//Created by libAntimony v2.4
model cui_2008__environment(time_)

  // Variable initializations:
  time_ = ;
end

model cui_2008__BMK1(BMK1, v10a, v10b, time_)

  // Rate Rules:
  BMK1' = v10b - v10a;

  // Variable initializations:
  BMK1 = 0.012;
  v10a = ;
  v10b = ;
  time_ = ;
end

model cui_2008__MRNA(MRNA, v18, v19, time_)

  // Rate Rules:
  MRNA' = v19 - v18;

  // Variable initializations:
  MRNA = 3.33E-4;
  v18 = ;
  v19 = ;
  time_ = ;
end

model cui_2008__NFATc(NFATc, v1, v14, v15, time_)

  // Rate Rules:
  NFATc' = v14 - (v1 + v15);

  // Variable initializations:
  NFATc = 2E-5;
  v1 = ;
  v14 = ;
  v15 = ;
  time_ = ;
end

model cui_2008__NFATn(NFATn, v1, v16, v17, v18, time_)

  // Rate Rules:
  NFATn' = (v1 + v16) - (v17 + v18);

  // Variable initializations:
  NFATn = 4.99E-4;
  v1 = ;
  v16 = ;
  v17 = ;
  v18 = ;
  time_ = ;
end

model cui_2008__NFATpc(NFATpc, v2, v9, v14, v15, time_)

  // Rate Rules:
  NFATpc' = (v2 + v15) - (v9 + v14);

  // Variable initializations:
  NFATpc = 4.94E-3;
  v2 = ;
  v9 = ;
  v14 = ;
  v15 = ;
  time_ = ;
end

model cui_2008__NFATpn(NFATpn, v2, v16, v17, time_)

  // Rate Rules:
  NFATpn' = v17 - (v2 + v16);

  // Variable initializations:
  NFATpn = 8.01E-5;
  v2 = ;
  v16 = ;
  v17 = ;
  time_ = ;
end

model cui_2008__GSK3betac(GSK3betac, v3, v12a, v12b, v15a, v15b, time_)

  // Rate Rules:
  GSK3betac' = (v12b + v15b) - (v3 + v12a + v15a);

  // Variable initializations:
  GSK3betac = 0.17;
  v3 = ;
  v12a = ;
  v12b = ;
  v15a = ;
  v15b = ;
  time_ = ;
end

model cui_2008__GSK3betan(GSK3betan, v3, v17a, v17b, time_)

  // Rate Rules:
  GSK3betan' = (v3 + v17b) - v17a;

  // Variable initializations:
  GSK3betan = 0.339;
  v3 = ;
  v17a = ;
  v17b = ;
  time_ = ;
end

model cui_2008__CaNc(CaNc, v6, time_)

  // Rate Rules:
  CaNc' = - v6;

  // Variable initializations:
  CaNc = 0.91;
  v6 = ;
  time_ = ;
end

model cui_2008__CaNc_star(CaNc_star, v4, v6, v7, v11a, v11b, v13a, v13b, v14a, v14b, time_)

  // Rate Rules:
  CaNc_star' = (v6 + v11b + v13b + v14b) - (v4 + v7 + v11a + v13a + v14a);

  // Variable initializations:
  CaNc_star = 0.0275;
  v4 = ;
  v6 = ;
  v7 = ;
  v11a = ;
  v11b = ;
  v13a = ;
  v13b = ;
  v14a = ;
  v14b = ;
  time_ = ;
end

model cui_2008__CaNn_star(CaNn_star, v4, v16a, v16b, time_)

  // Rate Rules:
  CaNn_star' = (v4 + v16b) - v16a;

  // Variable initializations:
  CaNn_star = 0.0568;
  v4 = ;
  v16a = ;
  v16b = ;
  time_ = ;
end

model cui_2008__CaNn(CaNn, v6, time_)

  // Rate Rules:
  CaNn' = - v6;

  // Variable initializations:
  CaNn = 0.0057;
  v6 = ;
  time_ = ;
end

model cui_2008__CaM(CaM, v5, time_)

