//Created by libAntimony v2.4 model goldbeter_2007__environment(time_) // Variable initializations: time_ = ; end model goldbeter_2007__RA(RA, v_s1, k_d1, time_) // Rate Rules: RA' = (v_s1 - k_d1 * C * RA) - k_d5 * RA; // Variable initializations: RA = 0.1; v_s1 = ; k_d1 = ; C = 0.1; k_d5 = 0; time_ = ; end model goldbeter_2007__M_C(M_C, F, k_d3, time_) // Rate Rules: M_C' = (V_0 + (V_sC * power(F, n)) / (power(K_A, n) + power(F, n))) - k_d3 * M_C; // Variable initializations: M_C = 0.1; V_0 = 0.365; V_sC = 7.1; F = ; n = 2; K_A = 0.2; k_d3 = ; time_ = ; end model goldbeter_2007__C(k_s2, M_C, k_d2, time_) // Rate Rules: C' = k_s2 * M_C - k_d2 * C; // Variable initializations: C = 0.1; k_s2 = ; M_C = ; k_d2 = ; time_ = ; end model goldbeter_2007__F(F, k_s3, M_F, RA, k_d4, time_) // Rate Rules: F' = (k_s3 * M_F * power(K_I, m)) / (power(K_I, m) + power(RA, m)) - k_d4 * F; // Variable initializations: F = 0.0001; k_s3 = ; M_F = ; m = 2; K_I = 0.2; RA = ; k_d4 = ; time_ = ; end model goldbeter_2007__v_s1(v_s1, k_s1, RALDH2_0, x, L) // Assignment Rules: v_s1 := k_s1 * RALDH2_0 * (1 - x / L); // Variable initializations: k_s1 = ; RALDH2_0 = ; x = ; L = ; end model goldbeter_2007__M_F(M_F, M_0, x, L) // Assignment Rules: M_F := (M_0 * x) / L; // Variable initializations: M_0 = ; x = ; L = ; end model goldbeter_2007__alpha_1(alpha_1, RA, K_r1) // Assignment Rules: alpha_1 := RA / (RA + K_r1); // Variable initializations: RA = ; K_r1 = ; end model goldbeter_2007__alpha_2(alpha_2, F, K_r2) // Assignment Rules: alpha_2 := F / (F + K_r2); // Variable initializations: F = ; K_r2 = ; end model goldbeter_2007__rho(rho, alpha_1, alpha_2) // Assignment Rules: rho := alpha_2 / alpha_1; // Variable initializations: alpha_1 = ; alpha_2 = ; end model goldbeter_2007__model_parameters(M_0, x, L, k_s1, k_s2, k_s3, k_d3, k_d4, k_d1, k_d2, RALDH2_0, K_r1, K_r2) // Variable initializations: M_0 = 5; x = 15; L = 50; k_s1 = 1; k_s2 = 1; k_s3 = 1; k_d3 = 1; k_d4 = 1; k_d1 = 1; k_d2 = 0.28; RALDH2_0 = 7.1; K_r1 = 1; K_r2 = 1; end model *goldbeter_2007____main() // Sub-modules, and any changes to those submodules: environment: goldbeter_2007__environment(time_); RA: goldbeter_2007__RA(RA0, v_s10, k_d1, time_); M_C: goldbeter_2007__M_C(M_C0, F0, k_d3, time_); C: goldbeter_2007__C(k_s2, M_C0, k_d2, time_); F: goldbeter_2007__F(F0, k_s3, M_F0, RA0, k_d4, time_); v_s1: goldbeter_2007__v_s1(v_s10, k_s1, RALDH2_0, x, L); M_F: goldbeter_2007__M_F(M_F0, M_0, x, L); alpha_1: goldbeter_2007__alpha_1(alpha_10, RA0, K_r1); alpha_2: goldbeter_2007__alpha_2(alpha_20, F0, K_r2); rho: goldbeter_2007__rho(rho0, alpha_10, alpha_20); model_parameters: goldbeter_2007__model_parameters(M_0, x, L, k_s1, k_s2, k_s3, k_d3, k_d4, k_d1, k_d2, RALDH2_0, K_r1, K_r2); end