//Created by libAntimony v2.4
model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__environment(time_)

  // Variable initializations:
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__membrane(V, R, T, F, time_, i_Na, i_Ca_L, i_t, i_ss, i_f, i_K1, i_B, i_NaK, i_NaCa, i_Ca_P)

  // Assignment Rules:
  i_Stim := piecewise( stim_amplitude , ( geq(time_ - floor(time_ / stim_period) * stim_period, 0)) && (time_ - floor(time_ / stim_period) * stim_period <= stim_duration ), 0 );

  // Rate Rules:
  V' = -(i_Na + i_Ca_L + i_t + i_ss + i_f + i_K1 + i_B + i_NaK + i_NaCa + i_Ca_P + i_Stim) / Cm;

  // Variable initializations:
  V = -80.50146;
  R = 8314.5;
  T = 295;
  F = 96487;
  Cm = 0.0001;
  time_ = ;
  i_Na = ;
  i_Ca_L = ;
  i_t = ;
  i_ss = ;
  i_f = ;
  i_K1 = ;
  i_B = ;
  i_NaK = ;
  i_NaCa = ;
  i_Ca_P = ;
  stim_period = 1;
  stim_duration = 5e-3;
  stim_amplitude = -0.6;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__sodium_current_m_gate(m, V, time_)

  // Assignment Rules:
  m_infinity := 1 / (1 + exp((V + 45) / -(6.5)));
  tau_m := 0.00136 / ((0.32 * (V + 47.13)) / (1 - exp(-(0.1) * (V + 47.13))) + 0.08 * exp(- V / 11));

  // Rate Rules:
  m' = (m_infinity - m) / tau_m;

  // Variable initializations:
  m = 0.004164108;
  V = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__sodium_current_h_gate(h, V, time_)

  // Assignment Rules:
  h_infinity := 1 / (1 + exp((V + 76.1) / 6.07));
  tau_h := piecewise( 0.0004537 * (1 + exp(-(V + 10.66) / 11.1)) , geq(V, -(40)) , 0.00349 / (0.135 * exp(-(V + 80) / 6.8) + 3.56 * exp(0.079 * V) + 310000 * exp(0.35 * V)) );

  // Rate Rules:
  h' = (h_infinity - h) / tau_h;

  // Variable initializations:
  h = 0.6735613;
  V = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__sodium_current_j_gate(j, V, time_)

  // Assignment Rules:
  j_infinity := 1 / (1 + exp((V + 76.1) / 6.07));
  tau_j := piecewise( (0.01163 * (1 + exp(-(0.1) * (V + 32)))) / exp(-(0.0000002535) * V) , geq(V, -(40)) , 0.00349 / (((V + 37.78) / (1 + exp(0.311 * (V + 79.23)))) * (-(127140) * exp(0.2444 * V) - 0.00003474 * exp(-(0.04391) * V)) + (0.1212 * exp(-(0.01052) * V)) / (1 + exp(-(0.1378) * (V + 40.14)))) );

  // Rate Rules:
  j' = (j_infinity - j) / tau_j;

  // Variable initializations:
  j = 0.6729362;
  V = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__sodium_current(i_Na, E_Na, Na_i, Na_o, R, F, T, time_, V, m, h, j)

  // Sub-modules, and any changes to those submodules:
  sodium_current_m_gate: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__sodium_current_m_gate(m, V, time_);
  sodium_current_h_gate: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__sodium_current_h_gate(h, V, time_);
  sodium_current_j_gate: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__sodium_current_j_gate(j, V, time_);

  // Assignment Rules:
  i_Na := g_Na * power(m, 3) * h * j * (V - E_Na);
  E_Na := ((R * T) / F) * ln(Na_o / Na_i);
  g_Na_endo := 1.33 * g_Na;

  // Variable initializations:
  g_Na = 1.064;
  Na_i = ;
  Na_o = ;
  R = ;
  F = ;
  T = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__L_type_Ca_channel_d_gate(d, V, time_)

  // Assignment Rules:
  d_infinity := 1 / (1 + exp((V + 15.3) / -(5)));
  tau_d := 0.00305 * exp(-(0.0045) * power(V + 7, 2)) + 0.00105 * exp(-(0.002) * power(V - 18, 2)) + 0.00025;

