//Created by libAntimony v2.4
model bi_model_1999_version01__environment(t)

  // Variable initializations:
  t = ;
end

model bi_model_1999_version01__RAF(t, PKC, MAPK_star, GTPRasRaf_star)

  // Rate Rules:
  Raf' = (- PKC * Raf * Vmax1) / (km1 + Raf) + (Raf_star * PP2A * Vmax3) / (km3 + Raf_star);
  Raf_star' = (((PKC * Raf * Vmax1) / (km1 + Raf) - (Raf_star * PP2A * Vmax3) / (km3 + Raf_star)) - (Raf_star * MAPK_star * Vmax2) / (km2 + Raf_star)) + (Raf_star_star * PP2A * Vmax4) / (km4 + Raf_star_star);
  Raf_star_star' = (Raf_star * MAPK_star * Vmax2) / (km2 + Raf_star) - (Raf_star_star * PP2A * Vmax4) / (km4 + Raf_star_star);
  GTPRas' = - GTPRas * Raf_star * kf5 + GTPRasRaf_star * kb5;
  GTPRasRaf_star' = GTPRas * Raf_star * kf5 - GTPRasRaf_star * kb5;

  // Variable initializations:
  t = ;
  kf5 = 0.00004;
  kb5 = 0.5;
  km1 = 66.666666667;
  km2 = 25.64166667;
  km3 = 15.6565;
  km4 = 15.6565;
  Vmax1 = 4;
  Vmax2 = 10;
  Vmax3 = 6;
  Vmax4 = 6;
  PKC = ;
  PP2A = 0.224;
  MAPK_star = ;
  Raf = 0.1;
  Raf_star = 0;
  Raf_star_star = 0;
  GTPRas = 0.1;
  GTPRasRaf_star = 0;
end

model bi_model_1999_version01__MAPKK(t, GTPRasRaf_star, MAPKK_star_star)

  // Rate Rules:
  MAPKK' = (- MAPKK * Vmax6 * GTPRasRaf_star) / (km6 + MAPKK) + (MAPKK_star * Vmax8 * PP2A) / (km8 + MAPKK_star);
  MAPKK_star' = (((MAPKK * Vmax6 * GTPRasRaf_star) / (km6 + MAPKK) - (MAPKK_star * Vmax8 * PP2A) / (km8 + MAPKK_star)) - (MAPKK_star * Vmax7 * GTPRasRaf_star) / (km7 + MAPKK_star)) + (MAPKK_star_star * Vmax9 * PP2A) / (km9 + MAPKK_star_star);
  MAPKK_star_star' = (MAPKK_star * Vmax7 * GTPRasRaf_star) / (km7 + MAPKK_star) - (MAPKK_star_star * Vmax9 * PP2A) / (km9 + MAPKK_star_star);

  // Variable initializations:
  t = ;
  km6 = 0.159091667;
  km7 = 0.159091667;
  km8 = 15.6565;
  km9 = 15.6565;
  Vmax6 = 0.105;
  Vmax7 = 0.105;
  Vmax8 = 6;
  Vmax9 = 6;
  PP2A = 0.224;
  GTPRasRaf_star = ;
  MAPKK = 0.18;
  MAPKK_star = 0;
  MAPKK_star_star = 0;
end

model bi_model_1999_version01__MAPK(t, MAPKK_star_star, MAPK_star)

  // Rate Rules:
  MAPK' = (- MAPK * Vmax10 * MAPKK_star_star) / (km10 + MAPK) + (MAPK_tyr * Vmax12 * MKP1) / (km12 + MAPK_tyr);
  MAPK_tyr' = (((MAPK * Vmax10 * MAPKK_star_star) / (km10 + MAPK) - (MAPK_tyr * Vmax12 * MKP1) / (km12 + MAPK_tyr)) - (MAPK_tyr * Vmax11 * MAPKK_star_star) / (km11 + MAPK_tyr)) + (MAPK_star * Vmax13 * MKP1) / (km13 + MAPK_star);
  MAPK_star' = (MAPK_tyr * Vmax11 * MAPKK_star_star) / (km11 + MAPK_tyr) - (MAPK_star * Vmax13 * MKP1) / (km13 + MAPK_star);

  // Variable initializations:
  t = ;
  km10 = 0.046296667;
  km11 = 0.046296667;
  km12 = 0.066666667;
  km13 = 0.066666667;
  Vmax10 = 0.15;
  Vmax11 = 0.15;
  Vmax12 = 1;
  Vmax13 = 1;
  MAPKK_star_star = ;
  MAPK = 0.36;
  MAPK_tyr = 0;
  MAPK_star = 0;
  MKP1 = 0.032;
end

model bi_model_1999_version01__undefinedvariables(t, PKC)

  // Variable initializations:
  t = ;
  PKC = 0.1;
end

model *bi_model_1999_version01____main()

  // Sub-modules, and any changes to those submodules:
  environment: bi_model_1999_version01__environment(t);
  RAF: bi_model_1999_version01__RAF(t, PKC, MAPK_star, GTPRasRaf_star);
  MAPKK: bi_model_1999_version01__MAPKK(t, GTPRasRaf_star, MAPKK_star_star);
  MAPK: bi_model_1999_version01__MAPK(t, MAPKK_star_star, MAPK_star);
  undefinedvariables: bi_model_1999_version01__undefinedvariables(t, PKC);
end