// Created by libAntimony v2.8.0 model *BIOMD0000000008() // Compartments and Species: compartment Cell; species C in Cell, X in Cell, M in Cell, Y in Cell, Z in Cell; // Assignment Rules: V1 := C*V1p*(C + K6)^-1; V3 := M*V3p; // Reactions: reaction1: => C; reaction1_vi; reaction2: C => ; C*reaction2_k1*X*(C + reaction2_K5)^-1; reaction3: C => ; C*reaction3_kd; reaction4: => M; (1 + -1*M)*V1*(reaction4_K1 + -1*M + 1)^-1; reaction5: M => ; M*reaction5_V2*(reaction5_K2 + M)^-1; reaction6: => X; V3*(1 + -1*X)*(reaction6_K3 + -1*X + 1)^-1; reaction7: X => ; reaction7_V4*X*(reaction7_K4 + X)^-1; reaction8: C + Y => Z; reaction8_a1*C*Y; reaction9: Z => C + Y; reaction9_a2*Z; reaction10: Z => C; reaction10_alpha*reaction10_d1*Z; reaction11: Z => Y; reaction11_alpha*reaction11_kd*Z; reaction12: => Y; reaction12_vs; reaction13: Y => ; reaction13_d1*Y; // Species initializations: C = 0; C has substance_per_volume; X = 0; X has substance_per_volume; M = 0; M has substance_per_volume; Y = 1/Cell; Y has substance_per_volume; Z = 1/Cell; Z has substance_per_volume; // Compartment initializations: Cell = 1; Cell has volume; // Variable initializations: V1p = 0.75; K6 = 0.3; V3p = 0.3; reaction1_vi = 0.1; reaction2_k1 = 0.5; reaction2_K5 = 0.02; reaction3_kd = 0.02; reaction4_K1 = 0.1; reaction5_V2 = 0.25; reaction5_K2 = 0.1; reaction6_K3 = 0.2; reaction7_K4 = 0.1; reaction7_V4 = 0.1; reaction8_a1 = 0.05; reaction9_a2 = 0.05; reaction10_alpha = 0.1; reaction10_d1 = 0.05; reaction11_kd = 0.02; reaction11_alpha = 0.1; reaction12_vs = 0.2; reaction13_d1 = 0.05; // Other declarations: var V1, V3; const Cell, V1p, K6, V3p; // Unit definitions: unit volume = litre; unit substance = mole; unit substance_per_volume = mole / litre; // Display Names: C is "cyclin"; X is "protease"; M is "cdc2k"; Y is "cyclin inhibitor"; Z is "complex inhibitor-cyclin"; reaction1 is "creation of cyclin"; reaction2 is "cdc2 kinase triggered degration of cyclin"; reaction3 is "default degradation of cyclin"; reaction4 is "activation of cdc2 kinase"; reaction5 is "deactivation of cdc2 kinase"; reaction6 is "activation of cyclin protease"; reaction7 is "deactivation of cyclin protease"; reaction10 is "desinhibition of cyclin"; reaction11 is "degradation of inhibited cyclin"; reaction12 is "creation of cyclin inhibitor"; reaction13 is "degradation of cyclin inhibitor"; end