  // Rate Rules:
  CaM' = - v5;

  // Variable initializations:
  CaM = 25.2;
  v5 = ;
  time_ = ;
end

model cui_2008__CaMCa(CaMCa, v5, v6, time_)

  // Rate Rules:
  CaMCa' = v5 - v6;

  // Variable initializations:
  CaMCa = 7.88E-7;
  v5 = ;
  v6 = ;
  time_ = ;
end

model cui_2008__MCIP(MCIP, v7, v10, v11, v19, time_)

  // Rate Rules:
  MCIP' = v11 - (v7 + v10 + v19);

  // Variable initializations:
  MCIP = 2.15E-4;
  v7 = ;
  v10 = ;
  v11 = ;
  v19 = ;
  time_ = ;
end

model cui_2008__MCIPp(MCIPp, v10, v11, v12, v13, time_)

  // Rate Rules:
  MCIPp' = (v10 + v13) - (v11 + v12);

  // Variable initializations:
  MCIPp = 7.76E-3;
  v10 = ;
  v11 = ;
  v12 = ;
  v13 = ;
  time_ = ;
end

model cui_2008__MCIPpp(MCIPpp, v8, v12, v13, time_)

  // Rate Rules:
  MCIPpp' = v12 - (v8 + v13);

  // Variable initializations:
  MCIPpp = 0.0798;
  v8 = ;
  v12 = ;
  v13 = ;
  time_ = ;
end

model cui_2008__Comp1(Comp1, v7, time_)

  // Rate Rules:
  Comp1' = v7;

  // Variable initializations:
  Comp1 = 5.21E-3;
  v7 = ;
  time_ = ;
end

model cui_2008__Comp2(Comp2, v8, time_)

  // Rate Rules:
  Comp2' = v8;

  // Variable initializations:
  Comp2 = 0.283;
  v8 = ;
  time_ = ;
end

model cui_2008__Comp3(Comp3, v9, time_)

  // Rate Rules:
  Comp3' = v9;

  // Variable initializations:
  Comp3 = 0.014;
  v9 = ;
  time_ = ;
end

model cui_2008__P1433(P1433, v8, v9, time_)

  // Rate Rules:
  P1433' = -(v8 + v9);

  // Variable initializations:
  P1433 = 0.708;
  v8 = ;
  v9 = ;
  time_ = ;
end

model cui_2008__MCIP_BMK1(MCIP_BMK1, v10a, v10b, time_)

  // Rate Rules:
  MCIP_BMK1' = v10a - v10b;

  // Variable initializations:
  MCIP_BMK1 = 2.14E-5;
  v10a = ;
  v10b = ;
  time_ = ;
end

model cui_2008__MCIPp_CaNc_star(MCIPp_CaNc_star, v11a, v11b, time_)

  // Rate Rules:
  MCIPp_CaNc_star' = v11a - v11b;

  // Variable initializations:
  MCIPp_CaNc_star = 1.07E-4;
  v11a = ;
  v11b = ;
  time_ = ;
end

model cui_2008__MCIPp_GSK3betac(MCIPp_GSK3betac, v12a, v12b, time_)

  // Rate Rules:
  MCIPp_GSK3betac' = v12a - v12b;

  // Variable initializations:
  MCIPp_GSK3betac = 1.1E-3;
  v12a = ;
  v12b = ;
  time_ = ;
end

model cui_2008__MCIPpp_CaNc_star(MCIPpp_CaNc_star, v13a, v13b, time_)

  // Rate Rules:
  MCIPpp_CaNc_star' = v13a - v13b;

  // Variable initializations:
  MCIPpp_CaNc_star = 1.1E-3;
  v13a = ;
  v13b = ;
  time_ = ;
end

model cui_2008__NFATpc_CaNc_star(NFATpc_CaNc_star, v14a, v14b, time_)

  // Rate Rules:
  NFATpc_CaNc_star' = v14a - v14b;

  // Variable initializations:
  NFATpc_CaNc_star = 8.15E-5;
  v14a = ;
  v14b = ;
  time_ = ;
end

model cui_2008__NFATc_GSK3betac(NFATc_GSK3betac, v15a, v15b, time_)

