// Created by libAntimony v2.8.0
model *Legewie2006_apoptosis_WT()

  // Compartments and Species:
  compartment cytosol;
  species A in cytosol, C9 in cytosol, C9X in cytosol, X in cytosol, AC9X in cytosol;
  species AC9 in cytosol, C3 in cytosol, C3_star in cytosol, C3_starX in cytosol;
  species C9_starX in cytosol, C9_star in cytosol, AC9_star in cytosol, AC9_starX in cytosol;

  // Reactions:
  v1: A + C9 -> AC9; cytosol*(k1*A*C9 - kb1*AC9);
  v2: C3 + C9 => C3_star + C9; cytosol*k2*C3*C9;
  v3: C3 + AC9 => C3_star + AC9; cytosol*k3*C3*AC9;
  v9: C9 + X -> C9X; cytosol*(k9*C9*X - k9b*C9X);
  v10: AC9 + X -> AC9X; cytosol*(k10*AC9*X - k10b*AC9X);
  v13: C9X + A -> AC9X; cytosol*(k13*C9X*A - k13b*AC9X);
  v15: C3_star + X -> C3_starX; cytosol*(k15*C3_star*X - k15b*C3_starX);
  v4: C9 + C3_star => C9_star + C3_star; cytosol*k4*C9*C3_star;
  v5: AC9 + C3_star => AC9_star + C3_star; cytosol*k5*AC9*C3_star;
  v8: C9_star + A -> AC9_star; cytosol*(k8*C9_star*A - k8b*AC9_star);
  v11: C9_star + X -> C9_starX; cytosol*(k11*C9_star*X - k11b*C9_starX);
  v12: AC9_star + X -> AC9_starX; cytosol*(k12*AC9_star*X - k12b*AC9_starX);
  v14: C9_starX + A -> AC9_starX; cytosol*(k14*C9_starX*A - k14b*AC9_starX);
  v6: C3 + C9_star => C3_star + C9_star; cytosol*k6*C3*C9_star;
  v7: C3 + AC9_star => C3_star + AC9_star; cytosol*k7*C3*AC9_star;
  v16:  => A; cytosol*(k16prod - k16*A);
  v17:  => C9; cytosol*(k17prod - k17*C9);
  v18:  => X; cytosol*(k18prod - k18*X);
  v19: C9X => ; cytosol*k19*C9X;
  v20: AC9X => ; cytosol*k20*AC9X;
  v21: AC9 => ; cytosol*k21*AC9;
  v22:  => C3; cytosol*(k22prod - k22*C3);
  v23: C3_star => ; cytosol*k23*C3_star;
  v24: C3_starX => ; cytosol*k24*C3_starX;
  v25: C9_starX => ; cytosol*k25*C9_starX;
  v26: C9_star => ; cytosol*k26*C9_star;
  v27: AC9_star => ; cytosol*k27*AC9_star;
  v28: AC9_starX => ; cytosol*k28*AC9_starX;

  // Species initializations:
  A = 20;
  C9 = 20;
  C9X = 0;
  X = 40;
  AC9X = 0;
  AC9 = 0;
  C3 = 200;
  C3_star = 0;
  C3_starX = 0;
  C9_starX = 0;
  C9_star = 0;
  AC9_star = 0;
  AC9_starX = 0;

  // Compartment initializations:
  cytosol = 1;

  // Variable initializations:
  k1 = 0.002;
  k1 has per_nM_per_sec;
  kb1 = 0.1;
  kb1 has sec_inverse;
  k2 = 5e-006;
  k2 has per_nM_per_sec;
  k3 = 0.00035;
  k3 has per_nM_per_sec;
  k4 = 0.0002;
  k4 has per_nM_per_sec;
  k5 = 0.0002;
  k5 has per_nM_per_sec;
  k6 = 5e-005;
  k6 has per_nM_per_sec;
  k7 = 0.0035;
  k7 has per_nM_per_sec;
  k8 = 0.002;
  k8 has per_nM_per_sec;
  k8b = 0.1;
  k8b has sec_inverse;
  k9 = 0.001;
  k9 has per_nM_per_sec;
  k9b = 0.001;
  k9b has sec_inverse;
  k10 = 0.001;
  k10 has per_nM_per_sec;
  k10b = 0.001;
  k10b has sec_inverse;
  k11 = 0.001;
  k11 has per_nM_per_sec;
  k11b = 0.001;
  k11b has sec_inverse;
  k12 = 0.001;
  k12 has per_nM_per_sec;
  k12b = 0.001;
  k12b has sec_inverse;
  k13 = 0.002;
  k13 has per_nM_per_sec;
  k13b = 0.1;
  k13b has sec_inverse;
  k14 = 0.002;
  k14 has per_nM_per_sec;
  k14b = 0.1;
  k14b has sec_inverse;
  k15 = 0.003;
  k15 has per_nM_per_sec;
  k15b = 0.001;
  k15b has sec_inverse;
  k16 = 0.001;
  k16 has sec_inverse;
  k16prod = 0.02;
  k16prod has nM_per_sec;
  k17 = 0.001;
  k17 has sec_inverse;
  k17prod = 0.02;
  k17prod has nM_per_sec;
  k18 = 0.001;
  k18 has sec_inverse;
  k18prod = 0.04;
  k18prod has nM_per_sec;
  k19 = 0.001;
  k19 has sec_inverse;
  k20 = 0.001;
  k20 has sec_inverse;
  k21 = 0.001;
  k21 has sec_inverse;
  k22 = 0.001;
  k22 has sec_inverse;
  k22prod = 0.2;
  k22prod has nM_per_sec;
  k23 = 0.001;
  k23 has sec_inverse;
  k24 = 0.001;
  k24 has sec_inverse;
  k25 = 0.001;
  k25 has sec_inverse;
  k26 = 0.001;
  k26 has sec_inverse;
  k27 = 0.001;
  k27 has sec_inverse;
  k28 = 0.001;
  k28 has sec_inverse;

