1 1 vS V_a A_a vS Cl_i Cl_o FF vS RR TT 1 FF vS RR TT g_Cl_bar a 4 g_Cl J_Cl 45 K_e del E_K FF RR TT G_K K_R 2 K_K K_R 2 1 1 K_S 1 K_R 2 K_K S_i 2 2 1 del vS FF RR TT -1 g_IR_bar y g_IR 1 J_K 0 0 J_K 50 alpha_n_bar vS V_n 1 vS V_n K_alpha_n beta_n_bar vS V_n K_beta_n 1 1 vS V_h_K_inf A_h_K_inf 1000 vS 40 25.75 alpha_n 1 n beta_n n h_K_inf h_K tau_h_K g_K_bar n 4 h_K g_DR J_K 50 alpha_h_bar vS V_h K_alpha_h beta_h_bar 1 vS V_h K_beta_h alpha_m_bar vS V_m 1 vS V_m K_alpha_m beta_m_bar vS V_m K_beta_m 1 1 vS V_S_inf A_S_inf 8571 0.2 5.65 vS V_tau 100 2 alpha_m 1 m beta_m m alpha_h 1 h beta_h h S_inf S tau_S g_Na_bar m 3 h S vS Na_i Na_e -1 FF vS RR TT 1 -1 FF vS RR TT g_Na J_Na 75 1 7 Na_e 67.3 1 1 0.12 -0.1 vS FF RR TT 0.04 sig vS FF RR TT -1 FF J_NaK_bar 1 K_m_K K_e 2 1 K_m_Na Na_i 3 I_NaK_bar f1 1 1 vT V_a A_a vT Cl_i_t Cl_o_t FF vT RR TT 1 FF vT RR TT eta_Cl g_Cl_t J_Cl_t 45 g_Cl_bar a_t 4 K_t del E_K_t FF RR TT G_K K_R_t 2 K_K K_R_t 2 1 1 K_S 1 K_R_t 2 K_K S_i 2 2 1 del vT FF RR TT -1 g_IR_bar_t y_t eta_IR g_IR_t J_K_t 50 alpha_n_bar vT V_n 1 vT V_n K_alpha_n beta_n_bar vT V_n K_beta_n 1 1 vT V_h_K_inf A_h_K_inf 1 vT 40 25.75 alpha_n_t 1 n_t beta_n_t n_t h_K_inf_t h_K_t tau_h_K_t g_K_bar n_t 4 h_K_t eta_DR g_DR_t J_K_t 50 alpha_h_bar vT V_h K_alpha_h beta_h_bar 1 vT V_h K_beta_h alpha_m_bar vT V_m 1 vT V_m K_alpha_m beta_m_bar vT V_m K_beta_m 1 1 vT V_S_inf A_S_inf 8571 0.2 5.65 vT V_tau 100 2 alpha_m_t 1 m_t beta_m_t m_t alpha_h_t 1 h_t beta_h_t h_t S_inf_t S_t tau_S_t g_Na_bar m_t 3 h_t S_t vT Na_i Na_t -1 FF vT RR TT 1 -1 FF vT RR TT eta_Na g_Na_t J_Na_t 75 1 7 Na_t 67.3 1 1 0.12 -0.1 vT FF RR TT 0.04 sig_t vT FF RR TT -1 FF J_NaK_bar 1 K_m_K K_t 2 1 K_m_Na Na_i 3 eta_NaK I_NaK_bar_t f1_t 1000 1 vS vT R_a I_ionic_s I_T C_m I_ionic_t I_T gam C_m I_Cl I_IR I_DR I_Na I_NaK I_HH I_Cl_t I_IR_t I_DR_t I_Na_t I_NaK_t I_IR_t I_DR_t I_K_rest -2 I_NaK_t 1000 1 FF tsi K_t K_e tau_K f_T I_IR_t I_DR_t I_K_rest -2 I_NaK_t 1000 1 FF tsi I_IR I_DR I_K_rest -2 I_NaK 1000 1 FF tsi2 I_IR