  // Rate Rules:
  d' = (d_infinity - d) / tau_d;

  // Variable initializations:
  d = 0.000002171081;
  V = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__L_type_Ca_channel_f_11_gate(f_11, V, time_)

  // Assignment Rules:
  f_11_infinity := 1 / (1 + exp((V + 26.7) / 5.4));
  tau_f_11 := 0.9 * (0.105 * exp(-power((V + 45) / 12, 2)) + 0.04 / (1 + exp((- V + 25) / 25)) + 0.015 / (1 + exp((V + 75) / 25)) + 0.0017);

  // Rate Rules:
  f_11' = (f_11_infinity - f_11) / tau_f_11;

  // Variable initializations:
  f_11 = 0.9999529;
  V = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__L_type_Ca_channel_f_12_gate(f_12, V, time_)

  // Assignment Rules:
  f_12_infinity := 1 / (1 + exp((V + 26.7) / 5.4));
  tau_f_12 := 0.041 * exp(-power((V + 47) / 12, 2)) + 0.08 / (1 + exp((V + 55) / -(5))) + 0.015 / (1 + exp((V + 75) / 25)) + 0.0017;

  // Rate Rules:
  f_12' = (f_12_infinity - f_12) / tau_f_12;

  // Variable initializations:
  f_12 = 0.9999529;
  V = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__L_type_Ca_channel_Ca_inact_gate(Ca_inact, V, time_, Ca_ss)

  // Assignment Rules:
  Ca_inact_infinity := 1 / (1 + Ca_ss / 0.01);

  // Rate Rules:
  Ca_inact' = (Ca_inact_infinity - Ca_inact) / tau_Ca_inact;

  // Variable initializations:
  Ca_inact = 0.9913102;
  tau_Ca_inact = 0.009;
  V = ;
  time_ = ;
  Ca_ss = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__L_type_Ca_channel(i_Ca_L, time_, V, Ca_ss, d, f_11, f_12, Ca_inact)

  // Sub-modules, and any changes to those submodules:
  L_type_Ca_channel_d_gate: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__L_type_Ca_channel_d_gate(d, V, time_);
  L_type_Ca_channel_f_11_gate: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__L_type_Ca_channel_f_11_gate(f_11, V, time_);
  L_type_Ca_channel_f_12_gate: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__L_type_Ca_channel_f_12_gate(f_12, V, time_);
  L_type_Ca_channel_Ca_inact_gate: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__L_type_Ca_channel_Ca_inact_gate(Ca_inact, V, time_, Ca_ss);

  // Assignment Rules:
  i_Ca_L := g_Ca_L * d * ((0.9 + Ca_inact / 10) * f_11 + (0.1 - Ca_inact / 10) * f_12) * (V - E_Ca_L);

  // Variable initializations:
  g_Ca_L = 0.025916;
  E_Ca_L = 65;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__Ca_independent_transient_outward_K_current_r_gate(r, V, time_)

  // Assignment Rules:
  tau_r := 1 / (45.16 * exp(0.03577 * (V + 50)) + 98.9 * exp(-(0.1) * (V + 38)));
  r_infinity := 1 / (1 + exp((V + 10.6) / -(11.42)));

  // Rate Rules:
  r' = (r_infinity - r) / tau_r;

  // Variable initializations:
  r = 0.002191519;
  V = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__Ca_independent_transient_outward_K_current_s_gate(s, V, time_)

  // Assignment Rules:
  tau_s := 0.35 * exp(-power((V + 70) / 15, 2)) + 0.035;
  s_infinity := 1 / (1 + exp((V + 45.3) / 6.8841));

  // Rate Rules:
  s' = (s_infinity - s) / tau_s;

  // Variable initializations:
  s = 0.9842542;
  V = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__Ca_independent_transient_outward_K_current_s_slow_gate(s_slow, V, time_)

  // Assignment Rules:
  tau_s_slow := 3.7 * exp(((-(V + 70) / 30) * (V + 70)) / 15) + 0.035;
  s_slow_infinity := 1 / (1 + exp((V + 45.3) / 6.8841));

  // Rate Rules:
  s_slow' = (s_slow_infinity - s_slow) / tau_s_slow;