  // Rate Rules:
  NFATc_GSK3betac' = v15a - v15b;

  // Variable initializations:
  NFATc_GSK3betac = 1.36E-6;
  v15a = ;
  v15b = ;
  time_ = ;
end

model cui_2008__NFATpn_CaNn_star(NFATpn_CaNn_star, v16a, v16b, time_)

  // Rate Rules:
  NFATpn_CaNn_star' = v16a - v16b;

  // Variable initializations:
  NFATpn_CaNn_star = 2.27E-6;
  v16a = ;
  v16b = ;
  time_ = ;
end

model cui_2008__NFATn_GSK3betan(NFATn_GSK3betan, v17a, v17b, time_)

  // Rate Rules:
  NFATn_GSK3betan' = v17a - v17b;

  // Variable initializations:
  NFATn_GSK3betan = 8.46E-5;
  v17a = ;
  v17b = ;
  time_ = ;
end

model cui_2008__v1(v1, NFATc, k29)

  // Assignment Rules:
  v1 := k29 * NFATc;

  // Variable initializations:
  NFATc = ;
  k29 = ;
end

model cui_2008__v2(v2, NFATpn, k30)

  // Assignment Rules:
  v2 := k30 * NFATpn;

  // Variable initializations:
  NFATpn = ;
  k30 = ;
end

model cui_2008__v3(v3, GSK3betac, GSK3betan, k31, k32)

  // Assignment Rules:
  v3 := k31 * GSK3betac - k32 * GSK3betan;

  // Variable initializations:
  GSK3betac = ;
  GSK3betan = ;
  k31 = ;
  k32 = ;
end

model cui_2008__v4(v4, CaNc_star, CaNn_star, k33, k34)

  // Assignment Rules:
  v4 := k33 * CaNc_star - k34 * CaNn_star;

  // Variable initializations:
  CaNc_star = ;
  CaNn_star = ;
  k33 = ;
  k34 = ;
end

model cui_2008__v5(v5, CaM, Ca, CaMCa, k1, k2)

  // Assignment Rules:
  v5 := k1 * CaM * power(Ca, 4) - k2 * CaMCa;

  // Variable initializations:
  CaM = ;
  Ca = ;
  CaMCa = ;
  k1 = ;
  k2 = ;
end

model cui_2008__v6(v6, CaNc, CaNc_star, CaMCa, k3, k4)

  // Assignment Rules:
  v6 := k3 * CaMCa * CaNc - k4 * CaNc_star;

  // Variable initializations:
  CaNc = ;
  CaNc_star = ;
  CaMCa = ;
  k3 = ;
  k4 = ;
end

model cui_2008__v7(v7, MCIP, CaNc_star, Comp1, k5, k6)

  // Assignment Rules:
  v7 := k5 * CaNc_star * MCIP - k6 * Comp1;

  // Variable initializations:
  MCIP = ;
  CaNc_star = ;
  Comp1 = ;
  k5 = ;
  k6 = ;
end

model cui_2008__v8(v8, MCIPpp, P1433, Comp2, k19, k20)

  // Assignment Rules:
  v8 := k19 * P1433 * MCIPpp - k20 * Comp2;

  // Variable initializations:
  MCIPpp = ;
  P1433 = ;
  Comp2 = ;
  k19 = ;
  k20 = ;
end

model cui_2008__v9(v9, NFATpc, P1433, Comp3, k27, k28)

  // Assignment Rules:
  v9 := k27 * NFATpc * P1433 - k28 * Comp3;

  // Variable initializations:
  NFATpc = ;
  P1433 = ;
  Comp3 = ;
  k27 = ;
  k28 = ;
end

model cui_2008__v10(v10, v10a, v10b, BMK1, MCIP_BMK1, MCIP, k7, k8, k9)

  // Assignment Rules:
  v10 := v10a + v10b;
  v10a := k7 * MCIP * BMK1 - k8 * MCIP_BMK1;
  v10b := k9 * MCIP_BMK1;