I_DR I_K_rest -2 I_NaK 1000 1 FF tsi3 K_t K_e tau_K2 f_T I_Na_t I_Na_rest 3 I_NaK_t 1000 1 FF tsi I_Na I_Na_rest 3 I_NaK 1000 1 FF tsi2 I_Na_t I_Na_rest 3 I_NaK_t 1000 1 FF tsi Na_t Na_e tau_Na I_Na I_Na_rest 3 I_NaK 1000 1 FF tsi3 Na_t Na_e tau_Na2 RR TT FF K_e K_i RR TT FF K_t K_i 156.5 5 FF E_K RR TT 156.5 5 Cl_i 156.5 5 FF E_K_t RR TT 156.5 5 Cl_i_t vS K_i K_e -1 FF vS RR TT 1 -1 FF vS RR TT vT K_i K_t -1 FF vT RR TT 1 -1 FF vT RR TT 150 time_ 0 time_ 0.5 150 time_ 50 time_ 50.5 150 time_ 100 time_ 100.5 150 time_ 150 time_ 150.5 150 time_ 200 time_ 200.5 150 time_ 250 time_ 250.5 150 time_ 300 time_ 300.5 150 time_ 350 time_ 350.5 150 time_ 400 time_ 400.5 0 k_L C_0 k_Lm O_0 -4 k_C O_0 f f k_Cm O_1 k_L C_1 f k_Lm f O_1 4 k_C O_0 f f k_Cm O_1 -3 k_C O_1 f 2 f k_Cm O_2 3 k_C O_1 f -2 f k_Cm O_2 k_L C_2 f 2 k_Lm f 2 O_2 -2 k_C O_2 f 3 f k_Cm O_3 k_L C_3 f 3 k_Lm f 3 O_3 2 k_C O_2 f -3 k_Cm f O_3 k_C O_3 f 4 f k_Cm O_4 k_C O_3 f -4 f k_Cm O_4 k_L C_4 f 4 k_Lm f 4 O_4 k_L C_0 k_Lm O_0 -4 k_C C_0 k_Cm C_1 4 k_C C_0 k_Cm C_1 k_L C_1 f f k_Lm O_1 -3 k_C C_1 2 k_Cm C_2 3 k_C C_1 -2 k_Cm C_2 k_L C_2 f 2 f 2 k_Lm O_2 -2 k_C C_2 3 k_Cm C_3 2 k_C C_2 -3 k_Cm C_3 k_L C_3 f 3 k_Lm f 3 O_3 k_C C_3 4 k_Cm C_4 k_C C_3 -4 k_Cm C_4 k_L C_4 f 4 k_Lm f 4 O_4 0.5 alpha1 vT Vbar 8 K 0.5 alpha1 Vbar vT 8 K 0.95 L_x R_R 2 0.01 V_o 0.99 V_o 0.05 L_x R_R 2 0.01 V_SR 0.99 V_SR T_tot Ca_T_2 Ca_CaT2 D_0 D_1 D_2 A_1 A_2 i2 O_0 O_1 O_2 O_3 O_4 Ca_SR1 Ca_1 V_1 nu_SR Ca_1 Ca_1 K_SR V_1 L_e Ca_SR1 Ca_1 V_1 tau_R Ca_1 Ca_2 V_1 k_P_on Ca_1 P_tot Ca_P1 Mg_P1 k_P_off Ca_P1 k_CATP_on Ca_1 ATP1 k_CATP_off Ca_ATP1 i2 O_0 O_1 O_2 O_3 O_4 Ca_SR1 Ca_1 V_SR1 nu_SR Ca_1 Ca_1 K_SR V_SR1 L_e Ca_SR1 Ca_1 V_SR1 tau_SR_R Ca_SR1 Ca_SR2 V_SR1 k_Cs_on Ca_SR1 Cs_tot Ca_Cs1 k_Cs_off Ca_Cs1 nu_SR Ca_2 Ca_2 K_SR V_2 L_e Ca_SR2 Ca_2 V_2 tau_R Ca_1 Ca_2 V_2 k_T_on Ca_2 T_0 k_T_off Ca_T_2 k_T_on Ca_2 Ca_T_2 k_T_off Ca_CaT2 k_T_on Ca_2 D_0 k_T_off D_1 k_T_on Ca_2 D_1 k_T_off D_2 k_P_on Ca_2 P_tot Ca_P2 Mg_P2 k_P_off Ca_P2 k_CATP_on