// Created by libAntimony v2.8.0 model *MODEL1308190000() // Compartments and Species: compartment default, c1, c2, c3; substanceOnly species s1 in default, s2 in c2, s3 in c1, s4 in c1, s5 in default; substanceOnly species s6 in c1, s7 in c1, s8 in c1, s9 in c1, s10 in c1; substanceOnly species s11 in c1, s12 in c1, s13 in c1, s14 in c1, s15 in c1; substanceOnly species s16 in c1, s17 in c1, s18 in c1, s19 in c1, s20 in c1; substanceOnly species s21 in c1, s22 in c1, s23 in c1, s24 in c1, s25 in c1; substanceOnly species s26 in c1, s27 in c1, s28 in c1, s35 in c1, s37 in c1; substanceOnly species s38 in c1, s39 in c1, s42 in c3, s43 in c1, s44 in c1; substanceOnly species s45 in c1, s47 in c1, s48 in c1, s49 in c1, s50 in c1; substanceOnly species s51 in c1, s52 in c1, s57 in c1, s58 in c1, s60 in c1; substanceOnly species s61 in c1, s62 in c1, s63 in c1, s64 in c1, s65 in c1; substanceOnly species s66 in c1, s91 in c1, s92 in c1, s93 in c1, s94 in c1; substanceOnly species s95 in c1, s96 in c1, s97 in c1, s98 in c1, s99 in c1; substanceOnly species s100 in c1, s101 in c1, s102 in c1, s103 in c1, s104 in c1; substanceOnly species s105 in c1, s106 in c1, s107 in c3, s108 in c3, s110 in c1; substanceOnly species s111 in c1, s112 in c1, s113 in c1, s114 in c1, s115 in c3; substanceOnly species s116 in c1, s117 in c1, s118 in c1, s119 in default; // Reactions: re3: s4 => s3; -k6*s3*(B_T - s4) + k7*s4; re4: s5 => s2; k_CCE*((fracK*Cao)/(K3 + Cao) - s2)*(s1 - s2); re5: s7 => s6; (0.5*k1*(R_T - half*R_T*(exp(-s12/tau_I) + exp(-s12/tau_II) + ((exp(-s12/tau_I) - exp(-s12/tau_II))*(tau_I + tau_II))/(tau_I - tau_II)))*s3)/(K1 + s3); re6: s6 => s8; 0.5*k2*s6; re7: s2 => s3; 0.5*k3*((k_CICR*s3)/(K_CICR + s3))*(s6/(K2 + s6))^3*s2 - 0.5*k4*(s3/(K3 + s3))^2 + 0.5*k5*s2*s2; re8: s3 => s9; (0.5*dot_Vhi*s3^4)/(K_hi^4 + s3^4); re9: s3 => s10; (0.5*dot_Vex*s3)/(K5 + s3); re10: s11 => s3; 0.5*dot_q_inpass; re11: s13 => s12; re11_unisec*0.5; re12: s3 => s9; (0.5*dot_Vp*s3^2)/(K4^2 + s3^2); re37: s51 + s47 => s45; k15*s47*s51; re38: s48 + s51 -> s50; k17*s51*s48 - k18*s50; re41: s52 -> s48; k11*s3*s52 - k12*s48; re42: s48 => s47; k13*s3*s48 - k14*s47; re50: s45 -> s50; gam*k14*s45 - k13*s3*s50; re51: s45 + s57 => s58; k90*s45*s57; re52: s58 -> s61; gam*k14*s58 - k13*s3*s61; re53: s61 => s50 + s57; kr90*s61; re54: s60 -> s62; gam*k14*s60 - k13*s3*s62; re55: s58 -> s60; (kp*s58*s27)/(s58 + Kmp) - (Vdp*s60)/(s60 + Kmdp); re56: s61 -> s62; (kp*s61*s27)/(s61 + Kmp) - (Vdp*s62)/(s62 + Kmdp); re57: s22 -> s20; exp(re57_unity - (s23/re57_tf)^1.8)*re57_normal*(s23/re57_unimol)^0.8*(re57_unity - (s23/re57_tf)^1.8); re58: s19 => s17; (re58_k58*s19*s20)/(re58_Km58 + s19); re59: s17 => s19; (re59_k59*s17*s18)/(re59_Km59 + s17); re60: s17 + s16 -> s28; re60_k60*s17*s16 - re60_kr60*s28; re61: s28 => s26; (re61_k61*s28*s14)/(re61_Km61 + s28); re62: s26 => s27; (re62_k62*s26*s24)/(re62_Km62 + s26); re63: s26 => s28; (re63_k63*s26*s15)/(re63_Km63 + s26); re64: s27 => s26; (re64_k64*s27*s15)/(re64_Km64 + s27); re65: s27 => s17 + s16; (re65_k65*s27*s15)/(re65_Km65 + s27); re66: s25 => s14; re66_k66*s17*s25; re67: s14 => s25; s14*re67_k67; re68: s21 => s23; re68_unitime; re69: s63 => s64; re69_K_cam_no*(s45 + s58) + re69_K_p_no*(s62 + s65) + re69_K_pcam_no*s60; re70: s65 => s66; (Vdp*s65)/(s65 + Kmdp); re71: s66 => s51 + s57; kr90*s66; re72: s62 -> s65 + s48; k18*s62 - k17*s65*s48; re102: s95 -> s93; exp(re102_unity - (s39/re102_tf)^0.35)*re102_normal*((s39 + re102_tiny_num)/re102_unimol)^-0.65*(re102_unity - (s39/re102_tf)^0.35); re103: s94 -> s92; exp(re103_unity - (s39/re103_tf)^1.3)*re103_normal*(s39/re103_unimol)^0.3*(re103_unity - (s39/re103_tf)^1.3); re104: s91 + s93 -> s110; re104_k105*s91*s93 - re104_k_105*s110; re105: s110 -> s112; re105_kcat_src*s110*s92 - re105_k_6*s112; re106: s112 + s111 -> s113; re106_k107*s111*s112 - re106_k_107*s113; re107: s113 -> s114 + s93; re107_k108*s113 - re107_k_108*s93*s114; re108: s98 => s91; (re108_V10*s98)/(re108_K10 + s98); re109: s114 => s98 + s111; re109_k9*s114; re110: s115 => s106; s115*re110_kT; re111: s108 => s115; re111_ktr1*s107 + re111_ktr1k2*s49; re112: s103 => s102; (re112_k111*s114*s103)/(s103 + re112_K111); re113: s102 => s103; (re113_V12*s102)/(re113_K12 + s102); re114: s97 => s101; (re114_k113*s102*s97)/(re114_K113 + s97); re115: s101 => s97; (re115_V18*s101)/(re115_K18 + s101); re116: s96 => s100; (re116_k19*s101*s96)/(re116_K19 + s96); re117: s100 => s96; (re117_V20*s100)/(s100 + re117_K20); re118: s99 => s104; (re118_k21*s99*s43)/(s99 + re118_K21); re119: s104 => s99; (re119_V22*s104)/(s104 + re119_K22); re120: s106 => s35; re120_kD*s106; re121: s37 => s51; (re121_kP*s106)/(s106 + re121_K30); re122: s38 => s39; re122_unitime; re123: s43 => s100; (re123_V37*s43)/(s43 + re123_K37); re124: s100 => s43; (re124_k38*s100*s101)/(re124_K38 + s100); re125: s44 => s104; (re125_V39*s44)/(re125_K39 + s44); re126: s104 => s44; (re126_k40*s104*s43)/(re126_K40 + s104); re127: s42 => s107; (s44*s42*re127_k43)/(re127_K43 + s42); re128: s107 => s42; (re128_V44*s107)/(s107 + re128_K44); re129: s105 => s49; exp(re129_tau*(re129_delay - s39/re129_tc))/(1 + 2*exp(re129_tau*(re129_delay - s39/re129_tc)) + exp(2*re129_tau*(re129_delay - s39/re129_tc)))/re129_uc*29.256; re131: s51 => s116; kDD*s51; re132: s45 => s117 + s47; kDD*s45; re133: s50 => s117 + s48; kDD*s50; re134: s66 => s57 + s118; kDD*s66; re135: s65 => s118 + s57; kDD*s65; re136: s61 => s57 + s48; kDD*s61; re137: s62 => s57 + s48; kDD*s62; re138: s58 => s57 + s47; kDD*s58; re139: s60 => s57 + s47; kDD*s60; // Species initializations: s1 = 1500000/default; s1 has substance_per_volume; s2 = 2830000/c2; s2 has substance_per_volume; s3 = 117.2/c1; s3 has substance_per_volume; s4 = 3870/c1; s4 has substance_per_volume; s5 = 0; s5 has substance_per_volume; s6 = 0; s6 has substance_per_volume; s7 = 0; s7 has substance_per_volume; s8 = 0; s8 has substance_per_volume; s9 = 0; s9 has substance_per_volume; s10 = 0; s10 has substance_per_volume; s11 = 0; s11 has substance_per_volume; s12 = 0; s12 has substance_per_volume; s13 = 0; s13 has substance_per_volume; s14 = 0.246/c1; s14 has substance_per_volume; s15 = 150/c1; s15 has substance_per_volume; s16 = 167.616/c1; s16 has substance_per_volume; s17 = 0.345/c1; s17 has substance_per_volume; s18 = 0.1/c1; s18 has substance_per_volume; s19 = 6967.271/c1; s19 has substance_per_volume; s20 = 0.03/c1; s20 has substance_per_volume; s21 = 0; s21 has substance_per_volume; s22 = 99.97/c1; s22 has substance_per_volume; s23 = 0; s23 has substance_per_volume; s24 = 3/c1; s24 has substance_per_volume; s25 = 999.754/c1; s25 has substance_per_volume; s26 = 1.457/c1; s26 has substance_per_volume; s27 = 1.723/c1; s27 has substance_per_volume; s28 = 29.203/c1; s28 has substance_per_volume; s35 = 0; s35 has substance_per_volume; s37 = 10000/c1; s37 has substance_per_volume; s38 = 0; s38 has substance_per_volume; s39 = 0; s39 has substance_per_volume; s42 = 50/c3; s42 has substance_per_volume; s43 = 0.006/c1; s43 has substance_per_volume; s44 = 0; s44 has substance_per_volume; s45 = 0.0415/c1; s45 has substance_per_volume; s47 = 2.827/c1; s47 has substance_per_volume; s48 = 347.52/c1; s48 has substance_per_volume; s49 = 10/c1; s49 has substance_per_volume; s50 = 2.12/c1; s50 has substance_per_volume; s51 = 34.98/c1; s51 has substance_per_volume; s52 = 7635.36/c1; s52 has substance_per_volume; s57 = 199987/c1; s57 has substance_per_volume; s58 = 1.037/c1; s58 has substance_per_volume; s60 = 0.0089/c1; s60 has substance_per_volume; s61 = 10.98/c1; s61 has substance_per_volume; s62 = 0.106/c1; s62 has substance_per_volume; s63 = 500000/c1; s63 has substance_per_volume; s64 = 0; s64 has substance_per_volume; s65 = 0.643/c1; s65 has substance_per_volume; s66 = 0.083/c1; s66 has substance_per_volume; s91 = 819.25/c1; s91 has substance_per_volume; s92 = 18/c1; s92 has substance_per_volume; s93 = 0.605/c1; s93 has substance_per_volume; s94 = 72/c1; s94 has substance_per_volume; s95 = 57/c1; s95 has substance_per_volume; s96 = 299.706/c1; s96 has substance_per_volume; s97 = 98.514/c1; s97 has substance_per_volume; s98 = 157.162/c1; s98 has substance_per_volume; s99 = 299.997/c1; s99 has substance_per_volume; s100 = 0.288/c1; s100 has substance_per_volume; s101 = 1.486/c1; s101 has