  // Variable initializations:
  s_slow = 0.6421196;
  V = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__Ca_independent_transient_outward_K_current(i_t, E_K, time_, V, R, F, T, K_o, K_i, r, s, s_slow)

  // Sub-modules, and any changes to those submodules:
  Ca_independent_transient_outward_K_current_r_gate: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__Ca_independent_transient_outward_K_current_r_gate(r, V, time_);
  Ca_independent_transient_outward_K_current_s_gate: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__Ca_independent_transient_outward_K_current_s_gate(s, V, time_);
  Ca_independent_transient_outward_K_current_s_slow_gate: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__Ca_independent_transient_outward_K_current_s_slow_gate(s_slow, V, time_);

  // Assignment Rules:
  i_t := g_t * r * (a * s + b * s_slow) * (V - E_K);
  E_K := ((R * T) / F) * ln(K_o / K_i);
  g_t_endo := 0.4647 * g_t;

  // Variable initializations:
  g_t = 0.02975;
  a = 0.69;
  b = 0.31;
  R = ;
  F = ;
  T = ;
  K_o = ;
  K_i = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__steady_state_outward_K_current_r_ss_gate(r_ss, V, time_)

  // Assignment Rules:
  tau_r_ss := 10 / (45.16 * exp(0.03577 * (V + 50)) + 98.9 * exp(-(0.1) * (V + 38)));
  r_ss_infinity := 1 / (1 + exp((V + 11.5) / -(11.82)));

  // Rate Rules:
  r_ss' = (r_ss_infinity - r_ss) / tau_r_ss;

  // Variable initializations:
  r_ss = 0.002907171;
  V = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__steady_state_outward_K_current_s_ss_gate(s_ss, V, time_)

  // Assignment Rules:
  tau_s_ss := 2.1;
  s_ss_infinity := 1 / (1 + exp((V + 87.5) / 10.3));

  // Rate Rules:
  s_ss' = (s_ss_infinity - s_ss) / tau_s_ss;

  // Variable initializations:
  s_ss = 0.3142767;
  V = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__steady_state_outward_K_current(i_ss, time_, V, E_K, r_ss, s_ss)

  // Sub-modules, and any changes to those submodules:
  steady_state_outward_K_current_r_ss_gate: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__steady_state_outward_K_current_r_ss_gate(r_ss, V, time_);
  steady_state_outward_K_current_s_ss_gate: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__steady_state_outward_K_current_s_ss_gate(s_ss, V, time_);

  // Assignment Rules:
  i_ss := g_ss * r_ss * s_ss * (V - E_K);

  // Variable initializations:
  g_ss = 0.005929;
  E_K = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__inward_rectifier(i_K1, V, R, F, T, K_o, K_i, E_K)

  // Assignment Rules:
  i_K1 := ((48 / (exp((V + 37) / 25) + exp((V + 37) / -(25))) + 10) * 0.001) / (1 + exp((V - (E_K + 76.77)) / -(17))) + (g_K1 * (V - (E_K + 1.73))) / ((1 + exp((1.613 * F * (V - (E_K + 1.73))) / (R * T))) * (1 + exp((K_o - 0.9988) / -(0.124))));

  // Variable initializations:
  g_K1 = 0.024;
  V = ;
  R = ;
  F = ;
  T = ;
  K_o = ;
  K_i = ;
  E_K = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__hyperpolarisation_activated_current_y_gate(y, V, time_)

  // Assignment Rules:
  tau_y := 1 / (0.11885 * exp((V + 80) / 28.37) + 0.5623 * exp((V + 80) / -(14.19)));
  y_infinity := 1 / (1 + exp((V + 138.6) / 10.48));

  // Rate Rules:
  y' = (y_infinity - y) / tau_y;

  // Variable initializations:
  y = 0.003578708;
  V = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__hyperpolarisation_activated_current(i_f, i_f_Na, i_f_K, time_, V, E_K, E_Na, y)

  // Sub-modules, and any changes to those submodules:
  hyperpolarisation_activated_current_y_gate: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__hyperpolarisation_activated_current_y_gate(y, V, time_);

