//Created by libAntimony v2.4 model csikasz_nagy_2006__environment(time_) // Variable initializations: time_ = ; end model csikasz_nagy_2006__CycA(CycA, k_assa, k_dissa, V_di, V_sa, V_da, Tri_A, CKI, time_) // Rate Rules: CycA' = ((k_dissa * Tri_A + V_di * Tri_A + V_sa) - V_da * CycA) - k_assa * CKI * CycA; // Variable initializations: CycA = 0.09450308233499527; k_assa = ; k_dissa = ; V_di = ; V_sa = ; V_da = ; Tri_A = ; CKI = ; time_ = ; end model csikasz_nagy_2006__CycB(CycB, k_assb, k_dissb, V_sb, V_db, V_25, V_wee, V_di, pB, CKI, BCKI, time_) // Rate Rules: CycB' = ((((V_sb - V_db * CycB) + V_25 * pB) - V_wee * CycB) - k_assb * CycB * CKI) + k_dissb * BCKI + V_di * BCKI; // Variable initializations: CycB = 0.1903585940599442; k_assb = ; k_dissb = ; V_sb = ; V_db = ; V_25 = ; V_wee = ; V_di = ; pB = ; CKI = ; BCKI = ; time_ = ; end model csikasz_nagy_2006__CycE(CycE, k_disse, k_asse, V_di, V_se, V_de, Tri_E, CKI, time_) // Rate Rules: CycE' = ((k_disse * Tri_E + V_di * Tri_E + V_se) - V_de * CycE) - k_asse * CKI * CycE; // Variable initializations: CycE = 0.2092024385929108; k_disse = ; k_asse = ; V_di = ; V_se = ; V_de = ; Tri_E = ; CKI = ; time_ = ; end model csikasz_nagy_2006__CycD(CycD, mass) // Assignment Rules: CycD := CycD_0 * mass; // Variable initializations: CycD_0 = 0.108; mass = ; end model csikasz_nagy_2006__Cdc20_A(Cdc20_A, k_a20, k_i20, k_d20, APCP, Cdc20_i, time_) // Rate Rules: Cdc20_A' = ((k_a20 * APCP * Cdc20_i) / (J_a20 + Cdc20_i) - (Cdc20_A * k_i20) / (J_i20 + Cdc20_A)) - Cdc20_A * k_d20; // Variable initializations: Cdc20_A = 0.3572723865509033; k_a20 = ; k_i20 = ; k_d20 = ; APCP = ; Cdc20_i = ; J_a20 = 1; J_i20 = 1; time_ = ; end model csikasz_nagy_2006__Cdc20_i(Cdc20_i, Cdc20_A, k_a20, k_i20, k_d20, k_s20p, k_s20pp, CycB, APCP, time_) // Rate Rules: Cdc20_i' = (((k_s20p + k_s20pp * power(CycB, n20)) / (power(J_20, n20) + power(CycB, n20)) + (Cdc20_A * k_i20) / (J_i20 + Cdc20_A)) - k_d20 * Cdc20_i) - (k_a20 * APCP * Cdc20_i) / (J_a20 + Cdc20_i); // Variable initializations: Cdc20_i = 0.7702387571334839; Cdc20_A = ; k_a20 = ; k_i20 = ; k_d20 = ; k_s20p = ; k_s20pp = ; CycB = ; APCP = ; n20 = 1; J_20 = 10; J_a20 = 1; J_i20 = 1; time_ = ; end model csikasz_nagy_2006__APC(APC, APCP) // Assignment Rules: APC := (APC_T - APCP) / 1; // Variable initializations: APCP = ; APC_T = 1; end model csikasz_nagy_2006__APCP(APCP, k_aie, k_iie, CycB, APC, time_) // Rate Rules: APCP' = (k_aie * CycB * APC) / (J_aie + APC) - (k_iie * APCP) / (J_iie + APCP); // Variable initializations: APCP = 0.07591402530670166; k_aie = ; k_iie = ; CycB = ; APC = ; J_aie = 0.1; J_iie = 0.1; time_ = ; end model