//Created by libAntimony v2.4 model bagci_2008a__environment(time_) // Variable initializations: time_ = ; end model bagci_2008a__NO(NO, O_2m, N2O3, GSNO, CcOX, FeLn, r_4NO, r_12bNOp, r_12bNOm, r_14NO, r_15NO, r_16NO, k_1NO, k_4NO, k_12aNO, k_12bNOp, k_12bNOm, k_14NO, k_15NO, k_16NO, time_) // Assignment Rules: r_1NO := k_1NO; r_4NO := k_4NO * NO * O_2m; r_12aNO := k_12aNO * power(NO, 2) * O_2; r_12bNOp := k_12bNOp * NO_2 * NO; r_12bNOm := k_12bNOm * N2O3; r_14NO := k_14NO * GSNO; r_15NO := k_15NO * CcOX * NO; r_16NO := k_16NO * FeLn * NO; // Rate Rules: NO' = (((((r_1NO - r_4NO) - 2 * r_12aNO) - r_12bNOp) + r_12bNOm + r_14NO) - r_15NO) - r_16NO; NO_2' = (2 * r_12aNO - r_12bNOp) + r_12bNOm; CcOX' = - r_15NO; // Variable initializations: NO = 0; O_2m = ; O_2 = 35; NO_2 = 0; N2O3 = ; GSNO = ; CcOX = 0.1; FeLn = ; k_1NO = ; k_4NO = ; k_12aNO = ; k_12bNOp = ; k_12bNOm = ; k_14NO = ; k_15NO = ; k_16NO = ; time_ = ; end model bagci_2008a__O_2m(O_2m, SOD, GSNO, r_4NO, r_5NO, r_10NO, k_2NO, k_5NO, k_10NO, time_) // Assignment Rules: r_2NO := k_2NO; r_5NO := k_5NO * SOD * O_2m; r_10NO := k_10NO * power(GSNO, 2) * O_2m; // Rate Rules: O_2m' = ((r_2NO - r_4NO) - r_5NO) - r_10NO; // Variable initializations: O_2m = 0; SOD = 10; GSNO = ; r_4NO = ; k_2NO = ; k_5NO = ; k_10NO = ; time_ = ; end model bagci_2008a__ONOO_m(ONOO_m, GSH, r_4NO, r_6NO, r_7NO, r_8NO, r_9NO, k_6NO, k_7NO, k_8NO, k_9NO, time_) // Assignment Rules: r_6NO := k_6NO * ONOO_m * GSH; r_7NO := k_7NO * ONOO_m * GPX; r_8NO := k_8NO * ONOO_m * CO_2; r_9NO := k_9NO * ONOO_m * Cyt_c; // Rate Rules: ONOO_m' = (((r_4NO - r_6NO) - r_7NO) - r_8NO) - r_9NO; // Variable initializations: ONOO_m = 0; GSH = ; GPX = 5.8; CO_2 = 1000; Cyt_c = 400; r_4NO = ; k_6NO = ; k_7NO = ; k_8NO = ; k_9NO = ; time_ = ; end model bagci_2008a__GSH(GSH, N2O3, FeLn, FeLn_0, GSH_0, GSNO, r_6NO, r_11NO, r_17NO, k_11NO, v_m, k_m, k_17NO, time_) // Assignment Rules: GSSG := ((GSH_0 - GSH) - GSNO) / 2; FeLnNO := FeLn_0 - FeLn; r_11NO := k_11NO * N2O3 * GSH; r_m := (v_m * GSSG) / (k_m + GSSG); r_17NO := k_17NO * FeLnNO * GSH; // Rate Rules: GSH' = ((- r_6NO - r_11NO) + 2 * r_m) - r_17NO; // Variable initializations: GSH = 10000; N2O3 = ; FeLn = ; FeLn_0 = ; GSH_0 = ; GSNO = ; r_6NO = ; k_11NO = ; v_m = ; k_m = ; k_17NO = ; time_ = ; end model