//Created by libAntimony v2.4 model fujita_2010__environment(time_) // Variable initializations: time_ = ; end model fujita_2010__EGF(EGF) // Variable initializations: EGF = 30.0; end model fujita_2010__pro_EGFR(pro_EGFR) // Variable initializations: pro_EGFR = 6.81902e4; end model fujita_2010__EGFR(EGFR, EGF_EGFR, EGF, pro_EGFR, k2_EGF_EGFR, k1_EGF_EGFR, EGFR_turnover, time_) // Rate Rules: EGFR' = (k2_EGF_EGFR * EGF_EGFR + EGFR_turnover * (pro_EGFR - EGFR)) - k1_EGF_EGFR * EGF * EGFR; // Variable initializations: EGFR = 6.81902e4; EGF_EGFR = ; EGF = ; pro_EGFR = ; k2_EGF_EGFR = ; k1_EGF_EGFR = ; EGFR_turnover = ; time_ = ; end model fujita_2010__EGF_EGFR(EGF_EGFR, EGFR, EGF, k2_EGF_EGFR, k1_EGF_EGFR, k1_EGFR_phosphorylation, time_) // Rate Rules: EGF_EGFR' = k1_EGF_EGFR * EGF * EGFR - (k2_EGF_EGFR * EGF_EGFR + k1_EGFR_phosphorylation * EGF_EGFR); // Variable initializations: EGF_EGFR = 0.0; EGFR = ; EGF = ; k2_EGF_EGFR = ; k1_EGF_EGFR = ; k1_EGFR_phosphorylation = ; time_ = ; end model fujita_2010__pEGFR(pEGFR, EGF_EGFR, pEGFR_Akt, Akt, k1_pEGFR_degradation, k1_Akt_phosphorylation, k1_EGFR_phosphorylation, k1_pEGFR_Akt, k2_pEGFR_Akt, time_) // Rate Rules: pEGFR' = (k1_EGFR_phosphorylation * EGF_EGFR + k1_Akt_phosphorylation * pEGFR_Akt + k2_pEGFR_Akt * pEGFR_Akt) - (k1_pEGFR_degradation * pEGFR + k1_pEGFR_Akt * pEGFR * Akt); // Variable initializations: pEGFR = 0.0; EGF_EGFR = ; pEGFR_Akt = ; Akt = ; k1_pEGFR_degradation = ; k1_Akt_phosphorylation = ; k1_EGFR_phosphorylation = ; k1_pEGFR_Akt = ; k2_pEGFR_Akt = ; time_ = ; end model fujita_2010__pEGFR_Akt(pEGFR_Akt, pEGFR, Akt, k1_Akt_phosphorylation, k1_pEGFR_Akt, k2_pEGFR_Akt, time_) // Rate Rules: pEGFR_Akt' = k1_pEGFR_Akt * pEGFR * Akt - (k2_pEGFR_Akt * pEGFR_Akt + k1_Akt_phosphorylation * pEGFR_Akt); // Variable initializations: pEGFR_Akt = 0.0; pEGFR = ; Akt = ; k1_Akt_phosphorylation = ; k1_pEGFR_Akt = ; k2_pEGFR_Akt = ; time_ = ; end model fujita_2010__Akt(Akt, pEGFR, pEGFR_Akt, pAkt, k1_pAkt_dephosphorylation, k1_pEGFR_Akt, k2_pEGFR_Akt, time_) // Rate Rules: Akt' = (k2_pEGFR_Akt * pEGFR_Akt + k1_pAkt_dephosphorylation * pAkt) - k1_pEGFR_Akt * pEGFR * Akt; // Variable initializations: Akt = 4.33090e-2; pEGFR = ; pEGFR_Akt = ; pAkt = ; k1_pAkt_dephosphorylation = ; k1_pEGFR_Akt = ; k2_pEGFR_Akt = ; time_ = ; end model fujita_2010__pAkt(pAkt, S6, pEGFR_Akt, pAkt_S6, k1_Akt_phosphorylation, k1_pAkt_S6, k2_pAkt_S6, k1_S6_phosphorylation, k1_pAkt_dephosphorylation, time_) // Rate Rules: pAkt' = (k1_Akt_phosphorylation * pEGFR_Akt + k2_pAkt_S6 * pAkt_S6 + k1_S6_phosphorylation * pAkt_S6) - (k1_pAkt_dephosphorylation * pAkt + k1_pAkt_S6 * pAkt * S6); // Variable initializations: pAkt = 0.0; S6 = ; pEGFR_Akt = ; pAkt_S6 = ; k1_Akt_phosphorylation = ; k1_pAkt_S6 = ; k2_pAkt_S6 = ; k1_S6_phosphorylation = ; k1_pAkt_dephosphorylation = ; time_ = ; end model fujita_2010__pAkt_S6(pAkt_S6, S6, pAkt, k1_pAkt_S6, k2_pAkt_S6, k1_S6_phosphorylation, time_) // Rate Rules: pAkt_S6' = k1_pAkt_S6 * pAkt * S6 - (k2_pAkt_S6 * pAkt_S6 + k1_S6_phosphorylation * pAkt_S6); // Variable initializations: pAkt_S6 = 0.0; S6 = ; pAkt = ; k1_pAkt_S6 = ; k2_pAkt_S6 = ; k1_S6_phosphorylation = ; time_ = ; end model fujita_2010__S6(S6, pAkt_S6, pS6, pAkt, k1_pAkt_S6, k2_pAkt_S6, k1_pS6_dephosphorylation, time_) // Rate Rules: S6' = (k2_pAkt_S6 * pAkt_S6 + k1_pS6_dephosphorylation * pS6) - k1_pAkt_S6 * pAkt * S6; // Variable initializations: S6 = 3.54317e0; pAkt_S6 = ; pS6 = ; pAkt = ; k1_pAkt_S6 = ; k2_pAkt_S6 = ; k1_pS6_dephosphorylation = ; time_ = ; end model fujita_2010__pS6(pS6, pAkt_S6, k1_S6_phosphorylation, k1_pS6_dephosphorylation, time_) // Rate Rules: pS6' = k1_S6_phosphorylation * pAkt_S6 - k1_pS6_dephosphorylation * pS6; // Variable initializations: pS6 = 0.0; pAkt_S6 = ; k1_S6_phosphorylation = ; k1_pS6_dephosphorylation = ; time_ = ; end model fujita_2010__pEGFR_total(pEGFR, pEGFR_Akt) // Assignment Rules: pEGFR_total := (pEGFR + pEGFR_Akt) * pEGFR_scalefactor; // Variable initializations: pEGFR_scalefactor = 1.81735e-4; pEGFR = ; pEGFR_Akt = ; end model fujita_2010__pAkt_total(pAkt, pAkt_S6) // Assignment Rules: pAkt_total := (pAkt + pAkt_S6) * pAkt_scalefactor; // Variable initializations: pAkt_scalefactor = 6.00588e1; pAkt = ; pAkt_S6 = ; end model fujita_2010__pS6_total(pS6) // Assignment Rules: pS6_total := pS6 * pS6_scalefactor; // Variable initializations: pS6_scalefactor = 4.98862e4; pS6 = ; end model fujita_2010__model_parameters(k2_EGF_EGFR, k1_EGF_EGFR, EGFR_turnover, k1_S6_phosphorylation, k1_pS6_dephosphorylation, k1_pAkt_S6, k2_pAkt_S6, k1_Akt_phosphorylation, k1_pAkt_dephosphorylation, k1_pEGFR_Akt, k2_pEGFR_Akt, k1_pEGFR_degradation, k1_EGFR_phosphorylation) // Variable initializations: k2_EGF_EGFR = 4.07490e-2; k1_EGF_EGFR = 6.73816e-3; EGFR_turnover = 1.06386129269658e-4; k1_S6_phosphorylation = 1.21498e-3; k1_pS6_dephosphorylation = 1.13102e-3; k1_pAkt_S6 = 2.10189e-6; k2_pAkt_S6 = 5.17940e-15; k1_Akt_phosphorylation = 3.05684e-2; k1_pAkt_dephosphorylation = 3.27962e-2; k1_pEGFR_Akt = 1.55430e-5; k2_pEGFR_Akt = 5.17473e-3; k1_pEGFR_degradation = 9.97194e-2; k1_EGFR_phosphorylation = 1.92391e-2; end model *fujita_2010____main() // Sub-modules, and any changes to those submodules: environment: fujita_2010__environment(time_); EGF: fujita_2010__EGF(EGF0); pro_EGFR: fujita_2010__pro_EGFR(pro_EGFR0); EGFR: fujita_2010__EGFR(EGFR0, EGF_EGFR0, EGF0, pro_EGFR0, k2_EGF_EGFR, k1_EGF_EGFR, EGFR_turnover, time_); EGF_EGFR: fujita_2010__EGF_EGFR(EGF_EGFR0, EGFR0, EGF0, k2_EGF_EGFR, k1_EGF_EGFR, k1_EGFR_phosphorylation, time_); pEGFR: fujita_2010__pEGFR(pEGFR0, EGF_EGFR0, pEGFR_Akt0, Akt0, k1_pEGFR_degradation, k1_Akt_phosphorylation, k1_EGFR_phosphorylation, k1_pEGFR_Akt, k2_pEGFR_Akt, time_); pEGFR_Akt: fujita_2010__pEGFR_Akt(pEGFR_Akt0, pEGFR0, Akt0, k1_Akt_phosphorylation, k1_pEGFR_Akt, k2_pEGFR_Akt, time_); Akt: fujita_2010__Akt(Akt0, pEGFR0, pEGFR_Akt0, pAkt0, k1_pAkt_dephosphorylation, k1_pEGFR_Akt, k2_pEGFR_Akt, time_); pAkt: fujita_2010__pAkt(pAkt0, S60, pEGFR_Akt0, pAkt_S60, k1_Akt_phosphorylation, k1_pAkt_S6, k2_pAkt_S6, k1_S6_phosphorylation, k1_pAkt_dephosphorylation, time_); pAkt_S6: fujita_2010__pAkt_S6(pAkt_S60, S60, pAkt0, k1_pAkt_S6, k2_pAkt_S6, k1_S6_phosphorylation, time_); S6: fujita_2010__S6(S60, pAkt_S60, pS60, pAkt0, k1_pAkt_S6, k2_pAkt_S6, k1_pS6_dephosphorylation, time_); pS6: fujita_2010__pS6(pS60, pAkt_S60, k1_S6_phosphorylation, k1_pS6_dephosphorylation, time_); pEGFR_total: fujita_2010__pEGFR_total(pEGFR0, pEGFR_Akt0); pAkt_total: fujita_2010__pAkt_total(pAkt0, pAkt_S60); pS6_total: fujita_2010__pS6_total(pS60); model_parameters: fujita_2010__model_parameters(k2_EGF_EGFR, k1_EGF_EGFR, EGFR_turnover, k1_S6_phosphorylation, k1_pS6_dephosphorylation, k1_pAkt_S6, k2_pAkt_S6, k1_Akt_phosphorylation, k1_pAkt_dephosphorylation, k1_pEGFR_Akt, k2_pEGFR_Akt, k1_pEGFR_degradation, k1_EGFR_phosphorylation); end