Total_current Cm i_Na i_K1 i_to i_Kur i_Kr i_Ks i_B_Na i_B_Ca i_NaK i_CaP i_NaCa i_Ca_L i_Ca_T i_f i_KACh -0.5 Total_current -20 0 -0.5 Total_current -2 Total_current -3 V 0 0 m_inf m tau_m 3.2 V -47.13 0.32 V 47.13 1 -0.1 V 47.13 0.08 V 11 alpha_m alpha_m beta_m 1 alpha_m beta_m h_inf h tau_h 0.135 V 80 -6.8 V -40 0 3.56 0.079 V 3.1 5 0.35 V V -40 1 0.13 1 V 10.66 -11.1 alpha_h alpha_h beta_h 1 alpha_h beta_h j_inf j tau_j -1.2714 5 0.2444 V 3.474 -5 -0.04391 V V 37.78 1 0.311 V 79.23 V -40 0 0.1212 -0.01052 V 1 -0.1378 V 40.14 V -40 0.3 -2.535 -7 V 1 -0.1 V 32 alpha_j alpha_j beta_j 1 alpha_j beta_j Cm g_Na m 3 h j V E_Na R T F Na_o Na_i Cm g_K1 V E_K 1 0.07 V 80 R T F K_o K_i oa_infinity oa tau_oa 0.65 V -10 -8.5 V -10 40 -59 -1 0.65 2.5 V -10 72 17 -1 alpha_oa beta_oa -1 K_Q10 1 V -10 10.47 -17.54 -1 oi_infinity oi tau_oi 18.53 1 V -10 103.7 10.95 -1 35.56 1 V -10 8.74 -7.44 -1 alpha_oi beta_oi -1 K_Q10 1 V -10 33.1 5.3 -1 Cm g_to oa 3 oi V E_K ua_infinity ua tau_ua 0.65 V -10 -8.5 V -10 40 -59 -1 0.65 2.5 V -10 72 17 -1 alpha_ua beta_ua -1 K_Q10 1 V -10 20.3 -9.6 -1 ui_infinity ui tau_ui 21 1 V -10 195 -28 -1 1 V -10 168 -16 alpha_ui beta_ui -1 K_Q10 1 V -10 109.45 27.48 -1 Cm g_Kur ua 3 ui V E_K 0.005 0.05 1 V 15 -13 0.13 xr_infinity xr tau_xr 0.0015 V 14.1 1 -10 0.0003 V 14.1 1 V 14.1 -5 3.7836118 -4 V 3.3328 1 -10 7.3898 -5 V 3.3328 V 3.3328 5.1237 1 alpha_xr beta_xr -1 1 V 14.1 -6.5 -1 Cm g_Kr xr V E_K 1 V 15 22.4 xs_infinity xs tau_xs 0.00068 V 19.9 1 -10 4 -5 V 19.9 1 V 19.9 -17 0.000315 V 19.9 1 -10 3.5 -5 V 19.9 V 19.9 9 1 0.5 alpha_xs beta_xs -1 1 V 19.9 -12.7 -0.5 Cm g_Ks xs 2 V E_K d_infinity d tau_d 1 V 10 -8 -1 4.579 1 V 10 -6.24 V 10 1 -10 1 V 10 -6.24 0.035 V 10 1 V 10 -6.24 f_infinity f tau_f V 28 6.9 1 V 28 6.9 9 0.0197 0.0337 2 V 10 2 0.02 -1 f_Ca_infinity f_Ca tau_f_Ca 1 Ca_i 0.00035 -1 2 Cm g_Ca_L d f f_Ca V 65 Cm i_NaK_max f_NaK 1 1 Km_Na_i Na_i 1.5 K_o K_o Km_K_o 1 0.1245 -0.1 F V R T 0.0365 sigma F V R T -1 1 7 Na_o 67.3 1 Cm g_B_Na V E_Na Cm g_B_Ca V E_Ca Cm g_B_K V E_K R T 2 F Ca_o Ca_i Cm I_NaCa_max gamma F V R T Na_i 3 Ca_o gamma 1 F V R T Na_o 3 Ca_i K_mNa 3 Na_o 3 K_mCa Ca_o 1 K_sat gamma 