// Created by libAntimony v2.8.0
model *Sivakumar2011_NeuralStemCellDifferentiation_Crosstalk()

  // Compartments and Species:
  compartment default, c1;
  species s53 in default, s57 in default, s58 in default, s60 in default;
  species s61 in default, s68 in default, s72 in default, s73 in c1, s81 in default;
  species s83 in default, s85 in default, s88 in default, s89 in default;
  species s96 in default, s98 in default, s100 in default, s101 in default;
  species s107 in default, s109 in default, s111 in default, s122 in default;
  species s124 in default, s135 in default, s142 in default, s144 in default;
  species s146 in default, s147 in default;

  // Reactions:
  re29: s57 -> s53 + s58; kI_re29_s61/(kI_re29_s61 + s61)*s60*kV_re29_s60*((s57/kM_re29_s60_s57*sqrt((kG_s57*kM_re29_s60_s57)/(kG_s53*kM_re29_s60_s53*kG_s58*kM_re29_s60_s58)) - s53/kM_re29_s60_s53*(s58/kM_re29_s60_s58)*sqrt((kG_s53*kM_re29_s60_s53*kG_s58*kM_re29_s60_s58)/(kG_s57*kM_re29_s60_s57)))/(s57/kM_re29_s60_s57 + (1 + s53/kM_re29_s60_s53)*(1 + s58/kM_re29_s60_s58)));
  re31: s53 + s68 -> s72; kass_re31*s53*s68 - kdiss_re31*s72;
  re32: s72 -> s73; kass_re32*s72 - kdiss_re32*s73;
  re33: s81 + s83 -> s85; kass_re33*s81*s83 - kdiss_re33*s85;
  re36: s96 + s98 -> s100; kI_re36_s101/(kI_re36_s101 + s101)*(kass_re36*s96*s98 - kdiss_re36*s100);
  re37: s100 -> s73; kass_re37*s100 - kdiss_re37*s73;
  re38: s107 + s109 -> s111; kass_re38*s107*s109 - kdiss_re38*s111;
  re40: s122 + s124 -> s135; (kcatp_re40/(ki_re40_s124*kM_re40_s124)*s111*s122*s124 - kcatn_re40/kM_re40_s124*s111*s135)/(1 + s122/ki_re40_s124 + s124/ki_re40_s124 + (s122*s124)/(ki_re40_s124*kM_re40_s124) + s135/kM_re40_s124);
  re42: s142 + s144 -> s146; kI_re42_s147/(kI_re42_s147 + s147)*(kI_re42_s135/(kI_re42_s135 + s135))*(kass_re42*s142*s144 - kdiss_re42*s146);
  re43: s144 -> s73; kass_re43*s144 - kdiss_re43*s73;
  re34: s88 -> s88; s85*(kass_re34_s85*s88 - kdiss_re34_s85*s88) + s89*(kass_re34_s89*s88 - kdiss_re34_s89*s88);
  re35: s88 -> s73; s89*(kass_re35_s89*s88 - kdiss_re35_s89*s73);

  // Species initializations:
  s53 = 0;
  s57 = 5/default;
  s58 = 0;
  s60 = 5/default;
  s61 = 100/default;
  s68 = 5/default;
  s72 = 0;
  s73 = 0;
  s81 = 5/default;
  s83 = 5/default;
  s85 = 0;
  s88 = 5/default;
  s89 = 0;
  s96 = 5/default;
  s98 = 5/default;
  s100 = 0;
  s101 = 100/default;
  s107 = 5/default;
  s109 = 5/default;
  s111 = 0;
  s122 = 5/default;
  s124 = 5/default;
  s135 = 0;
  s142 = 5/default;
  s144 = 5/default;
  s146 = 0;
  s147 = 100/default;

  // Compartment initializations:
  default = 1;
  c1 = 1;

  // Variable initializations:
  kV_re29_s60 = 1;
  kM_re29_s60_s57 = 1;
  kG_s57 = 1;
  kM_re29_s60_s53 = 1;
  kG_s53 = 1;
  kM_re29_s60_s58 = 1;
  kG_s58 = 1;
  kI_re29_s61 = 1;
  kass_re31 = 1;
  kdiss_re31 = 1;
  kass_re32 = 1;
  kdiss_re32 = 1;
  kass_re33 = 1;
  kdiss_re33 = 1;
  kass_re36 = 1;
  kdiss_re36 = 1;
  kI_re36_s101 = 1;
  kass_re37 = 1;
  kdiss_re37 = 1;
  kass_re38 = 1;
  kdiss_re38 = 1;
  kcatp_re40 = 1;
  kcatn_re40 = 1;
  kM_re40_s124 = 1;
  ki_re40_s124 = 1;
  kass_re42 = 1;
  kdiss_re42 = 1;
  kI_re42_s147 = 1;
  kI_re42_s135 = 1;
  kass_re43 = 1;
  kdiss_re43 = 1;
  kass_re34_s85 = 1;
  kdiss_re34_s85 = 1;
  kass_re34_s89 = 1;
  kdiss_re34_s89 = 1;
  kass_re35_s89 = 1;
  kdiss_re35_s89 = 1;

  // Other declarations:
  const default, c1, kV_re29_s60, kM_re29_s60_s57, kG_s57, kM_re29_s60_s53;
  const kG_s53, kM_re29_s60_s58, kG_s58, kI_re29_s61, kass_re31, kdiss_re31;
  const kass_re32, kdiss_re32, kass_re33, kdiss_re33, kass_re36, kdiss_re36;
  const kI_re36_s101, kass_re37, kdiss_re37, kass_re38, kdiss_re38, kcatp_re40;
  const kcatn_re40, kM_re40_s124, ki_re40_s124, kass_re42, kdiss_re42, kI_re42_s147;
  const kI_re42_s135, kass_re43, kdiss_re43, kass_re34_s85, kdiss_re34_s85;
  const kass_re34_s89, kdiss_re34_s89, kass_re35_s89, kdiss_re35_s89;

  // Display Names:
  c1 is "nucleus";
  s53 is "NICD";
  s57 is "Notch";
  s58 is "Notch TM";
  s60 is "Gamma secretase";
  s61 is "DAPT";
  s68 is "RBP-jk";
  s72 is "Complex NICD-RBP";
  s73 is "Hes-1";
  s81 is "Shh";
  s83 is "Ptch1";
  s85 is "Complex Shh Ptch1";
  s88 is "smo";
  s89 is "SAG";
  s96 is "EGF";
  s98 is "EGFR";
  s100 is "Complex EGF-EGFR";
  s101 is "Erlotinib";
  s107 is "Wnt";
  s109 is "Frzzl";
  s111 is "Complex Wnt-Frzzl";
  s122 is "Dishevelled";
  s124 is "FRAT-CK2";
  s135 is "Complex Dishevelled-FRAT-CK2";
  s142 is "GSK3B";
  s144 is "Beta-catenin";
  s146 is "Complex GSK3B-Bcatenin";
  s147 is "6 bromoindirubin 3`oxime";
end