Ca_2 ATP2 k_CATP_off Ca_ATP2 nu_SR Ca_2 Ca_2 K_SR V_SR2 L_e Ca_SR2 Ca_2 V_SR2 tau_SR_R Ca_SR1 Ca_SR2 V_SR2 k_Cs_on Ca_SR2 Cs_tot Ca_Cs2 k_Cs_off Ca_Cs2 1000 1 A_p P_SR 0.001 1 Ca_SR2 PP 1 P_SR 0.001 1 Ca_SR2 PP 0 0 0.001 1 P_SR Ca_SR2 B_p P_C_SR PP P_SR 0.001 1 Ca_SR2 1 PP P_SR 0.001 1 Ca_SR2 0 0 k_T_on Ca_2 T_0 k_T_off Ca_T_2 k_T_on Ca_2 Ca_T_2 k_T_off Ca_CaT2 k_0_on Ca_T_2 k_0_off D_1 k_P_on Ca_1 P_tot Ca_P1 Mg_P1 k_P_off Ca_P1 k_P_on Ca_2 P_tot Ca_P2 Mg_P2 k_P_off Ca_P2 k_Mg_on P_tot Ca_P1 Mg_P1 Mg1 k_Mg_off Mg_P1 k_Mg_on P_tot Ca_P2 Mg_P2 Mg2 k_Mg_off Mg_P2 k_Cs_on Ca_SR1 Cs_tot Ca_Cs1 k_Cs_off Ca_Cs1 k_Cs_on Ca_SR2 Cs_tot Ca_Cs2 k_Cs_off Ca_Cs2 k_CATP_on Ca_1 ATP1 k_CATP_off Ca_ATP1 tau_ATP Ca_ATP1 Ca_ATP2 V_1 k_CATP_on Ca_2 ATP2 k_CATP_off Ca_ATP2 tau_ATP Ca_ATP1 Ca_ATP2 V_2 k_MATP_on Mg1 ATP1 k_MATP_off Mg_ATP1 tau_ATP Mg_ATP1 Mg_ATP2 V_1 k_MATP_on Mg2 ATP2 k_MATP_off Mg_ATP2 tau_ATP Mg_ATP1 Mg_ATP2 V_2 k_CATP_on Ca_1 ATP1 k_CATP_off Ca_ATP1 k_MATP_on Mg1 ATP1 k_MATP_off Mg_ATP1 tau_ATP ATP1 ATP2 V_1 k_CATP_on Ca_2 ATP2 k_CATP_off Ca_ATP2 k_MATP_on Mg2 ATP2 k_MATP_off Mg_ATP2 tau_ATP ATP1 ATP2 V_2 k_Mg_on P_tot Ca_P1 Mg_P1 Mg1 k_Mg_off Mg_P1 k_MATP_on Mg1 ATP1 k_MATP_off Mg_ATP1 tau_Mg Mg1 Mg2 V_1 k_Mg_on P_tot Ca_P2 Mg_P2 Mg2 k_Mg_off Mg_P2 k_MATP_on Mg2 ATP2 k_MATP_off Mg_ATP2 tau_Mg Mg1 Mg2 V_2 k_T_on Ca_2 Ca_T_2 k_T_off Ca_CaT2 k_Ca_on Ca_CaT2 k_Ca_off D_2 k_T_on Ca_2 D_0 k_T_off D_1 k_0_on T_0 k_0_off D_0 k_T_on Ca_2 D_0 k_T_off D_1 k_0_on Ca_T_2 k_0_off D_1 k_T_on Ca_2 D_1 k_T_off D_2 k_T_on Ca_2 D_1 k_T_off D_2 k_Ca_on Ca_CaT2 k_Ca_off D_2 f_o D_2 f_p A_1 g_o A_2 f_o D_2 f_p A_1 h_p A_2 h_o A_1 h_p A_2 h_o A_1 g_o A_2 0.001 1 h_o A_1 h_p A_2 -1 b_p P -1 k_p P P_SR V_2 k_p P P_SR V_SR2 1 A_p P_SR 0.001 1 Ca_SR2 PP 1 P_SR 0.001 1 Ca_SR2 PP 0 0 0.001 1 P_SR Ca_SR2 B_p P_C_SR PP P_SR 0.001 1 Ca_SR2 1 PP P_SR 0.001 1 Ca_SR2 0 0 1 A_p P_SR 0.001 1 Ca_SR2 PP 1 P_SR 0.001 1 Ca_SR2 PP 0 0 0.001 1 P_SR Ca_SR2 B_p P_C_SR PP P_SR 0.001 1 Ca_SR2 1 PP P_SR 0.001 1 Ca_SR2 0 0