  // Other declarations:
  const cytosol, k1, kb1, k2, k3, k4, k5, k6, k7, k8, k8b, k9, k9b, k10, k10b;
  const k11, k11b, k12, k12b, k13, k13b, k14, k14b, k15, k15b, k16, k16prod;
  const k17, k17prod, k18, k18prod, k19, k20, k21, k22, k22prod, k23, k24;
  const k25, k26, k27, k28;

  // Unit definitions:
  unit substance = 1e-9 mole;
  unit nM_per_sec = 1e-9 mole / (litre * second);
  unit per_nM_per_sec = litre / (1e-9 mole * second);
  unit nM = 1e-9 mole / litre;
  unit sec_inverse = 1 / second;

  // Display Names:
  substance is "nanomole";
  cytosol is "Cytosol";
  A is "APAF-1";
  C9 is "Caspase 9";
  C9X is "Caspase 9-XIAP complex";
  X is "XIAP";
  AC9X is "APAF-1-Caspase 9-XIAP complex";
  AC9 is "APAF-1-Caspase 9 complex";
  C3 is "Caspase 3";
  C3_star is "Caspase 3 cleaved";
  C3_starX is "Caspase 3 cleaved - XIAP complex";
  C9_starX is "Caspase 9 cleaved-XIAP complex";
  C9_star is "Caspase 9 cleaved";
  AC9_star is "APAF-1-Caspase 9 cleaved complex";
  AC9_starX is "Apaf-1-Caspase 9 cleaved -XIAP complex";
  v1 is "Caspase 9 / Apaf-1 binding";
  v2 is "Caspase 3 cleavage by Caspase 9";
  v3 is "Caspase 3 cleavage by Caspase 9-Apaf-1";
  v9 is "Caspase 9 Xiap binding";
  v10 is "Caspase 9-Apaf-1 Xiap binding";
  v13 is "Caspase 9-Xiap Apaf-1 binding";
  v15 is "cleaved Caspase 3-Xiap binding";
  v4 is "Caspase 9 cleavage by cleaved caspase 3";
  v5 is "Caspase 9 cleavage by cleaved caspase 3 when Apaf-1 is bound";
  v8 is "cleaved Caspase 9 Apaf-1 binding";
  v11 is "cleaved Caspase 9 XIAP binding";
  v12 is "cleaved Caspase 9-Apaf-1 XIAP binding";
  v14 is "cleaved Caspase 9-Xiap Apaf-1 binding";
  v6 is "Caspase 3 cleavage by cleaved Caspase 9";
  v7 is "Caspase 3 cleavage by cleaved Caspase 9 - Apaf-1";
  v16 is "Apaf-1 turnover";
  v17 is "Caspase 9 turnover";
  v18 is "Xiap turnover";
  v19 is "Caspase 9-Xiap degradation";
  v20 is "Apaf-1-Caspase 9-Xiap degradation";
  v21 is "Apaf-1-Caspase 9 degradation";
  v22 is "Caspase 3 turnover";
  v23 is "Caspase 3 cleaved degradation";
  v24 is "Caspase 3 cleaved-Xiap degradation";
  v25 is "Caspase 9 cleaved-Xiap degradation";
  v26 is "Caspase 9 cleaved degradation";
  v27 is "Apaf-1 Caspase 9 cleaved degradation";
  v28 is "Apaf-1 Caspase 9 cleaved-Xiap degradation";
end