)/partialdiff(unknown-element)" in the Antimony format.  This variable may have been left undefined in that component.
//    Unable to figure out how to translate an assignment to "partialdiff(I)/partialdiff(unknown-element)" in the Antimony format.  This variable may have been left undefined in that component.

model keener_2001_version01__environment(time_, rho)

  // Variable initializations:
  time_ = ;
  rho = ;
end

model keener_2001_version01__intracellular_glucose(G_i, time_, Rm, R1, R2, rho)

  // Rate Rules:
  G_i' = ((R1 + R2) - Rm) / rho;

  // Variable initializations:
  G_i = 0.0;
  time_ = ;
  Rm = ;
  R1 = ;
  R2 = ;
  rho = ;
end

model keener_2001_version01__extracellular_glucose(G, x, V, time_, R1, R2, rho)

  // Variable initializations:
  G = 5.0;
  x = 0.1;
  V = 3.8;
  D_G = 6.6E-6;
  A = ;
  B = ;
  time_ = ;
  R1 = ;
  R2 = ;
  rho = ;
end

model keener_2001_version01__insulin(I, time_, Rs, x, V)

  // Variable initializations:
  I = 0.0;
  D_I = 2.1E-6;
  C = ;
  D = ;
  time_ = ;
  Rs = ;
  x = ;
  V = ;
end

model keener_2001_version01__insulin_inhibition(J, time_, I)

  // Assignment Rules:
  J_infinity := K_inh / (K_inh + I);

  // Rate Rules:
  J' = J_tau * (J_infinity - J);

  // Variable initializations:
  J = ;
  J_tau = 20.0;
  K_inh = 1.0E-6;
  time_ = ;
  I = ;
end

model keener_2001_version01__glucose_metabolism(Rm, time_, G_i, rho)

  // Assignment Rules:
  Rm := rho * ((Vm * G_i) / (Km + G_i));

  // Variable initializations:
  Vm = 0.24;
  Km = 9.8;
  time_ = ;
  G_i = ;
  rho = ;
end

model keener_2001_version01__GLUT_1_transporter(R1, time_, I, G, G_i, rho)

  // Assignment Rules:
  R1 := rho * ((V1 * (G - G_i)) / ((K1 + G_i) * (1.0 + G / K1))) * (I / (Ki + I));

  // Variable initializations:
  V1 = 120.0;
  K1 = 1.4;
  Ki = 4.0E-5;
  time_ = ;
  I = ;
  G = ;
  G_i = ;
  rho = ;
end

model keener_2001_version01__GLUT_2_transporter(R2, time_, G, G_i, rho)

  // Assignment Rules:
  R2 := rho * ((V2 * (G * Jm - G_i)) / ((K2 + G_i) * (1.0 + G / K2)));

  // Variable initializations:
  V2 = 32.0;
  K2 = 17.0;
  Jm = ;
  time_ = ;
  G = ;
  G_i = ;
  rho = ;
end

model keener_2001_version01__insulin_secretion(Rs, time_, Rm, rho)

  // Assignment Rules:
  Rs := (Vs * (power(Rm, 4.0) + power(rho, 4.0) * power(L, 4.0))) / (power(Rm, 4.0) + power(rho, 4.0) * power(Ks, 4.0) + power(rho, 4.0) * power(L, 4.0));

  // Variable initializations:
  Vs = 0.034;
  Ks = 0.13;
  L = 0.01;
  time_ = ;
  Rm = ;
  rho = ;
end

model *keener_2001_version01____main()

  // Sub-modules, and any changes to those submodules:
  environment: keener_2001_version01__environment(time_, rho);
  intracellular_glucose: keener_2001_version01__intracellular_glucose(G_i, time_, Rm, R1, R2, rho);
  extracellular_glucose: keener_2001_version01__extracellular_glucose(G, x, V, time_, R1, R2, rho);
  insulin: keener_2001_version01__insulin(I, time_, Rs, x, V);
  insulin_inhibition: keener_2001_version01__insulin_inhibition(J, time_, I);
  glucose_metabolism: keener_2001_version01__glucose_metabolism(Rm, time_, G_i, rho);
  GLUT_1_transporter: keener_2001_version01__GLUT_1_transporter(R1, time_, I, G, G_i, rho);
  GLUT_2_transporter: keener_2001_version01__GLUT_2_transporter(R2, time_, G, G_i, rho);
  insulin_secretion: keener_2001_version01__insulin_secretion(Rs, time_, Rm, rho);
end