//Created by libAntimony v2.4
model hynne_2001__environment(time_)

  // Variable initializations:
  time_ = ;
end

model hynne_2001__Glc_x_0(Glc_x_0)

  // Variable initializations:
  Glc_x_0 = 24.0;
end

model hynne_2001__Glc_x(Glc_x, GlcTrans, inGlc, time_)

  // Rate Rules:
  Glc_x' = inGlc - GlcTrans;

  // Variable initializations:
  Glc_x = 6.7;
  GlcTrans = ;
  inGlc = ;
  time_ = ;
end

model hynne_2001__Glc(Glc, GlcTrans, HK, time_)

  // Rate Rules:
  Glc' = 59 * GlcTrans - HK;

  // Variable initializations:
  Glc = 0.573074;
  GlcTrans = ;
  HK = ;
  time_ = ;
end

model hynne_2001__G6P(G6P, PGI, HK, storage, time_)

  // Rate Rules:
  G6P' = HK - (PGI + storage);

  // Variable initializations:
  G6P = 4.2;
  PGI = ;
  HK = ;
  storage = ;
  time_ = ;
end

model hynne_2001__F6P(F6P, PGI, PFK, time_)

  // Rate Rules:
  F6P' = PGI - PFK;

  // Variable initializations:
  F6P = 0.49;
  PGI = ;
  PFK = ;
  time_ = ;
end

model hynne_2001__FBP(FBP, PFK, ALD, time_)

  // Rate Rules:
  FBP' = PFK - ALD;

  // Variable initializations:
  FBP = 4.64;
  PFK = ;
  ALD = ;
  time_ = ;
end

model hynne_2001__GAP(GAP, GAPDH, ALD, TIM, time_)

  // Rate Rules:
  GAP' = (ALD + TIM) - GAPDH;

  // Variable initializations:
  GAP = 0.115;
  GAPDH = ;
  ALD = ;
  TIM = ;
  time_ = ;
end

model hynne_2001__DHAP(DHAP, ALD, TIM, lpGlyc, time_)

  // Rate Rules:
  DHAP' = ALD - (TIM + lpGlyc);

  // Variable initializations:
  DHAP = 2.95;
  ALD = ;
  TIM = ;
  lpGlyc = ;
  time_ = ;
end

model hynne_2001__BPG(BPG, lpPEP, GAPDH, time_)

  // Rate Rules:
  BPG' = GAPDH - lpPEP;

  // Variable initializations:
  BPG = 0.00027;
  lpPEP = ;
  GAPDH = ;
  time_ = ;
end

model hynne_2001__PEP(PEP, lpPEP, PK, time_)

  // Rate Rules:
  PEP' = lpPEP - PK;

  // Variable initializations:
  PEP = 0.04;
  lpPEP = ;
  PK = ;
  time_ = ;
end

model hynne_2001__Pyr(Pyr, PK, PDC, time_)

  // Rate Rules:
  Pyr' = PK - PDC;

  // Variable initializations:
  Pyr = 8.7;
  PK = ;
  PDC = ;
  time_ = ;
end

model hynne_2001__ATP(ATP, HK, lpPEP, PFK, PK, storage, consum, AK, time_)

  // Rate Rules:
  ATP' = (PK + lpPEP) - (PFK + storage + HK + consum + AK);

  // Variable initializations:
  ATP = 2.1;
  HK = ;
  lpPEP = ;
  PFK = ;
  PK = ;
  storage = ;
  consum = ;
  AK = ;
  time_ = ;
end

model hynne_2001__ADP(ADP, HK, lpPEP, PFK, PK, storage, consum, AK, time_)

  // Rate Rules:
  ADP' = (PFK + storage + HK + consum + 2 * AK) - (PK + lpPEP);

  // Variable initializations:
  ADP = 1.5;
  HK = ;
  lpPEP = ;
  PFK = ;
  PK = ;
  storage = ;
  consum = ;
  AK = ;
  time_ = ;
end

model hynne_2001__AMP(AMP, AK, time_)

  // Rate Rules:
  AMP' = - AK;

  // Variable initializations:
  AMP = 0.33;
  AK = ;
  time_ = ;
end

model hynne_2001__CN_x_0(CN_x_0)

  // Variable initializations:
  CN_x_0 = 5.60;
end

model hynne_2001__CN_x(CN_x, lacto, inCN, time_)

  // Rate Rules:
  CN_x' = inCN - lacto;

  // Variable initializations:
  CN_x = 5.20358;
  lacto = ;
  inCN = ;
  time_ = ;
end

model hynne_2001__ACA(ACA, difACA, PDC, ADH, time_)