  // Variable initializations:
  BMK1 = ;
  MCIP_BMK1 = ;
  MCIP = ;
  k7 = ;
  k8 = ;
  k9 = ;
end

model cui_2008__v11(v11, v11a, v11b, MCIPp_CaNc_star, CaNc_star, MCIPp, k10, k11, k12)

  // Assignment Rules:
  v11 := v11a + v11b;
  v11a := k10 * MCIPp * CaNc_star - k11 * MCIPp_CaNc_star;
  v11b := k12 * MCIPp_CaNc_star;

  // Variable initializations:
  MCIPp_CaNc_star = ;
  CaNc_star = ;
  MCIPp = ;
  k10 = ;
  k11 = ;
  k12 = ;
end

model cui_2008__v12(v12, v12a, v12b, MCIPp_GSK3betac, GSK3betac, MCIPp, k13, k14, k15)

  // Assignment Rules:
  v12 := v12a + v12b;
  v12a := k13 * MCIPp * GSK3betac - k14 * MCIPp_GSK3betac;
  v12b := k15 * MCIPp_GSK3betac;

  // Variable initializations:
  MCIPp_GSK3betac = ;
  GSK3betac = ;
  MCIPp = ;
  k13 = ;
  k14 = ;
  k15 = ;
end

model cui_2008__v13(v13, v13a, v13b, MCIPpp_CaNc_star, CaNc_star, MCIPpp, k16, k17, k18)

  // Assignment Rules:
  v13 := v13a + v13b;
  v13a := k16 * MCIPpp * CaNc_star - k17 * MCIPpp_CaNc_star;
  v13b := k18 * MCIPpp_CaNc_star;

  // Variable initializations:
  MCIPpp_CaNc_star = ;
  CaNc_star = ;
  MCIPpp = ;
  k16 = ;
  k17 = ;
  k18 = ;
end

model cui_2008__v14(v14, v14a, v14b, NFATpc_CaNc_star, CaNc_star, NFATpc, k21, k22, k23)

  // Assignment Rules:
  v14 := v14a + v14b;
  v14a := k21 * NFATpc * CaNc_star - k22 * NFATpc_CaNc_star;
  v14b := k23 * NFATpc_CaNc_star;

  // Variable initializations:
  NFATpc_CaNc_star = ;
  CaNc_star = ;
  NFATpc = ;
  k21 = ;
  k22 = ;
  k23 = ;
end

model cui_2008__v15(v15, v15a, v15b, NFATc_GSK3betac, GSK3betac, NFATc, k24, k25, k26)

  // Assignment Rules:
  v15 := v15a + v15b;
  v15a := k24 * NFATc * GSK3betac - k25 * NFATc_GSK3betac;
  v15b := k26 * NFATc_GSK3betac;

  // Variable initializations:
  NFATc_GSK3betac = ;
  GSK3betac = ;
  NFATc = ;
  k24 = ;
  k25 = ;
  k26 = ;
end

model cui_2008__v16(v16, v16a, v16b, NFATpn_CaNn_star, CaNn_star, NFATpn, k35, k36, k37)

  // Assignment Rules:
  v16 := v16a + v16b;
  v16a := k35 * NFATpn * CaNn_star - k36 * NFATpn_CaNn_star;
  v16b := k37 * NFATpn_CaNn_star;

  // Variable initializations:
  NFATpn_CaNn_star = ;
  CaNn_star = ;
  NFATpn = ;
  k35 = ;
  k36 = ;
  k37 = ;
end

model cui_2008__v17(v17, v17a, v17b, NFATn_GSK3betan, GSK3betan, NFATn, k38, k39, k40)

  // Assignment Rules:
  v17 := v17a + v17b;
  v17a := k38 * NFATn * GSK3betan - k39 * NFATn_GSK3betan;
  v17b := k40 * NFATn_GSK3betan;

  // Variable initializations:
  NFATn_GSK3betan = ;
  GSK3betan = ;
  NFATn = ;
  k38 = ;
  k39 = ;
  k40 = ;
end

model cui_2008__v18(v18, NFATn, MRNA, k41, k42)

