//Created by libAntimony v2.4
model chauhan_2008__environment(time_)

  // Variable initializations:
  time_ = ;
end

model chauhan_2008__CycE(CycE, v91, HBEGF, k91, v92, CycD, k92, d11, CycECKI, d9, deg, v11, CKI, time_)

  // Rate Rules:
  CycE' = ((1 * v91 * power(HBEGF, 2)) / (power(k91, 2) + power(HBEGF, 2)) + (1 * v92 * power(CycD, 4)) / (power(k92, 4) + power(CycD, 4)) + d11 * CycECKI) - (d9 * power(deg, 2) + v11 * CKI) * CycE;

  // Variable initializations:
  CycE = 0;
  v91 = ;
  HBEGF = ;
  k91 = ;
  v92 = ;
  CycD = ;
  k92 = ;
  d11 = ;
  CycECKI = ;
  d9 = ;
  deg = ;
  v11 = ;
  CKI = ;
  time_ = ;
end

model chauhan_2008__CycD(CycD, v8, IEG, HBEGF, k8, d10, d8, deg, v10, CKI, CycDCKI, time_)

  // Rate Rules:
  CycD' = ((v8 * IEG * HBEGF) / (k8 + IEG) + d10 * CycDCKI) - (d8 * power(deg / 1, 1.5) + v10 * CKI) * CycD;

  // Variable initializations:
  CycD = 0;
  v8 = ;
  IEG = ;
  HBEGF = ;
  k8 = ;
  d10 = ;
  d8 = ;
  deg = ;
  v10 = ;
  CKI = ;
  CycDCKI = ;
  time_ = ;
end

model chauhan_2008__CycECKI(v11, CKI, CycE, d11, CycECKI, time_)

  // Rate Rules:
  CycECKI' = v11 * CKI * CycE - d11 * CycECKI;

  // Variable initializations:
  v11 = ;
  CKI = ;
  CycE = ;
  d11 = ;
  CycECKI = 0;
  time_ = ;
end

model chauhan_2008__CycDCKI(v10, CKI, CycD, d10, CycDCKI, time_)

  // Rate Rules:
  CycDCKI' = v10 * CKI * CycD - d10 * CycDCKI;

  // Variable initializations:
  v10 = ;
  CKI = ;
  CycD = ;
  d10 = ;
  CycDCKI = 0;
  time_ = ;
end

model chauhan_2008__CKI(CKI, v7, PIC, d10, CycDCKI, d11, CycECKI, d7, v10, CycD, v11, CycE, time_)

  // Rate Rules:
  CKI' = (v7 * PIC + d10 * CycDCKI + d11 * CycECKI) - (d7 + v10 * CycD + v11 * CycE) * CKI;

  // Variable initializations:
  CKI = 0;
  v7 = ;
  PIC = ;
  d10 = ;
  CycDCKI = ;
  d11 = ;
  CycECKI = ;
  d7 = ;
  v10 = ;
  CycD = ;
  v11 = ;
  CycE = ;
  time_ = ;
end

model chauhan_2008__HGF(HGF, v5, IEG, k5, km5, PAI, f5, d5, time_)

  // Rate Rules:
  HGF' = ((v5 * IEG) / (1 + power(PAI / km5, 4))) * (1 + (f5 * HGF) / (k5 + HGF)) - d5 * HGF;

  // Variable initializations:
  HGF = 0;
  v5 = ;
  IEG = ;
  k5 = ;
  km5 = ;
  PAI = ;
  f5 = ;
  d5 = ;
  time_ = ;
end

model chauhan_2008__PGE(PGE, v2, PIC, d2, time_)

  // Rate Rules:
  PGE' = v2 * PIC - d2 * PGE;

  // Variable initializations:
  PGE = 0;
  v2 = ;
  PIC = ;
  d2 = ;
  time_ = ;
end

model chauhan_2008__PIC(PIC, v1, PGE, km1, D, k1, d1, time_)

  // Rate Rules:
  PIC' = (v1 / (1 + power(PGE / km1, 2))) * (D / (k1 + D)) - d1 * PIC;

  // Variable initializations:
  PIC = 0;
  v1 = ;
  PGE = ;
  km1 = ;
  D = ;
  k1 = ;
  d1 = ;
  time_ = ;
end

model chauhan_2008__D(D, I0, d0, time_)

  // Assignment Rules:
  D := I0 * exp(- d0 * t);

  // Variable initializations:
  I0 = ;
  d0 = ;
  t = 0;
  time_ = ;
end

model chauhan_2008__deg(deg, v12, CycE, d12, time_)

  // Rate Rules:
  deg' = v12 * root(CycE / 1) - d12 * deg;

  // Variable initializations:
  deg = 0;
  v12 = ;
  CycE = ;
  d12 = ;
  time_ = ;
end

model chauhan_2008__HBEGF(HBEGF, v6, D, k61, k62, k63, IEG, HGF, d6, time_)