csikasz_nagy_2006__pB(pB, k_assb, k_dissb, V_wee, V_25, V_db, V_di, CycB, CKI, pBCKI, time_) // Rate Rules: pB' = (((V_wee * CycB - V_db * pB) - k_assb * pB * CKI) + k_dissb * pBCKI + V_di * pBCKI) - V_25 * pB; // Variable initializations: pB = 0.01234426256269217; k_assb = ; k_dissb = ; V_wee = ; V_25 = ; V_db = ; V_di = ; CycB = ; CKI = ; pBCKI = ; time_ = ; end model csikasz_nagy_2006__BCKI(BCKI, k_assb, k_dissb, V_wee, V_25, V_db, V_di, CycB, CKI, pBCKI, time_) // Rate Rules: BCKI' = ((((k_assb * CycB * CKI - k_dissb * BCKI) + V_25 * pBCKI) - V_wee * BCKI) - V_db * BCKI) - V_di * BCKI; // Variable initializations: BCKI = 0.679449200630188; k_assb = ; k_dissb = ; V_wee = ; V_25 = ; V_db = ; V_di = ; CycB = ; CKI = ; pBCKI = ; time_ = ; end model csikasz_nagy_2006__pBCKI(pBCKI, k_assb, k_dissb, V_wee, V_25, V_db, V_di, pB, CKI, BCKI, time_) // Rate Rules: pBCKI' = ((((k_assb * pB * CKI - k_dissb * pBCKI) - V_25 * pBCKI) + V_wee * BCKI) - V_db * pBCKI) - V_di * pBCKI; // Variable initializations: pBCKI = 0.04795938357710838; k_assb = ; k_dissb = ; V_wee = ; V_25 = ; V_db = ; V_di = ; pB = ; CKI = ; BCKI = ; time_ = ; end model csikasz_nagy_2006__Tri_A(Tri_A, k_assa, k_dissa, CycA, CKI, V_da, V_di, time_) // Rate Rules: Tri_A' = ((k_assa * CKI * CycA - k_dissa * Tri_A) - V_di * Tri_A) - V_da * Tri_A; // Variable initializations: Tri_A = 0.3492224216461182; k_assa = ; k_dissa = ; CycA = ; CKI = ; V_da = ; V_di = ; time_ = ; end model csikasz_nagy_2006__Tri_E(Tri_E, k_asse, k_disse, CycE, CKI, V_de, V_di, time_) // Rate Rules: Tri_E' = ((k_asse * CKI * CycE - k_disse * Tri_E) - V_di * Tri_E) - V_de * Tri_E; // Variable initializations: Tri_E = 0; k_asse = ; k_disse = ; CycE = ; CKI = ; V_de = ; V_di = ; time_ = ; end model csikasz_nagy_2006__CKI(CKI, k_assb, k_dissb, k_assa, k_dissa, k_asse, k_disse, V_db, V_si, V_da, V_di, V_de, CycB, BCKI, pB, Tri_E, pBCKI, CycA, CycE, Tri_A, time_) // Rate Rules: CKI' = (((((((- k_assb * CycB * CKI + k_dissb * BCKI) - k_assb * pB * CKI) + k_dissb * pBCKI + V_db * BCKI + V_db * pBCKI + V_si) - V_di * CKI) - k_assa * CKI * CycA) + k_dissa * Tri_A + V_da * Tri_A) - k_asse * CKI * CycE) + k_disse * Tri_E + V_de * Tri_E; // Variable initializations: CKI = 0.02882070094347; k_assb = ; k_dissb = ; k_assa = ; k_dissa = ; k_asse = ; k_disse = ; V_db = ; V_si = ; V_da = ; V_di = ; V_de = ; CycB = ; BCKI = ; pB = ; Tri_E = ; pBCKI = ; CycA = ; CycE = ; Tri_A = ; time_ = ; end model csikasz_nagy_2006__Cdh1_i(Cdh1_i, Cdh1) // Assignment Rules: Cdh1_i := (Cdh1_T - Cdh1) / 1; // Variable initializations: Cdh1_T = 1; Cdh1 = ; end model csikasz_nagy_2006__Cdh1(Cdh1, V_ah1, V_ih1, Cdh1_i, time_) // Rate Rules: Cdh1' = (Cdh1_i * V_ah1) / (J_ah1 + Cdh1_i) - (Cdh1 * V_ih1) / (J_ih1 + Cdh1); // Variable initializations: Cdh1 = 0.7189393639564514; V_ah1 = ; V_ih1 = ; Cdh1_i = ; J_ah1 = 0.03; J_ih1 = 0.03; time_ = ; end model csikasz_nagy_2006__mass(mass, time_) // Rate Rules: mass' = mu * mass * (1 - mass / maxmass); // Variable initializations: mass = 1.338267803192139; mu = 0.005776; maxmass = 10000; time_ = ; end model csikasz_nagy_2006__V_atf(V_atf, k_atfp, k_atfapp, k_atfepp, k_atfdpp, CycA, CycE, CycD) // Assignment Rules: V_atf := k_atfp + k_atfapp * CycA + k_atfepp * CycE + k_atfdpp * CycD; // Variable initializations: k_atfp = ; k_atfapp = ; k_atfepp = ; k_atfdpp = ; CycA = ; CycE = ; CycD = ; end model csikasz_nagy_2006__V_itf(V_itf, k_itfp, k_itfapp, k_itfbpp, CycA, CycB) // Assignment Rules: V_itf := k_itfp + k_itfapp * CycA + k_itfbpp * CycB; // Variable initializations: k_itfp = ; k_itfapp = ; k_itfbpp = ; CycA = ; CycB = ; end model csikasz_nagy_2006__TF_E(TF_E, V_atf, V_itf) // Assignment Rules: TF_E := (2 * V_atf * J_itf) / ((V_itf - V_atf) + J_atf * V_itf + J_itf * V_atf + root(power((V_itf - V_atf) + J_atf * V_itf + J_itf * V_atf, 2) - 4 * (V_itf - V_atf) * J_itf * V_atf)); // Variable initializations: V_atf = ; V_itf = ; J_itf = 0.01; J_atf = 0.01; end model csikasz_nagy_2006__V_de(V_de, k_dep, k_deepp, k_deapp, k_debpp, CycA, CycE, CycB) // Assignment Rules: V_de := k_dep + k_deepp * CycE + k_deapp * CycA + k_debpp * CycB; // Variable initializations: k_dep = ; k_deepp = ; k_deapp = ; k_debpp = ; CycA = ; CycE = ; CycB = ; end model csikasz_nagy_2006__V_da(V_da, k_dap, k_dapp, k_dappp, Cdc20_A, Cdc20_i) // Assignment Rules: V_da := k_dap + (k_dapp + k_dappp) * Cdc20_A + k_dappp * Cdc20_i; // Variable initializations: k_dap = ; k_dapp = ; k_dappp = ; Cdc20_A = ; Cdc20_i = ; end model csikasz_nagy_2006__TF_I(TF_I, k_afi, k_ifip, k_ifibpp, Cdc14, CycB, Cdc20_A) // Assignment Rules: TF_I := (2 * k_afi * Cdc14 * J_ifi) / (((k_ifip + k_ifibpp * CycB) - k_afi * Cdc14) + J_afi * (k_ifip + k_ifibpp * CycB) + J_ifi * k_afi * Cdc14 + root(power(((k_ifip + k_ifibpp * CycB) - k_afi * Cdc14) + J_afi * (k_ifip + k_ifibpp * CycB) + J_ifi * k_afi * Cdc14, 2) - 4 * ((k_ifip + k_ifibpp * CycB) - k_afi * Cdc14) * J_ifi * k_afi * Cdc14)); Cdc14 := Cdc20_A; // Variable initializations: k_afi = ; k_ifip = ; k_ifibpp = ; J_ifi = 2; J_afi = 1; CycB = ; Cdc20_A = ; end model csikasz_nagy_2006__V_ah1(V_ah1, k_ah1p, k_ah1pp, Cdc14) // Assignment Rules: V_ah1 := k_ah1p + k_ah1pp * Cdc14; // Variable initializations: k_ah1p = ; k_ah1pp = ; Cdc14 = ; end model csikasz_nagy_2006__V_ih1(V_ih1, k_ih1p, k_ih1app, k_ih1bpp, k_ih1epp, k_ih1dpp, CycA, CycB, CycE, CycD) // Assignment Rules: V_ih1 := k_ih1p + k_ih1app * CycA + k_ih1bpp * CycB + k_ih1epp * CycE + k_ih1dpp * CycD; // Variable initializations: k_ih1p = ; k_ih1app = ; k_ih1bpp = ; k_ih1epp = ; k_ih1dpp = ; CycA = ; CycB = ; CycE = ; CycD = ; end model csikasz_nagy_2006__V_si(V_si, k_sip, k_sipp, TF_I) // Assignment Rules: V_si := k_sip + k_sipp * TF_I; // Variable initializations: k_sip = ; k_sipp = ; TF_I = ; end model csikasz_nagy_2006__V_di(V_di, k_dip, k_diapp, k_diepp, k_didpp, k_dibpp, k_14di, CycA, CycB, CycE, CycD, Cdc14) // Assignment Rules: V_di := (k_dip + k_diapp * CycA + k_dibpp * CycB + k_diepp * CycE + k_didpp * CycD) / (1 + k_14di * Cdc14); // Variable initializations: k_dip = ; k_diapp = ; k_diepp = ; k_didpp = ; k_dibpp = ; k_14di = ; CycA = ; CycB = ; CycE = ; CycD = ; Cdc14 = ; end model csikasz_nagy_2006__preMPF(preMPF, pB, BCKI) // Assignment Rules: preMPF := pB + BCKI; // Variable initializations: pB = ; BCKI = ; end model csikasz_nagy_2006__CycBT(CycBT, CycB, pB, BCKI, pBCKI) // Assignment Rules: CycBT := CycB + pB + BCKI + pBCKI; // Variable initializations: CycB = ; pB = ; BCKI = ; pBCKI = ; end model csikasz_nagy_2006__CycAT(CycAT, CycA, Tri_A) // Assignment Rules: CycAT := CycA + Tri_A; // Variable initializations: CycA = ; Tri_A = ; end model csikasz_nagy_2006__CycET(CycET, CycE, Tri_E) // Assignment Rules: CycET := CycE + Tri_E; // Variable initializations: CycE = ; Tri_E = ; end model csikasz_nagy_2006__Tri_B(Tri_B, BCKI, pBCKI) // Assignment Rules: Tri_B := BCKI + pBCKI; // Variable initializations: BCKI = ; pBCKI = ; end model csikasz_nagy_2006__CKIT(CKIT, CKI, BCKI, pBCKI, Tri_A, Tri_E) // Assignment Rules: CKIT := CKI + BCKI + pBCKI + Tri_A + Tri_E; // Variable initializations: CKI = ; BCKI = ; pBCKI = ; Tri_A = ; Tri_E = ; end model csikasz_nagy_2006__Cdc20_T(Cdc20_T, Cdc20_i, Cdc20_A) // Assignment Rules: Cdc20_T := Cdc20_i + Cdc20_A; // Variable initializations: Cdc20_i = ; Cdc20_A = ; end model csikasz_nagy_2006__TF_B(TF_B, k_afb, k_ifb, CycB) // Assignment Rules: TF_B := (2 * k_afb * CycB * J_ifb) / ((k_ifb - k_afb * CycB) + J_afb * k_ifb + J_ifb * k_afb * CycB + root(power((k_ifb - k_afb * CycB) + J_afb * k_ifb + J_ifb * k_afb * CycB, 2) - 4 * (k_ifb - k_afb * CycB) * k_afb * CycB * J_ifb)); // Variable initializations: k_afb = ; k_ifb = ; J_ifb = 0.1; J_afb = 0.1; CycB = ; end model csikasz_nagy_2006__V_sb(V_sb, k_sbp, k_sbpp, TF_B, mass) // Assignment Rules: V_sb := mass * (k_sbp + k_sbpp * TF_B); // Variable initializations: k_sbp = ; k_sbpp = ; TF_B = ; mass = ; end model csikasz_nagy_2006__V_sa(V_sa, k_sap, k_sapp, TF_E, mass) // Assignment Rules: V_sa := mass * (k_sap + k_sapp * TF_E); // Variable initializations: k_sap = ; k_sapp = ; TF_E = ; mass = ; end model csikasz_nagy_2006__V_se(V_se, k_sep, k_sepp, TF_E, mass) // Assignment Rules: V_se := mass * (k_sep + k_sepp * TF_E); // Variable initializations: k_sep = ; k_sepp = ; TF_E = ; mass = ; end model csikasz_nagy_2006__V_db(V_db, k_dbp, k_dbhpp, k_dbcpp, Cdc20_A, Cdh1) // Assignment Rules: V_db := k_dbp + k_dbhpp * Cdh1 + k_dbcpp * Cdc20_A; // Variable initializations: k_dbp = ; k_dbhpp = ; k_dbcpp = ; Cdc20_A = ; Cdh1 = ; end model csikasz_nagy_2006__Wee1(Wee1, k_aweep, k_aweepp, k_iweep, k_iweepp, Cdc14, CycB) // Assignment Rules: Wee1 := (2 * (k_aweep + k_aweepp * Cdc14) * J_iwee) / (((k_iweep + k_iweepp * CycB) - (k_aweep + k_aweepp * Cdc14)) + J_awee * (k_iweep + k_iweepp * CycB) + J_iwee * (k_aweep + k_aweepp * Cdc14) + root(power(((k_iweep + k_iweepp * CycB) - (k_aweep + k_aweepp * Cdc14)) + J_awee * (k_iweep + k_iweepp * CycB) + J_iwee * (k_aweep + k_aweepp * Cdc14), 2) - 4 * ((k_iweep + k_iweepp * CycB) - (k_aweep + k_aweepp * Cdc14)) * (k_aweep + k_aweepp * Cdc14) * J_iwee)); // Variable initializations: k_aweep = ; k_aweepp = ; k_iweep = ; k_iweepp = ; J_iwee = 0.05; J_awee = 0.05; Cdc14 = ; CycB = ; end model csikasz_nagy_2006__V_wee(V_wee, k_weep, k_weepp, Wee1) // Assignment Rules: V_wee := k_weep + k_weepp * Wee1; // Variable initializations: k_weep = ; k_weepp = ; Wee1 = ; end model csikasz_nagy_2006__Cdc25(Cdc25, k_a25p, k_a25pp, k_i25p, k_i25pp, Cdc14, CycB) // Assignment Rules: Cdc25 := (2 * (k_a25p + k_a25pp * CycB) * J_i25) / (((k_i25p + k_i25pp * Cdc14) - (k_a25p + k_a25pp * CycB)) + J_a25 * (k_i25p + k_i25pp * Cdc14) + (k_a25p + k_a25pp * CycB) * J_i25 + root(power(((k_i25p + k_i25pp * Cdc14) - (k_a25p + k_a25pp * CycB)) + J_a25 * (k_i25p + k_i25pp * Cdc14) + (k_a25p + k_a25pp * CycB) * J_i25, 2) - 4 * ((k_i25p + k_i25pp * Cdc14) - (k_a25p + k_a25pp * CycB)) * (k_a25p + k_a25pp * CycB) * J_i25)); // Variable initializations: k_a25p = ; k_a25pp = ; k_i25p = ; k_i25pp = ; J_i25 = 0.1; J_a25 = 0.1; Cdc14 = ; CycB = ; end model csikasz_nagy_2006__V_25(V_25, k_25p, k_25pp, Cdc25) // Assignment Rules: V_25 := k_25p + k_25pp * Cdc25; // Variable initializations: k_25p = ; k_25pp = ; Cdc25 = ; end model csikasz_nagy_2006__kinetic_parameters(k_25p, k_25pp, k_14di, k_a20, k_a25p, k_a25pp, k_afb, k_afi, k_ah1p, k_ah1pp, k_aie, k_assa, k_assb, k_asse, k_atfp, k_atfapp, k_atfdpp, k_atfepp, k_aweep, k_aweepp, k_d20, k_dap, k_dapp, k_dappp, k_dbp, k_dbhpp, k_dbcpp, k_dep, k_deapp, k_debpp, k_deepp, k_dip, k_diapp, k_dibpp, k_didpp, k_diepp, k_disse, k_dissb, k_dissa, k_i20, k_i25p, k_i25pp, k_ifb, k_ifip, k_ifibpp, k_ih1p, k_ih1app, k_ih1bpp, k_ih1dpp, k_ih1epp, k_iie, k_itfp, k_itfapp, k_itfbpp, k_iweep, k_iweepp, k_s20p, k_s20pp, k_sap, k_sapp, k_sbp, k_sbpp, k_sep, k_sepp, k_sip, k_sipp, k_weep, k_weepp) // Variable