//Created by libAntimony v2.4 model circulatory_dynamics_CellML1_0_model__environment(time_) // Variable initializations: time_ = ; end model circulatory_dynamics_CellML1_0_model__parameter_values(HTAUML, QRF, HSR, HSL, ANY, CV, PR1LL, RVSM, CN2, CN7, PAEX, RAR, RMULT1, RAM, FIS) // Variable initializations: HTAUML = 0.4; QRF = 0.15; HSR = 1; HSL = 1; ANY = -0.2; CV = 0.1; PR1LL = 0; RVSM = 1; CN2 = 0.0212; CN7 = 0.2; PAEX = 2; RAR = 30.52; RMULT1 = 1; RAM = 96.3; FIS = 0; end model circulatory_dynamics_CellML1_0_model__total_blood_volume_change(VP, VRC, VVS1, VAS1, VLA1, VPA1, VRA1, VBD) // Assignment Rules: VBD := ((((((VP + VRC) - VVS1) - VAS1) - VLA1) - VPA1) - VRA1) / 2; // Variable initializations: VP = ; VRC = ; VVS1 = ; VAS1 = ; VLA1 = ; VPA1 = ; VRA1 = ; end model circulatory_dynamics_CellML1_0_model__right_atrium() end model circulatory_dynamics_CellML1_0_model__right_atrial_blood_volume(QVO, QRO, VBD, time_, VRA, VRA1) // Assignment Rules: VRA := VRA1 + VBD * 0.0574; DRA := QVO - QRO; // Rate Rules: VRA1' = DRA; // Variable initializations: QVO = ; QRO = ; VBD = ; time_ = ; VRA1 = 0.100043; end model circulatory_dynamics_CellML1_0_model__right_atrial_pressure(VRA, PRA) // Assignment Rules: PRA := VRE / 0.005; VRE := VRA - 0.1; // Variable initializations: VRA = ; end model circulatory_dynamics_CellML1_0_model__autonomic_stimulation_effect_on_right_atrial_pressure(PRA, AU, PRA1, HTAUML) // Assignment Rules: PRA1 := (PRA + 8) * (HTAUML * (AU - 1) + 1) - 8; // Variable initializations: PRA = ; AU = ; HTAUML = ; end model circulatory_dynamics_CellML1_0_model__right_ventricle() end model circulatory_dynamics_CellML1_0_model__pressure_effect_on_right_ventricular_pumping(PPA, AUH, OSA, RVM) // Assignment Rules: RVM := piecewise( 1.06 , PP2 <= 0 , 1.06 + ((0.97 - 1.06) * (PP2 - 0)) / (32 - 0) , ( PP2 > 0) && (PP2 <= 32 ), 0.97 + ((0.93 - 0.97) * (PP2 - 32)) / (38.4 - 32) , ( PP2 > 32) && (PP2 <= 38.4 ), 0.93 + ((0.8 - 0.93) * (PP2 - 38.4)) / (48 - 38.4) , ( PP2 > 38.4) && (PP2 <= 48 ), 0.8 + ((0.46 - 0.8) * (PP2 - 48)) / (60.8 - 48) , ( PP2 > 48) && (PP2 <= 60.8 ), 0.46 + ((0 - 0.46) * (PP2 - 60.8)) / (72 - 60.8) , ( PP2 > 60.8) && (PP2 <= 72 ), 0 ); PP2 := (PPA / AUH) / OSA; // Variable initializations: PPA = ; AUH = ; OSA = ; end model circulatory_dynamics_CellML1_0_model__pumping_effectiveness_of_right_ventricle(AUH, RVM, HMD, HPR, QLO, QLN, HPEF, QRF, HSR) // Assignment Rules: HPEF := (1 - QRF) * AUH * RVM * HSR * HMD * HPR + (QRF * QLO) / QLN; // Variable initializations: AUH = ; RVM = ; HMD = ; HPR = ; QLO = ; QLN = ; QRF = ; HSR = ; end model circulatory_dynamics_CellML1_0_model__right_ventricular_output(PRA1, HPEF, QRO) // Assignment Rules: QRO := QRN * HPEF; QRN := piecewise( 