M_night tprime 3600 t_night tprime 3600 t_day M_day rem time_ 3600 1 day_length km M M_c c -1 M k T T_a kb kinc T T_b 1 pEtot BR f2_drug f_prime E_slow E_fast 1 BR kR BR AMT_dose pEs2 gNsTs1 gNsTs2 gNsTs3 pEf2 gNfTf1 gNfTf2 gNfTf3 0 T_b delta_T 2 T_b delta_T 2 M_b T_b T_a kb kinc T_day T_b T_day T_a 1 f_prime M_night_baseline f_prime M_day delta_high_dose 1 alpha time_ tdose1 t_prime -1 kb kinc T_night T_b T_night T_a Ks Ns 6 Ks X1 X1 Ns 1 X1 0 0 Ks Ns 6 Ks X2 X2 Ns 1 X2 0 0 Ks Ns 6 Ks X3 X3 Ns 1 X3 0 0 Kf Nf 6 Kf X1 X1 Nf 1 X1 0 0 Kf Nf 6 Kf X2 X2 Nf 1 X2 0 0 Kf Nf 6 Kf X3 X3 Nf 1 X3 0 0 time_ tdose1 24 time_ tdose2 24 time_ tdose3 24 Nf Tf Ns Ts