naiont kiont caiont clont ICaL ICab IpCa 2 INaCa INa 3 INaCa 3 INaK INal IKr IKs IK1 IKp 2 INaK Ito 0.5 i_Stim IClb Ito2 0.5 i_Stim 1000 a a l 2 a a 2 a l ageo 2 vcell 0.68 vcell 0.26 vcell 0.06 vcell 0.0552 vcell 0.0048 vcell 0.02 Acap F stim_amplitude time_ past stim_offset time_ past stim_offset stim_duration 0 time_ stim_period stim_period 11.5 tissue 0 4 11.5 GNa m m m H J ah 1 H bh H am 1 m bm m aj 1 J bj J 0.32 1 V 47.13 1 -0.1 V 47.13 0.08 V 11 0 V -40 0.135 80 V -6.8 1 0.13 1 V 10.66 -11.1 V -40 3.56 0.079 V 3.1 5 0.35 V 0 V -40 -1.2714 5 0.2444 V 3.474 -5 -0.04391 V 1 V 37.78 1 0.311 V 79.23 0.3 -2.535 -7 V 1 -0.1 V 32 V -40 0.1212 -0.01052 V 1 -0.1378 V 40.14 gNa V ENa dss d taud dpss dp 10 fss f tauf fcass fca taufca fca2ss fca2 taufca2 f2ss f2 tauf2 pca 4 V 15 F FonRT gacai Ca_ss 2 V 15 FonRT gacao Ca_o 2 V 15 FonRT 1 1 1 V 4 6.74 0.59 0.8 0.052 V 13 1 0.132 V 13 0.7 1 V 17.12 7 0.3 0.77 1 V 17.12 7 0.23 1 0.2411 0.045 V 9.6914 2 0.0529 1 0.0423 0.059 V 18.5726 2 0.0054 9 8 1 V 65 3.4 0.3 1 ICaL 0.05 0.55 1 Ca_ss 0.003 0.15 1 1 ICaL 0.01 10 CaMKactive 0.15 CaMKactive 1 1 Ca_ss 0.003 0.5 300 1 ICaL 0.175 0.04 125 d dp f f2 fca fca2 ibarca tissue 0 d f f2 fca fca2 ibarca 1.02 1 0.2385 V EK 59.215 0.49124 0.08032 V EK 5.476 1 0.06175 V EK 594.31 1 -0.5143 V EK 4.753 0.5 K_o 5.4 ak1 ak1 bk1 V EK 0.0138542 K_o 5.4 1 1 V 10 15.4 xrss xr tauxr 1 1 V 10.085 4.25 1 6 -4 V 1.7384 1 -0.136 V 1.7384 3 -4 V 38.3608 0.1522 V 38.3608 1 gkr xr r V EK 0.0224077 1 0.6 1 3.8 -5 Ca_i 1.4 1 1 V 10.5 24.7 1 7.61 -5 V 44.6 1 -9.97 V 44.6 3.6 -4 V 0.55 0.128 V 0.55 1 xss xs1 tauxs xss xs2 tauxs 2 gks xs1 xs2 V EKs V 300 25 V 40 25 1 V 40 25 25 V 90 25 1 V 90 25 0.03 1 V 60 5 0.2 V 25 5 1 V 25 5 0.0026 1 V 61 5 0.1 V 25 5 1 V 25 5 ay 1 ydv by ydv ay2 1 ydv2 by2 ydv2 ay3 1 zdv by3 zdv gitodv ydv 3 ydv2 zdv rv V EK Na_o 67.3 1 7 1 1 0.1245 -0.1 V FonRT 0.0365 sigma V FonRT ibarnak fnak 1 1 kmnai Na_i 2 K_o K_o kmko 1.5 Ca_i 1 1 KmCa ca_i_NaCa 2 Na_i 3 Ca_o eta V FonRT Na_o 3 ca_i_NaCa eta 1 V FonRT 1 ksat eta 1 V FonRT KmCao Na_i 3 KmNao 3 ca_i_NaCa KmNai 3 Ca_o 1 ca_i_NaCa KmCai KmCai Na_o 3 1 Na_i KmNai 3 Na_i 3 Ca_o Na_o 3 ca_i_NaCa NCXmax allo num denom1 denom2 denom3 0.00276 V EK 1 7.488 V 5.98 ibarpca Ca_i kmpca Ca_i 1.995084 -7 4 V F FonRT Ca_i 2 V FonRT 0.341 Ca_o 2 V FonRT 1 AAss AA 1 PCl V F FonRT Cl_i Cl_o V FonRT 1 V FonRT 1 1 Kmto2 Ca_ss Ito2_max AA GClb V ECl amL 1 mL bmL mL hLss hL 600 0.32 1 V 47.13 1 -0.1 V 47.13 0.08 V 11 1 1 V 91 6.1 GNaL mL 3 hL V ENa Na_o Na_i FonRT K_o K_i FonRT K_o prnak Na_o K_i prnak Na_i FonRT Cl_o Cl_i FonRT 3000 vg Ca_jsr 1.9 Ca_jsr 1.9 49.28 Ca_ss Ca_ss 0.0028 1.9 dtau_rel_max CaMKactive KmCaMK CaMKactive dro_inf 1 ICaL 2 1 1 1 Ca_ss 4 -4 0.002 cafac 2.5 -5 3 dtau_rel 350 dtau_rel 1 Ca_ss 0.003 0.003 cafac 2 -4 Grel ro ri Ca_jsr Ca_ss CaMK0 1 CaMKtrap 1 Km Ca_ss CaMKbound CaMKtrap 0.05 CaMKactive CaMKactive CaMKtrap 6.8 -4 CaMKtrap ross ro 3 riss ri tauri 1 1 ibarca 13 5 tissue 0 1 1 1 ICaL 0.05 0.015 dKmPLBmax CaMKactive KmCaMK CaMKactive dJupmax CaMKactive KmCaMK CaMKactive dJup 1 iupmax Ca_i Ca_i Kmup dKmPLB iupmax Ca_nsr nsrmax Ca_ss Ca_i 0.2 Ca_nsr Ca_jsr 120 naiont AF vmyo CTNaCl CTNaClmax ENa ECl 4 ENa ECl 4 87.8251 4 kiont AF vmyo CTKCl CTKClmax EK ECl EK ECl 87.8251 clont AF vmyo CTNaCl CTKCl bmyo ICab IpCa 2 INaCa AF vmyo 2 ileak iup vnsr vmyo idiff vss vmyo bcsqn itr irelcicr iup itr vjsr vnsr ileak bss ICaL AF vss 2 irelcicr vjsr vss idiff 1 1 kmcsqn csqnbar Ca_jsr kmcsqn 2 1 1 cbar kmc Ca_i kmc 2 kmt tbar Ca_i kmt 2 1 1 BSRmax KmBSR KmBSR Ca_ss 2 BSLmax KmBSL KmBSL Ca_ss 2