// Created by libAntimony v2.8.0 model *MODEL1311290000() // Compartments and Species: compartment cell; species E4P in cell, G6L in cell, NADPH in cell, P6G in cell, R5P in cell; species Ru5P in cell, S7P in cell, X5P in cell, $NADP in cell, $G6P in cell; species $F6P in cell, $GAP in cell, $GND1 in cell, $GND2 in cell, $NQM1 in cell; species $RKI1 in cell, $RPE1 in cell, $SOL3 in cell, $TAL1 in cell, $TKL1 in cell; species $ZWF1 in cell; // Assignment Rules: NADP := sum_NADP - NADPH; G6P := 0.9 + piecewise((44.1*time)/(48 + time + 0.45*time^2), time >= 0, 0); // Reactions: GND: P6G + $NADP => Ru5P + NADPH; cell*((GND1*GND_kcat_GND1*P6G*NADP)/(GND_Kp6g_GND1*GND_Knadp_GND1)/((1 + P6G/GND_Kp6g_GND1 + Ru5P/GND_Kru5p_GND1)*(1 + NADP/GND_Knadp_GND1 + NADPH/GND_Knadph_GND1)) + (GND2*GND_kcat_GND2*P6G*NADP)/((1 + P6G/GND_Kp6g_GND2 + Ru5P/GND_Kru5p_GND2)*(1 + NADP/GND_Knadp_GND2 + NADPH/GND_Knadph_GND2))); RKI: Ru5P -> R5P; (cell*RKI1*RKI_kcat*(Ru5P - R5P/RKI_Keq))/RKI_Kru5p/(1 + Ru5P/RKI_Kru5p + R5P/RKI_Kr5p); RPE: Ru5P -> X5P; (cell*RPE1*RPE_kcat*(Ru5P - X5P/RPE_Keq))/RPE_Kru5p/(1 + Ru5P/RPE_Kru5p + X5P/RPE_Kx5p); SOL: G6L => P6G; (cell*SOL3*SOL_kcat*G6L)/SOL_Kg6l/(1 + G6L/SOL_Kg6l + P6G/SOL_Kp6g); TAL: $GAP + S7P -> $F6P + E4P; cell*((TAL1*TAL_kcat_TAL1*(GAP*S7P - (F6P*E4P)/TAL_Keq))/(TAL_Kgap_TAL1*TAL_Ks7p_TAL1)/((1 + GAP/TAL_Kgap_TAL1 + F6P/TAL_Kf6p_TAL1)*(1 + S7P/TAL_Ks7p_TAL1 + E4P/TAL_Ke4p_TAL1)) + (NQM1*TAL_kcat_NQM1*(GAP*S7P - (F6P*E4P)/TAL_Keq))/(TAL_Kgap_NQM1*TAL_Ks7p_NQM1)/((1 + GAP/TAL_Kgap_NQM1 + F6P/TAL_Kf6p_NQM1)*(1 + S7P/TAL_Ks7p_NQM1 + E4P/TAL_Ke4p_NQM1))); TKL_E4P: X5P + E4P -> $GAP + $F6P; (cell*TKL1*TKL_E4P_kcat*(X5P*E4P - (GAP*F6P)/TKL_E4P_Keq))/(Kx5p_TAL*Ke4p_TAL)/((1 + X5P/Kx5p_TAL + GAP/Kgap_TAL)*(1 + E4P/Ke4p_TAL + F6P/Kf6p_TAL + R5P/Kr5p_TAL + S7P/Ks7p_TAL)); TKL_R5P: X5P + R5P -> $GAP + S7P; (cell*TKL1*TKL_R5P_kcat*(X5P*R5P - (GAP*S7P)/TKL_R5P_Keq))/(Kx5p_TAL*Kr5p_TAL)/((1 + X5P/Kx5p_TAL + GAP/Kgap_TAL)*(1 + E4P/Ke4p_TAL + F6P/Kf6p_TAL + R5P/Kr5p_TAL + S7P/Ks7p_TAL)); ZWF: $G6P + $NADP => G6L + NADPH; (cell*ZWF1*ZWF_kcat*G6P*NADP)/(ZWF_Kg6p*ZWF_Knadp)/((1 + G6P/ZWF_Kg6p + G6L/ZWF_Kg6l)*(1 + NADP/ZWF_Knadp + NADPH/ZWF_Knadph)); NADPH_oxidase: NADPH => $NADP; cell*NADPH_oxidase_k*NADPH; E4P_sink: E4P => ; cell*E4P_sink_k*E4P; R5P_sink: R5P => ; cell*R5P_sink_k*R5P; // Species initializations: E4P = 0.029; G6L = 0.1; NADPH = 0.16; P6G = 0.25; R5P = 0.118; Ru5P = 0.033; S7P = 0.082; X5P = 0.041; F6P = 0.325; GAP = 0.067; GND1 = 0.013; GND2 = 0.003; NQM1 = 0.02; RKI1 = 0.05; RPE1 = 0.03; SOL3 = 0.0296; TAL1 = 0.144; TKL1 = 0.455; ZWF1 = 