// Created by libAntimony v2.8.0 model *MODEL1302180005() // Compartments and Species: compartment default, c1, c3; substanceOnly species s35 in c1, s37 in c1, s38 in c1, s39 in c1, s42 in c3; substanceOnly species s43 in c1, s44 in c1, s49 in c1, s51 in c1, s91 in c1; substanceOnly species s92 in c1, s93 in c1, s94 in c1, s95 in c1, s96 in c1; substanceOnly species s97 in c1, s98 in c1, s99 in c1, s100 in c1, s101 in c1; substanceOnly species s102 in c1, s103 in c1, s104 in c1, s105 in c1, s106 in c1; substanceOnly species s107 in c3, s108 in c3, s110 in c1, s111 in c1, s112 in c1; substanceOnly species s113 in c1, s114 in c1, s115 in c3, s119 in default; // Reactions: re102: s95 -> s93; exp(re102_unity - (s39/re102_tf)^0.35)*re102_normal*((s39 + re102_tiny_num)/re102_unimol)^-0.65*(re102_unity - (s39/re102_tf)^0.35); re103: s94 -> s92; exp(re103_unity - (s39/re103_tf)^1.3)*re103_normal*(s39/re103_unimol)^0.3*(re103_unity - (s39/re103_tf)^1.3); re104: s91 + s93 -> s110; re104_k3*s91*s93 - re104_kr3*s110; re105: s110 -> s112; re105_k4*s110*s92 - re105_kr4*s112; re106: s112 + s111 -> s113; re106_k5*s111*s112 - re106_kr5*s113; re107: s113 -> s114 + s93; re107_k6*s113 - re107_kr6*s93*s114; re108: s98 => s91; (re108_V8*s98)/(re108_Km8 + s98); re109: s114 => s98 + s111; re109_k7*s114; re110: s115 => s106; re110_k25*s115; re111: s108 => s115; re111_k24t1*s107 + re111_k24t2*s49; re112: s103 => s102; (re112_k9*s114*s103)/(s103 + re112_Km9); re113: s102 => s103; (re113_V10*s102)/(re113_Km10 + s102); re114: s97 => s101; (re114_k11*s102*s97)/(re114_Km11 + s97); re115: s101 => s97; (re115_V12*s101)/(re115_Km12 + s101); re116: s96 => s100; (re116_k13*s101*s96)/(re116_Km13 + s96); re117: s100 => s96; (re117_V14*s100)/(s100 + re117_Km14); re118: s99 => s104; (re118_k17*s99*s43)/(s99 + re118_Km17); re119: s104 => s99; (re119_V18*s104)/(s104 + re119_Km18); re120: s106 => s35; re120_k26*s106; re121: s37 => s51; (re121_V27*s106)/(s106 + re121_Km27); re122: s38 => s39; re122_unitime; re123: s43 => s100; (re123_V16*s43)/(s43 + re123_Km16); re124: s100 => s43; (re124_k15*s100*s101)/(re124_Km15 + s100); re125: s44 => s104; (re125_V20*s44)/(re125_Km20 + s44); re126: s104 => s44; (re126_k19*s104*s43)/(re126_Km19 + s104); re127: s42 => s107; (s44*s42*re127_k21)/(re127_Km21 + s42); re128: s107 => s42; (re128_V22*s107)/(s107 + re128_Km22); re129: s105 => s49; exp(re129_tau*(re129_delay - s39/re129_tc))/(1 + 2*exp(re129_tau*(re129_delay - s39/re129_tc)) + exp(2*re129_tau*(re129_delay - s39/re129_tc)))/re129_uc*29.256; // Species initializations: s35 = 0; s35 has substance_per_volume; s37 = 10000/c1; s37 has substance_per_volume; s38 = 0; s38 has substance_per_volume; s39 = 0; s39 has substance_per_volume; s42 = 50/c3; s42 has substance_per_volume; s43 = 0.006/c1; s43 has substance_per_volume; s44 = 0; s44 has substance_per_volume; s49 = 10/c1; s49 has substance_per_volume; s51 = 34.98/c1; s51 has substance_per_volume; s91 = 819.25/c1; s91 has substance_per_volume; s92 = 18/c1; s92 has substance_per_volume; s93 = 0.605/c1; s93 has substance_per_volume; s94 = 72/c1; s94 has substance_per_volume; s95 = 57/c1; s95 has substance_per_volume; s96 = 299.706/c1; s96 has substance_per_volume; s97 = 98.514/c1; s97 has substance_per_volume; s98 = 157.162/c1; s98 has substance_per_volume; s99 = 299.997/c1; s99 has substance_per_volume; s100 = 0.288/c1; s100 has substance_per_volume; s101 = 1.486/c1; s101 has substance_per_volume; s102 = 0.616/c1; s102 has substance_per_volume; s103 = 119.384/c1; s103 has substance_per_volume; s104 = 0.003/c1; s104 has substance_per_volume; s105 = 0; s105 has substance_per_volume; s106 = 3.214/c1; s106 has substance_per_volume; s107 = 0; s107 has substance_per_volume; s108 = 0; s108 has substance_per_volume; s110 = 0.857/c1; s110 has substance_per_volume; s111 = 3.23/c1; s111 has substance_per_volume; s112 = 15.962/c1; s112 has substance_per_volume; s113 = 5.577/c1; s113 has