//Created by libAntimony v2.4
model dempsher_model_1984__environment(time_)

  // Variable initializations:
  time_ = ;
end

model dempsher_model_1984__cAMP(cAMP, time_)

  // Assignment Rules:
  ACTH := piecewise( 12E-6 , ( geq(time_, 0.0)) && (time_ < 10.0 ), 16E-6 , ( geq(time_, 10.0)) && (time_ < 20.0 ), 12E-6 , ( geq(time_, 20.0)) && (time_ < 35.0 ), 16E-6 , ( geq(time_, 35.0)) && (time_ < 45.0 ), 12E-6 );

  // Rate Rules:
  cAMP' = (Vmsm * Ko * (1.0 + Kb * ACTH)) / ((1.0 + Ka * ACTH) + Ko * (1.0 + Kb * ACTH)) - (Vdsm * cAMP) / (Kdsm + cAMP);

  // Variable initializations:
  cAMP = 0.95;
  Ko = 0.013;
  Ka = 10;
  Kb = 1000000.0;
  Kdsm = 10.0;
  Vmsm = 6.0;
  Vdsm = 10.0;
  time_ = ;
end

model dempsher_model_1984__IS(IS_, cAMP)

  // Assignment Rules:
  IS_ := (K * Crpt * power(cAMP, n)) / (power(Kd, n) + power(cAMP, n));

  // Variable initializations:
  Crpt = 3.0;
  K = 80.0;
  Kd = 2.11;
  n = 4.0;
  cAMP = ;
end

model dempsher_model_1984__V(V, IS_, time_)

  // Rate Rules:
  V' = P * IS_ - Q * V;

  // Variable initializations:
  V = 11.3;
  P = 0.052;
  Q = 0.042;
  IS_ = ;
  time_ = ;
end

model dempsher_model_1984__W(W, CHOC, time_)

  // Rate Rules:
  W' = T * power(CHOC, -1.0) - U * W;

  // Variable initializations:
  W = 10.0;
  T = 8.0;
  U = 0.0015;
  CHOC = ;
  time_ = ;
end

model dempsher_model_1984__CHOC(CHOC, Lmtr, Kmtr, CHOM, V, W, time_)

  // Rate Rules:
  CHOC' = (V + W + Lmtr * CHOM) - Kmtr * CHOC;

  // Variable initializations:
  CHOC = 532.0;
  Lmtr = ;
  Kmtr = ;
  CHOM = ;
  V = ;
  W = ;
  time_ = ;
end

model dempsher_model_1984__CHOM(CHOM, Kbac, Kfor, Kcb, Kcf, Lmtr, Kmtr, CHOC, CHON, CHOL, time_)

  // Rate Rules:
  CHOM' = (Kmtr * CHOC + Kbac * CHON + Kcf * CHOL) - (Lmtr * CHOM + Kcb * CHOM + Kfor * CHOM);

  // Variable initializations:
  CHOM = 139.0;
  Kbac = ;
  Kfor = ;
  Kcb = ;
  Kcf = ;
  Lmtr = ;
  Kmtr = ;
  CHOC = ;
  CHON = ;
  CHOL = ;
  time_ = ;
end

model dempsher_model_1984__CHOL(CHOL, Kcb, Kcf, CHOM, time_)

  // Rate Rules:
  CHOL' = Kcb * CHOM - Kcf * CHOL;

  // Variable initializations:
  CHOL = 3000.0;
  Kcb = ;
  Kcf = ;
  CHOM = ;
  time_ = ;
end

model dempsher_model_1984__Kmtr(Kmtr, IS_, time_)

  // Rate Rules:
  Kmtr' = C * IS_ - D * Kmtr;

  // Variable initializations:
  Kmtr = 0.446;
  C = 6.25;
  D = 125.0;
  IS_ = ;
  time_ = ;
end

model dempsher_model_1984__Kfor(Kfor, IS_, time_)

  // Rate Rules:
  Kfor' = R * IS_ - S * Kfor;

  // Variable initializations:
  Kfor = 0.370;
  R = 3.0;
  S = 76.0;
  IS_ = ;
  time_ = ;
end

model dempsher_model_1984__CHON(CHON, Kbac, Kfor, Vm, Km, CHOM, time_)