0.02; // Compartment initializations: cell = 1; // Variable initializations: sum_NADP = 0.33; sum_NADP has mM; Kx5p_TAL = 0.67; Kx5p_TAL has mM; Ke4p_TAL = 0.946; Ke4p_TAL has mM; Kr5p_TAL = 0.235; Kr5p_TAL has mM; Kgap_TAL = 0.1; Kgap_TAL has mM; Kf6p_TAL = 1.1; Kf6p_TAL has mM; Ks7p_TAL = 0.15; Ks7p_TAL has mM; GND_kcat_GND1 = 28; GND_kcat_GND1 has per_s; GND_Kp6g_GND1 = 0.062; GND_Kp6g_GND1 has mM; GND_Knadp_GND1 = 0.094; GND_Knadp_GND1 has mM; GND_Kru5p_GND1 = 0.1; GND_Kru5p_GND1 has mM; GND_Knadph_GND1 = 0.055; GND_Knadph_GND1 has mM; GND_kcat_GND2 = 27.3; GND_kcat_GND2 has per_s; GND_Kp6g_GND2 = 0.115; GND_Kp6g_GND2 has mM; GND_Knadp_GND2 = 0.094; GND_Knadp_GND2 has mM; GND_Kru5p_GND2 = 0.1; GND_Kru5p_GND2 has mM; GND_Knadph_GND2 = 0.055; GND_Knadph_GND2 has mM; RKI_kcat = 335; RKI_kcat has per_s; RKI_Kru5p = 2.47; RKI_Kru5p has mM; RKI_Kr5p = 5.7; RKI_Kr5p has mM; RKI_Kiru5p = 9.88; RKI_Kiru5p has mM; RKI_Keq = 4; RKI_Keq has dimensionless; RPE_kcat = 4020; RPE_kcat has per_s; RPE_Kru5p = 5.97; RPE_Kru5p has mM; RPE_Kx5p = 7.7; RPE_Kx5p has mM; RPE_Keq = 1.4; RPE_Keq has dimensionless; SOL_kcat = 4.3; SOL_kcat has per_s; SOL_Kg6l = 0.8; SOL_Kg6l has mM; SOL_Kp6g = 0.5; SOL_Kp6g has mM; TAL_kcat_TAL1 = 0.694; TAL_kcat_TAL1 has per_s; TAL_Kgap_TAL1 = 0.272; TAL_Kgap_TAL1 has mM; TAL_Ks7p_TAL1 = 0.786; TAL_Ks7p_TAL1 has mM; TAL_Kf6p_TAL1 = 1.44; TAL_Kf6p_TAL1 has mM; TAL_Ke4p_TAL1 = 0.362; TAL_Ke4p_TAL1 has mM; TAL_kcat_NQM1 = 0.694; TAL_kcat_NQM1 has per_s; TAL_Kgap_NQM1 = 0.272; TAL_Kgap_NQM1 has mM; TAL_Ks7p_NQM1 = 0.786; TAL_Ks7p_NQM1 has mM; TAL_Kf6p_NQM1 = 1.04; TAL_Kf6p_NQM1 has mM; TAL_Ke4p_NQM1 = 0.305; TAL_Ke4p_NQM1 has mM; TAL_Keq = 1.05; TAL_Keq has dimensionless; TKL_E4P_kcat = 47.1; TKL_E4P_kcat has per_s; TKL_E4P_Keq = 10; TKL_E4P_Keq has dimensionless; TKL_R5P_kcat = 40.5; TKL_R5P_kcat has per_s; TKL_R5P_Keq = 1.2; TKL_R5P_Keq has dimensionless; ZWF_kcat = 189; ZWF_kcat has per_s; ZWF_Kg6p = 0.042; ZWF_Kg6p has mM; ZWF_Knadp = 0.045; ZWF_Knadp has mM; ZWF_Kg6l = 0.01; ZWF_Kg6l has mM; ZWF_Knadph = 0.017; ZWF_Knadph has mM; NADPH_oxidase_k = 1; NADPH_oxidase_k has per_s; E4P_sink_k = 1; E4P_sink_k has per_s; R5P_sink_k = 1; R5P_sink_k has per_s; // Other declarations: const cell, sum_NADP, Kx5p_TAL, Ke4p_TAL, Kr5p_TAL, Kgap_TAL, Kf6p_TAL; const Ks7p_TAL; // Unit definitions: unit substance = 1e-3 mole; unit mM = 1e-3 mole / litre; unit per_s = 1 / second; // Display Names: substance is "mmol"; per_s is "per s"; TKL_E4P is "TKL (E4P:F6P)"; TKL_R5P is "TKL (R5P:S7P)"; NADPH_oxidase is "NADPH oxidase"; E4P_sink is "E4P sink"; R5P_sink is "R5P sink"; end