  // Assignment Rules:
  i_f := i_f_Na + i_f_K;
  i_f_Na := g_f * y * f_Na * (V - E_Na);
  i_f_K := g_f * y * f_K * (V - E_K);
  f_K := 1 - f_Na;

  // Variable initializations:
  g_f = 0.00145;
  f_Na = 0.2;
  E_K = ;
  E_Na = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__background_currents(i_B, i_B_Na, i_B_Ca, i_B_K, E_Na, E_K, Ca_o, Ca_i, R, T, F, V)

  // Assignment Rules:
  i_B := i_B_Na + i_B_Ca + i_B_K;
  i_B_Na := g_B_Na * (V - E_Na);
  i_B_Ca := g_B_Ca * (V - E_Ca);
  i_B_K := g_B_K * (V - E_K);

  // Variable initializations:
  g_B_Na = 0.000100188;
  g_B_Ca = 0.0000162;
  g_B_K = 0.000138;
  E_Ca = 65;
  E_Na = ;
  E_K = ;
  Ca_o = ;
  Ca_i = ;
  R = ;
  T = ;
  F = ;
  V = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__sodium_potassium_pump(i_NaK, K_o, Na_o, Na_i, R, F, T, V)

  // Assignment Rules:
  i_NaK := (((((i_NaK_max * 1) / (1 + 0.1245 * exp((-(0.1) * V * F) / (R * T)) + 0.0365 * sigma * exp((- V * F) / (R * T)))) * K_o) / (K_o + K_m_K)) * 1) / (1 + power(K_m_Na / Na_i, 1.5));
  sigma := (exp(Na_o / 67.3) - 1) / 7;

  // Variable initializations:
  i_NaK_max = 0.0504;
  K_m_K = 1.5;
  K_m_Na = 10;
  K_o = ;
  Na_o = ;
  Na_i = ;
  R = ;
  F = ;
  T = ;
  V = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__sarcolemmal_calcium_pump_current(i_Ca_P, Ca_i, time_)

  // Assignment Rules:
  i_Ca_P := (i_Ca_P_max * Ca_i) / (Ca_i + 0.0004);

  // Variable initializations:
  i_Ca_P_max = 0.004;
  Ca_i = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__Na_Ca_ion_exchanger_current(i_NaCa, Na_i, Na_o, Ca_i, Ca_o, V, time_)

  // Assignment Rules:
  i_NaCa := (K_NaCa * (power(Na_i, 3) * Ca_o * exp(0.03743 * V * gamma_NaCa) - power(Na_o, 3) * Ca_i * exp(0.03743 * V * (gamma_NaCa - 1)))) / (1 + d_NaCa * (Ca_i * power(Na_o, 3) + Ca_o * power(Na_i, 3)));

  // Variable initializations:
  K_NaCa = 0.000009984;
  d_NaCa = 0.0001;
  gamma_NaCa = 0.5;
  Na_i = ;
  Na_o = ;
  Ca_i = ;
  Ca_o = ;
  V = ;
  time_ = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__SR_Ca_release_channel(J_rel, time_, Ca_ss, Ca_JSR)

  // Assignment Rules:
  J_rel := v1 * (P_O1 + P_O2) * (Ca_JSR - Ca_ss);

  // Rate Rules:
  P_O1' = (k_a_plus * power(Ca_ss, n) * P_C1 - (k_a_minus * P_O1 + k_b_plus * power(Ca_ss, m) * P_O1 + k_c_plus * P_O1)) + k_b_minus * P_O2 + k_c_minus * P_C2;
  P_O2' = k_b_plus * power(Ca_ss, m) * P_O1 - k_b_minus * P_O2;
  P_C1' = - k_a_plus * power(Ca_ss, n) * P_C1 + k_a_minus * P_O1;
  P_C2' = k_c_plus * P_O1 - k_c_minus * P_C2;

  // Variable initializations:
  v1 = 1.8e3;
  k_a_plus = 12.15e12;
  k_a_minus = 576;
  k_b_plus = 4.05e9;
  k_b_minus = 1930;
  k_c_plus = 100;
  k_c_minus = 0.8;
  P_O1 = 0.0004327548;
  P_O2 = 0.000000000606254;
  P_C1 = 0.6348229;
  P_C2 = 0.3647471;
  n = 4;
  m = 3;
  time_ = ;
  Ca_ss = ;
  Ca_JSR = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__SERCA2a_pump(J_up, time_, Ca_i, Ca_NSR)