  // Assignment Rules:
  v18 := k41 * NFATn - k42 * MRNA;

  // Variable initializations:
  NFATn = ;
  MRNA = ;
  k41 = ;
  k42 = ;
end

model cui_2008__v19(v19, t_half, MRNA, MCIP, k43)

  // Assignment Rules:
  v19 := k43 * MRNA - (ln(2.0) / t_half) * MCIP;

  // Variable initializations:
  t_half = ;
  MRNA = ;
  MCIP = ;
  k43 = ;
end

model cui_2008__model_parameters(k1, k2, k3, k4, k5, k6, k7, k8, k9, k10, k11, k12, k13, k14, k15, k16, k17, k18, k19, k20, k21, k22, k23, k24, k25, k26, k27, k28, k29, k30, k31, k32, k33, k34, k35, k36, k37, k38, k39, k40, k41, k42, k43, t_half, Ca)

  // Variable initializations:
  k1 = 5;
  k2 = 100;
  k3 = 2760;
  k4 = 0.072;
  k5 = 50;
  k6 = 0.0567;
  k7 = 5;
  k8 = 0.1;
  k9 = 0.5;
  k10 = 0.1;
  k11 = 0.1;
  k12 = 0.1;
  k13 = 0.5;
  k14 = 0.5;
  k15 = 0.1;
  k16 = 0.1;
  k17 = 0.1;
  k18 = 0.1;
  k19 = 0.5;
  k20 = 0.1;
  k21 = 0.15;
  k22 = 0.15;
  k23 = 0.15;
  k24 = 0.1;
  k25 = 0.15;
  k26 = 0.1;
  k27 = 0.4;
  k28 = 0.1;
  k29 = 0.4;
  k30 = 0.1;
  k31 = 0.1;
  k32 = 0.05;
  k33 = 0.114;
  k34 = 0.0552;
  k35 = 0.15;
  k36 = 0.1;
  k37 = 0.2;
  k38 = 0.1;
  k39 = 0.1;
  k40 = 0.1;
  k41 = 0.02;
  k42 = 0.03;
  k43 = 0.03;
  t_half = 15;
  Ca = 0.2;
end

model *cui_2008____main()

