// Created by libAntimony v2.8.0 model *MODEL1309160000() // Compartments and Species: compartment Default, Vd_LTC, Vd_LTD, Vd_LTE, V_B, V_AW, Vd_Hn, Vd_IL5, V_BM; compartment Vd_AW_LTC, Vd_AW_LTD, Vd_AW_LTE, Vd_AW_Hn, Vd_ZF, Vd_AW_ZF; compartment Vd_ML; species AA_b in Default, HPETE_b in Default, HETE_b in Default, LTA4_b in Default; species LTC4_b in Default, LTC4_b_out in Vd_LTC, LTD4_b in Vd_LTD, LTE4_b in Vd_LTE; species EO_b in V_B, EO_i_b in V_B, EO_a_b in V_B, EO_i_aw in V_AW, EO_a_aw in V_AW; species EO_aw in V_AW, Hn_b in Vd_Hn, IL_b in Vd_IL5, IL_bm in V_BM, EO_bm in V_BM; species AA_aw in Default, HPETE_aw in Default, HETE_aw in Default, LTA4_aw in Default; species LTC4_aw in Default, LTC4_aw_out in Vd_AW_LTC, LTD4_aw in Vd_AW_LTD; species LTE4_aw in Vd_AW_LTE, Hn_aw in Vd_AW_Hn, IL_aw in V_AW, ZF_intes in Default; species ZF_blood in Vd_ZF, ZF_airways in Vd_AW_ZF, ML_intes in Default; species ML_blood in Vd_ML; // Assignment Rules: ft_zf := ceil(time/T) + ceil((time - 3.600000e+002)/T) + ceil((time - 6.600000e+002)/T) + ceil((time - 9.600000e+002)/T); ft_ml := ceil(time/T); ZF_blood_conc := fup_ZF*ZF_blood; ZF_airways_conc := ZF_airways; ML_blood_conc := fup_ML*ML_blood; ML_airways_conc := fup_ML*ML_blood; w_EO := (npi*diam_EO^3.000000e+000)/6.000000e+000; V_CB := (EO_a_b + EO_b + EO_i_b)*N_A_pmole*w_EO*V_B; V_aCB := EO_a_b*N_A_pmole*w_EO*V_B; V_LTC_CB := (naEO_LTCsyn*(EO_b + EO_i_b) + EO_a_b)*N_A_pmole*w_EO*V_B; V_CAW := (EO_a_aw + EO_aw + EO_i_aw)*N_A_pmole*w_EO*V_AW; V_aCAW := EO_a_aw*N_A_pmole*w_EO*V_AW; V_LTC_CAW := (naEO_LTCsyn*(EO_aw + EO_i_aw) + EO_a_aw)*N_A_pmole*w_EO*V_AW; GSSG_b := (GS_pool_b - GSH_b)/2.000000e+000; NADPH_b := NP_pool_b - NADP_b; PLA2_D := 1.000000e+000 + Ca/K_PLA2_Ca; PLA2_Ca := Ca/K_PLA2_Ca/PLA2_D; Ki_AA_AA := Ki_AA; K_AA_HETE := Ki_HETE; Ki_HPETE_AA := Ki_AA; OOH_b := HPETE_b + LOOH_b; OH_b := HETE_b + LOH_b; r1 := k_ox + (k_ox2*Ca)/K_Ca2; r2 := k_red + (k_red2*Ca)/K_Ca2; REDOX_b := (r2/Ke_red + (r1*OH_b)/Ke_ox + (al*ki*ZF_blood_conc)/KdZ*(1.000000e+000 + Ca/K_Ca3))/(r2 + r1*OOH_b); RELFLO5_b := ((k_lo*AA_b)/K_AA + k3*HPETE_b*(1.000000e+000 + AA_b/Ki_AA))/(k_lta_syn + k_3*(1.000000e+000 + AA_b/Ki_HPETE_AA)); DFLOa_b := (1.000000e+000 + Ca/K_Ca3)*(1.000000e+000 + (REDOX_b*(1.000000e+000 + Ca/K_Ca2))/(1.000000e+000 + Ca/K_Ca3) + AA_b/K_AA*(1.000000e+000 + AA_b/Ki_AA_AA) + AA_b/Ki_AA*(1.000000e+000 + HETE_b/K_AA_HETE) + RELFLO5_b*(1.000000e+000 + AA_b/Ki_HPETE_AA) + HETE_b/Ki_HETE + (al*ZF_blood_conc)/KdZ); FLO3_b := FLOa/DFLOa_b; FLO2_b := FLO3_b*REDOX_b; FLO3t_b := FLO3_b*(1.000000e+000 + Ca/K_Ca3); FLO2t_b := FLO2_b*(1.000000e+000 + Ca/K_Ca2); FLO5HP_b := FLO3t_b*RELFLO5_b; C_b := (HPETE_b*GSH_b*GSH_b)/(Km_gpx_HPETE5*Km_gpx_GSH*Km_gpx_GSH); A_b := (GSH_b*GSH_b)/(Km_gpx_GSH*Km_gpx_GSH)*(1.000000e+000 + GSSG_b/Kd_gpx_GSSG) + HPETE_b/Km_gpx_HPETE5*(1.000000e+000 + HETE_b/Kd_gpx_HETE5) + C_b; B_b := (k_gpx_cat*HPETE_b*GSH_b*GSH_b)/(Km_gpx_HPETE5*Km_gpx_GSH*Km_gpx_GSH); delta_LTCs_b := 1.000000e+000 + LTA4_b/K_LTA + GSH_b/K_GSH + (LTA4_b*GSH_b)/K_LTA/K_LTA_GSH + LTC4_b/K_LTC; nom_LTCs_b := Et_LTCs*(K_LTC*k_LTCs_fow*LTA4_b*GSH_b - k_LTCs_back*K_LTA_GSH*K_GSH*LTC4_b); den_LTCs_b := delta_LTCs_b*K_LTA_GSH*K_GSH*K_LTC; C_hedh_b := (1.000000e+000 + HETE_b/Kd_hedh_HETE5 + NADPH_b/Kd_hedh_NADPH)*((k_hedh_3*oxoETE_b)/Kd_hedh_oxoETE5 + (k_hedh_2*NADP_b)/Kd_hedh_NADP); A_hedh_b := (1.000000e+000 + NADP_b/Kd_hedh_NADP + oxoETE_b/Kd_hedh_oxoETE5)*((k_hedh_1*HETE_b)/Kd_hedh_HETE5 + (k_hedh_4*NADPH_b)/Kd_hedh_NADPH) + C_hedh_b; B_hedh_b := (k_hedh_1*k_hedh_2*HETE_b*NADP_b)/(Kd_hedh_HETE5*Kd_hedh_NADP) - (oxoETE_b*NADPH_b*k_hedh_3*k_hedh_4)/(Kd_hedh_oxoETE5*Kd_hedh_NADPH); GSSG_aw := (GS_pool_aw - GSH_aw)/2.000000e+000; NADPH_aw := NP_pool_aw - NADP_aw; OOH_aw := HPETE_aw + LOOH_aw; OH_aw := HETE_aw + LOH_aw; REDOX_aw := (r2/Ke_red + (r1*OH_aw)/Ke_ox + (al*ki*ZF_airways_conc)/KdZ*(1.000000e+000 + Ca/K_Ca3))/(r2 + r1*OOH_aw); RELFLO5_aw := ((k_lo*AA_aw)/K_AA + k3*HPETE_aw*(1.000000e+000 + AA_aw/Ki_AA))/(k_lta_syn + k_3*(1.000000e+000 + AA_aw/Ki_HPETE_AA)); DFLOa_aw := (1.000000e+000 + Ca/K_Ca3)*(1.000000e+000 + (REDOX_aw*(1.000000e+000 + Ca/K_Ca2))/(1.000000e+000 + Ca/K_Ca3) + AA_aw/K_AA*(1.000000e+000 + AA_aw/Ki_AA_AA) + AA_aw/Ki_AA*(1.000000e+000 + HETE_aw/K_AA_HETE) + RELFLO5_aw*(1.000000e+000 + AA_aw/Ki_HPETE_AA) + HETE_aw/Ki_HETE + (al*ZF_airways_conc)/KdZ); FLO3_aw := FLOa/DFLOa_aw; FLO2_aw := FLO3_aw*REDOX_aw; FLO3t_aw := FLO3_aw*(1.000000e+000 + Ca/K_Ca3); FLO2t_aw := FLO2_aw*(1.000000e+000 + Ca/K_Ca2); FLO5HP_aw := FLO3t_aw*RELFLO5_aw; C_aw := (HPETE_aw*GSH_aw*GSH_aw)/(Km_gpx_HPETE5*Km_gpx_GSH*Km_gpx_GSH); A_aw := (GSH_aw*GSH_aw)/(Km_gpx_GSH*Km_gpx_GSH)*(1.000000e+000 + GSSG_aw/Kd_gpx_GSSG) + HPETE_aw/Km_gpx_HPETE5*(1.000000e+000 + HETE_aw/Kd_gpx_HETE5) + C_aw; B_aw := (k_gpx_cat*HPETE_aw*GSH_aw*GSH_aw)/(Km_gpx_HPETE5*Km_gpx_GSH*Km_gpx_GSH); delta_LTCs_aw := 1.000000e+000 + LTA4_aw/K_LTA + GSH_aw/K_GSH + (LTA4_aw*GSH_aw)/K_LTA/K_LTA_GSH + LTC4_aw/K_LTC; nom_LTCs_aw := Et_LTCs*(K_LTC*k_LTCs_fow*LTA4_aw*GSH_aw - k_LTCs_back*K_LTA_GSH*K_GSH*LTC4_aw); den_LTCs_aw := delta_LTCs_aw*K_LTA_GSH*K_GSH*K_LTC; C_hedh_aw := (1.000000e+000 + HETE_aw/Kd_hedh_HETE5 + NADPH_aw/Kd_hedh_NADPH)*((k_hedh_3*oxoETE_aw)/Kd_hedh_oxoETE5 + (k_hedh_2*NADP_aw)/Kd_hedh_NADP); A_hedh_aw := (1.000000e+000 + NADP_aw/Kd_hedh_NADP + oxoETE_aw/Kd_hedh_oxoETE5)*((k_hedh_1*HETE_aw)/Kd_hedh_HETE5 + (k_hedh_4*NADPH_aw)/Kd_hedh_NADPH) + C_hedh_aw; B_hedh_aw := (k_hedh_1*k_hedh_2*HETE_aw*NADP_aw)/(Kd_hedh_HETE5*Kd_hedh_NADP) - (oxoETE_aw*NADPH_aw*k_hedh_3*k_hedh_4)/(Kd_hedh_oxoETE5*Kd_hedh_NADPH); OL_b := (R1_portion_EOa*((fup_LT*LTD4_b)/Kd_LT))/(1.000000e+000 + (fup_LT*LTD4_b)/Kd_LT + ML_blood_conc/Ki_ML_EOa) + ((1.000000e+000 - R1_portion_EOa)*((fup_LT*(LTC4_b_out + LTD4_b))/Kd_LT_2))/(1.000000e+000 + (fup_LT*(LTC4_b_out + LTD4_b))/Kd_LT_2); OL_aw := (R1_portion_EOa*(LTD4_aw/Kd_LT))/(1.000000e+000 + LTD4_aw/Kd_LT + ML_airways_conc/Ki_ML_EOa) + ((1.000000e+000 - R1_portion_EOa)*((LTC4_aw_out + LTD4_aw)/Kd_LT_2))/(1.000000e+000 + (LTC4_aw_out + LTD4_aw)/Kd_LT_2); Rec_occup_migr := (portion_migr*fup_LT*LTE4_b)/(Kd_LTE_migr + fup_LT*LTE4_b) + ((1.000000e+000 - portion_migr)*IL_b)/(Kd_IL_migr + IL_b); Ca_FEV := Cao_FEV + k_fev_eff*((R1_portion_FEV*(LTD4_aw/Kd_LTR1_FEV))/(1.000000e+000 + LTD4_aw/Kd_LTR1_FEV + ML_airways_conc/EC50_ML_FEV) + (R2_portion_FEV*((LTD4_aw + LTC4_aw_out)/Kd_LTR2_FEV))/(1.000000e+000 + (LTD4_aw + LTC4_aw_out)/Kd_LTR2_FEV) + ((1.000000e+000 - R1_portion_FEV - R2_portion_FEV)*(Hn_aw/Kd_Hn_FEV))/(1.000000e+000 + Hn_aw/Kd_Hn_FEV)); r_out_FEV := R_FEV - ((R_FEV - (R_FEV*(R_FEV - R_in_relax_FEV)^2.000000e+000)^(1.000000e+000/3.000000e+000))*Ca_FEV^n_FEV)/(K_Ca_FEV^n_FEV + Ca_FEV^n_FEV); r_in_FEV := r_out_FEV - (R_FEV - R_in_relax_FEV)*(R_FEV/r_out_FEV)^5.000000e-001; FEV1 := MAX_FEV*(r_in_FEV/R_in_relax_FEV)^2.000000e+000; TSN := (TSN_0*(R_FEV - (R_FEV*(R_FEV - R_in_relax_FEV)^2.000000e+000)^(1.000000e+000/3.000000e+000))*Ca_FEV_ex^n_FEV)/(K_Ca_FEV^n_FEV + Ca_FEV_ex^n_FEV); TSN_Hn := (TSN_0*(R_FEV - (R_FEV*(R_FEV - R_in_relax_FEV)^2.000000e+000)^(1.000000e+000/3.000000e+000))*Ca_FEV^n_FEV)/(K_Ca_FEV^n_FEV + Ca_FEV^n_FEV); FEV1_percent := (FEV1 - 3.528000e+000)/3.528000e+000*1.000000e+002; time_hour := time/6.000000e+001; time_day := time/1.440000e+003; N_EO_bm := EO_bm*6.020000e+000*1.000000e+001^8.000000e+000; N_EO_b := EO_b*6.020000e+000*1.000000e+001^8.000000e+000; N_EO_i_b := EO_i_b*6.020000e+000*1.000000e+001^8.000000e+000; N_EO_a_b := EO_a_b*6.020000e+000*1.000000e+001^8.000000e+000; EO_b_tot := EO_b + EO_i_b + EO_a_b; N_EO_b_tot := (EO_b + EO_i_b + EO_a_b)*6.020000e+000*1.000000e+001^8.000000e+000; N_EO_aw := EO_aw*6.020000e+000*1.000000e+001^8.000000e+000; N_EO_i_aw := EO_i_aw*6.020000e+000*1.000000e+001^8.000000e+000; N_EO_a_aw := EO_a_aw*6.020000e+000*1.000000e+001^8.000000e+000; EO_aw_tot := EO_aw + EO_i_aw + EO_a_aw; N_EO_aw_tot := (EO_aw + EO_i_aw + EO_a_aw)*6.020000e+000*1.000000e+001^8.000000e+000; EO_b_tot_per_ss := (1.000000e+002*(EO_b_tot - 5.330000e-004))/5.330000e-004; N_EO_aw_tot_perc := N_EO_aw_tot/8.187350e+005*1.000000e+002; N_EO_b_tot_perc := N_EO_b_tot/4.266021e+006*1.000000e+002; N_EO := (N_EO_b_tot*V_B + N_EO_aw_tot*V_AW)/(V_B + V_AW); N_EO_a := (N_EO_a_b*V_B + N_EO_a_aw*V_AW)/(V_B + V_AW); LTC4_b_pM := LTC4_b*1.000000e+006; LTs_aw_pg := (LTC4_aw_out/fup_LT*M_LTC + LTD4_aw/fup_LT*M_LTD + LTE4_aw/fup_LT*M_LTE)/1.000000e+003; LTD4_b_free := LTD4_b*fup_LT; ML_uM := ML_blood/1.000000e+006; LTD4_aw_pers := (1.000000e+002*LTD4_aw)/2.057600e+002; N_EO_perc := (1.000000e+002*N_EO)/3.587580e+005; Hn_aw_perc := (1.000000e+002*Hn_aw)/1.416200e+004; N_EO_aw_perc := (1.000000e+002*N_EO_aw_tot)/8.187350e+005; Ca_FEV_LTR1 := (k_fev_eff*((R1_portion_FEV*(LTD4_aw/Kd_LTR1_FEV))/(1.000000e+000 + LTD4_aw/Kd_LTR1_FEV + ML_airways_conc/EC50_ML_FEV)))/(Ca_FEV - Cao_FEV); Ca_FEV_LTR2 := (k_fev_eff*((R2_portion_FEV*((LTD4_aw + LTC4_aw_out)/Kd_LTR2_FEV))/(1.000000e+000 + (LTD4_aw + LTC4_aw_out)/Kd_LTR2_FEV) + ((1.000000e+000 - R1_portion_FEV - R2_portion_FEV)*(Hn_aw/Kd_Hn_FEV))/(1.000000e+000 + Hn_aw/Kd_Hn_FEV)))/(Ca_FEV - Cao_FEV); OL_ASM := (R1_portion_FEV*(LTD4_aw/Kd_LTR1_FEV))/(1.000000e+000 + LTD4_aw/Kd_LTR1_FEV + ML_airways_conc/EC50_ML_FEV) + (R2_portion_FEV*((LTD4_aw + LTC4_aw_out)/Kd_LTR2_FEV))/(1.000000e+000 + (LTD4_aw + LTC4_aw_out)/Kd_LTR2_FEV) + ((1.000000e+000 - R1_portion_FEV - R2_portion_FEV)*(Hn_aw/Kd_Hn_FEV))/(1.000000e+000 + Hn_aw/Kd_Hn_FEV); // Reactions: v1: => AA_b; Default*((Vmax_PLA2*PLA2_Ca*PL)/(Km_PLA2_APC + PL) - (V_CoA*AA_b)/(Km_CoA_AA + AA_b)); v2: AA_b => ; Default*((k_lo*AA_b*FLO3t_b)/K_AA); v3: => HPETE_b; Default*(k_3*FLO5HP_b - k3*FLO3t_b*HPETE_b)*(1.000000e+000 + AA_b/Ki_AA); v4: HPETE_b => HETE_b; Default*r1*(HPETE_b*FLO2_b - (HETE_b*FLO3_b)/Ke_ox); v5: HPETE_b => HETE_b; Default*((GPx*B_b)/A_b); v6: => LTA4_b; Default*k_lta_syn*FLO5HP_b; v7: LTA4_b => LTC4_b; Default*(nom_LTCs_b/den_LTCs_b); v8: HETE_b => ; Default*((HEDH5*B_hedh_b)/A_hedh_b); v9: LTA4_b => ; Default*Kd12*LTA4_b; v10in: LTC4_b => ; Default*Kd50*LTC4_b; v10out: => LTC4_b_out; Default*Kd50*LTC4_b*V_LTC_CB*1.000000e+001^6.000000e+000; v11: LTC4_b_out => LTD4_b; Vd_LTC*k_ggt*fup_LT*LTC4_b_out; v12: LTD4_b => LTE4_b; Vd_LTD*k_dp*fup_LT*LTD4_b; v13: LTC4_b_out => ; Vd_LTC*k_ltc_ltd_el*fup_LT*LTC4_b_out; v14: LTD4_b => ; Vd_LTD*k_ltc_ltd_el*fup_LT*LTD4_b; v15: LTE4_b => ; Vd_LTE*(k_lte_el + k_acet)*fup_LT*LTE4_b; v16: EO_b => EO_i_b; ca*V_B*((ka*EO_b*OL_b^h_act)/(EC50_act^h_act + OL_b^h_act)); v17: EO_i_b => EO_a_b; ca*V_B*k_EO_m*EO_i_b; v18: EO_a_b => EO_b; ca*V_B*kia*EO_a_b; v19: EO_b => ; V_B*k_EO_d*EO_b; v20: EO_a_b => ; V_B*k_EO_a_d*EO_a_b; v21: EO_i_b => EO_i_aw; V_B*((k_EO_t_baw*EO_i_b*Rec_occup_migr^h_migr)/(EC50_migr^h_migr + Rec_occup_migr^h_migr)); v22: EO_a_b => EO_a_aw; V_B*((k_EO_t_baw*EO_a_b*Rec_occup_migr^h_migr)/(EC50_migr^h_migr + Rec_occup_migr^h_migr)); v23: EO_b => EO_aw; V_B*((k_EO_t_baw*EO_b*Rec_occup_migr^h_migr)/(EC50_migr^h_migr + Rec_occup_migr^h_migr)); v24: => Hn_b; V_B*k_Hn_p*(EO_b + EO_i_b + EO_a_b); v25: Hn_b => ; Vd_Hn*k_Hn_d*fup_Hn*Hn_b; v26: => IL_b; V_B*k_IL_p*EO_a_b; v27: IL_b => ; Vd_IL5*k_IL_d*IL_b; v28: IL_b => IL_bm; k_IL_t_bbm*(IL_b - IL_bm) - J_BM_lymfl*IL_bm; v29: => EO_bm; V_BM*((k1*IL_bm^h_matur)/(Km_1^h_matur + IL_bm^h_matur) + k1_min); v30: EO_bm => EO_b; ca*V_BM*k_EO_t_bmb*EO_bm; v31: => AA_aw; Default*((Vmax_PLA2*PLA2_Ca*PL)/(Km_PLA2_APC + PL) - (V_CoA*AA_aw)/(Km_CoA_AA + AA_aw)); v32: AA_aw => ; Default*((k_lo*AA_aw*FLO3t_aw)/K_AA); v33: => HPETE_aw; Default*(k_3*FLO5HP_aw - k3*FLO3t_aw*HPETE_aw)*(1.000000e+000 + AA_aw/Ki_AA); v34: HPETE_aw => HETE_aw; Default*r1*(HPETE_aw*FLO2_aw - (HETE_aw*FLO3_aw)/Ke_ox); v35: HPETE_aw => HETE_aw; Default*((GPx*B_aw)/A_aw); v36: => LTA4_aw; Default*k_lta_syn*FLO5HP_aw; v37: LTA4_aw => LTC4_aw; Default*(nom_LTCs_aw/den_LTCs_aw); v38: HETE_aw => ; Default*((HEDH5*B_hedh_aw)/A_hedh_aw); v39: LTA4_aw => ; Default*Kd12*LTA4_aw; v40in: LTC4_aw => ; Default*Kd50*LTC4_aw; v40out: => LTC4_aw_out; Default*Kd50*LTC4_aw*V_LTC_CAW*1.000000e+001^6.000000e+000; v41: LTC4_aw_out => LTD4_aw; Vd_AW_LTC*k_ggt*LTC4_aw_out; v42: LTD4_aw => LTE4_aw; Vd_AW_LTD*k_dp*LTD4_aw; v43: LTE4_aw => LTE4_b; Q_AW_blf*R_LTE_B*((LTE4_aw*R_LTE_AW)/Kp_LTE_AW - LTE4_b); v44: LTD4_aw => LTD4_b; Q_AW_blf*R_LTD_B*((LTD4_aw*R_LTD_AW)/Kp_LTD_AW - LTD4_b); v45: LTC4_aw_out => LTC4_b_out; Q_AW_blf*R_LTC_B*((LTC4_aw_out*R_LTC_AW)/Kp_LTC_AW - LTC4_b_out); v46: EO_aw => EO_i_aw; ca*V_AW*((ka*EO_aw*OL_aw^h_act)/(EC50_act^h_act + OL_aw^h_act)); v47: EO_i_aw => EO_a_aw; ca*V_AW*k_EO_m*EO_i_aw; v48: EO_a_aw => EO_aw; ca*V_AW*kia*EO_a_aw; v49: EO_aw => ; V_AW*k_EO_d*EO_aw; v50: EO_a_aw => ; V_AW*k_EO_a_d*EO_a_aw; v51: => Hn_aw; V_AW*k_Hn_p*(EO_a_aw + EO_i_aw + EO_aw); v52: Hn_aw => Hn_b; Q_AW_blf*R_Hn_B*((Hn_aw*R_Hn_AW)/Kp_Hn_AW - Hn_b); v53: => IL_aw; V_AW*k_IL_p*EO_a_aw; v54: IL_aw => IL_b; k_IL_t_awb*(IL_aw - IL_b) + J_AW_lymfl*IL_aw; v55: LTE4_aw => ; Vd_AW_LTE*(k_lte_el + k_acet)*LTE4_aw; v56: LTD4_aw => ; Vd_AW_LTD*k_ltc_ltd_el*LTD4_aw; v57: LTC4_aw_out => ; Vd_AW_LTC*k_ltc_ltd_el*LTC4_aw_out; v58: IL_aw => ; V_AW*k_IL_d*IL_aw; v59: Hn_aw => ; Vd_AW_Hn*k_Hn_d*Hn_aw; v60: ZF_intes => ZF_blood; Default*k_abs_zf*(ZF_intes + (oral*F_zf*(a*ft_zf + (1.000000e+000 - a))*DOSE_zf*1.000000e+003)/M_ZF); v61: ZF_blood => ZF_airways; Q_AW_blf*R_ZF_B*(ZF_blood - (ZF_airways*R_ZF_AW)/Kp_ZF_AW); v62: ZF_blood => ; Vd_ZF*k_elim_zf*ZF_blood; v63: ML_intes => ML_blood; Default*k_abs_ml*(ML_intes + (oral*F_ml*(a*ft_ml + (1.000000e+000 - a))*DOSE_ml*1.000000e+009)/M_ML); v64: ML_blood => ; Vd_ML*k_elim_ml*ML_blood; // Species initializations: AA_b = 0.2890944; HPETE_b = 0.2965837; HETE_b = 5.037703; LTA4_b = 1.081167; LTC4_b = 0.8869873; LTC4_b_out = 2168.571; LTD4_b = 1308.488; LTE4_b = 2053.137; EO_b = 4.68114e-007; EO_i_b = 5.479176e-008; EO_a_b = 0.0005383185; EO_i_aw = 1.358698e-007; EO_a_aw = 0.001358713; EO_aw = 1.176558e-006; Hn_b = 14995.88; IL_b = 0.5994857; IL_bm = 0.4023394; EO_bm = 1.637391e-006; AA_aw = 0.1304887; HPETE_aw = 1.780604; HETE_aw = 1.960926; LTA4_aw = 41.69257; LTC4_aw = 6.806687; LTC4_aw_out = 359.9744; LTD4_aw = 205.7602; LTE4_aw = 322.6366; Hn_aw = 14162.15; IL_aw = 0.6627439; ZF_intes = 0; ZF_blood = 0; ZF_airways = 0; ML_intes = 0; ML_blood = 0; // Compartment initializations: Default = 1; Vd_LTC = 9.47999954223633; Vd_LTD = 9.47999954223633; Vd_LTE = 9.47999954223633; V_B = 2.80999994277954; V_AW = 0.209999993443489; Vd_Hn = 78100; Vd_IL5 = 10.1999998092651; V_BM = 0.824999988079071; Vd_AW_LTC = 1.53999996185303; Vd_AW_LTD = 1.53999996185303; Vd_AW_LTE = 1.53999996185303; Vd_AW_Hn = 5640; Vd_ZF = 9.44999980926514; Vd_AW_ZF = 3.25999999046326; Vd_ML = 10; // Variable initializations: Ca = 1; Ca_FEV_ex = 10000; Cao_FEV = 10000; DOSE_ml = 0; DOSE_zf = 0; EC50_ML_FEV = 500; EC50_act = 0.75; EC50_migr = 0.115; Et_LTCs = 1; FLOa = 1.5; F_ml = 0.660688; F_zf = 0.082; GPx = 1.6; GSH_aw = 1000; GSH_b = 5000; GS_pool_aw = 10000; GS_pool_b = 10000; HEDH5 = 0.5; J_AW_lymfl = 0.00115; J_BM_lymfl = 0.00049; K_AA = 10.74959; K_Ca2 = 14.36738; K_Ca3 = 7116.527; K_Ca_FEV = 150000; K_GSH = 744.9176; K_LTA = 1.75951; K_LTA_GSH = 1696.6; K_LTC = 