  // Assignment Rules:
  J_up := (K_SR * (Vmaxf * fb - Vmaxr * rb)) / (1 + fb + rb);
  fb := power(Ca_i / K_fb, N_fb);
  rb := power(Ca_NSR / K_rb, N_rb);

  // Variable initializations:
  K_fb = 0.000168;
  K_rb = 3.29;
  Vmaxf = 0.032;
  Vmaxr = 0.9;
  K_SR = 0.55;
  N_fb = 1.2;
  N_rb = 1;
  time_ = ;
  Ca_i = ;
  Ca_NSR = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__intracellular_and_SR_Ca_fluxes(J_tr, J_xfer, J_trpn, time_, Ca_ss, Ca_i, Ca_NSR, Ca_JSR)

  // Assignment Rules:
  J_tr := (Ca_NSR - Ca_JSR) / tau_tr;
  J_xfer := (Ca_ss - Ca_i) / tau_xfer;
  J_trpn := J_HTRPNCa + J_LTRPNCa;
  J_HTRPNCa := k_htrpn_plus * Ca_i * (HTRPN_tot - HTRPNCa) - k_htrpn_minus * HTRPNCa;
  J_LTRPNCa := k_ltrpn_plus * Ca_i * (LTRPN_tot - LTRPNCa) - k_ltrpn_minus * LTRPNCa;

  // Rate Rules:
  HTRPNCa' = J_HTRPNCa;
  LTRPNCa' = J_LTRPNCa;

  // Variable initializations:
  tau_tr = 0.0005747;
  tau_xfer = 0.0267;
  HTRPNCa = 1.394301e-1;
  LTRPNCa = 5.1619e-3;
  HTRPN_tot = 0.14;
  LTRPN_tot = 0.07;
  k_htrpn_plus = 200000;
  k_htrpn_minus = 0.066;
  k_ltrpn_plus = 40000;
  k_ltrpn_minus = 40;
  time_ = ;
  Ca_ss = ;
  Ca_i = ;
  Ca_NSR = ;
  Ca_JSR = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__intracellular_ion_concentrations(Na_i, Ca_i, K_i, Ca_ss, Ca_JSR, Ca_NSR, time_, F, i_Na, i_Ca_L, i_B_Na, i_NaCa, i_NaK, i_f_Na, i_f_K, i_B_K, i_K1, i_t, i_ss, i_Ca_P, i_B_Ca, J_up, J_rel, J_xfer, J_trpn, J_tr)

  // Assignment Rules:
  beta_i := 1 / (1 + (CMDN_tot * K_mCMDN) / power(K_mCMDN + Ca_i, 2) + (EGTA_tot * K_mEGTA) / power(K_mEGTA + Ca_i, 2));
  beta_SS := 1 / (1 + (CMDN_tot * K_mCMDN) / power(K_mCMDN + Ca_ss, 2));
  beta_JSR := 1 / (1 + (CSQN_tot * K_mCSQN) / power(K_mCSQN + Ca_JSR, 2));

  // Rate Rules:
  Na_i' = (-(i_Na + i_B_Na + i_NaCa * 3 + i_NaK * 3 + i_f_Na) * 1) / (V_myo * F);
  Ca_i' = beta_i * (J_xfer - (J_up + J_trpn + (((i_B_Ca - 2 * i_NaCa) + i_Ca_P) * 1) / (2 * V_myo * F)));
  K_i' = (-(i_ss + i_B_K + i_t + i_K1 + i_f_K + i_NaK * -(2)) * 1) / (V_myo * F);
  Ca_ss' = beta_SS * (((J_rel * V_JSR) / V_SS - (J_xfer * V_myo) / V_SS) - (i_Ca_L * 1) / (2 * V_SS * F));
  Ca_JSR' = beta_JSR * (J_tr - J_rel);
  Ca_NSR' = (J_up * V_myo) / V_NSR - (J_tr * V_JSR) / V_NSR;

