//Created by libAntimony v2.4 model houart_1999__environment(time_) // Variable initializations: time_ = ; end model houart_1999__Vin(beta, V_in) // Assignment Rules: V_in := V_0 + V_1 * beta; // Variable initializations: V_0 = 2; V_1 = 2; beta = 0.6; end model houart_1999__V2(Z, V_2) // Assignment Rules: V_2 := (V_M2 * power(Z, 2)) / (power(K_2, 2) + power(Z, 2)); // Variable initializations: V_M2 = 6; Z = ; K_2 = 0.1; end model houart_1999__V3(Y, A, Z, V_3) // Assignment Rules: V_3 := (((((V_M3 * power(Z, m)) / (power(K_Z, m) + power(Z, m))) * power(Y, 2)) / (power(K_Y, 2) + power(Y, 2))) * power(A, 4)) / (power(K_A, 4) + power(A, 4)); // Variable initializations: V_M3 = 20; K_Z = 0.5; K_A = 0.2; K_Y = 0.2; m = 2; Y = ; A = ; Z = ; end model houart_1999__V5(A, Z, V_5) // Assignment Rules: V_5 := (((V_M5 * power(A, p)) / (power(K_5, p) + power(A, p))) * power(Z, n)) / (power(K_d, n) + power(Z, n)); // Variable initializations: V_M5 = 5; K_5 = 1; K_d = 0.4; p = 2; n = 4; A = ; Z = ; end model houart_1999__cytosol(time_, V_in, V_2, V_3, k_f, Z, Y) // Rate Rules: Z' = ((V_in - V_2) + V_3 + k_f * Y) - k * Z; // Variable initializations: time_ = ; V_in = ; V_2 = ; V_3 = ; k = 10; k_f = 1; Z = 0.15; Y = ; end model houart_1999__internal_pool(time_, V_2, V_3, k_f, Y) // Rate Rules: Y' = (V_2 - V_3) - k_f * Y; // Variable initializations: time_ = ; V_2 = ; V_3 = ; k_f = ; Y = 1; end model houart_1999__InsP3_conc(time_, beta, V_5, A) // Rate Rules: A' = (beta * V_4 - V_5) - epsilon * A; // Variable initializations: time_ = ; beta = ; epsilon = 0.1; V_4 = 2; V_5 = ; A = 0.42; end model *houart_1999____main() // Sub-modules, and any changes to those submodules: environment: houart_1999__environment(time_); Vin: houart_1999__Vin(beta, V_in); V2: houart_1999__V2(Z, V_2); V3: houart_1999__V3(Y, A, Z, V_3); V5: houart_1999__V5(A, Z, V_5); cytosol: houart_1999__cytosol(time_, V_in, V_2, V_3, k_f, Z, Y); internal_pool: houart_1999__internal_pool(time_, V_2, V_3, k_f, Y); InsP3_conc: houart_1999__InsP3_conc(time_, beta, V_5, A); end