0.1951215; K_PLA2_Ca = 0.1; Kd12 = 0.007; Kd50 = 0.43; KdZ = 20; Kd_Hn_FEV = 6300000; Kd_IL_migr = 50; Kd_LT = 1000; Kd_LTE_migr = 50000; Kd_LTR1_FEV = 1000; Kd_LTR2_FEV = 10000; Kd_LT_2 = 10000; Kd_gpx_GSSG = 0.07154222; Kd_gpx_HETE5 = 6.043446; Kd_hedh_HETE5 = 0.331696; Kd_hedh_NADP = 2.895899; Kd_hedh_NADPH = 2.685581; Kd_hedh_oxoETE5 = 1.667019; Ke_ox = 99.99979; Ke_red = 5.761955e-007; Ki_AA = 551.8748; Ki_HETE = 0.5408177; Ki_ML_EOa = 500; Km_1 = 2; Km_CoA_AA = 0.005; Km_PLA2_APC = 20; Km_gpx_GSH = 600; Km_gpx_HPETE5 = 5.974381; Kp_Hn_AW = 3950; Kp_LTC_AW = 0.22; Kp_LTD_AW = 0.22; Kp_LTE_AW = 0.22; Kp_ZF_AW = 0.204; Kp_ZF_IW = 0.631; LOH_aw = 0; LOH_b = 0; LOOH_aw = 20; LOOH_b = 1; MAX_FEV = 4.94; ML_airways = 0; ML_ex = 0; M_Hn = 111.2; M_IL5 = 45000; M_LTC = 625.8; M_LTD = 496.7; M_LTE = 439.6; M_ML = 586.18; M_ZF = 236; NADP_aw = 2900; NADP_b = 2000; NP_pool_aw = 3000; NP_pool_b = 3000; N_A_pmole = 602000000000; OL_b_ex = 0; PL = 110; Q_AW_blf = 5.23; R1_portion_EOa = 0.39; R1_portion_FEV = 0.016; R2_portion_FEV = 0.037; R_FEV = 3.007; R_Hn_AW = 5130; R_Hn_B = 141; R_LTC_AW = 1.4; R_LTC_B = 0.538; R_LTD_AW = 1.4; R_LTD_B = 0.538; R_LTE_AW = 1.4; R_LTE_B = 0.538; R_ZF_AW = 2.96; R_ZF_B = 0.533; R_in_relax_FEV = 2.073; T = 1440; TSN_0 = 15.5; V_CoA = 350; Vmax_PLA2 = 450; a = 1; al = 1; ca = 10; diam_EO = 0.00012; fup_Hn = 0.77; fup_LT = 0.16; fup_ML = 0.004; fup_ZF = 0.069; h_act = 3; h_matur = 1; h_migr = 3; k1 = 1e-006; k1_min = 1.6e-007; k3 = 34; k_3 = 263640; k_EO_a_d = 0.00015; k_EO_d = 0.0003; k_EO_m = 10; k_EO_t_baw = 0.04; k_EO_t_bmb = 0.02; k_Hn_d = 0.033; k_Hn_p = 18000000000; k_IL_d = 0.0046; k_IL_p = 16; k_IL_t_awb = 0.05; k_IL_t_bbm = 0.001; k_LTCs_back = 1003.709; k_LTCs_fow = 1068016; k_abs_ml = 0.012; k_abs_zf = 0.018; k_acet = 0.002703885; k_dp = 0.067; k_elim_ml = 0.00225; k_elim_zf = 0.004; k_fev_eff = 3000000; k_ggt = 0.1; k_gpx_cat = 0.4884995; k_hedh_1 = 88.33768; k_hedh_2 = 1724.404; k_hedh_3 = 31.49749; k_hedh_4 = 8.077531; k_lo = 4642.68; k_lta_syn = 54420; k_ltc_ltd_el = 0.1; k_lte_el = 0.04; k_ox = 0.0002658; k_ox2 = 67.2; k_red = 0.0002538; k_red2 = 4.428e-005; ka = 500; ki = 25000; kia = 0.001; n_FEV = 1; naEO_LTCsyn = 0; npi = 3.14; oral = 1; oxoETE_aw = 0; oxoETE_b = 0; portion_migr = 0.3; zf_inh = 0; // Other declarations: var Ca, Ca_FEV_ex, Cao_FEV, DOSE_ml, DOSE_zf, EC50_ML_FEV, EC50_act, EC50_migr; var Et_LTCs, FLOa, F_ml, F_zf, GPx, GSH_aw, GSH_b, GS_pool_aw, GS_pool_b; var HEDH5, J_AW_lymfl, J_BM_lymfl, K_AA, K_Ca2, K_Ca3, K_Ca_FEV, K_GSH; var