1 L KDL -1 kt 1 r c1 2 k_minusx c2 kxR0 c1 2 L r KDL kxR0 c1 2 k_minusx ke c2 1 kappa_PI3K 2 alpha_PI3K c2 1 kappa_PI3K 2 alpha_PI3K c2 2 2 k_3PI e_PI3K m_3PI K_GR c2 K_GP m_3PI 1 K_GR c2 K_GP m_3PI f_GEF k_Ras 1 gamma e_GEF 1 gamma e_GEF m_Ras kd_x1 m_Ras x1 1 y KM_x11 yp KM_x12 kd_x2 1 K_x2 m_3PI 1 K_x2 m_3PI x2 1 y KM_x21 yp KM_x22 Vmax_yph1_KM_yph1 yp 1 yp KM_yph1 ypp KM_yph2 Vmax_x11_KM_x11 x1 y 1 y KM_x11 yp KM_x12 Vmax_x21_KM_x21 x2 y 1 y KM_x21 yp KM_x22 1 y ypp Vmax_zph1_KM_zph1 e_ph zp 1 zp KM_zph1 zpp KM_zph2 Vmax_y1_KM_y1 ypp 1 z KM_y1 zp KM_y2 1 z zpp Vmax_y2_KM_y2 zp 1 z KM_y1 zp KM_y2 Vmax_zph2_KM_zph2 e_ph zpp 1 zp KM_zph1 zpp KM_zph2 k_FB_f zpp n Zf n zpp n f_GEF 1 Kf 1 f_GEF kd_w zpp w k_FB_ph w p Wph p w p 1 Kph e_ph 1