  // Rate Rules:
  ACA' = PDC - (59 * difACA + ADH);

  // Variable initializations:
  ACA = 1.48153;
  difACA = ;
  PDC = ;
  ADH = ;
  time_ = ;
end

model hynne_2001__ACA_x(ACA_x, lacto, difACA, outACA, time_)

  // Rate Rules:
  ACA_x' = difACA - (lacto + outACA);

  // Variable initializations:
  ACA_x = 1.28836;
  lacto = ;
  difACA = ;
  outACA = ;
  time_ = ;
end

model hynne_2001__EtOH(EtOH, difEtOH, ADH, time_)

  // Rate Rules:
  EtOH' = ADH - 59 * difEtOH;

  // Variable initializations:
  EtOH = 19.2379;
  difEtOH = ;
  ADH = ;
  time_ = ;
end

model hynne_2001__EtOH_x(EtOH_x, difEtOH, outEtOH, time_)

  // Rate Rules:
  EtOH_x' = difEtOH - outEtOH;

  // Variable initializations:
  EtOH_x = 16.4514;
  difEtOH = ;
  outEtOH = ;
  time_ = ;
end

model hynne_2001__Glyc(Glyc, difGlyc, lpGlyc, time_)

  // Rate Rules:
  Glyc' = lpGlyc - 59 * difGlyc;

  // Variable initializations:
  Glyc = 4.196;
  difGlyc = ;
  lpGlyc = ;
  time_ = ;
end

model hynne_2001__Glyc_x(Glyc_x, difGlyc, outGlyc, time_)

  // Rate Rules:
  Glyc_x' = difGlyc - outGlyc;

  // Variable initializations:
  Glyc_x = 1.68478;
  difGlyc = ;
  outGlyc = ;
  time_ = ;
end

model hynne_2001__NADH(NADH, GAPDH, ADH, lpGlyc, time_)

  // Rate Rules:
  NADH' = GAPDH - (ADH + lpGlyc);

  // Variable initializations:
  NADH = 0.33;
  GAPDH = ;
  ADH = ;
  lpGlyc = ;
  time_ = ;
end

model hynne_2001__NAD(NAD, GAPDH, ADH, lpGlyc, time_)

  // Rate Rules:
  NAD' = (ADH + lpGlyc) - GAPDH;

  // Variable initializations:
  NAD = 0.65;
  GAPDH = ;
  ADH = ;
  lpGlyc = ;
  time_ = ;
end

model hynne_2001__inGlc(inGlc, Glc_x_0, Glc_x, k0)

  // Assignment Rules:
  inGlc := k0 * (Glc_x_0 - Glc_x);

  // Variable initializations:
  Glc_x_0 = ;
  Glc_x = ;
  k0 = ;
end

model hynne_2001__GlcTrans(GlcTrans, Glc_x, Glc, G6P, y_vol)

  // Assignment Rules:
  GlcTrans := (V_2m / y_vol) * ((Glc_x / K2_Glc) / (1.0 + Glc_x / K2_Glc + ((P2 * (Glc_x / K2_Glc) + 1.0) / (P2 * (Glc / K2_Glc) + 1.0)) * (1.0 + Glc / K2_Glc + G6P / K2_IG6P + (Glc * G6P) / (K2_Glc * K2_IIG6P)))) - (V_2m / y_vol) * ((Glc / K2_Glc) / (1.0 + Glc / K2_Glc + ((P2 * (Glc / K2_Glc) + 1.0) / (P2 * (Glc_x / K2_Glc) + 1.0)) * (1.0 + Glc_x / K2_Glc) + G6P / K2_IG6P + (Glc * G6P) / (K2_Glc * K2_IIG6P)));

  // Variable initializations:
  Glc_x = ;
  Glc = ;
  G6P = ;
  K2_Glc = 1.7;
  K2_IG6P = 1.2;
  K2_IIG6P = 7.2;
  V_2m = 1014.96;
  P2 = 1.0;
  y_vol = ;
end

model hynne_2001__HK(HK, Glc, ATP)

  // Assignment Rules:
  HK := (V_3m * ATP * Glc) / (K3_DGlc * K3_ATP + K3_Glc * ATP + K3_ATP * Glc + Glc * ATP);

  // Variable initializations:
  Glc = ;
  ATP = ;
  K3_DGlc = 0.37;
  K3_Glc = 0.0;
  K3_ATP = 0.1;
  V_3m = 51.7547;
end

model hynne_2001__PGI(PGI, G6P, F6P)

