// Created by libAntimony v2.8.0
model *BIOMD0000000188()

  // Compartments and Species:
  compartment cell;
  substanceOnly species Mdm2 in cell, p53 in cell, Mdm2_p53 in cell, Mdm2_mRNA in cell;
  substanceOnly species p53_mRNA in cell, ATMA in cell, ATMI in cell, p53_P in cell;
  substanceOnly species Mdm2_P in cell, damDNA in cell, $Sink in cell, $Source in cell;
  substanceOnly species p53deg in cell, p53syn in cell, mdm2deg in cell, mdm2syn in cell;
  substanceOnly species Mdm2mRNAdeg in cell, Mdm2mRNAsyn in cell, $totp53 in cell;
  substanceOnly species $totMdm2 in cell;

  // Assignment Rules:
  totp53 := p53 + Mdm2_p53 + p53_P;
  totMdm2 := Mdm2 + Mdm2_p53 + Mdm2_P;

  // Reactions:
  p53mRNASynthesis: $Source => p53_mRNA; ksynp53mRNA*Source;
  p53mRNADegradation: p53_mRNA => $Sink; kdegp53mRNA*p53_mRNA;
  Mdm2Synthesis: Mdm2_mRNA => Mdm2_mRNA + Mdm2 + mdm2syn; ksynMdm2*Mdm2_mRNA;
  Mdm2mRNASynthesis1: p53 => p53 + Mdm2_mRNA + Mdm2mRNAsyn; ksynMdm2mRNA*p53;
  Mdm2mRNASynthesis2: p53_P => p53_P + Mdm2_mRNA + Mdm2mRNAsyn; ksynMdm2mRNA*p53_P;
  Mdm2mRNADegradation: Mdm2_mRNA => $Sink + Mdm2mRNAdeg; kdegMdm2mRNA*Mdm2_mRNA;
  Mdm2Degradation: Mdm2 => $Sink + mdm2deg; kdegMdm2*Mdm2*kproteff;
  p53Synthesis: p53_mRNA => p53 + p53_mRNA + p53syn; ksynp53*p53_mRNA;
  p53Degradation: Mdm2_p53 => Mdm2 + p53deg; kdegp53*Mdm2_p53*kproteff;
  P53_Mdm2Binding: p53 + Mdm2 => Mdm2_p53; kbinMdm2p53*p53*Mdm2;
  P53_Mdm2Release: Mdm2_p53 => p53 + Mdm2; krelMdm2p53*Mdm2_p53;
  DNAdamage:  => damDNA; kdam*IR;
  DNArepair: damDNA => $Sink; krepair*damDNA;
  ATMactivation: damDNA + ATMI => damDNA + ATMA; kactATM*damDNA*ATMI;
  p53phoshorylation: p53 + ATMA => p53_P + ATMA; kphosp53*p53*ATMA;
  p53dephosorylation: p53_P => p53; kdephosp53*p53_P;
  Mdm2phoshorylation: Mdm2 + ATMA => Mdm2_P + ATMA; kphosMdm2*Mdm2*ATMA;
  Mdm2dephosorylation: Mdm2_P => Mdm2; kdephosMdm2*Mdm2_P;
  Mdm2Pdegradation: Mdm2_P => $Sink + mdm2deg; kdegATMMdm2*Mdm2_P;
  ATMInactivation: ATMA => ATMI; kinactATM*ATMA;

  // Events:
  stressCell: at time >= 3600: IR = 25;
  stopStress: at time >= 3660: IR = 0;

  // Species initializations:
  Mdm2 = 5/cell;
  p53 = 5/cell;
  Mdm2_p53 = 95/cell;
  Mdm2_mRNA = 10/cell;
  p53_mRNA = 10/cell;
  ATMA = 0;
  ATMI = 200/cell;
  p53_P = 0;
  Mdm2_P = 0;
  damDNA = 0;
  Sink = 1/cell;
  Source = 1/cell;
  p53deg = 0;
  p53syn = 0;
  mdm2deg = 0;
  mdm2syn = 0;
  Mdm2mRNAdeg = 0;
  Mdm2mRNAsyn = 0;

  // Compartment initializations:
  cell = 1;

  // Variable initializations:
  IR = 0;
  IR has decagray;
  ksynMdm2 = 0.000495;
  ksynMdm2 has psec;
  kdegMdm2 = 0.000433;
  kdegMdm2 has psec;
  ksynp53 = 0.006;
  ksynp53 has psec;
  kdegp53 = 0.000825;
  kdegp53 has psec;
  kbinMdm2p53 = 0.001155;
  kbinMdm2p53 has pmolepsec;
  krelMdm2p53 = 1.155e-005;
  krelMdm2p53 has psec;
  ksynMdm2mRNA = 0.0001;
  ksynMdm2mRNA has psec;
  kdegMdm2mRNA = 0.0001;
  kdegMdm2mRNA has psec;
  kactATM = 0.0001;
  kactATM has pmolepsec;
  kdegATMMdm2 = 0.0004;
  kdegATMMdm2 has psec;
  kinactATM = 0.0005;
  kinactATM has psec;
  kphosp53 = 0.0005;
  kphosp53 has pmolepsec;
  kdephosp53 = 0.5;
  kdephosp53 has psec;
  kphosMdm2 = 2;
  kphosMdm2 has pmolepsec;
  kdephosMdm2 = 0.5;
  kdephosMdm2 has psec;
  kdam = 0.08;
  kdam has molepsecpdGy;
  krepair = 2e-005;
  krepair has psec;
  kproteff = 1;
  kproteff has dimensionless;
  ksynp53mRNA = 0.001;
  ksynp53mRNA has psec;
  kdegp53mRNA = 0.0001;
  kdegp53mRNA has psec;

  // Other declarations:
  var IR;
  const cell, ksynMdm2, kdegMdm2, ksynp53, kdegp53, kbinMdm2p53, krelMdm2p53;
  const ksynMdm2mRNA, kdegMdm2mRNA, kactATM, kdegATMMdm2, kinactATM, kphosp53;
  const kdephosp53, kphosMdm2, kdephosMdm2, kdam, krepair, kproteff, ksynp53mRNA;
  const kdegp53mRNA;

  // Unit definitions:
  unit molepsecpdGy = mole / (second * 10 gray);
  unit decagray = 10 gray;
  unit molepsec = mole / second;
  unit pmolepsec = 1 / (mole * second);
  unit psec = 1 / second;

  // Display Names:
  decagray is "dGy";
  molepsec is "molpsec";
  pmolepsec is "pmolpsec";
end