K_LTA, K_LTA_GSH, K_LTC, K_PLA2_Ca, Kd12, Kd50, KdZ, Kd_Hn_FEV, Kd_IL_migr; var Kd_LT, Kd_LTE_migr, Kd_LTR1_FEV, Kd_LTR2_FEV, Kd_LT_2, Kd_gpx_GSSG; var Kd_gpx_HETE5, Kd_hedh_HETE5, Kd_hedh_NADP, Kd_hedh_NADPH, Kd_hedh_oxoETE5; var Ke_ox, Ke_red, Ki_AA, Ki_HETE, Ki_ML_EOa, Km_1, Km_CoA_AA, Km_PLA2_APC; var Km_gpx_GSH, Km_gpx_HPETE5, Kp_Hn_AW, Kp_LTC_AW, Kp_LTD_AW, Kp_LTE_AW; var Kp_ZF_AW, Kp_ZF_IW, LOH_aw, LOH_b, LOOH_aw, LOOH_b, MAX_FEV, ML_airways; var ML_ex, M_Hn, M_IL5, M_LTC, M_LTD, M_LTE, M_ML, M_ZF, NADP_aw, NADP_b; var NP_pool_aw, NP_pool_b, N_A_pmole, OL_b_ex, PL, Q_AW_blf, R1_portion_EOa; var R1_portion_FEV, R2_portion_FEV, R_FEV, R_Hn_AW, R_Hn_B, R_LTC_AW, R_LTC_B; var R_LTD_AW, R_LTD_B, R_LTE_AW, R_LTE_B, R_ZF_AW, R_ZF_B, R_in_relax_FEV; var T, TSN_0, V_CoA, Vmax_PLA2, a, al, ca, diam_EO, fup_Hn, fup_LT, fup_ML; var fup_ZF, h_act, h_matur, h_migr, k1, k1_min, k3, k_3, k_EO_a_d, k_EO_d; var k_EO_m, k_EO_t_baw, k_EO_t_bmb, k_Hn_d, k_Hn_p, k_IL_d, k_IL_p, k_IL_t_awb; var k_IL_t_bbm, k_LTCs_back, k_LTCs_fow, k_abs_ml, k_abs_zf, k_acet, k_dp; var k_elim_ml, k_elim_zf, k_fev_eff, k_ggt, k_gpx_cat, k_hedh_1, k_hedh_2; var k_hedh_3, k_hedh_4, k_lo, k_lta_syn, k_ltc_ltd_el, k_lte_el, k_ox, k_ox2; var k_red, k_red2, ka, ki, kia, n_FEV, naEO_LTCsyn, npi, oral, oxoETE_aw; var oxoETE_b, portion_migr, zf_inh, ft_zf, ft_ml, ZF_blood_conc, ZF_airways_conc; var ML_blood_conc, ML_airways_conc, w_EO, V_CB, V_aCB, V_LTC_CB, V_CAW; var V_aCAW, V_LTC_CAW, GSSG_b, NADPH_b, PLA2_D, PLA2_Ca, Ki_AA_AA, K_AA_HETE; var Ki_HPETE_AA, OOH_b, OH_b, r1, r2, REDOX_b, RELFLO5_b, DFLOa_b, FLO3_b; var FLO2_b, FLO3t_b, FLO2t_b, FLO5HP_b, C_b, A_b, B_b, delta_LTCs_b, nom_LTCs_b; var den_LTCs_b, C_hedh_b, A_hedh_b, B_hedh_b, GSSG_aw, NADPH_aw, OOH_aw; var OH_aw, REDOX_aw, RELFLO5_aw, DFLOa_aw, FLO3_aw, FLO2_aw, FLO3t_aw, FLO2t_aw; var FLO5HP_aw, C_aw, A_aw, B_aw, delta_LTCs_aw, nom_LTCs_aw, den_LTCs_aw; var C_hedh_aw, A_hedh_aw, B_hedh_aw, OL_b, OL_aw, Rec_occup_migr, Ca_FEV; var r_out_FEV, r_in_FEV, FEV1, TSN, TSN_Hn, FEV1_percent, time_hour, time_day; var N_EO_bm, N_EO_b, N_EO_i_b, N_EO_a_b, EO_b_tot, N_EO_b_tot, N_EO_aw; var N_EO_i_aw, N_EO_a_aw, EO_aw_tot, N_EO_aw_tot, EO_b_tot_per_ss, N_EO_aw_tot_perc; var N_EO_b_tot_perc, N_EO, N_EO_a, LTC4_b_pM, LTs_aw_pg, LTD4_b_free, ML_uM; var LTD4_aw_pers, N_EO_perc, Hn_aw_perc, N_EO_aw_perc, Ca_FEV_LTR1, Ca_FEV_LTR2; var OL_ASM; const Default, Vd_LTC, Vd_LTD, Vd_LTE, V_B, V_AW, Vd_Hn, Vd_IL5, V_BM, Vd_AW_LTC; const Vd_AW_LTD, Vd_AW_LTE, Vd_AW_Hn, Vd_ZF, Vd_AW_ZF, Vd_ML; end