  // Assignment Rules:
  PGI := (V_4m * G6P) / (K4_G6P + G6P + (K4_G6P / K4_F6P) * F6P) - (V_4m * (F6P / K4_eq)) / (K4_G6P + G6P + (K4_G6P / K4_F6P) * F6P);

  // Variable initializations:
  G6P = ;
  F6P = ;
  V_4m = 496.042;
  K4_G6P = 0.8;
  K4_F6P = 0.15;
  K4_eq = 0.13;
end

model hynne_2001__PFK(PFK, F6P, ATP, AMP)

  // Assignment Rules:
  PFK := (V_5m * power(F6P, 2.0)) / (K5 * (1.0 + kappa5 * (ATP / AMP) * (ATP / AMP)) + power(F6P, 2.0));

  // Variable initializations:
  F6P = ;
  ATP = ;
  AMP = ;
  K5 = 0.021;
  kappa5 = 0.15;
  V_5m = 45.4327;
end

model hynne_2001__ALD(ALD, GAP, DHAP, FBP)

  // Assignment Rules:
  ALD := (V_6f * FBP) / (K6_FBP + FBP + (GAP * K6_DHAP * V_6f) / (K6_eq * V_6r) + (DHAP * K6_GAP * V_6f) / (K6_eq * V_6r) + (FBP * GAP) / K6_IGAP + (GAP * DHAP * V_6f) / (K6_eq * V_6r)) - (V_6f * ((GAP * DHAP) / K6_eq)) / (K6_FBP + FBP + (GAP * K6_DHAP * V_6f) / (K6_eq * V_6r) + (DHAP * K6_GAP * V_6f) / (K6_eq * V_6r) + (FBP * GAP) / K6_IGAP + (GAP * DHAP * V_6f) / (K6_eq * V_6r));

  // Variable initializations:
  GAP = ;
  DHAP = ;
  FBP = ;
  K6_eq = 0.081;
  K6_FBP = 0.3;
  K6_DHAP = 2.0;
  K6_GAP = 4.0;
  K6_IGAP = 10.0;
  V_6r = 1.10391E4;
  V_6f = 2.20782E3;
end

model hynne_2001__TIM(TIM, GAP, DHAP)

  // Assignment Rules:
  TIM := (V_7m * DHAP) / (K7_DHAP + DHAP + (K7_DHAP / K7_GAP) * GAP) - (V_7m * (GAP / K7_eq)) / (K7_DHAP + DHAP + (K7_DHAP / K7_GAP) * GAP);

  // Variable initializations:
  GAP = ;
  DHAP = ;
  K7_eq = 0.055;
  K7_DHAP = 1.23;
  K7_GAP = 1.27;
  V_7m = 1.16365E2;
end

model hynne_2001__GAPDH(GAPDH, GAP, NAD, NADH, BPG)

  // Assignment Rules:
  GAPDH := (V_8m * GAP * NAD) / (K8_GAP * K8_NAD * (1.0 + GAP / K8_GAP + BPG / K8_BPG) * (1.0 + NAD / K8_NAD + NADH / K8_NADH)) - (V_8m * ((BPG * NADH) / K8_eq)) / (K8_GAP * K8_NAD * (1.0 + GAP / K8_GAP + BPG / K8_BPG) * (1.0 + NAD / K8_NAD + NADH / K8_NADH));

  // Variable initializations:
  GAP = ;
  NAD = ;
  NADH = ;
  BPG = ;
  K8_NAD = 0.1;
  K8_NADH = 0.06;
  K8_GAP = 0.6;
  K8_BPG = 0.01;
  K8_eq = 0.0055;
  V_8m = 8.33858E2;
end

model hynne_2001__lpPEP(lpPEP, PEP, ADP, ATP, BPG)

  // Assignment Rules:
  lpPEP := k9f * BPG * ADP - k9r * PEP * ATP;

  // Variable initializations:
  PEP = ;
  ADP = ;
  ATP = ;
  BPG = ;
  k9f = 4.43866E5;
  k9r = 1.52862E3;
end

model hynne_2001__PK(PK, PEP, ADP)

  // Assignment Rules:
  PK := (V_10m * ADP * PEP) / ((K10_PEP + PEP) * (K10_ADP + ADP));

  // Variable initializations:
  PEP = ;
  ADP = ;
  K10_PEP = 0.2;
  K10_ADP = 0.17;
  V_10m = 3.43096E2;
end

model hynne_2001__PDC(PDC, Pyr)

  // Assignment Rules:
  PDC := (V_11m * Pyr) / (K11 + Pyr);