0 , PRA1 <= -(8) , 0 + ((0.75 - 0) * (PRA1 - -(8))) / (-(6) - -(8)) , ( PRA1 > -(8)) && (PRA1 <= -(6) ), 0.75 + ((2.6 - 0.75) * (PRA1 - -(6))) / (-(2) - -(6)) , ( PRA1 > -(6)) && (PRA1 <= -(2) ), 2.6 + ((9.8 - 2.6) * (PRA1 - -(2))) / (4 - -(2)) , ( PRA1 > -(2)) && (PRA1 <= 4 ), 9.8 + ((13.5 - 9.8) * (PRA1 - 4)) / (12 - 4) , ( PRA1 > 4) && (PRA1 <= 12 ), 13.5 ); // Variable initializations: PRA1 = ; HPEF = ; end model circulatory_dynamics_CellML1_0_model__pulmonary_vasculature() end model circulatory_dynamics_CellML1_0_model__pulmonary_vasculature_blood_volume(QRO, QPO, VBD, time_, VPA, VPA1) // Assignment Rules: VPA := VPA1 + VBD * 0.155; DPA := QRO - QPO; // Rate Rules: VPA1' = DPA; // Variable initializations: QRO = ; QPO = ; VBD = ; time_ = ; VPA1 = 0.38131; end model circulatory_dynamics_CellML1_0_model__pulmonary_vasculature_pressure(VPA, PPA) // Assignment Rules: PPA := VPE / 0.0048; VPE := VPA - 0.30625; // Variable initializations: VPA = ; end model circulatory_dynamics_CellML1_0_model__pulmonary_arterial_resistance(PPA, RPA) // Assignment Rules: RPA := 1 / CPA; PP1T := 0.026 * PPA; PP1 := piecewise( 0.00001 , PP1T < 0.00001 , PP1T ); CPA := power(PP1, 0.5); // Variable initializations: PPA = ; end model circulatory_dynamics_CellML1_0_model__pulmonary_venous_resistance(PLA, RPV) // Assignment Rules: RPV := 1 / (PL1 * 0.0357); PL1 := PLA + 18; // Variable initializations: PLA = ; end model circulatory_dynamics_CellML1_0_model__total_pulmonary_vascular_resistance(RPV, RPA, RPT) // Assignment Rules: RPT := RPV + RPA; // Variable initializations: RPV = ; RPA = ; end model circulatory_dynamics_CellML1_0_model__pressure_gradient_through_the_lungs(PPA, PLA, PGL) // Assignment Rules: PGL := PPA - PLA; // Variable initializations: PPA = ; PLA = ; end model circulatory_dynamics_CellML1_0_model__rate_of_blood_flow_from_pulmonary_veins_to_left_atrium(PGL, RPT, QLO, QPO) // Assignment Rules: QPO := PGL / RPT; // Variable initializations: PGL = ; RPT = ; QLO = ; end model circulatory_dynamics_CellML1_0_model__left_atrium() end model circulatory_dynamics_CellML1_0_model__left_atrial_blood_volume(QPO, QLO, VBD, time_, VLA, VLA1) // Assignment Rules: VLA := VLA1 + VBD * 0.128; DLA := QPO - QLO; // Rate Rules: VLA1' = DLA; // Variable initializations: QPO = ; QLO = ; VBD = ; time_ = ; VLA1 = 0.379883; end model circulatory_dynamics_CellML1_0_model__left_atrial_pressure(VLA, PLA) // Assignment Rules: PLA := VLE / 0.01; VLE := VLA - 0.38; // Variable initializations: VLA = ; end model circulatory_dynamics_CellML1_0_model__autonomic_stimulation_effect_on_left_atrial_pressure(PLA, AU, PLA1, HTAUML) // Assignment Rules: PLA1 := (PLA + 4) * (HTAUML * (AU - 1) + 1) - 4; // Variable initializations: PLA = ; AU = ; HTAUML = ; end model circulatory_dynamics_CellML1_0_model__left_ventricle() end model circulatory_dynamics_CellML1_0_model__pumping_effectiveness_of_left_ventricle(PA, AUH, OSA, LVM) // Assignment Rules: LVM := piecewise( 1.04 , PA2 <= 0 , 1.04 + ((1.025 - 1.04) * (PA2 - 0)) / (60 - 0) , ( PA2 > 0) && (PA2 <= 60 ), 1.025 + ((0.97 - 1.025) * (PA2 - 60)) / (125 - 60) , ( PA2 > 60) && (PA2 <= 125 ), 0.97 + ((0.88 - 0.97) * (PA2 - 125)) / (160 - 125) , ( PA2 > 125) && (PA2 <= 160 ), 0.88 + ((0.59 - 0.88) * (PA2 - 160)) / (200 - 160) , ( PA2 > 160) && (PA2 <= 200 ), 0.59 + ((0 - 0.59) * (PA2 - 200)) / (240 - 200) , ( PA2 > 200) && (PA2 <= 240 ), 0 ); PA2 := PA / (AUH * OSA); // Variable initializations: PA = ; AUH = ; OSA = ; end model circulatory_dynamics_CellML1_0_model__left_ventricular_output(PLA1, LVM, AUH, HMD, HPL, PLA, PA, QLO, QLOT, QLN, HSL) // Assignment Rules: QLO := piecewise( QLOT + QLO1 , QLO1 > 0 , QLOT ); QLOT := LVM * QLN * AUH * HSL * HMD * HPL; QLN := piecewise( 0.01 , PLA1 <= -(2) , 0.01 + ((3.6 - 0.01) * (PLA1 - -(2))) / (1 - -(2)) , ( PLA1 > -(2)) && (PLA1 <= 1 ), 3.6 + ((9.4 - 3.6) * (PLA1 - 1)) / (5 - 1) , ( PLA1 > 1) && (PLA1 <= 5 ), 9.4 + ((11.6 - 9.4) * (PLA1 - 5)) / (8 - 5) , ( PLA1 > 5) && (PLA1 <= 8 ), 11.6 + ((13.5 - 11.6) * (PLA1 - 8)) / (12 - 8) , ( PLA1 > 8) && (PLA1 <= 12 ), 13.5 ); QLO1 := (PLA - PA) / 3; // Variable initializations: PLA1 = ; LVM = ; AUH = ; HMD = ; HPL = ; PLA = ; PA = ; HSL = ; end model circulatory_dynamics_CellML1_0_model__systemic_venous_system() end model circulatory_dynamics_CellML1_0_model__venous_blood_volume(QAO, QVO, VBD, time_, VVS, VVS1) // Assignment Rules: VVS := VVS1 + VBD * 0.3986; DVS := QAO - QVO; // Rate Rules: VVS1' = DVS; // Variable initializations: QAO = ; QVO = ; VBD = ; time_ = ; VVS1 = 3.28246; end model circulatory_dynamics_CellML1_0_model__angiotensin_induced_venous_constriction(ANU, VVA, ANY) // Assignment Rules: VVA := (ANU - 1) * ANY; // Variable initializations: ANU = ; ANY = ; end model circulatory_dynamics_CellML1_0_model__venous_excess_volume(VVS, VVR, VVA, VV6, VV7, ATRVFB, VVE) // Assignment Rules: VVE := piecewise( 0.0001 , VVE1 < 0.0001 , VVE1 ); VVE1 := ((((VVS - VVR) - VVA) - VV7) - VV6) - ATRVFB; // Variable initializations: VVS = ; VVR = ; VVA = ; VV6 = ; VV7 = ; ATRVFB = ; end model circulatory_dynamics_CellML1_0_model__venous_average_pressure(VVE, PVS, CV) // Assignment Rules: PVS := piecewise( 0.0001 , PVS1 < 0.0001 , PVS1 ); PVS1 := 3.7 + (VVE - 0.74) / CV; // Variable initializations: VVE = ; CV = ; end model circulatory_dynamics_CellML1_0_model__venous_outflow_pressure_into_heart(PRA, PR1, PR1LL) // Assignment Rules: PR1 := piecewise( PR1LL , PRA < PR1LL , PRA ); // Variable initializations: PRA = ; PR1LL = ; end model circulatory_dynamics_CellML1_0_model__resistance_from_veins_to_right_atrium(PVS, VIM, RVG) // Assignment Rules: RVG := 0.74 / power(PVS / (VIM * 3.7), 0.5); // Variable initializations: PVS = ; VIM = ; end model circulatory_dynamics_CellML1_0_model__rate_of_blood_flow_from_veins_to_right_atrium(PVS, PR1, RVG, QRO, QVO) // Assignment Rules: QVO := PGV / RVG; PGV := PVS - PR1; // Variable initializations: PVS = ; PR1 = ; RVG = ; QRO = ; end model circulatory_dynamics_CellML1_0_model__venous_resistance(PC, VIM, AVE, ANUVN, RVS, CN7, CN2, RVSM) // Assignment Rules: RVS := AVE * RV1 * VIM * ANUVN; CN3 := ((PC - 17) * CN7 + 17) * CN2; RV1 := RVSM / CN3; // Variable initializations: PC = ; VIM = ; AVE = ; ANUVN = ; CN7 = ; CN2 = ; RVSM = ; end model circulatory_dynamics_CellML1_0_model__NM_NR_venous_resistance(RVS, NNRVR) // Assignment Rules: NNRVR := RVS * 1.79; // Variable initializations: RVS = ; end model circulatory_dynamics_CellML1_0_model__systemic_arterial_system() end model circulatory_dynamics_CellML1_0_model__arterial_blood_volume(QLO, QAO, VBD, time_, VAS, VAS1) // Assignment Rules: VAS := VAS1 + VBD * 0.261; DAS := QLO - QAO; // Rate Rules: VAS1' = DAS; // Variable initializations: QLO = ; QAO = ; VBD = ; time_ = ; VAS1 = 0.862514; end model circulatory_dynamics_CellML1_0_model__arterial_pressure_and_pressure_gradient(VAS, PRA, PA, PAG) // Assignment Rules: PA := VAE / 0.00355; PAG := PA - PRA; VAE := VAS - 0.495; // Variable initializations: VAS = ; PRA = ; end model circulatory_dynamics_CellML1_0_model__pressure_effect_on_arterial_distention(PA, PAM, PAEX) // Assignment Rules: PAM := power(PA / 100, PAEX); // Variable initializations: PA = ; PAEX = ; end model circulatory_dynamics_CellML1_0_model__non_renal_systemic_arterial_resistance_multiplier(ANU, ADHMV, AUM, VIM, PAMK, PAM, ATRRFB, R1) // Assignment Rules: R1 := ((ANU * ADHMV * AUM * VIM * PAMK) / PAM) / ATRRFB; // Variable initializations: ANU = ; ADHMV = ; AUM = ; VIM = ; PAMK = ; PAM = ; ATRRFB = ; end model circulatory_dynamics_CellML1_0_model__NM_NR_arterial_resistance(R1, ARM, MYOGRS, NNRAR, RAR, RMULT1) // Assignment Rules: NNRAR := RAR * ARM * R1 * MYOGRS * RMULT1; // Variable initializations: R1 = ; ARM = ; MYOGRS = ; RAR = ; RMULT1 = ; end model circulatory_dynamics_CellML1_0_model__pressure_gradient_from_arteries_to_veins(PA, PVS, PGS) // Assignment Rules: PGS := PA - PVS; // Variable initializations: PA = ; PVS = ; end model circulatory_dynamics_CellML1_0_model__M_systemic_resistance(R1, AMM, MYOGRS, RSM, RAM, RMULT1) // Assignment Rules: RSM := RAM * AMM * R1 * MYOGRS * RMULT1; // Variable initializations: R1 = ; AMM = ; MYOGRS = ; RAM = ; RMULT1 = ; end model circulatory_dynamics_CellML1_0_model__total_NM_NR_systemic_resistance(NNRAR, NNRVR, RSN) // Assignment Rules: RSN := NNRAR + NNRVR; // Variable initializations: NNRAR = ; NNRVR = ; end model circulatory_dynamics_CellML1_0_model__blood_flow_through_M_tissues(PGS, RSM, BFM) // Assignment Rules: BFM := PGS / RSM; // Variable initializations: PGS = ; RSM = ; end model circulatory_dynamics_CellML1_0_model__blood_flow_through_NM_NR_tissues(PGS, RSN, BFN) // Assignment Rules: BFN := PGS / RSN; // Variable initializations: PGS = ; RSN = ; end model circulatory_dynamics_CellML1_0_model__blood_flow_through_AV_fistulas(PAG, FISFLO, FIS) // Assignment Rules: FISFLO := PAG * FIS; // Variable initializations: PAG = ; FIS = ; end model circulatory_dynamics_CellML1_0_model__systemic_blood_flow(BFM, BFN, RBF, FISFLO, SYSFLO, QAO) // Assignment Rules: SYSFLO := BFM + BFN + RBF; QAO := SYSFLO + FISFLO; // Variable initializations: BFM = ; BFN = ; RBF = ; FISFLO = ; end model circulatory_dynamics_CellML1_0_model__total_peripheral_resistance(PAG, QAO, RTP) // Assignment Rules: RTP := PAG / QAO; // Variable initializations: PAG = ; QAO = ; end model circulatory_dynamics_CellML1_0_model__circulatory_dynamics(time_, ADHMV, AMM, ANU, ANUVN, ARM, ATRRFB, ATRVFB, AU, AUH, AUM, AVE, HMD, HPL, HPR, MYOGRS, OSA, PAMK, PC, RBF, VIM, VP, VRC, VV6, VV7, VVR) // Sub-modules, and any changes to those submodules: parameter_values: circulatory_dynamics_CellML1_0_model__parameter_values(HTAUML, QRF, HSR, HSL, ANY, CV, PR1LL, RVSM, CN2, CN7, PAEX, RAR, RMULT1, RAM, FIS); total_blood_volume_change: circulatory_dynamics_CellML1_0_model__total_blood_volume_change(VP, VRC, VVS1, VAS1, VLA1, VPA1, VRA1, VBD); right_atrium: circulatory_dynamics_CellML1_0_model__right_atrium(); right_atrial_blood_volume: circulatory_dynamics_CellML1_0_model__right_atrial_blood_volume(QVO, QRO, VBD, time_, VRA, VRA1); right_atrial_pressure: circulatory_dynamics_CellML1_0_model__right_atrial_pressure(VRA, PRA); autonomic_stimulation_effect_on_right_atrial_pressure: circulatory_dynamics_CellML1_0_model__autonomic_stimulation_effect_on_right_atrial_pressure(PRA, AU, PRA1, HTAUML); right_ventricle: circulatory_dynamics_CellML1_0_model__right_ventricle(); pressure_effect_on_right_ventricular_pumping: circulatory_dynamics_CellML1_0_model__pressure_effect_on_right_ventricular_pumping(PPA, AUH, OSA, RVM); pumping_effectiveness_of_right_ventricle: circulatory_dynamics_CellML1_0_model__pumping_effectiveness_of_right_ventricle(AUH, RVM, HMD, HPR, QLO, QLN, HPEF, QRF, HSR); right_ventricular_output: circulatory_dynamics_CellML1_0_model__right_ventricular_output(PRA1, HPEF, QRO); pulmonary_vasculature: circulatory_dynamics_CellML1_0_model__pulmonary_vasculature(); pulmonary_vasculature_blood_volume: circulatory_dynamics_CellML1_0_model__pulmonary_vasculature_blood_volume(QRO, QPO, VBD, time_, VPA, VPA1); pulmonary_vasculature_pressure: circulatory_dynamics_CellML1_0_model__pulmonary_vasculature_pressure(VPA, PPA); pulmonary_arterial_resistance: circulatory_dynamics_CellML1_0_model__pulmonary_arterial_resistance(PPA, RPA); pulmonary_venous_resistance: circulatory_dynamics_CellML1_0_model__pulmonary_venous_resistance(PLA, RPV); total_pulmonary_vascular_resistance: circulatory_dynamics_CellML1_0_model__total_pulmonary_vascular_resistance(RPV, RPA, RPT); pressure_gradient_through_the_lungs: circulatory_dynamics_CellML1_0_model__pressure_gradient_through_the_lungs(PPA, PLA, PGL); rate_of_blood_flow_from_pulmonary_veins_to_left_atrium: circulatory_dynamics_CellML1_0_model__rate_of_blood_flow_from_pulmonary_veins_to_left_atrium(PGL, RPT, QLO, QPO); left_atrium: circulatory_dynamics_CellML1_0_model__left_atrium(); left_atrial_blood_volume: circulatory_dynamics_CellML1_0_model__left_atrial_blood_volume(QPO, QLO, VBD, time_, VLA, VLA1); left_atrial_pressure: circulatory_dynamics_CellML1_0_model__left_atrial_pressure(VLA, PLA); autonomic_stimulation_effect_on_left_atrial_pressure: circulatory_dynamics_CellML1_0_model__autonomic_stimulation_effect_on_left_atrial_pressure(PLA, AU, PLA1, HTAUML); left_ventricle: circulatory_dynamics_CellML1_0_model__left_ventricle(); pumping_effectiveness_of_left_ventricle: circulatory_dynamics_CellML1_0_model__pumping_effectiveness_of_left_ventricle(PA, AUH, OSA, LVM); left_ventricular_output: circulatory_dynamics_CellML1_0_model__left_ventricular_output(PLA1, LVM, AUH, HMD, HPL, PLA, PA, QLO, QLOT, QLN, HSL); systemic_venous_system: circulatory_dynamics_CellML1_0_model__systemic_venous_system(); venous_blood_volume: circulatory_dynamics_CellML1_0_model__venous_blood_volume(QAO, QVO, VBD, time_, VVS, VVS1); angiotensin_induced_venous_constriction: circulatory_dynamics_CellML1_0_model__angiotensin_induced_venous_constriction(ANU, VVA, ANY); venous_excess_volume: circulatory_dynamics_CellML1_0_model__venous_excess_volume(VVS, VVR, VVA, VV6, VV7, ATRVFB, VVE); venous_average_pressure: circulatory_dynamics_CellML1_0_model__venous_average_pressure(VVE, PVS, CV); venous_outflow_pressure_into_heart: circulatory_dynamics_CellML1_0_model__venous_outflow_pressure_into_heart(PRA, PR1, PR1LL); resistance_from_veins_to_right_atrium: circulatory_dynamics_CellML1_0_model__resistance_from_veins_to_right_atrium(PVS, VIM, RVG); rate_of_blood_flow_from_veins_to_right_atrium: circulatory_dynamics_CellML1_0_model__rate_of_blood_flow_from_veins_to_right_atrium(PVS, PR1, RVG, QRO, QVO); venous_resistance: circulatory_dynamics_CellML1_0_model__venous_resistance(PC, VIM, AVE, ANUVN, RVS, CN7, CN2, RVSM); NM_NR_venous_resistance: circulatory_dynamics_CellML1_0_model__NM_NR_venous_resistance(RVS, NNRVR); systemic_arterial_system: circulatory_dynamics_CellML1_0_model__systemic_arterial_system(); arterial_blood_volume: circulatory_dynamics_CellML1_0_model__arterial_blood_volume(QLO, QAO, VBD, time_, VAS, VAS1); arterial_pressure_and_pressure_gradient: circulatory_dynamics_CellML1_0_model__arterial_pressure_and_pressure_gradient(VAS, PRA, PA, PAG); pressure_effect_on_arterial_distention: circulatory_dynamics_CellML1_0_model__pressure_effect_on_arterial_distention(PA, PAM, PAEX); non_renal_systemic_arterial_resistance_multiplier: circulatory_dynamics_CellML1_0_model__non_renal_systemic_arterial_resistance_multiplier(ANU, ADHMV, AUM, VIM, PAMK, PAM, ATRRFB, R1); NM_NR_arterial_resistance: circulatory_dynamics_CellML1_0_model__NM_NR_arterial_resistance(R1, ARM, MYOGRS, NNRAR, RAR, RMULT1); pressure_gradient_from_arteries_to_veins: circulatory_dynamics_CellML1_0_model__pressure_gradient_from_arteries_to_veins(PA, PVS, PGS); M_systemic_resistance: circulatory_dynamics_CellML1_0_model__M_systemic_resistance(R1, AMM, MYOGRS, RSM, RAM, RMULT1); total_NM_NR_systemic_resistance: circulatory_dynamics_CellML1_0_model__total_NM_NR_systemic_resistance(NNRAR, NNRVR, RSN); blood_flow_through_M_tissues: circulatory_dynamics_CellML1_0_model__blood_flow_through_M_tissues(PGS, RSM, BFM); blood_flow_through_NM_NR_tissues: circulatory_dynamics_CellML1_0_model__blood_flow_through_NM_NR_tissues(PGS, RSN, BFN); blood_flow_through_AV_fistulas: circulatory_dynamics_CellML1_0_model__blood_flow_through_AV_fistulas(PAG, FISFLO, FIS); systemic_blood_flow: circulatory_dynamics_CellML1_0_model__systemic_blood_flow(BFM, BFN, RBF, FISFLO, SYSFLO, QAO); total_peripheral_resistance: circulatory_dynamics_CellML1_0_model__total_peripheral_resistance(PAG, QAO, RTP); // Variable initializations: ADHMV = 1.0; AMM = 1.0; ANU = 0.925271; ANUVN = 1.0; ARM = 1.16463; ATRRFB = 1.0; ATRVFB = 0.0; AU = 1.00022; AUH = 1.00012; AUM = 1.00066; AVE = 1.0; HMD = 1.0; HPL = 1.00163; HPR = 1.00237; MYOGRS = 1.0; OSA = 0.97287; PAMK = 1.0; PC = 16.9144; RBF = 1.22057; VIM = 1.00076; VP = 3.00449; VRC = 2.00439; VV6 = 0.0101913; VV7 = 0.00366525; VVR = 2.50967; end model *circulatory_dynamics_CellML1_0_model____main() // Sub-modules, and any changes to those submodules: environment: circulatory_dynamics_CellML1_0_model__environment(time_); circulatory_dynamics: circulatory_dynamics_CellML1_0_model__circulatory_dynamics(time_, ADHMV, AMM, ANU, ANUVN, ARM, ATRRFB, ATRVFB, AU, AUH, AUM, AVE, HMD, HPL, HPR, MYOGRS, OSA, PAMK, PC, RBF, VIM, VP, VRC, VV6, VV7, VVR); end