bagci_2008a__GSNO(GSNO, r_6NO, r_10NO, r_11NO, r_14NO, r_17NO, time_) // Rate Rules: GSNO' = (((r_6NO - 2 * r_10NO) + r_11NO) - r_14NO) + r_17NO; // Variable initializations: GSNO = 0; r_6NO = ; r_10NO = ; r_11NO = ; r_14NO = ; r_17NO = ; time_ = ; end model bagci_2008a__N2O3(N2O3, r_11NO, r_12bNOp, r_12bNOm, k_13NO, time_) // Assignment Rules: r_13NO := k_13NO * N2O3; // Rate Rules: N2O3' = ((- r_11NO + r_12bNOp) - r_12bNOm) - r_13NO; // Variable initializations: N2O3 = 0; r_11NO = ; r_12bNOp = ; r_12bNOm = ; k_13NO = ; time_ = ; end model bagci_2008a__FeLn(FeLn, r_16NO, r_17NO, time_) // Rate Rules: FeLn' = - r_16NO + r_17NO; // Variable initializations: FeLn = 0.05; r_16NO = ; r_17NO = ; time_ = ; end model bagci_2008a__model_constant(k_1NO, k_2NO, k_4NO, k_5NO, k_6NO, k_7NO, k_8NO, k_9NO, k_10NO, k_11NO, k_12aNO, k_12bNOm, k_12bNOp, k_13NO, v_m, k_m, k_14NO, k_15NO, k_16NO, k_17NO, k_17bNO, FeLn_0, GSH_0) // Variable initializations: k_1NO = 1; k_2NO = 0.1; k_4NO = 6700; k_5NO = 2400; k_6NO = 0.00135; k_7NO = 2; k_8NO = 0.058; k_9NO = 0.025; k_10NO = 0.0006; k_11NO = 66; k_12aNO = 0.000006; k_12bNOm = 81000; k_12bNOp = 1100; k_13NO = 1600; v_m = 320; k_m = 50; k_14NO = 0.0002; k_15NO = 100; k_16NO = 1.21; k_17NO = 66; k_17bNO = 0.0002; FeLn_0 = 0.05; GSH_0 = 10000; end model *bagci_2008a____main() // Sub-modules, and any changes to those submodules: environment: bagci_2008a__environment(time_); NO: bagci_2008a__NO(NO0, O_2m0, N2O30, GSNO0, CcOX, FeLn0, r_4NO, r_12bNOp, r_12bNOm, r_14NO, r_15NO, r_16NO, k_1NO, k_4NO, k_12aNO, k_12bNOp, k_12bNOm, k_14NO, k_15NO, k_16NO, time_); O_2m: bagci_2008a__O_2m(O_2m0, SOD, GSNO0, r_4NO, r_5NO, r_10NO, k_2NO, k_5NO, k_10NO, time_); ONOO_m: bagci_2008a__ONOO_m(ONOO_m0, GSH0, r_4NO, r_6NO, r_7NO, r_8NO, r_9NO, k_6NO, k_7NO, k_8NO, k_9NO, time_); GSH: bagci_2008a__GSH(GSH0, N2O30, FeLn0, FeLn_0, GSH_0, GSNO0, r_6NO, r_11NO, r_17NO, k_11NO, v_m, k_m, k_17NO, time_); GSNO: bagci_2008a__GSNO(GSNO0, r_6NO, r_10NO, r_11NO, r_14NO, r_17NO, time_); N2O3: bagci_2008a__N2O3(N2O30, r_11NO, r_12bNOp, r_12bNOm, k_13NO, time_); FeLn: bagci_2008a__FeLn(FeLn0, r_16NO, r_17NO, time_); model_constant: bagci_2008a__model_constant(k_1NO, k_2NO, k_4NO, k_5NO, k_6NO, k_7NO, k_8NO, k_9NO, k_10NO, k_11NO, k_12aNO, k_12bNOm, k_12bNOp, k_13NO, v_m, k_m, k_14NO, k_15NO, k_16NO, k_17NO, k_17bNO, FeLn_0, GSH_0); end