  // Variable initializations:
  Pyr = ;
  K11 = 0.3;
  V_11m = 5.31328E1;
end

model hynne_2001__ADH(ADH, NADH, ACA)

  // Assignment Rules:
  ADH := (V_12m * ACA * NADH) / ((K12_NADH + NADH) * (K12_ACA + ACA));

  // Variable initializations:
  NADH = ;
  ACA = ;
  K12_NADH = 0.1;
  K12_ACA = 0.71;
  V_12m = 8.98023E1;
end

model hynne_2001__outEtOH(outEtOH, EtOH_x, k0)

  // Assignment Rules:
  outEtOH := k0 * EtOH_x;

  // Variable initializations:
  EtOH_x = ;
  k0 = ;
end

model hynne_2001__difEtOH(difEtOH, EtOH_x, EtOH, y_vol)

  // Assignment Rules:
  difEtOH := (k13 / y_vol) * (EtOH - EtOH_x);

  // Variable initializations:
  k13 = 16.72;
  EtOH_x = ;
  EtOH = ;
  y_vol = ;
end

model hynne_2001__lpGlyc(lpGlyc, NAD, NADH, DHAP)

  // Assignment Rules:
  lpGlyc := (V_15m * DHAP) / (K15_DHAP * (1.0 + (K15_INADH / NADH) * (1.0 + NAD / K15_INAD)) + DHAP * (1.0 + (K15_NADH / NADH) * (1.0 + NAD / K15_INAD)));

  // Variable initializations:
  NAD = ;
  NADH = ;
  DHAP = ;
  K15_NADH = 0.13;
  K15_INADH = 0.034;
  K15_INAD = 0.13;
  K15_DHAP = 25.0;
  V_15m = 8.14797E1;
end

model hynne_2001__outGlyc(outGlyc, Glyc_x, k0)

  // Assignment Rules:
  outGlyc := k0 * Glyc_x;

  // Variable initializations:
  Glyc_x = ;
  k0 = ;
end

model hynne_2001__difGlyc(difGlyc, Glyc_x, Glyc, y_vol)

  // Assignment Rules:
  difGlyc := (k16 / y_vol) * (Glyc - Glyc_x);

  // Variable initializations:
  k16 = 1.9;
  Glyc_x = ;
  Glyc = ;
  y_vol = ;
end

model hynne_2001__outACA(outACA, ACA_x, k0)

  // Assignment Rules:
  outACA := k0 * ACA_x;

  // Variable initializations:
  ACA_x = ;
  k0 = ;
end

model hynne_2001__difACA(difACA, ACA, ACA_x, y_vol)

  // Assignment Rules:
  difACA := (k18 / y_vol) * (ACA - ACA_x);

  // Variable initializations:
  ACA = ;
  ACA_x = ;
  y_vol = ;
  k18 = 24.7;
end

model hynne_2001__lacto(lacto, ACA_x, CN_x)

  // Assignment Rules:
  lacto := k20 * ACA_x * CN_x;

  // Variable initializations:
  ACA_x = ;
  CN_x = ;
  k20 = 2.83828E-3;
end

model hynne_2001__inCN(inCN, CN_x_0, CN_x, k0)

  // Assignment Rules:
  inCN := k0 * (CN_x_0 - CN_x);

  // Variable initializations:
  CN_x_0 = ;
  CN_x = ;
  k0 = ;
end

model hynne_2001__storage(storage, ATP, G6P)

  // Assignment Rules:
  storage := k22 * ATP * G6P;

  // Variable initializations:
  ATP = ;
  G6P = ;
  k22 = 2.25932;
end

model hynne_2001__consum(consum, ATP)

  // Assignment Rules:
  consum := k23 * ATP;

  // Variable initializations:
  ATP = ;
  k23 = 3.20760;
end

model hynne_2001__AK(AK, ATP, ADP, AMP)

  // Assignment Rules:
  AK := k24f * AMP * ATP - k24r * power(ADP, 2.0);

  // Variable initializations:
  ATP = ;
  ADP = ;
  AMP = ;
  k24f = 4.32900E2;
  k24r = 1.33333E2;
end

model hynne_2001__model_parameters(y_vol, k0)

  // Variable initializations:
  y_vol = 59.0;
  k0 = 0.048;
end

model *hynne_2001____main()

