// Created by libAntimony v2.8.0
model *Sivakumar2011_HedgehogSignalingPathway()

  // Compartments and Species:
  compartment default, c1, c4, c5;
  species s9 in c1, s10 in c1, s1 in c1, s75 in c5, s135 in c5, s7 in default;
  species s21 in c1, s46 in c1, s48 in c1, s69 in c4, s71 in c5, s68 in c1;
  species s70 in c5, s128 in c5, s140 in c5, s148 in c1, s150 in c1, s152 in c1;
  species s157 in c1, s158 in c5, s159 in c4, s160 in c4, s161 in c1;

  // Reactions:
  r52: s140 => s75; kass_r52*s140 - kdiss_r52*s75;
  r55: s158 => s75; kass_r55*s158;
  r7: s7 + s1 -> s21; kass_r7*s7*s1 - kdiss_r7*s21;
  r14: s69 -> s46; s21*((kcatp_r14/kM_r14_s69*s69 - kcatn_r14/kM_r14_s46*s46)/(1 + s69/kM_r14_s69 + s46/kM_r14_s46));
  r51: s135 + s128 -> s140; kass_r51*s135*s128 - kdiss_r51*s140;
  r53: s70 -> s70; s48*((kcatp_r53/kM_r53_s70*s70 - kcatn_r53/kM_r53_s70*s70)/(1 + s70/kM_r53_s70 + s70/kM_r53_s70));
  re24: s148 + s150 => s159; s157*kass_re24_s157*s148*s150;
  r15: s46 + s9 -> s48 + s10; s21*(kass_r15_s21*s46*s9 - kdiss_r15_s21*s48*s10);
  r23: s159 -> s68 + s160; s21*(kass_r23_s21*s159 - kdiss_r23_s21*s68*s160);
  r54: s70 + s71 -> s158; kass_r54*s70*s71 - kdiss_r54*s158;
  r26: s161 -> s70; kass_r26*s161 - kdiss_r26*s70;
  r25: s160 -> s161 + s69; kass_r25*s160 - kdiss_r25*s161*s69;

  // Species initializations:
  s9 = 2/c1;
  s10 = 0;
  s1 = 5/c1;
  s75 = 0;
  s135 = 2.5/c5;
  s7 = 5/default;
  s21 = 0;
  s46 = 0;
  s48 = 0;
  s69 = 0;
  s71 = 2/c5;
  s68 = 0;
  s70 = 0;
  s128 = 2.5/c5;
  s140 = 0;
  s148 = 3/c1;
  s150 = 3/c1;
  s152 = 0;
  s157 = 0.5/c1;
  s158 = 0;
  s159 = 0;
  s160 = 0;
  s161 = 0;

  // Compartment initializations:
  default = 1;
  c1 = 1;
  c4 = 1;
  c5 = 1;

  // Variable initializations:
  kass_r7 = 1.13;
  kdiss_r7 = 1.122;
  kcatp_r14 = 1.146;
  kM_r14_s69 = 1.03;
  kcatn_r14 = 1.75;
  kM_r14_s46 = 0.215;
  kass_r25 = 1.27;
  kdiss_r25 = 0.73;
  kass_r26 = 1.33;
  kdiss_r26 = 0.61;
  kass_r51 = 1.23;
  kdiss_r51 = 0.46;
  kass_r52 = 0.6;
  kdiss_r52 = 1.67;
  kcatp_r53 = 1.29;
  kM_r53_s70 = 0.79;
  kcatn_r53 = 1.62;
  kass_r54 = 1.28;
  kdiss_r54 = 0.71;
  kass_r55 = 1.56;
  kass_r15_s21 = 1.53;
  kdiss_r15_s21 = 0.89;
  kass_re24_s157 = 1;
  kass_r23_s21 = 1;
  kdiss_r23_s21 = 1;

  // Other declarations:
  const default, c1, c4, c5, kass_r7, kdiss_r7, kcatp_r14, kM_r14_s69, kcatn_r14;
  const kM_r14_s46, kass_r25, kdiss_r25, kass_r26, kdiss_r26, kass_r51, kdiss_r51;
  const kass_r52, kdiss_r52, kcatp_r53, kM_r53_s70, kcatn_r53, kass_r54, kdiss_r54;
  const kass_r55, kass_r15_s21, kdiss_r15_s21, kass_re24_s157, kass_r23_s21;
  const kdiss_r23_s21;

  // Display Names:
  c1 is "Receiving cell";
  c4 is "lipid raft";
  c5 is "nucleus";
  s9 is "ATP";
  s10 is "ADP";
  s1 is "Patched";
  s75 is "Hedgehog target gene";
  s135 is "Sap18";
  s7 is "Hedgehog";
  s21 is "Complex_br_(Patched/Hedgehog)";
  s46 is "Complex_br_(Costal2/Fused/_br_Smoothened)";
  s48 is "Complex_br_(Costal2/Smoothened/_br_Fused)";
  s69 is "Complex_br_(Costal2/Fused/_br_Smoothened)";
  s71 is "CBP";
  s68 is "Microtubule";
  s70 is "Cubitus_space_interruptus";
  s128 is "Complex_br_(Cubitus_space_interruptus_space_repressor/Su(fu))";
  s140 is "Complex_br_(Sap18/Su(fu)/_br_Cubitus_space_interruptus_space_repressor)";
  s148 is "smoothened";
  s150 is "complex";
  s152 is "MIcrotubule";
  s157 is "sag";
  s158 is "Complex_br_(CBP/Cubitus)";
  s159 is "Complex_br_(Costal2/Fused/../microtubule)";
  s160 is "Complex_br_(Su(fu)/Fused/../_br_Smoothened)";
  s161 is "Complex_br_(Su(fu)/Cubitus)";
end