// Created by libAntimony v2.8.0
model *Markevich2004_MAPK_orderedMM()

  // Compartments and Species:
  compartment uVol;
  species M in uVol, Mp in uVol, Mpp in uVol, $MAPKK in uVol, $MKP3 in uVol;

  // Reactions:
  v1: M => Mp; uVol*((k1cat*MAPKK*M)/Km1/(1 + M/Km1 + Mp/Km2));
  v2: Mp => Mpp; uVol*((k2cat*MAPKK*Mp)/Km2/(1 + M/Km1 + Mp/Km2));
  v3: Mpp => Mp; uVol*((k3cat*MKP3*Mpp)/Km3/(1 + Mpp/Km3 + Mp/Km4 + M/Km5));
  v4: Mp => M; uVol*((k4cat*MKP3*Mp)/Km4/(1 + Mpp/Km3 + Mp/Km4 + M/Km5));

  // Species initializations:
  M = 500/uVol;
  Mp = 0;
  Mpp = 0;
  MAPKK = 50/uVol;
  MKP3 = 100/uVol;

  // Compartment initializations:
  uVol = 1;

  // Variable initializations:
  k1cat = 0.01;
  Km1 = 50;
  k2cat = 15;
  Km2 = 500;
  k3cat = 0.084;
  Km3 = 22;
  k4cat = 0.06;
  Km4 = 18;
  Km5 = 78;

  // Other declarations:
  const uVol, k1cat, Km1, k2cat, Km2, k3cat, Km3, k4cat, Km4, Km5;

  // Unit definitions:
  unit substance = 1e-9 mole;

  // Display Names:
  substance is "nanomole (default)";
  v1 is "phosphorylation of MAPK";
  v2 is "phosphorylation of P-MAPK";
  v3 is "dephosphorylation of PP-MAPK";
  v4 is "dephosphorylation of P-MAPK";
end