1 V F R T Cm i_CaP_max Ca_i 0.0005 Ca_i u_infinity u tau_u 8 1 Fn 3.4175 -13 13.67 -16 -1 v_infinity v tau_v 1.91 2.09 1 Fn 3.4175 -13 13.67 -16 -1 1 1 Fn 6.835 -14 13.67 -16 -1 w_infinity w tau_w 6 0.2 1.3 V 7.9 1 -10 6 1 V 7.9 5 1 0.3 V 7.9 5 1 V 7.9 1 1 V 40 17 -1 K_rel u 2 v w Ca_rel Ca_i 1 3 1 -15 V_rel i_rel 1 -15 2 F 0.5 i_Ca_L 0.2 i_NaCa Ca_up Ca_rel tau_tr I_up_max 1 K_up Ca_i I_up_max Ca_up Ca_up_max CMDN_max Ca_i Ca_i Km_CMDN TRPN_max Ca_i Ca_i Km_TRPN CSQN_max Ca_rel Ca_rel Km_CSQN -3 i_NaK 3 i_NaCa i_B_Na i_Na V_i F B1 B2 2 i_NaK i_K1 i_to i_Kur i_Kr i_Ks i_B_K V_i F i_tr i_rel 1 CSQN_max Km_CSQN Ca_rel Km_CSQN 2 -1 i_up i_up_leak i_tr V_rel V_up V_cell 0.68 0.0048 V_cell 0.0552 V_cell 2 i_NaCa i_CaP i_Ca_L i_B_Ca 2 V_i F V_up i_up_leak i_up i_rel V_rel V_i 1 TRPN_max Km_TRPN Ca_i Km_TRPN 2 CMDN_max Km_CMDN Ca_i Km_CMDN 2 d_f_infinity d_f tau_d_f 0.36 V 148.8 0.066 V 148.8 1 0.1 V 87.3 1 -0.21 V 87.3 1 alpha_d_f beta_d_f 1 alpha_d_f beta_d_f 0.054 g_f d_f V E_f d_T_infinity d_T tau_d_T 1068 V 26.3 30 1068 V 26.3 -30 1 1 V 26.3 -6 1 alpha_d_T beta_d_T f_T_infinity f_T tau_f_T 15.3 V 61.7 -83.3 15 V 61.7 15.38 1 1 V 61.7 5.6 1 alpha_f_T beta_f_T g_Ca_T d_T f_T V E_Ca_T alpha_y 1 y beta_y y 0.0002475 ACh 0 0.01232 1 Km_ACh ACh 0.0002475 0.01 0.0133 Vm 40 g_ACh Vm E_K 1 Vm 20 20 y 1000 HR 60 realtime start realtime start hrf hrf 1000 realtime ISAin 0 TsK hrf 1000 Edia Esys Edia 1 time_ Ts 2 time_ 0 time_ Ts Edia Esys Edia 1 2 time_ Ts Ts 2 time_ 1.5 Ts time_ Ts Edia F_LA F_LV 1000 E_LA V_LA V_LA_0 P_LA_ext P_PV P_LA R_LA sub_X_LA V_LA conc_X_PV F_LA conc_X_LA F_LV 1000 F_LV F_AO F_CO 1000 P_LA P_LV R_LV P_LA P_LV 0 sub_X_LV V_LV conc_X_LA F_LV conc_X_LV F_AO F_CO 1000 P_LVin P_LA_ext F_AO F_AR F_CR 1000 1 L_AO P_LV P_AO R_AO L_AO F_AOalways 1000 F_AOalways P_LV P_AO 0 1 C_AO V_AO V_AO_0 sub_X_AO V_AO conc_X_LV F_AO conc_X_AO F_CR F_AR 1000 P_LV P_CO R_CO P_LV P_CO 0 P_CO P_RA R_COV F_CO F_COV 1000 1 C_CO V_CO V_CO_0 sub_X_CO V_CO conc_X_LV F_CO conc_X_CO F_COV 1000 P_AO P_CR R_CR P_CR P_VC R_CRV F_CR F_CRV 1000 1 C_CR V_CR V_CR_0 sub_X_CR V_CR conc_X_AO F_CR conc_X_CR F_CRV conc_X_CR conc_X_CRtissue D_CRtissue 1000 