substance_per_volume; s114 = 1.193/c1; s114 has substance_per_volume; s115 = 0.09/c3; s115 has substance_per_volume; s119 = 0; s119 has substance_per_volume; // Compartment initializations: default = 1; default has volume; c1 = 1; c1 has volume; c3 = 1; c3 has volume; // Variable initializations: re102_normal = 4; re102_normal has nM_inv_s; re102_tf = 60; re102_tf has substance; re102_unity = 1; re102_unity has dimensionless; re102_unimol = 1; re102_unimol has substance; re102_tiny_num = 1e-006; re102_tiny_num has substance; re103_normal = 0.026; re103_normal has nM_inv_s; re103_tf = 540; re103_tf has substance; re103_unity = 1; re103_unity has dimensionless; re103_unimol = 1; re103_unimol has substance; re104_k3 = 0.1; re104_k3 has inv_nM_s; re104_kr3 = 1; re104_kr3 has inv_sec; re105_k4 = 8.33; re105_k4 has inv_nM_s; re105_kr4 = 5; re105_kr4 has inv_sec; re106_k5 = 60; re106_k5 has inv_nM_s; re106_kr5 = 546; re106_kr5 has inv_sec; re107_k6 = 2040; re107_k6 has inv_sec; re107_kr6 = 15700; re107_kr6 has inv_nM_s; re108_V8 = 154; re108_V8 has nM_inv_s; re108_Km8 = 340; re108_Km8 has substance; re109_k7 = 40.8; re109_k7 has inv_sec; re110_k25 = 0.001; re110_k25 has inv_sec; re111_k24t1 = 0.00012; re111_k24t1 has nM_inv_s; re111_k24t2 = 9e-006; re111_k24t2 has nM_inv_s; re112_k9 = 0.222; re112_k9 has inv_sec; re112_Km9 = 0.181; re112_Km9 has substance; re113_V10 = 0.289; re113_V10 has nM_inv_s; re113_Km10 = 0.0571; re113_Km10 has substance; re114_k11 = 0.035; re114_k11 has inv_sec; re114_Km11 = 10; re114_Km11 has substance; re115_Km12 = 8; re115_Km12 has substance; re115_V12 = 0.125; re115_V12 has nM_inv_s; re116_k13 = 0.005; re116_k13 has inv_sec; re116_Km13 = 15; re116_Km13 has substance; re117_Km14 = 15; re117_Km14 has substance; re117_V14 = 0.375; re117_V14 has nM_inv_s; re118_k17 = 0.002; re118_k17 has inv_sec; re118_Km17 = 30; re118_Km17 has substance; re119_Km18 = 15; re119_Km18 has substance; re119_V18 = 0.05; re119_V18 has nM_inv_s; re120_k26 = 2.8e-005; re120_k26 has inv_sec; re121_V27 = 0.02824; re121_V27 has nM_inv_s; re121_Km27 = 16; re121_Km27 has substance; re122_unitime = 1; re122_unitime has nM_inv_s; re123_V16 = 0.375; re123_V16 has nM_inv_s; re123_Km16 = 15; re123_Km16 has substance; re124_k15 = 0.005; re124_k15 has inv_sec; re124_Km15 = 15; re124_Km15 has substance; re125_V20 = 0.05; re125_V20 has nM_inv_s; re125_Km20 = 15; re125_Km20 has substance; re126_k19 = 0.002; re126_k19 has inv_sec; re126_Km19 = 30; re126_Km19 has substance; re127_Km21 = 25; re127_Km21 has substance; re127_k21 = 4e-005; re127_k21 has inv_sec; re128_Km22 = 5; re128_Km22 has substance; re128_V22 = 0.002; re128_V22 has nM_inv_s; re129_tau = 0.55; re129_tau has dimensionless; re129_tc = 3600; re129_tc has substance; re129_uc = 3600; re129_uc has dimensionless; re129_delay = 5; re129_delay has dimensionless; re129_unity = 20; re129_unity has nM_inv_s; // Other declarations: const default, c1, c3; // Unit definitions: unit time_unit = second; unit substance = 1e-009 mole; unit area = metre^2; unit length = metre; unit volume = litre; unit sub_sec = 1e-009 mole / second; unit inv_sec = 1 / second; unit inv_sec_sub = 1 / (1e-009 mole * second); unit nM_inv_s = 1e-9 mole / second; unit inv_nM_s = 1 / (1e-9 mole * second); unit substance_per_volume = 1e-009 mole / litre; // Display Names: time_unit is "time"; c1 is "Cell"; c3 is "nucleus"; s38 is "pre_time"; s39 is "Time"; s42 is "AP-1"; s43 is "pp-JNKK"; s44 is "pp-JNK"; s49 is "KLF2"; s51 is "eNOS-Cav-1"; s91 is "Shc"; s92 is "p-Src"; s93 is "p-FAK"; s94 is "Src"; s95 is "FAK"; s96 is "JNKK"; s97 is "MEKK1"; s98 is "p-Shc"; s99 is "JNK"; s100 is "p-JNKK"; s101 is "p-MEKK1"; s102 is "Ras:GTP"; s103 is "Ras:GDP"; s104 is "p-JNK"; s105 is "KLF2"; s106 is "eNOS"; s107 is "aAP-1"; s108 is "eNOS"; s110 is "p-FAK:Shc"; s111 is "Grb2:Sos"; s112 is "p-FAK:p-Shc"; s113 is "p-FAK:p-Shc:Grb2:Sos"; s114 is "p-Shc:Grb2:Sos"; s115 is "eNOS"; s119 is "Shear Stress"; end