substance_per_volume; s102 = 0.616/c1; s102 has substance_per_volume; s103 = 119.384/c1; s103 has substance_per_volume; s104 = 0.003/c1; s104 has substance_per_volume; s105 = 0; s105 has substance_per_volume; s106 = 3.214/c1; s106 has substance_per_volume; s107 = 0; s107 has substance_per_volume; s108 = 0; s108 has substance_per_volume; s110 = 0.857/c1; s110 has substance_per_volume; s111 = 3.23/c1; s111 has substance_per_volume; s112 = 15.962/c1; s112 has substance_per_volume; s113 = 5.577/c1; s113 has substance_per_volume; s114 = 1.193/c1; s114 has substance_per_volume; s115 = 0.09/c3; s115 has substance_per_volume; s116 = 0; s116 has substance_per_volume; s117 = 0; s117 has substance_per_volume; s118 = 0; s118 has substance_per_volume; s119 = 0; s119 has substance_per_volume; // Compartment initializations: default = 1; default has volume; c1 = 1; c1 has volume; c2 = 1; c2 has volume; c3 = 1; c3 has volume; // Variable initializations: R_T = 44000; R_T has dimensionless; k1 = 0.0012; k1 has sub_sec; k2 = 2; k2 has inv_sec; k3 = 6.64; k3 has inv_sec; k4 = 5000; k4 has sub_sec; k5 = 1e-010; k5 has inv_sec_sub; k6 = 0.1; k6 has inv_sec_sub; k7 = 300; k7 has inv_sec; K1 = 0; K1 has substance; K2 = 200; K2 has substance; K3 = 150; K3 has substance; K4 = 80; K4 has substance; K5 = 321; K5 has substance; K_hi = 380; K_hi has substance; k_CICR = 1; k_CICR has dimensionless; K_CICR = 0; K_CICR has substance; k_CCE = 0; k_CCE has inv_sec_sub; B_T = 120000; B_T has substance; Vc_Vs = 3.5; Vc_Vs has dimensionless; dot_Vp = 1630; dot_Vp has sub_sec; dot_Vex = 18330; dot_Vex has sub_sec; dot_Vhi = 4760; dot_Vhi has sub_sec; dot_q_inpass = 6000; dot_q_inpass has sub_sec; dot_q_instim = 2500; dot_q_instim has sub_sec; Cao = 100; Cao has substance; tau_I = 33; tau_I has substance; tau_II = 0.005; tau_II has substance; half = 0.5; half has dimensionless; fracK = 7071067.81; fracK has substance; alp = 10; alp has time_unit; gam = 0.1; gam has time_unit; k8 = 7.5e-005; k8 has time_unit; k11 = 0.004; k11 has inv_sec_sub; k12 = 10.3; k12 has inv_sec; k13 = 0.08; k13 has inv_sec_sub; k14 = 1152; k14 has inv_sec; k15 = 0.015; k15 has inv_sec_sub; k16 = 0; k16 has inv_sec; k17 = 0.00015; k17 has inv_sec_sub; k18 = 1.5; k18 has inv_sec; kp = 0.1; kp has inv_sec; Kmp = 5; Kmp has substance; Kmdp = 20; Kmdp has substance; Vdp = 4; Vdp has sub_sec; k90 = 0.002; k90 has inv_sec_sub; kr90 = 1.5; kr90 has inv_sec; kDD = 9.45e-005; kDD has inv_sec; re11_unisec = 1; re11_unisec has sub_sec; re57_normal = 0.907; re57_normal has sub_sec; re57_unity = 1; re57_unity has dimensionless; re57_unimol = 1; re57_unimol has substance; re57_tf = 15; re57_tf has substance; re58_k58 = 0.2; re58_k58 has inv_sec; re58_Km58 = 6170; re58_Km58 has substance; re59_k59 = 