// Created by libAntimony v2.8.0
model *MODEL1301020001()

  // Compartments and Species:
  compartment default, Vex, Vin;
  species GP in default, pGP in default, mRNA in default, PEPCK in default;
  species IRS in default, p1IRS in default, p2IRS in default, p1p2IRS in default;
  species Akt in default, pAkt in default, mTOR in default, pmTOR in default;
  species Foxo in default, pFoxo in default, PYRout in Vex, GLCex in Vex;
  species F16P in Vin, PYRin in Vin, LAC in Vin, OAA in Vin, GLY in Vin, G1P in Vin;
  species G6P in Vin;

  // Reactions:
  v1: GLCex -> G6P; (V1*(GLCex/K1) - V1*(G6P/K1))/(1 + GLCex/K1 + G6P/K1);
  v2: pAkt + G6P -> pAkt + F16P; (((1 + s1*pAkt)*V2_G6P*G6P)/K2_G6P - (V2_F16P*F16P)/K2_F16P)/(1 + G6P/K2_G6P + F16P/K2_F16P);
  v3: F16P => PYRin; (V3*F16P)/(K3 + F16P);
  v4: PYRin -> LAC; ((V4_PYR*PYRin)/K4_PYR - (V4_LAC*LAC)/K4_LAC)/(1 + PYRin/K4_PYR + LAC/K4_LAC);
  v5: PYRout -> PYRin; ((V5*PYRout)/K5 - (V5*PYRin)/K5)/(1 + PYRout/K5 + PYRin/K5);
  v6: PYRin => OAA; (V6*PYRin)/(K6 + PYRin);
  v7: PEPCK + OAA => PEPCK + F16P; ((1 + s3*PEPCK)*V7*OAA)/(K7 + OAA);
  v8: pAkt + G6P -> pAkt + G1P; (((1 + s4*pAkt)*V8_G6P*G6P)/K8_G6P - (V8_G1P*G1P)/K8_G1P)/(1 + G6P/K8_G6P + G1P/K8_G1P);
  v9: pGP + G1P -> pGP + GLY; ((V9_G1P*G1P)/K9_G1P - ((1 + s2*pGP)*V9_GLY*GLY)/K9_GLY)/(1 + G1P/K9_G1P + GLY/K9_GLY);
  metabolicENZ: pGP + G6P => GP + G6P; pGP*G6P*k4;
  reaction1:  => IRS; (proIRS - IRS)*param1;
  reaction2: IRS -> p1IRS; IRS*insulin*param2 - p1IRS*param3;
  reaction3: p1IRS => ; p1IRS*param4;
  reaction4: p1IRS + pmTOR => p1p2IRS + pmTOR; p1IRS*pmTOR*param5;
  reaction5: p1p2IRS => p1IRS; p1p2IRS*param6;
  reaction6: IRS + pmTOR => p2IRS + pmTOR; IRS*pmTOR*param7;
  reaction7: p2IRS => IRS; p2IRS*param8;
  reaction8: p2IRS => ; p2IRS*param9;
  reaction9: p2IRS -> p1p2IRS; p2IRS*insulin*param10 - p1p2IRS*param11;
  reaction10: p1p2IRS => ; p1p2IRS*param12;
  reaction11: Akt + p1IRS => pAkt + p1IRS; p1IRS*Akt*param13;
  reaction12: pAkt => Akt; pAkt*param14;
  reaction13: mTOR + pAkt => pmTOR + pAkt; mTOR*pAkt*param15;
  reaction14: pmTOR => mTOR; pmTOR*param16;
  reaction15: Foxo + pAkt => pFoxo + pAkt; pAkt*Foxo*k1_PEPCK;
  reactionPEP1: Foxo => mRNA + Foxo; Foxo*k3_PEPCK - mRNA*k4_PEPCK;
  reactionPEP2: mRNA => PEPCK + mRNA; k5_PEPCK*mRNA - k6_PEPCK*PEPCK;
  mw7c079c91_51e3_4732_8dca_23fb3cd716a7: pFoxo => Foxo; pFoxo*k2_PEPCK;
  mwfc720c89_b1b3_416a_8958_e9d0aff9f4a6: GP => pGP; GP*k3;