  // Sub-modules, and any changes to those submodules:
  environment: cui_2008__environment(time_);
  BMK1: cui_2008__BMK1(BMK10, v10a, v10b, time_);
  MRNA: cui_2008__MRNA(MRNA0, v180, v190, time_);
  NFATc: cui_2008__NFATc(NFATc0, v110, v140, v150, time_);
  NFATn: cui_2008__NFATn(NFATn0, v110, v160, v170, v180, time_);
  NFATpc: cui_2008__NFATpc(NFATpc0, v20, v90, v140, v150, time_);
  NFATpn: cui_2008__NFATpn(NFATpn0, v20, v160, v170, time_);
  GSK3betac: cui_2008__GSK3betac(GSK3betac0, v30, v12a, v12b, v15a, v15b, time_);
  GSK3betan: cui_2008__GSK3betan(GSK3betan0, v30, v17a, v17b, time_);
  CaNc: cui_2008__CaNc(CaNc0, v60, time_);
  CaNc_star: cui_2008__CaNc_star(CaNc_star0, v40, v60, v70, v11a, v11b, v13a, v13b, v14a, v14b, time_);
  CaNn_star: cui_2008__CaNn_star(CaNn_star0, v40, v16a, v16b, time_);
  CaNn: cui_2008__CaNn(CaNn0, v60, time_);
  CaM: cui_2008__CaM(CaM0, v50, time_);
  CaMCa: cui_2008__CaMCa(CaMCa0, v50, v60, time_);
  MCIP: cui_2008__MCIP(MCIP0, v70, v100, v111, v190, time_);
  MCIPp: cui_2008__MCIPp(MCIPp0, v100, v111, v120, v130, time_);
  MCIPpp: cui_2008__MCIPpp(MCIPpp0, v80, v120, v130, time_);
  Comp1: cui_2008__Comp1(Comp10, v70, time_);
  Comp2: cui_2008__Comp2(Comp20, v80, time_);
  Comp3: cui_2008__Comp3(Comp30, v90, time_);
  P1433: cui_2008__P1433(P14330, v80, v90, time_);
  MCIP_BMK1: cui_2008__MCIP_BMK1(MCIP_BMK10, v10a, v10b, time_);
  MCIPp_CaNc_star: cui_2008__MCIPp_CaNc_star(MCIPp_CaNc_star0, v11a, v11b, time_);
  MCIPp_GSK3betac: cui_2008__MCIPp_GSK3betac(MCIPp_GSK3betac0, v12a, v12b, time_);
  MCIPpp_CaNc_star: cui_2008__MCIPpp_CaNc_star(MCIPpp_CaNc_star0, v13a, v13b, time_);
  NFATpc_CaNc_star: cui_2008__NFATpc_CaNc_star(NFATpc_CaNc_star0, v14a, v14b, time_);
  NFATc_GSK3betac: cui_2008__NFATc_GSK3betac(NFATc_GSK3betac0, v15a, v15b, time_);
  NFATpn_CaNn_star: cui_2008__NFATpn_CaNn_star(NFATpn_CaNn_star0, v16a, v16b, time_);
  NFATn_GSK3betan: cui_2008__NFATn_GSK3betan(NFATn_GSK3betan0, v17a, v17b, time_);
  v1: cui_2008__v1(v110, NFATc0, k29);
  v2: cui_2008__v2(v20, NFATpn0, k30);
  v3: cui_2008__v3(v30, GSK3betac0, GSK3betan0, k31, k32);
  v4: cui_2008__v4(v40, CaNc_star0, CaNn_star0, k33, k34);
  v5: cui_2008__v5(v50, CaM0, Ca, CaMCa0, k1, k2);
  v6: cui_2008__v6(v60, CaNc0, CaNc_star0, CaMCa0, k3, k4);
  v7: cui_2008__v7(v70, MCIP0, CaNc_star0, Comp10, k5, k6);
  v8: cui_2008__v8(v80, MCIPpp0, P14330, Comp20, k19, k20);
  v9: cui_2008__v9(v90, NFATpc0, P14330, Comp30, k27, k28);
  v10: cui_2008__v10(v100, v10a, v10b, BMK10, MCIP_BMK10, MCIP0, k7, k8, k9);
  v11: cui_2008__v11(v111, v11a, v11b, MCIPp_CaNc_star0, CaNc_star0, MCIPp0, k10, k11, k12);
  v12: cui_2008__v12(v120, v12a, v12b, MCIPp_GSK3betac0, GSK3betac0, MCIPp0, k13, k14, k15);
  v13: cui_2008__v13(v130, v13a, v13b, MCIPpp_CaNc_star0, CaNc_star0, MCIPpp0, k16, k17, k18);
  v14: cui_2008__v14(v140, v14a, v14b, NFATpc_CaNc_star0, CaNc_star0, NFATpc0, k21, k22, k23);
  v15: cui_2008__v15(v150, v15a, v15b, NFATc_GSK3betac0, GSK3betac0, NFATc0, k24, k25, k26);
  v16: cui_2008__v16(v160, v16a, v16b, NFATpn_CaNn_star0, CaNn_star0, NFATpn0, k35, k36, k37);
  v17: cui_2008__v17(v170, v17a, v17b, NFATn_GSK3betan0, GSK3betan0, NFATn0, k38, k39, k40);
  v18: cui_2008__v18(v180, NFATn0, MRNA0, k41, k42);
  v19: cui_2008__v19(v190, t_half, MRNA0, MCIP0, k43);
  model_parameters: cui_2008__model_parameters(k1, k2, k3, k4, k5, k6, k7, k8, k9, k10, k11, k12, k13, k14, k15, k16, k17, k18, k19, k20, k21, k22, k23, k24, k25, k26, k27, k28, k29, k30, k31, k32, k33, k34, k35, k36, k37, k38, k39, k40, k41, k42, k43, t_half, Ca);
end