initializations: k_25p = 0.01; k_25pp = 5; k_14di = 12; k_a20 = 1; k_a25p = 0; k_a25pp = 1; k_afb = 1; k_afi = 6; k_ah1p = 0.02; k_ah1pp = 0.8; k_aie = 0.1; k_assa = 50; k_assb = 60; k_asse = 0; k_atfp = 0; k_atfapp = 1.5; k_atfdpp = 3; k_atfepp = 0.38; k_aweep = 0.3; k_aweepp = 0; k_d20 = 0.05; k_dap = 0.01; k_dapp = 0.16; k_dappp = 0; k_dbp = 0.003; k_dbhpp = 0.4; k_dbcpp = 0.15; k_dep = 0.12; k_deapp = 0; k_debpp = 0; k_deepp = 0; k_dip = 0.02; k_diapp = 0.1; k_dibpp = 0.8; k_didpp = 0.1; k_diepp = 0.12; k_disse = 0; k_dissb = 0.05; k_dissa = 0.06; k_i20 = 0.16; k_i25p = 0.3; k_i25pp = 0; k_ifb = 0.15; k_ifip = 0.008; k_ifibpp = 0.05; k_ih1p = 0.001; k_ih1app = 0.35; k_ih1bpp = 0.1; k_ih1dpp = 0.005; k_ih1epp = 0.06; k_iie = 0.15; k_itfp = 0.75; k_itfapp = 0; k_itfbpp = 8; k_iweep = 0; k_iweepp = 1; k_s20p = 0.001; k_s20pp = 1; k_sap = 0.0015; k_sapp = 0.01; k_sbp = 0.004; k_sbpp = 0.04; k_sep = 0; k_sepp = 0.15; k_sip = 0.018; k_sipp = 0.18; k_weep = 0.02; k_weepp = 0.2; end model *csikasz_nagy_2006____main() // Sub-modules, and any changes to those submodules: environment: csikasz_nagy_2006__environment(time_); CycA: csikasz_nagy_2006__CycA(CycA0, k_assa, k_dissa, V_di0, V_sa0, V_da0, Tri_A0, CKI0, time_); CycB: csikasz_nagy_2006__CycB(CycB0, k_assb, k_dissb, V_sb0, V_db0, V_250, V_wee0, V_di0, pB0, CKI0, BCKI0, time_); CycE: csikasz_nagy_2006__CycE(CycE0, k_disse, k_asse, V_di0, V_se0, V_de0, Tri_E0, CKI0, time_); CycD: csikasz_nagy_2006__CycD(CycD0, mass0); Cdc20_A: csikasz_nagy_2006__Cdc20_A(Cdc20_A0, k_a20, k_i20, k_d20, APCP0, Cdc20_i0, time_); Cdc20_i: csikasz_nagy_2006__Cdc20_i(Cdc20_i0, Cdc20_A0, k_a20, k_i20, k_d20, k_s20p, k_s20pp, CycB0, APCP0, time_); APC: csikasz_nagy_2006__APC(APC0, APCP0); APCP: csikasz_nagy_2006__APCP(APCP0, k_aie, k_iie, CycB0, APC0, time_); pB: csikasz_nagy_2006__pB(pB0, k_assb, k_dissb, V_wee0, V_250, V_db0, V_di0, CycB0, CKI0, pBCKI0, time_); BCKI: csikasz_nagy_2006__BCKI(BCKI0, k_assb, k_dissb, V_wee0, V_250, V_db0, V_di0, CycB0, CKI0, pBCKI0, time_); pBCKI: csikasz_nagy_2006__pBCKI(pBCKI0, k_assb, k_dissb, V_wee0, V_250, V_db0, V_di0, pB0, CKI0, BCKI0, time_); Tri_A: csikasz_nagy_2006__Tri_A(Tri_A0, k_assa, k_dissa, CycA0, CKI0, V_da0, V_di0, time_); Tri_E: csikasz_nagy_2006__Tri_E(Tri_E0, k_asse, k_disse, CycE0, CKI0, V_de0, V_di0, time_); CKI: csikasz_nagy_2006__CKI(CKI0, k_assb, k_dissb, k_assa, k_dissa, k_asse, k_disse, V_db0, V_si0, V_da0, V_di0, V_de0, CycB0, BCKI0, pB0, Tri_E0, pBCKI0, CycA0, CycE0, Tri_A0, time_); Cdh1_i: csikasz_nagy_2006__Cdh1_i(Cdh1_i0, Cdh10); Cdh1: csikasz_nagy_2006__Cdh1(Cdh10, V_ah10, V_ih10, Cdh1_i0, time_); mass: csikasz_nagy_2006__mass(mass0, time_); V_atf: csikasz_nagy_2006__V_atf(V_atf0, k_atfp, k_atfapp, k_atfepp, k_atfdpp, CycA0, CycE0, CycD0); V_itf: csikasz_nagy_2006__V_itf(V_itf0, k_itfp, k_itfapp, k_itfbpp, CycA0, CycB0); TF_E: csikasz_nagy_2006__TF_E(TF_E0, V_atf0, V_itf0); V_de: csikasz_nagy_2006__V_de(V_de0, k_dep, k_deepp, k_deapp, k_debpp, CycA0, CycE0, CycB0); V_da: csikasz_nagy_2006__V_da(V_da0, k_dap, k_dapp, k_dappp, Cdc20_A0, Cdc20_i0); TF_I: csikasz_nagy_2006__TF_I(TF_I0, k_afi, k_ifip, k_ifibpp, Cdc14, CycB0, Cdc20_A0); V_ah1: csikasz_nagy_2006__V_ah1(V_ah10, k_ah1p, k_ah1pp, Cdc14); V_ih1: csikasz_nagy_2006__V_ih1(V_ih10, k_ih1p, k_ih1app, k_ih1bpp, k_ih1epp, k_ih1dpp, CycA0, CycB0, CycE0, CycD0); V_si: csikasz_nagy_2006__V_si(V_si0, k_sip, k_sipp, TF_I0); V_di: csikasz_nagy_2006__V_di(V_di0, k_dip, k_diapp, k_diepp, k_didpp, k_dibpp, k_14di, CycA0, CycB0, CycE0, CycD0, Cdc14); preMPF: csikasz_nagy_2006__preMPF(preMPF0, pB0, BCKI0); CycBT: csikasz_nagy_2006__CycBT(CycBT0, CycB0, pB0, BCKI0, pBCKI0); CycAT: csikasz_nagy_2006__CycAT(CycAT0, CycA0, Tri_A0); CycET: csikasz_nagy_2006__CycET(CycET0, CycE0, Tri_E0); Tri_B: csikasz_nagy_2006__Tri_B(Tri_B0, BCKI0, pBCKI0); CKIT: csikasz_nagy_2006__CKIT(CKIT0, CKI0, BCKI0, pBCKI0, Tri_A0, Tri_E0); Cdc20_T: csikasz_nagy_2006__Cdc20_T(Cdc20_T0, Cdc20_i0, Cdc20_A0); TF_B: csikasz_nagy_2006__TF_B(TF_B0, k_afb, k_ifb, CycB0); V_sb: csikasz_nagy_2006__V_sb(V_sb0, k_sbp, k_sbpp, TF_B0, mass0); V_sa: csikasz_nagy_2006__V_sa(V_sa0, k_sap, k_sapp, TF_E0, mass0); V_se: csikasz_nagy_2006__V_se(V_se0, k_sep, k_sepp, TF_E0, mass0); V_db: csikasz_nagy_2006__V_db(V_db0, k_dbp, k_dbhpp, k_dbcpp, Cdc20_A0, Cdh10); Wee1: csikasz_nagy_2006__Wee1(Wee10, k_aweep, k_aweepp, k_iweep, k_iweepp, Cdc14, CycB0); V_wee: csikasz_nagy_2006__V_wee(V_wee0, k_weep, k_weepp, Wee10); Cdc25: csikasz_nagy_2006__Cdc25(Cdc250, k_a25p, k_a25pp, k_i25p, k_i25pp, Cdc14, CycB0); V_25: csikasz_nagy_2006__V_25(V_250, k_25p, k_25pp, Cdc250); kinetic_parameters: csikasz_nagy_2006__kinetic_parameters(k_25p, k_25pp, k_14di, k_a20, k_a25p, k_a25pp, k_afb, k_afi, k_ah1p, k_ah1pp, k_aie, k_assa, k_assb, k_asse, k_atfp, k_atfapp, k_atfdpp, k_atfepp, k_aweep, k_aweepp, k_d20, k_dap, k_dapp, k_dappp, k_dbp, k_dbhpp, k_dbcpp, k_dep, k_deapp, k_debpp, k_deepp, k_dip, k_diapp, k_dibpp, k_didpp, k_diepp, k_disse, k_dissb, k_dissa, k_i20, k_i25p, k_i25pp, k_ifb, k_ifip, k_ifibpp, k_ih1p, k_ih1app, k_ih1bpp, k_ih1dpp, k_ih1epp, k_iie, k_itfp, k_itfapp, k_itfbpp, k_iweep, k_iweepp, k_s20p, k_s20pp, k_sap, k_sapp, k_sbp, k_sbpp, k_sep, k_sepp, k_sip, k_sipp, k_weep, k_weepp); end