  // Sub-modules, and any changes to those submodules:
  environment: hynne_2001__environment(time_);
  Glc_x_0: hynne_2001__Glc_x_0(Glc_x_00);
  Glc_x: hynne_2001__Glc_x(Glc_x0, GlcTrans0, inGlc0, time_);
  Glc: hynne_2001__Glc(Glc0, GlcTrans0, HK0, time_);
  G6P: hynne_2001__G6P(G6P0, PGI0, HK0, storage0, time_);
  F6P: hynne_2001__F6P(F6P0, PGI0, PFK0, time_);
  FBP: hynne_2001__FBP(FBP0, PFK0, ALD0, time_);
  GAP: hynne_2001__GAP(GAP0, GAPDH0, ALD0, TIM0, time_);
  DHAP: hynne_2001__DHAP(DHAP0, ALD0, TIM0, lpGlyc0, time_);
  BPG: hynne_2001__BPG(BPG0, lpPEP0, GAPDH0, time_);
  PEP: hynne_2001__PEP(PEP0, lpPEP0, PK0, time_);
  Pyr: hynne_2001__Pyr(Pyr0, PK0, PDC0, time_);
  ATP: hynne_2001__ATP(ATP0, HK0, lpPEP0, PFK0, PK0, storage0, consum0, AK0, time_);
  ADP: hynne_2001__ADP(ADP0, HK0, lpPEP0, PFK0, PK0, storage0, consum0, AK0, time_);
  AMP: hynne_2001__AMP(AMP0, AK0, time_);
  CN_x_0: hynne_2001__CN_x_0(CN_x_00);
  CN_x: hynne_2001__CN_x(CN_x0, lacto0, inCN0, time_);
  ACA: hynne_2001__ACA(ACA0, difACA0, PDC0, ADH0, time_);
  ACA_x: hynne_2001__ACA_x(ACA_x0, lacto0, difACA0, outACA0, time_);
  EtOH: hynne_2001__EtOH(EtOH0, difEtOH0, ADH0, time_);
  EtOH_x: hynne_2001__EtOH_x(EtOH_x0, difEtOH0, outEtOH0, time_);
  Glyc: hynne_2001__Glyc(Glyc0, difGlyc0, lpGlyc0, time_);
  Glyc_x: hynne_2001__Glyc_x(Glyc_x0, difGlyc0, outGlyc0, time_);
  NADH: hynne_2001__NADH(NADH0, GAPDH0, ADH0, lpGlyc0, time_);
  NAD: hynne_2001__NAD(NAD0, GAPDH0, ADH0, lpGlyc0, time_);
  inGlc: hynne_2001__inGlc(inGlc0, Glc_x_00, Glc_x0, k0);
  GlcTrans: hynne_2001__GlcTrans(GlcTrans0, Glc_x0, Glc0, G6P0, y_vol);
  HK: hynne_2001__HK(HK0, Glc0, ATP0);
  PGI: hynne_2001__PGI(PGI0, G6P0, F6P0);
  PFK: hynne_2001__PFK(PFK0, F6P0, ATP0, AMP0);
  ALD: hynne_2001__ALD(ALD0, GAP0, DHAP0, FBP0);
  TIM: hynne_2001__TIM(TIM0, GAP0, DHAP0);
  GAPDH: hynne_2001__GAPDH(GAPDH0, GAP0, NAD0, NADH0, BPG0);
  lpPEP: hynne_2001__lpPEP(lpPEP0, PEP0, ADP0, ATP0, BPG0);
  PK: hynne_2001__PK(PK0, PEP0, ADP0);
  PDC: hynne_2001__PDC(PDC0, Pyr0);
  ADH: hynne_2001__ADH(ADH0, NADH0, ACA0);
  outEtOH: hynne_2001__outEtOH(outEtOH0, EtOH_x0, k0);
  difEtOH: hynne_2001__difEtOH(difEtOH0, EtOH_x0, EtOH0, y_vol);
  lpGlyc: hynne_2001__lpGlyc(lpGlyc0, NAD0, NADH0, DHAP0);
  outGlyc: hynne_2001__outGlyc(outGlyc0, Glyc_x0, k0);
  difGlyc: hynne_2001__difGlyc(difGlyc0, Glyc_x0, Glyc0, y_vol);
  outACA: hynne_2001__outACA(outACA0, ACA_x0, k0);
  difACA: hynne_2001__difACA(difACA0, ACA0, ACA_x0, y_vol);
  lacto: hynne_2001__lacto(lacto0, ACA_x0, CN_x0);
  inCN: hynne_2001__inCN(inCN0, CN_x_00, CN_x0, k0);
  storage: hynne_2001__storage(storage0, ATP0, G6P0);
  consum: hynne_2001__consum(consum0, ATP0);
  AK: hynne_2001__AK(AK0, ATP0, ADP0, AMP0);
  model_parameters: hynne_2001__model_parameters(y_vol, k0);
end