// Created by libAntimony v2.8.0 model *Rohwer2001_Sucrose() // Compartments and Species: compartment compartment_; species Fru in compartment_, Glc in compartment_, HexP in compartment_; species Suc6P in compartment_, Suc in compartment_, $Sucvac in compartment_; species $glycolysis in compartment_, $phos in compartment_, $UDP in compartment_; species $ADP in compartment_, $ATP in compartment_, $Glcex in compartment_; species $Fruex in compartment_; // Reactions: v1: $Fruex -> Fru; compartment_*((v1_Vmax1*Fruex)/(v1_Km1Fruex*(1 + Fru/v1_Ki1Fru) + Fruex)); v2: $Glcex -> Glc; compartment_*((v2_Vmax2*Glcex)/(v2_Km2Glcex*(1 + Glc/v2_Ki2Glc) + Glcex)); v3: $ATP + Glc -> HexP + $ADP; compartment_*((v3_Vmax3*(Glc/v3_Km3Glc)*(ATP/v3_Km3ATP))/((1 + ATP/v3_Km3ATP)*(1 + Glc/v3_Km3Glc + Fru/v3_Km4Fru + (0.113*HexP)/v3_Ki3G6P + (0.0575*HexP)/v3_Ki4F6P))); v4: Fru + $ATP -> HexP + $ADP; compartment_*((v4_Vmax4*(Fru/v4_Km4Fru)*(ATP/v4_Km4ATP))/((1 + ATP/v4_Km4ATP)*(1 + Glc/v4_Km3Glc + Fru/v4_Km4Fru + (0.113*HexP)/v4_Ki3G6P + (0.0575*HexP)/v4_Ki4F6P))); v5: Fru + $ATP -> HexP + $ADP; compartment_*((v5_Vmax5/(1 + Fru/v5_Ki5Fru)*(Fru/v5_Km5Fru)*(ATP/v5_Km5ATP))/(1 + Fru/v5_Km5Fru + ATP/v5_Km5ATP + (Fru*ATP)/(v5_Km5Fru*v5_Km5ATP) + ADP/v5_Ki5ADP)); v6: 2HexP -> $UDP + Suc6P; compartment_*((v6_Vmax6f*(0.0575*HexP*0.8231*HexP - (Suc6P*UDP)/v6_Keq6))/(0.0575*HexP*0.8231*HexP*(1 + Suc6P/v6_Ki6Suc6P) + v6_Km6F6P*(1 + phos/v6_Ki6Pi)*(0.8231*HexP + v6_Ki6UDPGlc) + v6_Km6UDPGlc*0.0575*HexP + v6_Vmax6f/(v6_Vmax6r*v6_Keq6)*(v6_Km6UDP*Suc6P*(1 + (0.8231*HexP)/v6_Ki6UDPGlc) + UDP*(v6_Km6Suc6P*(1 + (v6_Km6UDPGlc*0.0575*HexP)/(v6_Ki6UDPGlc*v6_Km6F6P*(1 + phos/v6_Ki6Pi))) + Suc6P*(1 + (0.0575*HexP)/v6_Ki6F6P))))); v7: Suc6P -> Suc + $phos; compartment_*((v7_Vmax7*Suc6P)/(v7_Km7Suc6P + Suc6P)); v8: HexP + Fru -> Suc + $UDP; compartment_*((-v8_Vmax8f*(Suc*UDP - (Fru*0.8231*HexP)/v8_Keq8))/(Suc*UDP*(1 + Fru/v8_Ki8Fru) + v8_Km8Suc*(UDP + v8_Ki8UDP) + v8_Km8UDP*Suc + v8_Vmax8f/(v8_Vmax8r*v8_Keq8)*(v8_Km8UDPGlc*Fru*(1 + UDP/v8_Ki8UDP) + 0.8231*HexP*(v8_Km8Fru*(1 + (v8_Km8UDP*Suc)/(v8_Ki8UDP*v8_Km8Suc)) + Fru*(1 + Suc/v8_Ki8Suc))))); v9: Suc -> Fru + Glc; compartment_*((v9_Vmax9/(1 + Glc/v9_Ki9Glc)*Suc)/(v9_Km9Suc*(1 + Fru/v9_Ki9Fru) + Suc)); v10: HexP -> $glycolysis; compartment_*((v10_Vmax10*0.0575*HexP)/(v10_Km10F6P + 0.0575*HexP)); v11: Suc -> $Sucvac; compartment_*((v11_Vmax11*Suc)/(v11_Km11Suc + Suc)); // Species initializations: Fru = 1; Glc = 1; HexP = 1; Suc6P = 1; Suc = 1; Sucvac = 0; glycolysis = 0; phos = 5.1; UDP = 0.2; ADP = 0.2; ATP = 1; Glcex = 5; Fruex = 5; // Compartment initializations: compartment_ = 1; // Variable initializations: v1_Vmax1 = 0.286; v1_Km1Fruex = 0.2; v1_Ki1Fru = 1; v2_Vmax2 = 0.286; v2_Km2Glcex = 0.2; v2_Ki2Glc = 1; v3_Vmax3 = 0.197; v3_Km3Glc = 0.07; v3_Km3ATP = 0.25; v3_Km4Fru = 10; v3_Ki3G6P = 0.1; v3_Ki4F6P = 10; v4_Vmax4 = 0.197; v4_Km4Fru = 10; v4_Km4ATP = 0.25; v4_Km3Glc = 0.07; v4_Ki3G6P = 0.1; v4_Ki4F6P = 10; v5_Vmax5 = 0.164; v5_Ki5Fru = 12; v5_Km5Fru = 0.1; v5_Km5ATP = 0.085; v5_Ki5ADP = 2; v6_Vmax6f = 0.379; v6_Keq6 = 10; v6_Ki6Suc6P = 0.07; v6_Km6F6P = 0.6; v6_Ki6Pi = 3; v6_Ki6UDPGlc = 1.4; v6_Km6UDPGlc = 1.8; v6_Vmax6r = 0.2; v6_Km6UDP = 0.3; v6_Km6Suc6P = 0.1; v6_Ki6F6P = 0.4; v7_Vmax7 = 0.5; v7_Km7Suc6P = 0.1; v8_Vmax8f = 0.677; v8_Keq8 = 5; v8_Ki8Fru = 4; v8_Km8Suc = 50; v8_Ki8UDP = 0.3; v8_Km8UDP = 0.3; v8_Vmax8r = 0.3; v8_Km8UDPGlc = 0.3; v8_Km8Fru = 4; v8_Ki8Suc = 40; v9_Vmax9 = 0.372; v9_Ki9Glc = 15; v9_Km9Suc = 10; v9_Ki9Fru = 15; v10_Vmax10 = 0.1; v10_Km10F6P = 0.2; v11_Vmax11 = 1; v11_Km11Suc = 100; // Other declarations: const compartment_; // Unit definitions: unit substance = 1e-3 mole; unit time_unit = 60 second; // Display Names: substance is "millimole (default)"; time_unit is "minute (default)"; compartment_ is "cell"; end