  // Species initializations:
  GP = 0.4726/default;
  pGP = 0.1723/default;
  mRNA = 2.905/default;
  PEPCK = 0.7686/default;
  IRS = 888.77/default;
  p1IRS = 0;
  p2IRS = 0;
  p1p2IRS = 0;
  Akt = 1.1182/default;
  pAkt = 0;
  mTOR = 880.25/default;
  pmTOR = 0;
  Foxo = 1.069e-005/default;
  pFoxo = 0;
  PYRout = 137.5/Vex;
  GLCex = 114.9/Vex;
  F16P = 9.571/Vin;
  PYRin = 0.9872/Vin;
  LAC = 1001/Vin;
  OAA = 0.0022/Vin;
  GLY = 4.8248/Vin;
  G1P = 5.303/Vin;
  G6P = 0.5188/Vin;

  // Compartment initializations:
  default = 1;
  Vex = 0.004;
  Vex has litre;
  Vin = 2.64e-005;
  Vin has litre;

  // Variable initializations:
  V1 = 8.97;
  K1 = 0.0451;
  V2_G6P = 7.71;
  K2_G6P = 925;
  V2_F16P = 0.0839;
  K2_F16P = 0.597;
  V3 = 0.00229;
  K3 = 2.92;
  V6 = 0.00247;
  K6 = 0.996;
  V7 = 2.84e-005;
  K7 = 8.43;
  V4_PYR = 23.6;
  K4_PYR = 56.4;
  V4_LAC = 1.2e-006;
  K4_LAC = 0.0154;
  V8_G6P = 2.02e-005;
  K8_G6P = 0.791;
  V8_G1P = 0.04;
  K8_G1P = 69.8;
  V5 = 0.00112;
  K5 = 0.228;
  V9_G1P = 0.488;
  K9_G1P = 2.69;
  V9_GLY = 1.02e-006;
  K9_GLY = 0.000623;
  k3 = 112.76;
  k4 = 1.9448;
  s1 = 1.722;
  s2 = 214.7;
  s3 = 46.54;
  s4 = 1.19;
  k1_PEPCK = 0.12225;
  k2_PEPCK = 0.0045985;
  k3_PEPCK = 486.28;
  k4_PEPCK = 0.0046101;
  k5_PEPCK = 0.00010958;
  k6_PEPCK = 0.0018592;
  param1 = 5.5702;
  param2 = 2.3969;
  param3 = 0.020934;
  param4 = 1.214e-005;
  param5 = 0.2751;
  param6 = 0.0072509;
  param7 = 758.12;
  param8 = 0.91758;
  param9 = 0.041292;
  param10 = 0.00013032;
  param11 = 0.000192;
  param12 = 0.029311;
  param13 = 4.4307e-005;
  param14 = 0.35211;
  param15 = 3.1385e-005;
  param16 = 0.0095934;
  proIRS = 888.77;
  insulin = 100;
  insulin has MWDERIVEDUNIT_nanomole__litre;

  // Other declarations:
  const default, Vex, Vin, V1, K1, V2_G6P, K2_G6P, V2_F16P, K2_F16P, V3, K3;
  const V6, K6, V7, K7, V4_PYR, K4_PYR, V4_LAC, K4_LAC, V8_G6P, K8_G6P, V8_G1P;
  const K8_G1P, V5, K5, V9_G1P, K9_G1P, V9_GLY, K9_GLY, k3, k4, s1, s2, s3;
  const s4, k1_PEPCK, k2_PEPCK, k3_PEPCK, k4_PEPCK, k5_PEPCK, k6_PEPCK, param1;
  const param2, param3, param4, param5, param6, param7, param8, param9, param10;
  const param11, param12, param13, param14, param15, param16, proIRS, insulin;

  // Unit definitions:
  unit MWDERIVEDUNIT_nanomole__litre = mole * 1e-006 dimensionless / metre^3;

  // Display Names:
  MWDERIVEDUNIT_nanomole__litre is "nanomole/litre";
  s2 is "s4";
  s3 is "s2";
  s4 is "s3";
  metabolicENZ is "metabolicENZ1";
  mw7c079c91_51e3_4732_8dca_23fb3cd716a7 is "reaction16";
  mwfc720c89_b1b3_416a_8958_e9d0aff9f4a6 is "metabolicENZ2";
end