//Created by libAntimony v2.4
model ciliberto_tyson_2000_version01__environment(time_)

  // Variable initializations:
  time_ = ;
end

model ciliberto_tyson_2000_version01__Y(Y, k2, k3, C, time_)

  // Rate Rules:
  Y' = k1 - (k2 * Y + k3 * Y * C);

  // Variable initializations:
  Y = 0.01577552;
  k1 = 0.024;
  k2 = ;
  k3 = ;
  C = ;
  time_ = ;
end

model ciliberto_tyson_2000_version01__M(M, k2, k3, kwee, kcdc25, C, Y, preMPF, time_)

  // Rate Rules:
  M' = (kcdc25 * preMPF + k3 * Y * C) - (k2 * M + kwee * M);

  // Variable initializations:
  M = 0.0142077;
  k2 = ;
  k3 = ;
  kwee = ;
  kcdc25 = ;
  C = ;
  Y = ;
  preMPF = ;
  time_ = ;
end

model ciliberto_tyson_2000_version01__preMPF(preMPF, k2, kwee, kcdc25, M, time_)

  // Rate Rules:
  preMPF' = kwee * M - (k2 * preMPF + kcdc25 * preMPF);

  // Variable initializations:
  preMPF = 0.02541723;
  k2 = ;
  kwee = ;
  kcdc25 = ;
  M = ;
  time_ = ;
end

model ciliberto_tyson_2000_version01__Cdc25P(Cdc25P, p, Cdc25, M, time_)

  // Assignment Rules:
  k25ro := k25r / p;

  // Rate Rules:
  Cdc25P' = (k25 * M * Cdc25) / (Km25 + Cdc25) - (k25r * Cdc25P) / (Km25r + Cdc25P);

  // Variable initializations:
  Cdc25P = 0.4844362;
  k25 = 18;
  Km25 = 0.1;
  k25r = 0.8;
  Km25r = 1;
  p = ;
  Cdc25 = ;
  M = ;
  time_ = ;
end

model ciliberto_tyson_2000_version01__Wee1(Wee1, p, M, Wee1P, time_)

  // Assignment Rules:
  kwro := kwr / p;

  // Rate Rules:
  Wee1' = (- kw * M * Wee1) / (Kmw + Wee1) + (kwr * Wee1P) / (Kmwr + Wee1P);

  // Variable initializations:
  Wee1 = 0.5155638;
  kw = 18;
  Kmw = 0.1;
  kwr = 0.8;
  Kmwr = 1;
  p = ;
  M = ;
  Wee1P = ;
  time_ = ;
end

model ciliberto_tyson_2000_version01__IEP(IEP, IE, M, time_)

  // Rate Rules:
  IEP' = (kie * M * IE) / (Kmie + IE) - (kier * IEP) / (Kmier + IEP);

  // Variable initializations:
  IEP = 0.002287817;
  kie = 4.5;
  Kmie = 0.01;
  kier = 0.34;
  Kmier = 0.01;
  IE = ;
  M = ;
  time_ = ;
end

model ciliberto_tyson_2000_version01__APC_(APC_, IEP, APC, time_)

  // Rate Rules:
  APC_' = (kap * IEP * APC) / (Kmap + APC) - (kapr * APC_) / (Kmapr + APC_);

  // Variable initializations:
  APC_ = 0.5051103;
  kap = 0.3;
  Kmap = 0.01;
  kapr = 0.3;
  Kmapr = 1;
  IEP = ;
  APC = ;
  time_ = ;
end

model ciliberto_tyson_2000_version01__C(C, preMPF, M)

  // Assignment Rules:
  C := Cdc2tot - (M + preMPF);

  // Variable initializations:
  Cdc2tot = 1;
  preMPF = ;
  M = ;
end

model ciliberto_tyson_2000_version01__Cdc25(Cdc25, Cdc25P)

  // Assignment Rules:
  Cdc25 := Cdc25tot - Cdc25P;

  // Variable initializations:
  Cdc25tot = 1;
  Cdc25P = ;
end

model ciliberto_tyson_2000_version01__Wee1P(Wee1P, Wee1)

  // Assignment Rules:
  Wee1P := Wee1tot - Wee1;

  // Variable initializations:
  Wee1tot = 1;
  Wee1 = ;
end

model ciliberto_tyson_2000_version01__IE(IE, IEP)

  // Assignment Rules:
  IE := IEtot - IEP;

  // Variable initializations:
  IEtot = 1;
  IEP = ;
end

model ciliberto_tyson_2000_version01__APC(APC, APC_)

  // Assignment Rules:
  APC := APCtot - APC_;

  // Variable initializations:
  APCtot = 1;
  APC_ = ;
end

model ciliberto_tyson_2000_version01__p(p)

  // Assignment Rules:
  p := s * R + q;

  // Variable initializations:
  R = 1;
  s = 0.021;
  q = 1;
end

model ciliberto_tyson_2000_version01__kinetic_parameters(k2, k3, kwee, kcdc25, Cdc25, Cdc25P, Wee1, APC_, APC, Wee1P)

  // Assignment Rules:
  k2 := V2 * APC + V2_ * APC_;
  kwee := Vwee * Wee1P + Vwee_ * Wee1;
  kcdc25 := V25 * Cdc25 + V25_ * Cdc25P;

  // Variable initializations:
  k3 = 1.15;
  V2 = 0.01;
  V2_ = 0.6;
  V25 = 0.04;
  V25_ = 0.4;
  Vwee = 0.025;
  Vwee_ = 2.5;
  Cdc25 = ;
  Cdc25P = ;
  Wee1 = ;
  APC_ = ;
  APC = ;
  Wee1P = ;
end

model *ciliberto_tyson_2000_version01____main()

  // Sub-modules, and any changes to those submodules:
  environment: ciliberto_tyson_2000_version01__environment(time_);
  Y: ciliberto_tyson_2000_version01__Y(Y0, k2, k3, C0, time_);
  M: ciliberto_tyson_2000_version01__M(M0, k2, k3, kwee, kcdc25, C0, Y0, preMPF0, time_);
  preMPF: ciliberto_tyson_2000_version01__preMPF(preMPF0, k2, kwee, kcdc25, M0, time_);
  Cdc25P: ciliberto_tyson_2000_version01__Cdc25P(Cdc25P0, p0, Cdc250, M0, time_);
  Wee1: ciliberto_tyson_2000_version01__Wee1(Wee10, p0, M0, Wee1P0, time_);
  IEP: ciliberto_tyson_2000_version01__IEP(IEP0, IE0, M0, time_);
  APC_: ciliberto_tyson_2000_version01__APC_(APC_0, IEP0, APC0, time_);
  C: ciliberto_tyson_2000_version01__C(C0, preMPF0, M0);
  Cdc25: ciliberto_tyson_2000_version01__Cdc25(Cdc250, Cdc25P0);
  Wee1P: ciliberto_tyson_2000_version01__Wee1P(Wee1P0, Wee10);
  IE: ciliberto_tyson_2000_version01__IE(IE0, IEP0);
  APC: ciliberto_tyson_2000_version01__APC(APC0, APC_0);
  p: ciliberto_tyson_2000_version01__p(p0);
  kinetic_parameters: ciliberto_tyson_2000_version01__kinetic_parameters(k2, k3, kwee, kcdc25, Cdc250, Cdc25P0, Wee10, APC_0, APC0, Wee1P0);
end