sub_X_CRtissue V_CRtissue conc_X_CR conc_X_CRtissue D_CRtissue 1000 F_AR F_AD F_MU F_GI F_LI F_KI F_OT F_SK 1000 P_AO P_AR R_AR 1 C_AR V_AR V_AR_0 sub_X_AR V_AR conc_X_AO F_AR conc_X_AR F_SK F_AD F_MU F_GI F_LI F_KI F_OT 1000 F_AD F_ADV 1000 P_AR P_AD R_AD P_AD P_VE R_ADV 1 C_AD V_AD V_AD_0 sub_X_AD V_AD conc_X_AR F_AD conc_X_AD F_ADV 1000 F_MU F_MUV 1000 P_AR P_MU R_MU P_MU P_VE R_MUV 1 C_MU V_MU V_MU_0 sub_X_MU V_MU conc_X_AR F_MU conc_X_MU F_MUV 1000 F_GI F_GIV 1000 P_AR P_GI R_GI P_GI P_LI R_GIV 1 C_GI V_GI V_GI_0 sub_X_GI V_GI conc_X_AR F_GI conc_X_GI F_GIV 1000 F_GIV F_LI F_LIV 1000 P_AR P_LI R_LI P_LI P_VE R_LIV 1 C_LI V_LI V_LI_0 sub_X_LI V_LI conc_X_GI F_GIV conc_X_AR F_LI conc_X_LI F_LIV conc_X_LI metabolism 1000 F_KI F_KIV 1000 P_AR P_KI R_KI P_KI P_VE R_KIV 1 C_KI V_KI V_KI_0 sub_X_KI V_KI conc_X_AR F_KI conc_X_KI F_KIV 1000 F_SK F_SKV 1000 P_AR P_SK R_SK P_SK P_VE R_SKV 1 C_SK V_SK V_SK_0 sub_X_SK V_SK conc_X_AR F_SK conc_X_SK F_SKV 1000 F_OT F_OTV 1000 P_AR P_OT R_OT P_OT P_VE R_OTV 1 C_OT V_OT V_OT_0 sub_X_OT V_OT conc_X_AR F_OT conc_X_OT F_OTV 1000 F_VE F_VEV 1000 F_SKV F_ADV F_MUV F_LIV F_KIV F_OTV P_VE P_VC R_VEV 1 C_VE V_VE V_VE_0 sub_X_VE V_VE conc_X_SK F_SKV conc_X_AD F_ADV conc_X_MU F_MUV conc_X_LI F_LIV conc_X_KI F_KIV conc_X_OT F_OTV conc_X_VE F_VEV 1000 F_VC F_VCV 1000 F_CRV F_VEV P_VC P_RA R_VCV 1 C_VC V_VC V_VC_0 sub_X_VC V_VC conc_X_VE F_VEV conc_X_CR F_CRV conc_X_VC F_VCV 1000 realtime start realtime start hrf hrf 1000 realtime ISAin 0 TsK hrf 1000 Edia Esys Edia 1 time_ Ts 2 time_ 0 time_ Ts Edia Esys Edia 1 2 time_ Ts Ts 2 time_ 1.5 Ts time_ Ts Edia F_RA F_RV 1000 E_RA V_RA V_RA_0 P_RA_ext F_VCV F_COV sub_X_RA V_RA conc_X_VC F_VCV conc_X_CO F_COV conc_X_RA F_RV 1000 F_RV F_PA 1000 P_LV lvb rva lva lvb lva P_LV rvb lva lvb P_RA P_RV R_RV P_RA P_RV 0 sub_X_RV V_RV conc_X_RA F_RV conc_X_RV F_PA 1000 EmaxLV 10 EmaxRV 10 P0lv kelv V_LV 1 P0rv kerv V_RV 1 P_RV P_PA R_PA P_RV P_PA 0 F_PA F_Pa 1000 1 C_PA V_PA V_PA_0 sub_X_PA V_PA conc_X_RV F_PA conc_X_PA F_Pa 1000 F_Pa F_PC F_SH 1000 P_PA P_Pa R_Pa 1 C_Pa V_Pa V_Pa_0 sub_X_Pa V_Pa conc_X_PA F_Pa conc_X_Pa F_PC F_SH 1000 P_Pa P_PC R_SH F_PC F_PCV 