  // Rate Rules:
  CHON' = Kfor * CHOM - (Kbac * CHON + (Vm * CHON) / (Km + CHON));

  // Variable initializations:
  CHON = 3.03;
  Kbac = ;
  Kfor = ;
  Vm = ;
  Km = ;
  CHOM = ;
  time_ = ;
end

model dempsher_model_1984__PREG(PREG, Vmptr, Kmptr, Vm, Km, CHON, time_)

  // Rate Rules:
  PREG' = (Vm * CHON) / (Km + CHON) - (Vmptr * PREG) / (Kmptr + PREG);

  // Variable initializations:
  PREG = 6.56;
  Vmptr = ;
  Kmptr = ;
  Vm = ;
  Km = ;
  CHON = ;
  time_ = ;
end

model dempsher_model_1984__PRO(PRO, Vmptr, Kmptr, AH, PREG, time_)

  // Rate Rules:
  PRO' = HA * ((Vmptr * PREG) / (Kmptr + PREG)) - AH * PRO;

  // Variable initializations:
  PRO = 0.64;
  HA = 0.5;
  Vmptr = ;
  Kmptr = ;
  AH = ;
  PREG = ;
  time_ = ;
end

model dempsher_model_1984__HYPR(HYPR, HY, AH, PRO, time_)

  // Rate Rules:
  HYPR' = AH * PRO - HY * HYPR;

  // Variable initializations:
  HYPR = 0.64;
  HY = ;
  AH = ;
  PRO = ;
  time_ = ;
end

model dempsher_model_1984__CORT(HY, HYPR, time_)

  // Rate Rules:
  CORT' = HY * HYPR - LH * CORT;

  // Variable initializations:
  CORT = 5.2;
  LH = 0.724;
  HY = ;
  HYPR = ;
  time_ = ;
end

model dempsher_model_1984__model_parameters(Lmtr, Kbac, Kcb, Kcf, Vm, Km, Vmptr, Kmptr, AH, HY)

  // Variable initializations:
  Lmtr = 1.65;
  Kbac = 10.0;
  Kcb = 0.01;
  Kcf = 0.00033;
  Vm = 1890.0;
  Km = 270.0;
  Vmptr = 500.0;
  Kmptr = 150.0;
  AH = 16.4;
  HY = 16.4;
end

model *dempsher_model_1984____main()

  // Sub-modules, and any changes to those submodules:
  environment: dempsher_model_1984__environment(time_);
  cAMP: dempsher_model_1984__cAMP(cAMP0, time_);
  IS_: dempsher_model_1984__IS(IS_0, cAMP0);
  V: dempsher_model_1984__V(V0, IS_0, time_);
  W: dempsher_model_1984__W(W0, CHOC0, time_);
  CHOC: dempsher_model_1984__CHOC(CHOC0, Lmtr, Kmtr0, CHOM0, V0, W0, time_);
  CHOM: dempsher_model_1984__CHOM(CHOM0, Kbac, Kfor0, Kcb, Kcf, Lmtr, Kmtr0, CHOC0, CHON0, CHOL0, time_);
  CHOL: dempsher_model_1984__CHOL(CHOL0, Kcb, Kcf, CHOM0, time_);
  Kmtr: dempsher_model_1984__Kmtr(Kmtr0, IS_0, time_);
  Kfor: dempsher_model_1984__Kfor(Kfor0, IS_0, time_);
  CHON: dempsher_model_1984__CHON(CHON0, Kbac, Kfor0, Vm, Km, CHOM0, time_);
  PREG: dempsher_model_1984__PREG(PREG0, Vmptr, Kmptr, Vm, Km, CHON0, time_);
  PRO: dempsher_model_1984__PRO(PRO0, Vmptr, Kmptr, AH, PREG0, time_);
  HYPR: dempsher_model_1984__HYPR(HYPR0, HY, AH, PRO0, time_);
  CORT: dempsher_model_1984__CORT(HY, HYPR0, time_);
  model_parameters: dempsher_model_1984__model_parameters(Lmtr, Kbac, Kcb, Kcf, Vm, Km, Vmptr, Kmptr, AH, HY);
end