//Created by libAntimony v2.4 model renal_H_ATPase_model__environment(time_) // Variable initializations: time_ = ; end model renal_H_ATPase_model__EH(EH, k1, k2, k3, k4, E, EH2, Ha, time_) // Rate Rules: EH' = (k1 * Ha * E + k4 * EH2) - (k2 * EH + k3 * Ha * EH); // Variable initializations: EH = ; k1 = ; k2 = ; k3 = ; k4 = ; E = ; EH2 = ; Ha = ; time_ = ; end model renal_H_ATPase_model__E(E, k1, k2, k9, k10, EH, E_, Ha, ATP_, ADP_, Pi_, time_) // Rate Rules: E' = (k10 * ADP_ * Pi_ * E_ + k2 * EH) - (k1 * Ha * E + k9 * ATP_ * E); // Variable initializations: E = ; k1 = ; k2 = ; k9 = ; k10 = ; EH = ; E_ = ; Ha = ; ATP_ = ; ADP_ = ; Pi_ = ; time_ = ; end model renal_H_ATPase_model__EH2(EH2, k11, k12, k3, k4, EH, EH2_, Ha, time_) // Rate Rules: EH2' = (k3 * Ha * EH + k12 * EH2_) - (k4 * EH2 + k11 * EH2); // Variable initializations: EH2 = ; k11 = ; k12 = ; k3 = ; k4 = ; EH = ; EH2_ = ; Ha = ; time_ = ; end model renal_H_ATPase_model__EH_(EH_, k5, k6, k7, k8, E_, EH2_, H_, time_) // Rate Rules: EH_' = (k5 * H_ * E_ + k8 * EH2_) - (k6 * EH_ + k7 * H_ * EH_); // Variable initializations: EH_ = ; k5 = ; k6 = ; k7 = ; k8 = ; E_ = ; EH2_ = ; H_ = ; time_ = ; end model renal_H_ATPase_model__E_(E_, k5, k6, k9, k10, EH_, E, H_, ATP_, ADP_, Pi_, time_) // Rate Rules: E_' = (k9 * ATP_ * E + k6 * EH_) - (k5 * H_ * E_ + k10 * ADP_ * Pi_ * E_); // Variable initializations: E_ = ; k5 = ; k6 = ; k9 = ; k10 = ; EH_ = ; E = ; H_ = ; ATP_ = ; ADP_ = ; Pi_ = ; time_ = ; end model renal_H_ATPase_model__EH2_(EH2_, k11, k12, k7, k8, EH_, EH2, H_, time_) // Rate Rules: EH2_' = (k7 * H_ * EH_ + k11 * EH2) - (k8 * EH2_ + k12 * EH2_); // Variable initializations: EH2_ = ; k11 = ; k12 = ; k7 = ; k8 = ; EH_ = ; EH2 = ; H_ = ; time_ = ; end model renal_H_ATPase_model__reaction_constants(k1, k2, k3, k4, k5, k6, k7, k8, k9, k10, k11, k12, Ha, H_, ADP_, ATP_, Pi_) // Assignment Rules: Ha := H * exp((F * (psi + psi_)) / (R * T)); // Variable initializations: k1 = 8.33E9; k2 = 1.00E3; k3 = 8.33E9; k4 = 1.00E4; k5 = 2.5E10; k6 = 1.0E3; k7 = 2.5E10; k8 = 2.5E2; k9 = 1.00E9; k10 = 1.80E5; k11 = 5.00E2; k12 = 1.00E2; H_ = 1.0; ADP_ = 1.0; ATP_ = 1.0; Pi_ = 1.0; psi = 1.0; psi_ = -89.6; H = 1.0; R = 8.314; T = 310.0; F = 96500.0; end model *renal_H_ATPase_model____main() // Sub-modules, and any changes to those submodules: environment: renal_H_ATPase_model__environment(time_); EH: renal_H_ATPase_model__EH(EH0, k1, k2, k3, k4, E0, EH20, Ha, time_); E: renal_H_ATPase_model__E(E0, k1, k2, k9, k10, EH0, E_0, Ha, ATP_, ADP_, Pi_, time_); EH2: renal_H_ATPase_model__EH2(EH20, k11, k12, k3, k4, EH0, EH2_0, Ha, time_); EH_: renal_H_ATPase_model__EH_(EH_0, k5, k6, k7, k8, E_0, EH2_0, H_, time_); E_: renal_H_ATPase_model__E_(E_0, k5, k6, k9, k10, EH_0, E0, H_, ATP_, ADP_, Pi_, time_); EH2_: renal_H_ATPase_model__EH2_(EH2_0, k11, k12, k7, k8, EH_0, EH20, H_, time_); reaction_constants: renal_H_ATPase_model__reaction_constants(k1, k2, k3, k4, k5, k6, k7, k8, k9, k10, k11, k12, Ha, H_, ADP_, ATP_, Pi_); end