//Created by libAntimony v2.4
model colegrove_albrecht_friel_2000_version01__environment(time_)

  // Variable initializations:
  time_ = ;
end

model colegrove_albrecht_friel_2000_version01__Ca_extrusion_across_the_plasma_membrane(J_pm, Ca_i, time_)

  // Assignment Rules:
  J_pm := J_leak + J_extru;
  J_leak := k_leak * (Ca_i - Ca_o);
  J_extru := Vmax_extru / (1.0 + power(EC50_extru / Ca_i, n_extru));

  // Variable initializations:
  k_leak = 0.00000037;
  Vmax_extru = 28.3;
  EC50_extru = 378.8;
  n_extru = 1.8;
  Ca_o = 0.002;
  Ca_i = ;
  time_ = ;
end

model colegrove_albrecht_friel_2000_version01__mitochondrial_Ca_uptake(J_uni, Ca_i, time_)

  // Assignment Rules:
  J_uni := (kuni_max * Ca_i) / (1.0 + power(EC50_uni / Ca_i, n_uni));

  // Variable initializations:
  kuni_max = 75.9;
  EC50_uni = 10.0;
  n_uni = 2.0;
  Ca_i = ;
  time_ = ;
end

model colegrove_albrecht_friel_2000_version01__mitochondrial_Ca_release(J_NaCa, Ca_inhibited_J_NaCa, J_mito, J_uni, Ca_i, Ca_m, time_)

  // Assignment Rules:
  J_NaCa := - Vmax_NaCa / (1.0 + EC50_NaCa / Ca_m);
  Ca_inhibited_J_NaCa := -(delta_Ca_i * Vmax_NaCa) / (1.0 + EC50_NaCa / Ca_i);
  J_mito := J_uni + J_NaCa;
  delta_Ca_i := 1.0 - 1.0 / (1.0 - power(k_inhib / Ca_i, n_inhib));

  // Variable initializations:
  Vmax_NaCa = -35.0;
  EC50_NaCa = 307.0;
  n_inhib = 6.0;
  k_inhib = 500.0;
  J_uni = ;
  Ca_i = ;
  Ca_m = ;
  time_ = ;
end

model colegrove_albrecht_friel_2000_version01__intracellular_calcium(Ca_i, J_pm, J_mito, time_)

  // Rate Rules:
  Ca_i' = -(J_pm + J_mito);

  // Variable initializations:
  Ca_i = 0.002;
  J_pm = ;
  J_mito = ;
  time_ = ;
end

model colegrove_albrecht_friel_2000_version01__mitochondrial_calcium(Ca_m, J_mito, time_)

  // Rate Rules:
  Ca_m' = J_mito / gamma;

  // Variable initializations:
  Ca_m = 50.0e-9;
  gamma = 2.0;
  J_mito = ;
  time_ = ;
end

model *colegrove_albrecht_friel_2000_version01____main()

  // Sub-modules, and any changes to those submodules:
  environment: colegrove_albrecht_friel_2000_version01__environment(time_);
  Ca_extrusion_across_the_plasma_membrane: colegrove_albrecht_friel_2000_version01__Ca_extrusion_across_the_plasma_membrane(J_pm, Ca_i, time_);
  mitochondrial_Ca_uptake: colegrove_albrecht_friel_2000_version01__mitochondrial_Ca_uptake(J_uni, Ca_i, time_);
  mitochondrial_Ca_release: colegrove_albrecht_friel_2000_version01__mitochondrial_Ca_release(J_NaCa, Ca_inhibited_J_NaCa, J_mito, J_uni, Ca_i, Ca_m, time_);
  intracellular_calcium: colegrove_albrecht_friel_2000_version01__intracellular_calcium(Ca_i, J_pm, J_mito, time_);
  mitochondrial_calcium: colegrove_albrecht_friel_2000_version01__mitochondrial_calcium(Ca_m, J_mito, time_);
end