//Created by libAntimony v2.4
model grange_holford_guentert_2001__environment(time_)

  // Variable initializations:
  time_ = ;
end

model grange_holford_guentert_2001__gastrointestinal_compartment_L_dopa(F_b_dopa, A_dopa_b, ka_b_dopa, CL_dopa_0, time_)

  // Assignment Rules:
  F_b_dopa := F_H * F_G;
  F_G := 0.244;
  F_H := 1 - CL_H / Q;
  CL_H := f_H * CL_dopa_0;

  // Rate Rules:
  A_dopa_b' = - ka_b_dopa * A_dopa_b;

  // Variable initializations:
  A_dopa_b = 101;
  ka_b_dopa = 2.11;
  Q = 0.828;
  f_H = 0.13;
  CL_dopa_0 = ;
  time_ = ;
end

model grange_holford_guentert_2001__body_compartment_L_dopa(C_dopa_b, time_, A_dopa_b, F_b_dopa, ka_b_dopa, CL_dopa)

  // Rate Rules:
  C_dopa_b' = (1 / V_dopa) * (ka_b_dopa * A_dopa_b * F_b_dopa - CL_dopa * C_dopa_b);

  // Variable initializations:
  C_dopa_b = 0;
  V_dopa = 0.496;
  time_ = ;
  A_dopa_b = ;
  F_b_dopa = ;
  ka_b_dopa = ;
  CL_dopa = ;
end

model grange_holford_guentert_2001__body_compartment_3_OMD(time_, C_dopa_b, CL_COMT)

  // Rate Rules:
  C_OMD_b' = (1 / V_OMD_b) * (CL_COMT * C_dopa_b - CL_OMD_b * C_OMD_b);

  // Variable initializations:
  C_OMD_b = 0;
  CL_OMD_b = 0.012;
  V_OMD_b = 0.196;
  time_ = ;
  C_dopa_b = ;
  CL_COMT = ;
end

model grange_holford_guentert_2001__L_dopa_clearance(CL_dopa, CL_dopa_0, CL_COMT, C1_M)

  // Assignment Rules:
  CL_dopa := CL_AADC + CL_COMT + CL_REST;
  CL_COMT := CL_dopa_0 * 0.1;
  CL_AADC := CL_AADC0 / (1 + C1_M / ki);
  CL_AADC0 := CL_dopa_0 * 0.69;
  CL_REST := CL_dopa_0 * 0.21;

  // Variable initializations:
  CL_dopa_0 = 0.823;
  C1_M = ;
  ki = 0.00246;
end

model grange_holford_guentert_2001__gastrointestinal_compartment_benserazide(A_bens, ka_Bens, F_Bens, time_)

  // Rate Rules:
  A_bens' = - ka_Bens * A_bens;

  // Variable initializations:
  A_bens = 19.51;
  ka_Bens = 0.94;
  F_Bens = 0.022;
  time_ = ;
end

model grange_holford_guentert_2001__central_compartment_benserazide(C_bens_central, CLd_B, time_, A_bens, ka_Bens, F_Bens, C_bens_peripheral, CL_bens_total)

  // Rate Rules:
  C_bens_central' = (1 / V1_B) * ((ka_Bens * A_bens * F_Bens - CL_bens_total * C_bens_central) + CLd_B * (C_bens_peripheral - C_bens_central));

  // Variable initializations:
  C_bens_central = 0;
  V1_B = 0.202;
  CLd_B = 0.072;
  time_ = ;
  A_bens = ;
  ka_Bens = ;
  F_Bens = ;
  C_bens_peripheral = ;
  CL_bens_total = ;
end

model grange_holford_guentert_2001__peripheral_compartment_benserazide(C_bens_peripheral, time_, CLd_B, C_bens_central)

  // Rate Rules:
  C_bens_peripheral' = (1 / V2_B) * CLd_B * (C_bens_central - C_bens_peripheral);

  // Variable initializations:
  C_bens_peripheral = 0;
  V2_B = 0.127;
  time_ = ;
  CLd_B = ;
  C_bens_central = ;
end

model grange_holford_guentert_2001__benserazide_clearance(CL_bens_total, CL_Ro)

