//Created by libAntimony v2.4
model fink_slepchenko_loew_1999_version01__environment(time_)

  // Variable initializations:
  time_ = ;
end

model fink_slepchenko_loew_1999_version01__Calcium_dynamics(Ca, time_, J_channel, J_pump, J_leak, beta)

  // Rate Rules:
  Ca' = beta * ((J_channel - J_pump) + J_leak);

  // Variable initializations:
  Ca = 0.05;
  time_ = ;
  J_channel = ;
  J_pump = ;
  J_leak = ;
  beta = ;
end

model fink_slepchenko_loew_1999_version01__ER(Ca_ER)

  // Variable initializations:
  Ca_ER = 400.0;
end

model fink_slepchenko_loew_1999_version01__Channel_kinetics(J_channel, time_, Ca, Ca_ER)

  // Assignment Rules:
  J_channel := J_max * power((I / (I + K_I)) * (Ca / (Ca + K_act)) * h, 3.0) * (1.0 - Ca / Ca_ER);

  // Rate Rules:
  h' = k_on * (K_inh - h * (Ca + K_inh));

  // Variable initializations:
  J_max = 2880.0;
  h = 0.667;
  K_act = 0.17;
  K_I = 0.03;
  K_inh = 0.1;
  k_on = 8.0;
  I = 0.01;
  time_ = ;
  Ca = ;
  Ca_ER = ;
end

model fink_slepchenko_loew_1999_version01__SERCA_pump_kinetics(J_pump, time_, Ca)

  // Assignment Rules:
  J_pump := V_max * (power(Ca, 2.0) / (power(Ca, 2.0) + power(K_p, 2.0)));

  // Variable initializations:
  V_max = 5.85;
  K_p = 0.24;
  time_ = ;
  Ca = ;
end

model fink_slepchenko_loew_1999_version01__Calcium_buffering(beta, time_)

  // Assignment Rules:
  beta := power(1.0 + B_end / K_end + (B_ex * K_ex) / power(Ca_ex + K_ex, 2.0), -1.0);

  // Variable initializations:
  B_end = 12.0;
  B_ex = 11.35;
  K_end = 0.3;
  K_ex = 0.26;
  Ca_ex = ;
  time_ = ;
end

model fink_slepchenko_loew_1999_version01__Leak(J_leak, time_, Ca, Ca_ER)

  // Assignment Rules:
  J_leak := L * (1.0 - Ca / Ca_ER);

  // Variable initializations:
  L = 0.0804;
  time_ = ;
  Ca = ;
  Ca_ER = ;
end

model *fink_slepchenko_loew_1999_version01____main()

  // Sub-modules, and any changes to those submodules:
  environment: fink_slepchenko_loew_1999_version01__environment(time_);
  Calcium_dynamics: fink_slepchenko_loew_1999_version01__Calcium_dynamics(Ca, time_, J_channel, J_pump, J_leak, beta);
  ER: fink_slepchenko_loew_1999_version01__ER(Ca_ER);
  Channel_kinetics: fink_slepchenko_loew_1999_version01__Channel_kinetics(J_channel, time_, Ca, Ca_ER);
  SERCA_pump_kinetics: fink_slepchenko_loew_1999_version01__SERCA_pump_kinetics(J_pump, time_, Ca);
  Calcium_buffering: fink_slepchenko_loew_1999_version01__Calcium_buffering(beta, time_);
  Leak: fink_slepchenko_loew_1999_version01__Leak(J_leak, time_, Ca, Ca_ER);
end