7.5; re59_k59 has inv_sec; re59_Km59 = 80.9; re59_Km59 has substance; re60_k60 = 0.045; re60_k60 has inv_sec_sub; re60_kr60 = 0.089; re60_kr60 has inv_sec; re61_k61 = 20; re61_k61 has inv_sec; re61_Km61 = 80000; re61_Km61 has substance; re62_k62 = 20; re62_k62 has inv_sec; re62_Km62 = 80000; re62_Km62 has substance; re63_k63 = 0.037; re63_k63 has inv_sec; re63_Km63 = 8800; re63_Km63 has substance; re64_k64 = 0.04; re64_k64 has inv_sec; re64_Km64 = 48000; re64_Km64 has substance; re65_k65 = 0.163; re65_k65 has inv_sec; re65_Km65 = 48000; re65_Km65 has substance; re66_k66 = 0.0007; re66_k66 has inv_sec_sub; re67_k67 = 0.98; re67_k67 has inv_sec; re68_unitime = 1; re68_unitime has sub_sec; re69_K_cam_no = 17; re69_K_cam_no has inv_sec; re69_K_p_no = 5; re69_K_p_no has inv_sec; re69_K_pcam_no = 17; re69_K_pcam_no has inv_sec; re102_normal = 4; re102_normal has nM_inv_s; re102_tf = 60; re102_tf has substance; re102_unity = 1; re102_unity has dimensionless; re102_unimol = 1; re102_unimol has substance; re102_tiny_num = 1e-006; re102_tiny_num has substance; re103_normal = 0.026; re103_normal has nM_inv_s; re103_tf = 540; re103_tf has substance; re103_unity = 1; re103_unity has dimensionless; re103_unimol = 1; re103_unimol has substance; re104_k105 = 0.1; re104_k105 has inv_nM_s; re104_k_105 = 1; re104_k_105 has inv_sec; re105_kcat_src = 8.33; re105_kcat_src has inv_nM_s; re105_k_6 = 5; re105_k_6 has inv_sec; re106_k107 = 60; re106_k107 has inv_nM_s; re106_k_107 = 546; re106_k_107 has inv_sec; re107_k108 = 2040; re107_k108 has inv_sec; re107_k_108 = 15700; re107_k_108 has inv_nM_s; re108_V10 = 154; re108_V10 has nM_inv_s; re108_K10 = 340; re108_K10 has substance; re109_k9 = 40.8; re109_k9 has inv_sec; re110_kT = 0.001; re110_kT has inv_sec; re111_ktr1 = 0.00012; re111_ktr1 has nM_inv_s; re111_ktr1k2 = 9e-006; re111_ktr1k2 has nM_inv_s; re111_tr2 = 3e-006; re111_tr2 has nM_inv_s; re112_k111 = 0.222; re112_k111 has inv_sec; re112_K111 = 0.181; re112_K111 has substance; re113_V12 = 0.289; re113_V12 has nM_inv_s; re113_K12 = 0.0571; re113_K12 has substance; re114_k113 = 0.035; re114_k113 has inv_sec; re114_K113 = 10; re114_K113 has substance; re115_K18 = 8; re115_K18 has substance; re115_V18 = 0.125; re115_V18 has nM_inv_s; re116_k19 = 0.005; re116_k19 has inv_sec; re116_K19 = 15; re116_K19 has substance; re117_K20 = 15; re117_K20 has substance; re117_V20 = 0.375; re117_V20 has nM_inv_s; re118_k21 = 0.002; re118_k21 has inv_sec; re118_K21 = 30; re118_K21 has substance; re119_K22 = 15; re119_K22 has substance; re119_V22 = 0.05; re119_V22 has nM_inv_s; re120_kD = 2.8e-005; re120_kD has inv_sec; re121_kP = 0.02824; re121_kP has nM_inv_s; re121_K30 = 16; re121_K30 has substance; re122_unitime = 1; re122_unitime has nM_inv_s; re123_V37 = 