// Created by libAntimony v2.8.0
model *Romond1999_CellCycle()

  // Compartments and Species:
  compartment compartment_;
  species C1 in compartment_, C2 in compartment_;
  substanceOnly species $M1 in compartment_, $X1 in compartment_, $M2 in compartment_;
  substanceOnly species $X2 in compartment_;

  // Assignment Rules:
  V1 := C1/(Kc1 + C1)*V_M1;
  V3 := M1*V_M3;
  U1 := C2/(Kc2 + C2)*U_M1;
  U3 := M2*U_M3;

  // Rate Rules:
  M1' = (V1*(1 - M1))/(K1 + (1 - M1)) - (V2*M1)/(K2 + M1);
  X1' = (V3*(1 - X1))/(K3 + (1 - X1)) - (V4*X1)/(K4 + X1);
  M2' = (U1*(1 - M2))/(H1 + (1 - M2)) - (U2*M2)/(H2 + M2);
  X2' = (U3*(1 - X2))/(H3 + (1 - X2)) - (U4*X2)/(H4 + X2);

  // Reactions:
  R1:  => C1; (compartment_*vi1*Kim1)/(Kim1 + M2);
  R2: C1 => ; (compartment_*vd1*X1*C1)/(K_d1 + C1);
  R3: C1 => ; compartment_*kd1*C1;
  R8:  => C2; (compartment_*vi2*Kim2)/(Kim2 + M1);
  R9: C2 => ; (compartment_*vd2*X2*C2)/(K_d2 + C2);
  R10: C2 => ; compartment_*kd2*C2;

  // Species initializations:
  C1 = 2;
  C1 has uM;
  M1 = 1/compartment_;
  M1 has dimensionless_per_volume;
  X1 = 0;
  X1 has dimensionless_per_volume;
  C2 = 0;
  C2 has uM;
  M2 = 0;
  M2 has dimensionless_per_volume;
  X2 = 0;
  X2 has dimensionless_per_volume;

  // Compartment initializations:
  compartment_ = 1;
  V1 has min_1;

  // Variable initializations:
  K1 = 0.01;
  K1 has dimensionless;
  V2 = 0.15;
  V2 has min_1;
  K2 = 0.01;
  K2 has dimensionless;
  V3 has min_1;
  K3 = 0.01;
  K3 has dimensionless;
  V4 = 0.05;
  V4 has min_1;
  K4 = 0.01;
  K4 has dimensionless;
  U1 has min_1;
  H1 = 0.01;
  H1 has dimensionless;
  U2 = 0.15;
  U2 has min_1;
  H2 = 0.01;
  H2 has dimensionless;
  U3 has min_1;
  H3 = 0.01;
  H3 has dimensionless;
  U4 = 0.05;
  U4 has min_1;
  H4 = 0.01;
  H4 has dimensionless;
  Kc1 = 0.5;
  Kc1 has uM;
  V_M1 = 0.3;
  V_M1 has min_1;
  V_M3 = 0.1;
  V_M3 has min_1;
  Kc2 = 0.5;
  Kc2 has uM;
  U_M1 = 0.3;
  U_M1 has min_1;
  U_M3 = 0.1;
  U_M3 has min_1;
  vi1 = 0.05;
  vi1 has uM_min_1;
  Kim1 = 0.03;
  Kim1 has dimensionless;
  vd1 = 0.025;
  vd1 has uM_min_1;
  K_d1 = 0.02;
  K_d1 has uM;
  kd1 = 0.001;
  kd1 has min_1;
  vi2 = 0.05;
  vi2 has uM_min_1;
  Kim2 = 0.03;
  Kim2 has dimensionless;
  vd2 = 0.025;
  vd2 has uM_min_1;
  K_d2 = 0.02;
  K_d2 has uM;
  kd2 = 0.001;
  kd2 has min_1;

  // Other declarations:
  var V1, V3, U1, U3;
  const compartment_, K1, V2, K2, K3, V4, K4, H1, U2, H2, H3, U4, H4, Kc1;
  const V_M1, V_M3, Kc2, U_M1, U_M3, vi1, Kim1, vd1, K_d1, kd1, vi2, Kim2;
  const vd2, K_d2, kd2;

  // Unit definitions:
  unit time_unit = 60 second;
  unit uM = 1e-6 mole / litre;
  unit micromole = 1e-6 mole;
  unit min_1 = 1 / 60 second;
  unit uM_min_1 = 1e-6 mole / (litre * 60 second);
  unit dimensionless_per_volume = dimensionless / litre;

  // Display Names:
  time_unit is "minute";
  C1 is "cyclinB";
  M1 is "cdk1";
  X1 is "ubiquitin ligase";
  C2 is "cyclinE";
  M2 is "cdk2";
  X2 is "Ubiquitin ligase 2";
  R1 is "cdk2 mediated cyclinB synthesis";
  R2 is "Ubiquitin ligase mediated cyclinB degradation";
  R3 is "cyclinB degradation";
  R8 is "cyclinE synthesis";
  R9 is "Ubiquitin ligase mediated cyclinE degradation";
  R10 is "cyclinE degradation";
end