// Created by libAntimony v2.8.0
model *BIOMD0000000320()

  // Compartments and Species:
  compartment gut, Vdopa, V_3_OMD, V1_B, V2_B, V1_M, V2_M;
  species C_dopa in Vdopa, C_OMD in V_3_OMD, C1_M in V1_M, C2_M in V2_M, C1_B in V1_B;
  species C2_B in V2_B;
  substanceOnly species A_dopa in gut, A_B in gut, A_M in gut;

  // Assignment Rules:
  F_c := F_H*F_G;
  F_H := 1 - CL_H/Q;
  CL_H := f_H*CL_dopa;
  CL_dopa := CL_AADC + CL_rest + CL_COMT;
  CL_AADC := CL_AADC0/(1 + C1_M/ki);
  CL_rest := CL_dopa0*f_rest;
  CL_COMT := CL_dopa0*f_COMT;
  f_rest := 1 - (f_AADC + f_COMT);
  CL_AADC0 := CL_dopa0*f_AADC;

  // Reactions:
  l_dopa_absorption: A_dopa => C_dopa; ka_c*A_dopa*F_c;
  l_dopa_blood_hepa_clearance: A_dopa => ; ka_c*A_dopa*(1 - F_c);
  ro_04_5127_absorption: A_M => C1_M; ka_M*A_M;
  benserazide_absorption: A_B => C1_B; ka_B*A_B*F_B;
  benserazide_gut_clearance: A_B => ; ka_B*A_B*(1 - F_B);
  AADC_clearance: C_dopa => ; CL_AADC*C_dopa;
  COMT_clearance: C_dopa => C_OMD; CL_COMT*C_dopa;
  rest_clearance: C_dopa => ; CL_rest*C_dopa;
  _3_OMD_clearance: C_OMD => ; CL_OMD*C_OMD;
  bens_clearance: C1_B => ; CL_B*C1_B;
  bens_metabolism: C1_B => C1_M; fm/(1 - fm)*CL_B*C1_B;
  ro_clearance: C1_M => ; CL_M*C1_M;
  bens_distribution: C1_B -> C2_B; CL_dB*(C1_B - C2_B);
  ro_distribution: C1_M -> C2_M; CL_dM*(C1_M - C2_M);

  // Species initializations:
  A_dopa = L_Dopa_per_kg_rat*rat_body_mass;
  A_B = A_bens_tot*(1 - B_M_frac);
  A_M = A_bens_tot*B_M_frac;
  C_dopa = 0;
  C_OMD = 0;
  C1_M = 0;
  C2_M = 0;
  C1_B = 0;
  C2_B = 0;

  // Compartment initializations:
  gut = 1;
  Vdopa = 0.496;
  V_3_OMD = 0.128;
  V1_B = 0.202;
  V2_B = 0.127;
  V1_M = 0.0691;
  V2_M = 3.2;

  // Variable initializations:
  L_Dopa_per_kg_rat = 404;
  L_Dopa_per_kg_rat has umol_per_kg;
  rat_body_mass = 0.25;
  rat_body_mass has kilogram;
  A_bens_tot = Benserazide_per_kg_rat*rat_body_mass;
  A_bens_tot has substance;
  B_M_frac = 0.07;
  F_c has dimensionless;
  F_H has dimensionless;
  F_G = 1;
  F_G has dimensionless;
  CL_H has l_per_h;
  Q = 0.828;
  f_H = 0.13;
  f_H has dimensionless;
  CL_dopa has l_per_h;
  CL_AADC has l_per_h;
  CL_rest has l_per_h;
  CL_COMT has l_per_h;
  f_rest has dimensionless;
  f_AADC = 0.69;
  f_AADC has dimensionless;
  f_COMT = 0.1;
  f_COMT has dimensionless;
  CL_AADC0 has l_per_h;
  ki = 0.00246;
  CL_dopa0 = 0.823;
  CL_dopa0 has l_per_h;
  ka_c = 1.29;
  ka_M = 2.47;
  ka_B = 0.94;
  F_B = 0.022;
  F_B has dimensionless;
  CL_OMD = 0.00895;
  CL_OMD has l_per_h;
  CL_B = 1.67;
  CL_B has l_per_h;
  fm = 0.15;
  fm has dimensionless;
  CL_M = 4.29;
  CL_M has l_per_h;
  CL_dB = 0.072;
  CL_dB has l_per_h;
  CL_dM = 1.06;
  CL_dM has l_per_h;
  Benserazide_per_kg_rat = 78;
  Benserazide_per_kg_rat has umol_per_kg;

  // Other declarations:
  var F_c, F_H, CL_H, CL_dopa, CL_AADC, CL_rest, CL_COMT, f_rest, CL_AADC0;
  const gut, Vdopa, V_3_OMD, V1_B, V2_B, V1_M, V2_M, L_Dopa_per_kg_rat, rat_body_mass;
  const A_bens_tot, B_M_frac, F_G, Q, f_H, f_AADC, f_COMT, ki, CL_dopa0, ka_c;
  const ka_M, ka_B, F_B, CL_OMD, CL_B, fm, CL_M, CL_dB, CL_dM, Benserazide_per_kg_rat;

  // Unit definitions:
  unit substance = 1e-9 mole;
  unit umol_per_kg = 1e-9 mole / kilogram;
  unit per_h = 1 / 3600 second;
  unit l_per_h = litre / 3600 second;
  unit time_unit = 3600 second;

  // Display Names:
  substance is "micromole";
  umol_per_kg is "micromole_per_kg";
  time_unit is "hours";
  Vdopa is "V_L_Dopa";
  B_M_frac is "Bens_Ro04-5127_fraction_gut";
  C_OMD is "C_3-OMD";
  ka_M is "ka_m";
  ka_B is "ka_b";
  CL_OMD is "CL_3_OMD";
  l_dopa_absorption is "L_Dopa absorption from gut";
  l_dopa_blood_hepa_clearance is "hepatic and blood L-Dopa clearance";
  ro_04_5127_absorption is "ro 04-5127 absorption from gut";
  benserazide_absorption is "benserazide absorption from gut";
  benserazide_gut_clearance is "benserazide clearance from gut";
  AADC_clearance is "L-Dopa clearance via AADC ";
  COMT_clearance is "L-Dopa clearance via COMT";
  rest_clearance is "rest clearance of L-Dopa";
  _3_OMD_clearance is "3-OMD clearance";
  bens_clearance is "benserazide clearance";
  bens_metabolism is "benserazide metabolism to ro 04-5127";
  ro_clearance is "ro 04-5127 clearance";
  bens_distribution is "benserazide distribution";
  ro_distribution is "ro 04-5127 distribution";
end