0.375; re123_V37 has nM_inv_s; re123_K37 = 15; re123_K37 has substance; re124_k38 = 0.005; re124_k38 has inv_sec; re124_K38 = 15; re124_K38 has substance; re125_V39 = 0.05; re125_V39 has nM_inv_s; re125_K39 = 15; re125_K39 has substance; re126_k40 = 0.002; re126_k40 has inv_sec; re126_K40 = 30; re126_K40 has substance; re127_K43 = 25; re127_K43 has substance; re127_k43 = 4e-005; re127_k43 has inv_sec; re128_K44 = 5; re128_K44 has substance; re128_V44 = 0.002; re128_V44 has nM_inv_s; re129_tau = 0.55; re129_tau has dimensionless; re129_tc = 3600; re129_tc has substance; re129_uc = 3600; re129_uc has dimensionless; re129_delay = 5; re129_delay has dimensionless; re129_unity = 20; re129_unity has nM_inv_s; // Other declarations: const default, c1, c2, c3, R_T, k1, k2, k3, k4, k5, k6, k7, K1, K2, K3; const K4, K5, K_hi, k_CICR, K_CICR, k_CCE, B_T, Vc_Vs, dot_Vp, dot_Vex; const dot_Vhi, dot_q_inpass, dot_q_instim, Cao, tau_I, tau_II, half, fracK; const alp, gam, k8, k11, k12, k13, k14, k15, k16, k17, k18, kp, Kmp, Kmdp; const Vdp, k90, kr90, kDD; // Unit definitions: unit time_unit = second; unit substance = 1e-009 mole; unit area = metre^2; unit length = metre; unit volume = litre; unit sub_sec = 1e-009 mole / second; unit inv_sec = 1 / second; unit inv_sec_sub = 1 / (1e-009 mole * second); unit nM_inv_s = 1e-9 mole / second; unit inv_nM_s = 1 / (1e-9 mole * second); unit substance_per_volume = 1e-009 mole / litre; // Display Names: time_unit is "time"; c1 is "Cell"; c2 is "ER"; c3 is "nucleus"; s1 is "Ca_ex"; s2 is "Ca_s"; s3 is "Ca_c"; s4 is "Ca_B"; s6 is "IP3"; s12 is "TimeT"; s14 is "PDK1"; s15 is "PP2A"; s16 is "AKT"; s17 is "PI3P"; s18 is "PTEN"; s19 is "PIP2"; s20 is "p-PI3K"; s21 is "s3"; s22 is "PI3K"; s23 is "Time"; s24 is "PDK2"; s25 is "PDK1_cyto"; s26 is "p-AKT:PI3P"; s27 is "pp-AKT:PI3P"; s28 is "AKT:PI3P"; s38 is "pre_time"; s39 is "Time"; s42 is "AP-1"; s43 is "pp-JNKK"; s44 is "pp-JNK"; s45 is "eNOS-CaM-Ca4"; s47 is "CaM-Ca4"; s48 is "CaM-Ca2"; s49 is "KLF2"; s50 is "eNOS-CaM-Ca2"; s51 is "eNOS-Cav-1"; s52 is "Calmodulin"; s57 is "Hsp90"; s58 is "Hsp90-eNOS-CaM-Ca4"; s60 is "Hsp90-p-eNOS-CaM-Ca4"; s61 is "Hsp90-eNOS-CaM-Ca2"; s62 is "Hsp90-p-eNOS-CaM-Ca2"; s63 is "L-Arg"; s64 is "NO"; s65 is "Hsp90-p-eNOS"; s66 is "Hsp90-eNOS"; s91 is "Shc"; s92 is "p-Src"; s93 is "p-FAK"; s94 is "Src"; s95 is "FAK"; s96 is "JNKK"; s97 is "MEKK1"; s98 is "p-Shc"; s99 is "JNK"; s100 is "p-JNKK"; s101 is "p-MEKK1"; s102 is "Ras:GTP"; s103 is "Ras:GDP"; s104 is "p-JNK"; s105 is "KLF2"; s106 is "eNOS"; s107 is "aAP-1"; s108 is "eNOS"; s110 is "p-FAK:Shc"; s111 is "Grb2:Sos"; s112 is "p-FAK:p-Shc"; s113 is "p-FAK:p-Shc:Grb2:Sos"; s114 is "p-Shc:Grb2:Sos"; s115 is "eNOS"; s116 is "sa49_degraded"; s119 is "Shear Stress"; re3 is "re1"; end