1000 P_Pa P_PC R_PC P_PC P_PV R_PCV 1 C_PC V_PC V_PC_0 sub_X_PC V_PC conc_X_Pa F_PC conc_X_PC F_PCV 1000 F_PV F_LA 1000 F_PCV F_SH 1 C_PV V_PV V_PV_0 sub_X_PV V_PV conc_X_PC F_PCV conc_X_Pa F_SH conc_X_PV F_LA 1000 Istim topOUt Cai Itotal Cm ISAstim ICa_additional INa_additional IK_additional INa IK1 Ito IKr IKs ICaL INaCa INaK IbNa IbCa IpCa IpK Am vC F IK_additional IK1 Ito IKr IKs IpK INaK 2 Am vC F INa INa_additional IbNa INaK 3 INaCa 3 Am 2 vC F 2 INaCa ICa_additional ICaL IbCa IpCa Jleak Jrel JCaSR_additional Jup g_Na m 3 h j V E_Na g_K1 Ko 5.4 K1_infinity V E_K g_to r s V E_K g_Kr Ko 5.4 Xr1 Xr2 V E_K g_Ks Xs 2 V E_Ks P_NaK Ko Nai Ko K_mK Nai K_mNa 1 0.1245 -0.1 V F R T 0.0353 V F R T g_pK V E_K 1 25 V 5.98 g_bNa V E_Na g_CaL d f fCa 4 V F 2 R T Cai 2 V F R T 0.341 Cao 2 V F R T 1 g_pCa Cai K_pCa Cai k_NaCa gamma V F R T Nai 3 Cao gamma 1 V F R T Nao 3 Cai alpha K_mNai 3 Nao 3 K_mCa Cao 1 k_sat gamma 1 V F R T g_bCa V E_Ca R T z F extracellular_concentration intracellular_concentration R T z F extracellular_concentration intracellular_concentration R T z F extracellular_concentration intracellular_concentration R T z F multiplier_1 extracellular_concentration_1 multiplier_2 extracellular_concentration_2 multiplier_1 intracellular_concentration_1 multiplier_2 intracellular_concentration_2 Na_flux K_flux Cai_total Cai_buf CaSR_total CaSR_buf Ca_flux Ca_SR_flux vC vSR Ca_SR_flux bCai 2 4 aCai cCai bCai 2 aCai bCaSR 2 4 aCaSR cCaSR bCaSR 2 aCaSR -1 Cai_total Kbufc Bufc Bufc Cai_total -1 CaSR_total Kbufsr Bufsr Bufsr CaSR_total V_leak CaSR Cai Vmax_up 1 K_up 2 Cai 2 a_rel CaSR 2 b_rel 2 CaSR 2 c_rel d g m_infinity m tau_m 1 alpha_m beta_m 1 1 -56.86 V 9.03 2 1 1 -60 V 5 0.1 1 35 V 5 0.1 1 V 50 200 h_infinity h tau_h 1 alpha_h beta_h 1 1 71.55 V 7.43 2 0.057 80 V 6.8 V -40 0 2.7 0.079 V 3.1 5 0.3485 V V -40 0.77 0.13 1 V 10.66 11.1 j_infinity j tau_j 1 alpha_j beta_j 1 1 71.55 V 7.43 2 -2.5428 4 0.2444 V 6.948 -6 -0.04391 V V 37.78 1 0.311 V 79.23 V -40 0 0.02424 -0.01052 V 1 -0.1378 V 40.14 V -40 0.6 0.057 V 1 -0.1 V 32 alpha_K1 alpha_K1 beta_K1 0.1 1 0.06 V E_K 200 3 0.0002 V E_K 100 0.1 V E_K 10 1 -0.5 V E_K r_infinity r