  // Assignment Rules:
  CL_bens_total := CL_B / (1 - fm);
  CL_Ro := CL_bens_total * fm;

  // Variable initializations:
  CL_B = 1.67;
  fm = 0.15;
end

model grange_holford_guentert_2001__gastrointestinal_compartment_Ro(A_Ro, ka_M, F_Ro, time_)

  // Rate Rules:
  A_Ro' = - ka_M * A_Ro;

  // Variable initializations:
  A_Ro = 1.3658;
  ka_M = 2.47;
  F_Ro = 1;
  time_ = ;
end

model grange_holford_guentert_2001__central_compartment_Ro(C_Ro_central, CLd_M, time_, C_bens_central, CL_Ro, A_Ro, ka_M, F_Ro, C_Ro_peripheral)

  // Rate Rules:
  C_Ro_central' = (1 / V1_M) * ((ka_M * A_Ro * F_Ro - CL_M * C_Ro_central) + CL_Ro * C_bens_central + CLd_M * (C_Ro_peripheral - C_Ro_central));

  // Variable initializations:
  C_Ro_central = 0;
  V1_M = 0.0691;
  CLd_M = 1.06;
  CL_M = 4.29;
  time_ = ;
  C_bens_central = ;
  CL_Ro = ;
  A_Ro = ;
  ka_M = ;
  F_Ro = ;
  C_Ro_peripheral = ;
end

model grange_holford_guentert_2001__peripheral_compartment_Ro(C_Ro_peripheral, time_, CLd_M, C_Ro_central)

  // Rate Rules:
  C_Ro_peripheral' = (1 / V2_M) * CLd_M * (C_Ro_central - C_Ro_peripheral);

  // Variable initializations:
  C_Ro_peripheral = 0;
  V2_M = 3.2;
  time_ = ;
  CLd_M = ;
  C_Ro_central = ;
end

model *grange_holford_guentert_2001____main()

  // Sub-modules, and any changes to those submodules:
  environment: grange_holford_guentert_2001__environment(time_);
  gastrointestinal_compartment_L_dopa: grange_holford_guentert_2001__gastrointestinal_compartment_L_dopa(F_b_dopa, A_dopa_b, ka_b_dopa, CL_dopa_0, time_);
  body_compartment_L_dopa: grange_holford_guentert_2001__body_compartment_L_dopa(C_dopa_b, time_, A_dopa_b, F_b_dopa, ka_b_dopa, CL_dopa);
  body_compartment_3_OMD: grange_holford_guentert_2001__body_compartment_3_OMD(time_, C_dopa_b, CL_COMT);
  L_dopa_clearance: grange_holford_guentert_2001__L_dopa_clearance(CL_dopa, CL_dopa_0, CL_COMT, C_Ro_central);
  gastrointestinal_compartment_benserazide: grange_holford_guentert_2001__gastrointestinal_compartment_benserazide(A_bens, ka_Bens, F_Bens, time_);
  central_compartment_benserazide: grange_holford_guentert_2001__central_compartment_benserazide(C_bens_central, CLd_B, time_, A_bens, ka_Bens, F_Bens, C_bens_peripheral, CL_bens_total);
  peripheral_compartment_benserazide: grange_holford_guentert_2001__peripheral_compartment_benserazide(C_bens_peripheral, time_, CLd_B, C_bens_central);
  benserazide_clearance: grange_holford_guentert_2001__benserazide_clearance(CL_bens_total, CL_Ro);
  gastrointestinal_compartment_Ro: grange_holford_guentert_2001__gastrointestinal_compartment_Ro(A_Ro, ka_M, F_Ro, time_);
  central_compartment_Ro: grange_holford_guentert_2001__central_compartment_Ro(C_Ro_central, CLd_M, time_, C_bens_central, CL_Ro, A_Ro, ka_M, F_Ro, C_Ro_peripheral);
  peripheral_compartment_Ro: grange_holford_guentert_2001__peripheral_compartment_Ro(C_Ro_peripheral, time_, CLd_M, C_Ro_central);
end