// Created by libAntimony v2.8.0 model *Model_1() // Compartments and Species: compartment compartment_1; species TF in compartment_1, TF_VII in compartment_1, VII in compartment_1; species TF_VIIa in compartment_1, VIIa in compartment_1, Xa in compartment_1; species IIa in compartment_1, TF_VIIa_X in compartment_1, X in compartment_1; species TF_VIIa_Xa in compartment_1, IX in compartment_1, TF_VIIa_IX in compartment_1; species IXa in compartment_1, II in compartment_1, VIII in compartment_1; species VIIIa in compartment_1, IXa_VIIIa in compartment_1, IXa_VIIIa_X in compartment_1; species VIIIa1_L in compartment_1, VIIIa2 in compartment_1, V in compartment_1; species Va in compartment_1, Xa_Va in compartment_1, Xa_Va_II in compartment_1; species mIIa in compartment_1, TFPI in compartment_1, Xa_TFPI in compartment_1; species TF_VIIa_Xa_TFPI in compartment_1, ATIII in compartment_1, Xa_ATIII in compartment_1; species mIIa_ATIII in compartment_1, IXa_ATIII in compartment_1, IIa_ATIII in compartment_1; species TF_VIIa_ATIII in compartment_1; // Assignment Rules: IIa_plus_1_2mIIa := IIa + 1.2*mIIa; // Reactions: R1: TF + VII -> TF_VII; compartment_1*(k2*TF*VII - k1*TF_VII); R2: TF + VIIa -> TF_VIIa; compartment_1*(k4*TF*VIIa - k3*TF_VIIa); R3: TF_VIIa + VII => TF_VIIa + VIIa; compartment_1*k5*TF_VIIa*VII; R4: Xa + VII => Xa + VIIa; compartment_1*k6*Xa*VII; R5: IIa + VII => IIa + VIIa; compartment_1*k7*IIa*VII; R6: TF_VIIa + X -> TF_VIIa_X; compartment_1*(k9*TF_VIIa*X - k8*TF_VIIa_X); R7: TF_VIIa + Xa -> TF_VIIa_Xa; compartment_1*(k12*TF_VIIa*Xa - k11*TF_VIIa_Xa); R8: TF_VIIa + IX -> TF_VIIa_IX; compartment_1*(k14*TF_VIIa*IX - k13*TF_VIIa_IX); R9: Xa + II => Xa + IIa; compartment_1*k16*Xa*II; R10: IIa + VIII => IIa + VIIIa; compartment_1*k17*IIa*VIII; R11: IXa + VIIIa -> IXa_VIIIa; compartment_1*(k19*IXa*VIIIa - k18*IXa_VIIIa); R12: IXa_VIIIa + X -> IXa_VIIIa_X; compartment_1*(k21*IXa_VIIIa*X - k20*IXa_VIIIa_X); R13: VIIIa -> VIIIa1_L + VIIIa2; compartment_1*(k24*VIIIa - k23*VIIIa1_L*VIIIa2); R14: IXa_VIIIa_X => VIIIa1_L + VIIIa2 + X + IXa; compartment_1*k25*IXa_VIIIa_X; R15: IXa_VIIIa => VIIIa1_L + VIIIa2 + IXa; compartment_1*k25*IXa_VIIIa; R16: IIa + V => IIa + Va; compartment_1*k26*IIa*V; R17: Xa + Va -> Xa_Va; compartment_1*(k28*Xa*Va - k27*Xa_Va); R18: Xa_Va + II -> Xa_Va_II; compartment_1*(k30*Xa_Va*II - k29*Xa_Va_II); R19: mIIa + Xa_Va => IIa + Xa_Va; compartment_1*k32*mIIa*Xa_Va; R20: Xa + TFPI -> Xa_TFPI; compartment_1*(k34*Xa*TFPI - k33*Xa_TFPI); R21: TF_VIIa_Xa + TFPI -> TF_VIIa_Xa_TFPI; compartment_1*(k36*TF_VIIa_Xa*TFPI - k35*TF_VIIa_Xa_TFPI); R22: TF_VIIa + Xa_TFPI => TF_VIIa_Xa_TFPI; compartment_1*k37*TF_VIIa*Xa_TFPI; R23: Xa + ATIII => Xa_ATIII; compartment_1*k38*Xa*ATIII; R24: mIIa + ATIII => mIIa_ATIII; compartment_1*k39*mIIa*ATIII; R25: IXa + ATIII => IXa_ATIII; compartment_1*k40*IXa*ATIII; R26: IIa + ATIII => IIa_ATIII; compartment_1*k41*IIa*ATIII; R27: TF_VIIa + ATIII => TF_VIIa_ATIII; compartment_1*k42*TF_VIIa*ATIII; R6b: TF_VIIa_X => TF_VIIa_Xa; compartment_1*k10*TF_VIIa_X; R8b: TF_VIIa_IX => TF_VIIa + IXa; compartment_1*k15*TF_VIIa_IX; R12b: IXa_VIIIa_X => IXa_VIIIa + Xa; compartment_1*k22*IXa_VIIIa_X; R18b: Xa_Va_II => Xa_Va + mIIa; compartment_1*k31*Xa_Va_II; R28: IXa + X => IXa + Xa; compartment_1*k43*IXa*X; R29: mIIa + V => mIIa + Va; compartment_1*k44*mIIa*V; // Species initializations: TF = 0; TF_VII = 0; VII = 1e-008; TF_VIIa = 0; VIIa = 1e-010; Xa = 9.4e-011; IIa = 1e-009; TF_VIIa_X = 0; X = 1.6e-007; TF_VIIa_Xa = 0; IX = 9e-008; TF_VIIa_IX = 0; IXa = 2.1e-010; II = 1.4e-006; VIII = 7e-010; VIIIa = 0; IXa_VIIIa = 0; IXa_VIIIa_X = 0; VIIIa1_L = 0; VIIIa2 = 0; V = 2e-008; Va = 0; Xa_Va = 0; Xa_Va_II = 0; mIIa = 0; TFPI = 2.5e-009; Xa_TFPI = 0; TF_VIIa_Xa_TFPI = 0; ATIII = 3.4e-006; Xa_ATIII = 0; mIIa_ATIII = 0; IXa_ATIII = 0; IIa_ATIII = 0; TF_VIIa_ATIII = 0; // Compartment initializations: compartment_1 = 1; // Variable initializations: k1 = 0.0031; k2 = 3200000; k3 = 0.0031; k4 = 23000000; k5 = 440000; k6 = 13000000; k7 = 23000; k8 = 1.05; k9 = 25000000; k10 = 6; k11 = 19; k12 = 22000000; k13 = 2.4; k14 = 10000000; k15 = 1.8; k16 = 7500; k17 = 20000000; k18 = 0.005; k19 = 10000000; k20 = 0.001; k21 = 100000000; k22 = 8.2; k23 = 22000; k24 = 0.006; k25 = 0.001; k26 = 20000000; k27 = 0.2; k28 = 400000000; k29 = 103; k30 = 100000000; k31 = 63.5; k32 = 15000000; k33 = 0.00036; k34 = 900000; k35 = 0.00011; k36 = 320000000; k37 = 50000000; k38 = 1500; k39 = 7100; k40 = 490; k41 = 7100; k42 = 230; k43 = 5700; k44 = 3000000; // Other declarations: var IIa_plus_1_2mIIa; const compartment_1, k1, k2, k3, k4, k5, k6, k7, k8, k9, k10, k11, k12; const k13, k14, k15, k16, k17, k18, k19, k20, k21, k22, k23, k24, k25, k26; const k27, k28, k29, k30, k31, k32, k33, k34, k35, k36, k37, k38, k39, k40; const k41, k42, k43, k44; // Display Names: IIa_plus_1_2mIIa is "IIa+1.2mIIa"; end