// Created by libAntimony v2.8.0 model *voit03() // Compartments and Species: compartment cell, external; species $X0 in external, $X1 in cell, $X2 in cell, $X3 in cell, $X4 in cell; species $X5 in cell, $X6 in cell, $X7 in cell; // Assignment Rules: flux_X1_in := 31.912*X0^0.968*X2^-0.194*X7^0.00968*X8^0.968*X19^0.0323; flux_X1_out := 89.935*X1^0.75*X6^-0.4*X9; flux_X2_in := 142.72*X1^0.517*X2^-0.179*X3^0.183*X6^-0.276*X9^0.689*X12r^0.311; flux_X2_out := 30.12*X1^-0.00333*X2^0.575*X3^-0.17*X4^0.00333*X10^0.5111*X11^0.0667*X12f^0.411*X17^0.0111; flux_X3_in := 7.8819*X2^0.394*X3^-0.392*X4^-0.01*X5^0.0128*X12f^0.949*X15r^0.0513; flux_X3_out := 76.434*X2^-0.412*X3^0.593*X12r^0.718*X13^0.18*X15f^0.103; flux_X4_in := 11.07*X3^0.5*X13; flux_X4_out := 3.4556*X1^-0.0429*X2^0.214*X4^0.386*X14^0.857*X17^0.143; flux_X5_in := 11.06*X2^0.04*X3^0.32*X4^0.16*X14^0.6*X15f^0.4; flux_X5_out := 4.929*X2^-0.04*X4^-0.04*X5^0.25*X15r^0.2*X16^0.8; flux_X6_in := 0.19424*X1^-0.3*X2^0.3*X4^0.3*X17; flux_X6_out := 1.0939*X6^0.2*X18; flux_X7_in := 1.0939*X6^0.2*X18; flux_X7_out := 1.2288*X7^0.3*X19; X8 := piecewise(8, heat_shock == 1, 1); X10 := piecewise(1, heat_shock == 1, 1); X12r := piecewise(16, heat_shock == 1, 1); X13 := piecewise(16, heat_shock == 1, 1); X15r := piecewise(50, heat_shock == 1, 1); X16 := piecewise(16, heat_shock == 1, 1); X18 := piecewise(18, heat_shock == 1, 1); // Rate Rules: X1' = flux_X1_in - flux_X1_out; X2' = flux_X2_in - flux_X2_out; X3' = flux_X3_in - flux_X3_out; X4' = flux_X4_in - flux_X4_out; X5' = flux_X5_in - flux_X5_out; X6' = flux_X6_in - flux_X6_out; X7' = flux_X7_in - flux_X7_out; // Species initializations: X0 = 1; X1 = 0.03; X2 = 1; X3 = 0.1; X4 = 0.7; X5 = 1; X6 = 0.02; X7 = 0.05; // Compartment initializations: cell = 1; external = 1; flux_X1_in has flux; flux_X1_out has flux; flux_X2_in has flux; flux_X2_out has flux; flux_X3_in has flux; flux_X3_out has flux; flux_X4_in has flux; flux_X4_out has flux; flux_X5_in has flux; flux_X5_out has flux; flux_X6_in has flux; flux_X6_out has flux; flux_X7_in has flux; flux_X7_out has flux; // Variable initializations: heat_shock = 0; heat_shock has dimensionless; X8 has dimensionless; X9 = ; X9 has dimensionless; X10 has dimensionless; X11 = ; X11 has dimensionless; X12r has dimensionless; X12f = ; X12f has dimensionless; X13 has dimensionless; X14 = ; X14 has dimensionless; X15r has dimensionless; X15f = ; X15f has dimensionless; X16 has dimensionless; X17 = ; X17 has dimensionless; X18 has dimensionless; X19 = ; X19 has dimensionless; // Other declarations: var flux_X1_in, flux_X1_out, flux_X2_in, flux_X2_out, flux_X3_in, flux_X3_out; var flux_X4_in, flux_X4_out, flux_X5_in, flux_X5_out, flux_X6_in, flux_X6_out; var flux_X7_in, flux_X7_out, X8, X9, X10, X11, X12r, X12f, X13, X14, X15r; var X15f, X16, X17, X18, X19; const cell, external, heat_shock; // Unit definitions: unit substance = 1e-3 mole; unit time_unit = 60 second; unit flux = 1e-3 mole / (60 second * litre); unit mM = 1e-3 mole / litre; // Display Names: substance is "milimole"; time_unit is "minutes"; flux is "mM per minute"; X0 is "glucose"; X1 is "glucose"; flux_X1_in is "flux_to_glucose"; flux_X1_out is "flux_from_glucose"; X2 is "G6P"; flux_X2_in is "flux_to_G6P"; flux_X2_out is "flux_from_G6P"; X3 is "G1P"; flux_X3_in is "flux_to_G1P"; flux_X3_out is "flux_from_G1P"; X4 is "UDPG"; flux_X4_in is "flux_to_UDPG"; flux_X4_out is "flux_from_UDPG"; X5 is "glycogen"; flux_X5_in is "flux_to_glycogen"; flux_X5_out is "flux_from_glucogen"; X6 is "T6P"; flux_X6_in is "flux_to_T6P"; flux_X6_out is "flux_from_T6P"; X7 is "trehalose"; flux_X7_in is "flux_to_trehalose"; flux_X7_out is "flux_from_trehalose"; X8 is "glucose transport into cell"; X9 is "hexokinase/glucokinase"; X10 is "phosphofructokinase"; X11 is "G6P dehydrogenase"; X12r is "phoshpoglucomutase"; X12f is "phoshpoglucomutase"; X13 is "UDPG pyrophosphorylase"; X14 is "glycogen synthase"; X15r is "glycogen phosphorylase"; X15f is "glycogen phosphorylase"; X16 is "glycogen use"; X17 is "alpha,alpha-T6P synthase"; X18 is "alpha,alpha--T6P phosphatase"; X19 is "trehalase"; end