tau_r 1 1 20 V 6 9.5 V 40 2 1800 0.8 s_infinity s tau_s 1 1 20 V 5 85 V 45 2 320 5 1 V 20 5 3 Xr1_infinity Xr1 tau_Xr1 450 1 -45 V 10 6 1 V 30 11.5 1 1 -26 V 7 1 alpha_Xr1 beta_Xr1 Xr2_infinity Xr2 tau_Xr2 3 1 -60 V 20 1.12 1 V 60 20 1 1 88 V 24 1 alpha_Xr2 beta_Xr2 Xs_infinity Xs tau_Xs 1100 1 -10 V 6 1 1 V 60 20 1 1 -5 V 14 1 alpha_Xs beta_Xs d_infinity d tau_d 1.4 1 -35 V 13 0.25 1.4 1 5 V 5 1 alpha_d beta_d gamma_d 1 1 50 V 20 1 1 -5 V 7.5 f_infinity f tau_f 1125 V 27 2 240 165 1 25 V 10 80 1 1 20 V 7 0 fCa_infinity fCa V -60 fCa_infinity fCa tau_fCa 1 1 Cai 0.000325 8 0.1 1 Cai 0.0005 0.0001 0.2 1 Cai 0.00075 0.0008 alpha_fCa beta_fCa gamma_fCa 0.23 1.46 0 g_infinity g V -60 g_infinity g tau_g 1 1 Cai 6 0.00035 6 Cai 0.00035 1 1 Cai 16 0.00035 16 10000 2 radiusLV xDen ForceP ForceB cTnCa R xHalfSL OptiHSL 2 Q_b 1 Q_a 1 Q_a 1 Q_r 1 Q_d1 1 Q_r 1 Q_d 1 Q_d2 1 Y_2 cTnCaEff 1 Z_2 cTnCaCB 1 Y_1 Cai cTn 1 Z_1 cTnCa 1 Y_3 cTnCaCB 1 Z_3 cTnCB Cai 1 Y_4 cTnCB 1 Y_d SlidingR xHalfSL xInext xLLimitCB 2 cTnCaCB 1 Y_d SlidingR xHalfSL xInext xLLimitCB 2 cTnCB 1 SlidingR xHalfSL xInext xLLimitCB 1 cTnCa cTnCaCB cTnCB trpnbar Q_r Q_d2 Q_b 1 xHalfSL xInext cTnCaCB cTnCB trpnbar 1 AForceCB cTnCaCB cTnCB trpnbar 1 xKcoeff xHalfSL 0.97 5 xHalfSL 0.97 xKcoeff2 xHalfSL 0.97 xNewCBF xhhh 3 V_LV 2 1 3 ForceExt Fmult 2 Tension radiusLV 1000 133 offset Cai_in F_PC 0.06 F_MU 0.06 V_PC V_MU Fpc CtO2_sc CtO2_pc DL_O2 PA_O2 PO2_pc 0.00267857142857143 Vpc alphaO2 H CHb dSHbO2dPO2_pc 0.0166666666666667 Fsc CtO2_pc CtO2_sc PS alphaO2 PO2_isf PO2_sc 10 -4 Vsc alphaO2 H CHb dSHbO2dPO2_sc 0.0166666666666667 PO2_pc P50_O2 nH PO2_pc P50_O2 nH 1 PO2_sc P50_O2 nH PO2_sc P50_O2 nH 1 nH PO2_pc -1 PO2_pc P50_O2 nH PO2_pc P50_O2 nH 1 2 nH PO2_sc -1 PO2_sc P50_O2 nH PO2_sc P50_O2 nH 1 2 alphaO2 PO2_pc CHb SHbO2_pc H alphaO2 PO2_sc CHb SHbO2_sc H QdotCA PC_O2 PA_O2 dVAdt 1000000 VA Pstp Tbody Tstp O2flux VA 0.0166666666666667 1 -6 dVAdt 0 QdotCA PA_O2 PA_O2 dVAdt 1000000 VA Pstp Tbody Tstp O2flux VA 0.0166666666666667 1 -6 Vpc Vpcmax 0.397 0.0085 PO2_pc 1.3 -4 PO2_pc 2 5.1 -7 PO2_pc 3 31.6227766016838 0.0316227766016838 PS PO2_sc PO2_isf Visf V_O2 alphaO2 Visf 1 