  // Variable initializations:
  Na_i = 10.73519;
  Ca_i = 0.00007901351;
  K_i = 139.2751;
  Ca_ss = 0.00008737212;
  Ca_JSR = 0.06607948;
  Ca_NSR = 0.06600742;
  V_myo = 9.36e-6;
  V_JSR = 0.056e-6;
  V_NSR = 0.504e-6;
  V_SS = 1.2e-9;
  K_mCMDN = 0.00238;
  K_mCSQN = 0.8;
  K_mEGTA = 0.00015;
  CMDN_tot = 0.05;
  CSQN_tot = 15;
  EGTA_tot = 0;
  time_ = ;
  F = ;
  i_Na = ;
  i_Ca_L = ;
  i_B_Na = ;
  i_NaCa = ;
  i_NaK = ;
  i_f_Na = ;
  i_f_K = ;
  i_B_K = ;
  i_K1 = ;
  i_t = ;
  i_ss = ;
  i_Ca_P = ;
  i_B_Ca = ;
  J_up = ;
  J_rel = ;
  J_xfer = ;
  J_trpn = ;
  J_tr = ;
end

model pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__standard_ionic_concentrations(Na_o, Ca_o, K_o)

  // Variable initializations:
  Na_o = 140;
  Ca_o = 1.2;
  K_o = 5.4;
end

model *pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes____main()

  // Sub-modules, and any changes to those submodules:
  environment: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__environment(time_);
  membrane: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__membrane(V, R, T, F, time_, i_Na, i_Ca_L, i_t, i_ss, i_f, i_K1, i_B, i_NaK, i_NaCa, i_Ca_P);
  sodium_current: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__sodium_current(i_Na, E_Na, Na_i, Na_o, R, F, T, time_, V, m, h, j);
  L_type_Ca_channel: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__L_type_Ca_channel(i_Ca_L, time_, V, Ca_ss, d, f_11, f_12, Ca_inact);
  Ca_independent_transient_outward_K_current: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__Ca_independent_transient_outward_K_current(i_t, E_K, time_, V, R, F, T, K_o, K_i, r, s, s_slow);
  steady_state_outward_K_current: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__steady_state_outward_K_current(i_ss, time_, V, E_K, r_ss, s_ss);
  inward_rectifier: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__inward_rectifier(i_K1, V, R, F, T, K_o, K_i, E_K);
  hyperpolarisation_activated_current: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__hyperpolarisation_activated_current(i_f, i_f_Na, i_f_K, time_, V, E_K, E_Na, y);
  background_currents: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__background_currents(i_B, i_B_Na, i_B_Ca, i_B_K, E_Na, E_K, Ca_o, Ca_i, R, T, F, V);
  sodium_potassium_pump: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__sodium_potassium_pump(i_NaK, K_o, Na_o, Na_i, R, F, T, V);
  sarcolemmal_calcium_pump_current: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__sarcolemmal_calcium_pump_current(i_Ca_P, Ca_i, time_);
  Na_Ca_ion_exchanger_current: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__Na_Ca_ion_exchanger_current(i_NaCa, Na_i, Na_o, Ca_i, Ca_o, V, time_);
  SR_Ca_release_channel: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__SR_Ca_release_channel(J_rel, time_, Ca_ss, Ca_JSR);
  SERCA2a_pump: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__SERCA2a_pump(J_up, time_, Ca_i, Ca_NSR);
  intracellular_and_SR_Ca_fluxes: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__intracellular_and_SR_Ca_fluxes(J_tr, J_xfer, J_trpn, time_, Ca_ss, Ca_i, Ca_NSR, Ca_JSR);
  intracellular_ion_concentrations: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__intracellular_ion_concentrations(Na_i, Ca_i, K_i, Ca_ss, Ca_JSR, Ca_NSR, time_, F, i_Na, i_Ca_L, i_B_Na, i_NaCa, i_NaK, i_f_Na, i_f_K, i_B_K, i_K1, i_t, i_ss, i_Ca_P, i_B_Ca, J_up, J_rel, J_xfer, J_trpn, J_tr);
  standard_ionic_concentrations: pandit_model_2001_rat_ventricular_myocytes_typeIdiabetes__standard_ionic_concentrations(Na_o, Ca_o, K_o);
end