//Created by libAntimony v2.4 model conradie_2009__environment(time_) // Variable initializations: time_ = ; end model conradie_2009__A(eps, Cdc20, CYCA, CYCB, CYCE, time_) // Assignment Rules: v_20 := ((K3a + K3 * Cdc20) * (1 - Cdh1)) / ((J3 - Cdh1) + 1); v_21 := (V_4 * Cdh1) / (J4 + Cdh1); v_42 := eps * ((K1 * power(CYCB / J1, 2)) / (power(CYCB / J1, 2) + 1) + K1a); v_19 := V_2 * CYCB; V_2 := K2aa * Cdc20 + K2a * (1 - Cdh1) + K2 * Cdh1; V_4 := K4 * (GA * CYCA + GB * CYCB + GE * CYCE); // Rate Rules: Cdh1' = v_20 - v_21; CYCB' = v_42 - v_19; // Variable initializations: eps = ; K1 = 0.6; K1a = 0.1; K2 = 20; K2a = 0.05; K2aa = 1; K3 = 140; K3a = 7.5; K4 = 40; J1 = 0.1; J3 = 0.01; J4 = 0.04; GA = 0.3; GB = 1; GE = 0; Cdh1 = 0.000653278; Cdc20 = ; CYCA = ; CYCB = 2.72898; CYCE = ; time_ = ; end model conradie_2009__B(eps, v_39, time_) // Assignment Rules: v_1 := k16 * ERG; v_2 := k18 * DRG; v_34 := (eps * k15) / (power(DRG / J15, 2) + 1); v_39 := eps * K9 * DRG; v_41 := eps * ((k17 * power(DRG / J17, 2)) / (power(DRG / J17, 2) + 1) + k17a * ERG); // Rate Rules: DRG' = v_41 - v_2; ERG' = v_34 - v_1; // Variable initializations: eps = ; k15 = 0.25; k16 = 0.25; k17 = 10; k17a = 0.35; k18 = 10; K9 = 2.5; J17 = 0.3; J15 = 0.1; DRG = 0.900533; ERG = 0.0121809; time_ = ; end model conradie_2009__C(E2F, CYCA, CYCB, CYCE, time_) // Assignment Rules: v_29 := E2FRb * K20 * (CYCDT * LD + LA * CYCA + LB * CYCB + LE * CYCE); v_30 := PE2FRb * K20 * (CYCDT * LD + LA * CYCA + LB * CYCB + LE * CYCE); v_43 := Rb * K20 * (CYCDT * LD + LA * CYCA + LB * CYCB + LE * CYCE); v_44 := PPRb * (K19a * (PP1T - PP1A) + K19 * PP1A); v_45 := E2FRb * K26R; v_46 := E2F * (K23a + K23 * (CYCA + CYCB)); v_47 := PE2F * K22; v_48 := E2F * Rb * K26; v_49 := PE2FRb * K26R; v_50 := Rb * PE2F * K26; v_51 := PE2FRb * K22; v_52 := E2FRb * (K23a + K23 * (CYCA + CYCB)); PP1A := PP1T / (K21 * FE * (CYCA + CYCE + FB * CYCB) + 1); // Rate Rules: Rb' = (((v_44 + v_45 + v_49) - v_48) - v_50) - v_43; PPRb' = (v_29 + v_30 + v_43) - v_44; E2F' = ((v_29 + v_45 + v_47) - v_46) - v_48; PE2F' = ((v_30 + v_49 + v_46) - v_47) - v_50; E2FRb' = (((v_51 + v_48) - v_52) - v_29) - v_45; PE2FRb' = (((v_52 + v_50) - v_51) - v_30) - v_49; // Variable initializations: K19 = 20; K19a = 0; K20 = 10; K21 = 1; K22 = 1; K23a = 0.005; K23 = 1; K26 = 10000; K26R = 200; LA = 3; LB = 5; LD = 3.3; LE = 5; FE = 25; FB = 2; Rb = 0.000190871; PPRb = 9.97574; E2F = 0.989986; PE2F = 3.98594; E2FRb = 0.00478911; PE2FRb = 0.0192822; PP1T = 1; CYCA = ; CYCB = ; CYCDT = 0.010976; CYCE = ; time_ = ; end model conradie_2009__D(eps, v_39, V_6, V_8, E2F, MASS, Cdc20, CYCA, CYCB, CYCE, time_) // Assignment Rules: v_3 := K10 * CD; v_4 := K10 * CYCD; v_5 := K25 * p27 * CYCE; v_6 := K25 * p27 * CYCA; v_7 := k24 * p27 * CYCD; v_8 := k24r * CD; v_9 := K30 * Cdc20 * CYCA; v_10 := K30 * Cdc20 * CA; v_11 := K25R * CE; v_12 := K25R * CA; v_13 := V_8 * CE; v_14 := V_8 * CYCE; v_15 := V_6 * p27; v_16 := V_6 * CE; v_17 := V_6 * CD; v_18 := V_6 * CA; v_36 := eps * K29 * E2F * MASS; v_38 := eps * (K7a + K7 * E2F); v_40 := eps * K5; V_6 := K6a + K6 * (HA * CYCA + HB * CYCB + HE * CYCE); V_8 := (K8 * (YE * (CYCA + CYCE) + YB * CYCB)) / (CYCET + J8) + K8a; // Rate Rules: p27' = (((((v_40 + v_3 + v_8) - v_15) - v_5) - v_6) - v_7) + v_11 + v_12 + v_13 + v_10; CA' = ((v_6 - v_12) - v_18) - v_10; CD' = ((v_7 - v_8) - v_17) - v_3; CE' = ((v_5 - v_11) - v_13) - v_16; CYCA' = ((v_36 - v_9) - v_6) + v_12 + v_18; CYCD' = ((v_39 + v_17 + v_8) - v_7) - v_4; CYCE' = ((v_38 - v_14) - v_5) + v_11 + v_16; // Variable initializations: eps = ; K5 = 20; K6a = 10; K6 = 100; K7a = 0; K7 = 0.6; K8a = 0.1; K8 = 2; K10 = 5; k24 = 1000; k24r = 10; K25 = 1000; K25R = 10; K29 = 0.05; K30 = 20; J8 = 0.1; v_39 = ; HA = 0.5; HB = 1; HE = 0.5; YE = 1; YB = 0.05; p27 = 0.00922806; E2F = ; MASS = ; Cdc20 = 0.00220177; CA = 0.0356927; CD = 0.010976; CE = 0.000542587; CYCA = 1.4094; CYCB = ; CYCD = 0.43929; CYCE = 0.0229112; CYCET = 0.000542587; time_ = ; end model conradie_2009__E(eps, MASS, time_) // Assignment Rules: v_31 := K27 * MASS * r31switch; v_32 := K28 * GM; v_33 := eps * MU * GM; // Rate Rules: GM' = v_31 - v_32; MASS' = v_33; // Variable initializations: eps = 1; K27 = 0.2; K28 = 0.2; r31switch = 1; MU = 0.061; GM = 1.35565; MASS = 1.68776; time_ = ; end model conradie_2009__F(eps, Cdc20, CYCB, time_) // Assignment Rules: v_22 := K34 * PPX; v_23 := (K31 * CYCB * (1 - IEP)) / ((J31 - IEP) + 1); v_24 := (K32 * PPX * IEP) / (J32 + IEP); v_25 := K12 * Cdc20T; v_26 := (K13 * IEP * (Cdc20T - Cdc20)) / ((J13 - Cdc20) + Cdc20T); v_27 := (K14 * Cdc20) / (J14 + Cdc20); v_28 := K12 * Cdc20; v_35 := eps * K11a + K11 * CYCB; v_37 := eps * K33; // Rate Rules: IEP' = v_23 - v_24; PPX' = v_37 - v_22; Cdc20T' = v_35 - v_25; // Variable initializations: eps = ; K11a = 0; K11 = 1.5; K12 = 1.5; K13 = 5; K14 = 2.5; K31 = 0.7; K32 = 1.8; K33 = 0.05; K34 = 0.05; J13 = 0.005; J14 = 0.005; J31 = 0.01; J32 = 0.01; IEP = 0.154655; PPX = 1; Cdc20 = ; Cdc20T = 2.36733; CYCB = ; time_ = ; end model *conradie_2009____main() // Sub-modules, and any changes to those submodules: environment: conradie_2009__environment(time_); A: conradie_2009__A(eps, Cdc20, CYCA, CYCB, CYCE, time_); B: conradie_2009__B(eps, v_39, time_); C: conradie_2009__C(E2F, CYCA, CYCB, CYCE, time_); D: conradie_2009__D(eps, v_39, V_6, V_8, E2F, MASS, Cdc20, CYCA, CYCB, CYCE, time_); E: conradie_2009__E(eps, MASS, time_); F: conradie_2009__F(eps, Cdc20, CYCB, time_); end