3 1.66666666666667 -5 Vcytox alphaO2 PO2_isf Kcytox alphaO2 PO2_isf DL_O2 PA_O2 PO2_pc 22400 0.00267857142857143 Fpc CtCO2_sc CtCO2_pc DL_CO2 PA_CO2 PCO2_pc 0.00267857142857143 Vpc alphaCO2 H CHb dSHbCO2dPCO2_pc 0.0166666666666667 Fsc CtCO2_pc CtCO2_sc PS alphaCO2 PCO2_isf PCO2_sc 10 -4 Vsc alphaCO2 H CHb dSHbCO2dPCO2_sc 0.0166666666666667 PCO2_pc P50_CO2 PO2_pc P50_CO2 1 PCO2_sc P50_CO2 PCO2_sc P50_CO2 1 PCO2_pc -1 PCO2_pc P50_CO2 PCO2_pc P50_CO2 1 2 alphaCO2 PCO2_pc CHb SHbCO2_pc H PCO2_sc -1 PCO2_sc P50_CO2 PCO2_sc P50_CO2 1 2 alphaCO2 PCO2_sc CHb SHbCO2_sc H QdotCA PC_CO2 PA_CO2 dVAdt 1000000 VA Pstp Tbody Tstp CO2flux VA 0.0166666666666667 1 -6 dVAdt 0 QdotCA PA_CO2 PA_CO2 dVAdt 1000000 VA Pstp Tbody Tstp CO2flux VA 0.0166666666666667 1 -6 Vpc Vpcmax 16.67 0.0316227766016838 PS PCO2_sc PCO2_isf Visf V_CO2 alphaCO2 Visf 1 3 1.66666666666667 -5 RQ V_O2 DL_CO2 PA_CO2 PCO2_pc 22400 0.00267857142857143 Pc Ppl PA Rs 1000 PD Pc Ppl Rc 1000 QdotDC Pao PH2O 0.21 Pao PH2O 3 -4 Pao PH2O Pao_O2 Pao_CO2 QdotED Pao_O2 QdotDC PD_O2 VD 1 -6 dVAdt 0 QdotED PD_O2 QdotDC PC_O2 VD 1 -6 QdotDC PD_O2 QdotCA PC_O2 PC_O2 dVcdt 1000000 Vc 1 -6 dVAdt 0 QdotDC PC_O2 QdotCA PA_O2 PC_O2 dVcdt 1000000 Vc 1 -6 PD Pao 1.3565 PD_O2 1.3565 PD_CO2 1.3565 0.737191301142647 Pc Ppl Pao 1.3565 PC_O2 1.3565 PC_CO2 1.3565 0.737191301142647 PA Pao 1.3565 PA_O2 1.3565 PA_CO2 1.3565 0.737191301142647 As Ks VA RV Vstar RV Bs Kc Vcmax Vc 2 Au Ku dVdt 1000 Pmus Pc Pcw Ru Rs Pc Pl Pve Rs 0.001 Vcw dV tau 0.001 VA VD Pc Pl Pve Rs Pstp Tbody PA 1030.94 Tstp O2flux CO2flux 2.26083333333333 -5 0.001 Acw -1 Bcw TLC RV Vcw RV 0.999 Al Kl VA Bl Ppl Pl Pve Ac Bc Vc Vcmax 0.7 2 Vc Vcmax 0.5 5.6 Bcp Vcmax Vc 0.999 Vve Cve Pcw Pmus Ppl 0.737191301142647 Pc Ppl Rc dVcdt Pc Ppl PA Rs 0.001 1 3 Amus 6.28318530717959 f time_ 1.66666666666667 -5 Amus QdotED Pao_CO2 QdotDC PD_CO2 VD 1 -6 dVAdt 0 QdotED PD_CO2 QdotDC PC_CO2 VD 1 -6 QdotDC PD_CO2 QdotCA PC_CO2 PC_CO2 dVcdt 1000000 Vc 1 -6 dVAdt 0 QdotDC PC_CO2 QdotCA PA_CO2 PC_CO2 dVcdt 1000000 Vc 1 -6 Vcw dV tau 0.001 Pmus Pc Pcw Ru Rs Pc Pl Pve Rs 0.001 Pc Pl Pve Rs Pstp Tbody PA 1030.94 Tstp O2flux CO2flux 2.26083333333333 -5 0.001