  // Rate Rules:
  HBEGF' = v6 * (power(D, 4) / (power(k61, 4) + power(D, 4))) * (IEG / (k62 + IEG)) * (HGF / (k63 + HGF)) - d6 * HBEGF;

  // Variable initializations:
  HBEGF = 0;
  v6 = ;
  D = ;
  k61 = ;
  k62 = ;
  k63 = ;
  IEG = ;
  HGF = ;
  d6 = ;
  time_ = ;
end

model chauhan_2008__IEG(IEG, v3, PIC, k3, d3, time_)

  // Rate Rules:
  IEG' = (v3 * power(PIC, 3)) / (power(k3, 3) + power(PIC, 3)) - d3 * IEG;

  // Variable initializations:
  IEG = 0;
  v3 = ;
  PIC = ;
  k3 = ;
  d3 = ;
  time_ = ;
end

model chauhan_2008__PAI(PAI, v4, PIC, k4, d4, time_)

  // Rate Rules:
  PAI' = (v4 * power(PIC, 3)) / (power(k4, 3) + power(PIC, 3)) - d4 * PAI;

  // Variable initializations:
  PAI = 0;
  v4 = ;
  PIC = ;
  k4 = ;
  d4 = ;
  time_ = ;
end

model chauhan_2008__model_parameters(I0, d0, v1, km1, k1, d1, v2, d2, v3, k3, d3, v4, k4, d4, v5, f5, k5, km5, d5, v6, k61, k62, k63, d6, v7, d7, v8, k8, d8, v91, k91, v92, k92, d9, v10, d10, v11, d11, v12, d12)

  // Variable initializations:
  I0 = 4;
  d0 = 0.05;
  v1 = 2;
  km1 = 1;
  k1 = 0.5;
  d1 = 0.7;
  v2 = 0.8;
  d2 = 0.01;
  v3 = 6;
  k3 = 0.5;
  d3 = 10;
  v4 = 60;
  k4 = 0.5;
  d4 = 10;
  v5 = 8.1;
  f5 = 5;
  k5 = 0.125;
  km5 = 0.18;
  d5 = 0.008;
  v6 = 24;
  k61 = 0.9;
  k62 = 0.0005;
  k63 = 1;
  d6 = 0.1;
  v7 = 1.6;
  d7 = 0.3;
  v8 = 0.8;
  k8 = 0.005;
  d8 = 0.002;
  v91 = 0.8;
  k91 = 40;
  v92 = 0.16;
  k92 = 10;
  d9 = 0.0002;
  v10 = 0.8;
  d10 = 8.1;
  v11 = 800;
  d11 = 800;
  v12 = 0.56;
  d12 = 0.025;
end

model *chauhan_2008____main()

  // Sub-modules, and any changes to those submodules:
  environment: chauhan_2008__environment(time_);
  CycE: chauhan_2008__CycE(CycE0, v91, HBEGF0, k91, v92, CycD0, k92, d11, CycECKI0, d9, deg0, v11, CKI0, time_);
  CycD: chauhan_2008__CycD(CycD0, v8, IEG0, HBEGF0, k8, d10, d8, deg0, v10, CKI0, CycDCKI0, time_);
  CycECKI: chauhan_2008__CycECKI(v11, CKI0, CycE0, d11, CycECKI0, time_);
  CycDCKI: chauhan_2008__CycDCKI(v10, CKI0, CycD0, d10, CycDCKI0, time_);
  CKI: chauhan_2008__CKI(CKI0, v7, PIC0, d10, CycDCKI0, d11, CycECKI0, d7, v10, CycD0, v11, CycE0, time_);
  HGF: chauhan_2008__HGF(HGF0, v5, IEG0, k5, km5, PAI0, f5, d5, time_);
  PGE: chauhan_2008__PGE(PGE0, v2, PIC0, d2, time_);
  PIC: chauhan_2008__PIC(PIC0, v1, PGE0, km1, D0, k1, d1, time_);
  D: chauhan_2008__D(D0, I0, d0, time_);
  deg: chauhan_2008__deg(deg0, v12, CycE0, d12, time_);
  HBEGF: chauhan_2008__HBEGF(HBEGF0, v6, D0, k61, k62, k63, IEG0, HGF0, d6, time_);
  IEG: chauhan_2008__IEG(IEG0, v3, PIC0, k3, d3, time_);
  PAI: chauhan_2008__PAI(PAI0, v4, PIC0, k4, d4, time_);
  model_parameters: chauhan_2008__model_parameters(I0, d0, v1, km1, k1, d1, v2, d2, v3, k3, d3, v4, k4, d4, v5, f5, k5, km5, d5, v6, k61, k62, k63, d6, v7, d7, v8, k8, d8, v91, k91, v92, k92, d9, v10, d10, v11, d11, v12, d12);
end