//Created by libAntimony v2.4 model curien_2003__v_cystathionine(v_cystathionine, Cys, CGS, Pi_, Phser) // Assignment Rules: v_cystathionine := (kcat_CGS_app_Cys * CGS * Cys) / (Km_CGS_app_Cys + Cys); Km_CGS_app_Cys := Km_CGS_Cys / (1.0 + (Km_CGS_Phser / Phser) * (1.0 + Pi_ / Ki_CGS_Pi)); kcat_CGS_app_Cys := kcat_CGS / (1.0 + (Km_CGS_Phser / Phser) * (1.0 + Pi_ / Ki_CGS_Pi)); // Variable initializations: Cys = ; CGS = ; Pi_ = ; Phser = ; Km_CGS_Cys = 460.0; kcat_CGS = 30.0; Km_CGS_Phser = 2500.0; Ki_CGS_Pi = 2500.0; end model curien_2003__v_Thr(v_Thr, TS, AdoMet, Pi_, Phser) // Assignment Rules: v_Thr := (TS * kcat_TS * Phser) / (Km_TS + Phser); Km_TS := ((250.0 * ((1.0 + AdoMet / 0.5) / (1.0 + AdoMet / 1.1))) / (1.0 + power(AdoMet, 2.0) / 140.0)) * (1.0 + Pi_ / Ki_TS_Pi); kcat_TS := (kcat_TS_noAdoMet + kcat_TS_AdoMet * (power(AdoMet, 2.0) / K1K2)) / (1.0 + power(AdoMet, 2.0) / K1K2); // Variable initializations: TS = ; AdoMet = ; Pi_ = ; Phser = ; kcat_TS_noAdoMet = 0.42; kcat_TS_AdoMet = 3.5; K1K2 = 73.0; Ki_TS_Pi = 1000.0; end model curien_2003__J_Phser(v_cystathionine, v_Thr) // Assignment Rules: J_Phser := v_cystathionine + v_Thr; // Variable initializations: v_cystathionine = ; v_Thr = ; end model curien_2003__CGS(CGS) // Variable initializations: CGS = 0.7; end model curien_2003__Phser(Phser) // Variable initializations: Phser = 500.0; end model curien_2003__AdoMet(AdoMet) // Variable initializations: AdoMet = 20.0; end model curien_2003__Cys(Cys) // Variable initializations: Cys = 15.0; end model curien_2003__Pi(Pi_) // Variable initializations: Pi_ = 10000.0; end model curien_2003__TS(TS) // Variable initializations: TS = 5.0; end model *curien_2003____main() // Sub-modules, and any changes to those submodules: v_cystathionine: curien_2003__v_cystathionine(v_cystathionine0, Cys0, CGS0, Pi_0, Phser0); v_Thr: curien_2003__v_Thr(v_Thr0, TS0, AdoMet0, Pi_0, Phser0); J_Phser: curien_2003__J_Phser(v_cystathionine0, v_Thr0); CGS: curien_2003__CGS(CGS0); Phser: curien_2003__Phser(Phser0); AdoMet: curien_2003__AdoMet(AdoMet0); Cys: curien_2003__Cys(Cys0); Pi_: curien_2003__Pi(Pi_0); TS: curien_2003__TS(TS0); end